View Item 

Show simple item record

Gene and other biological therapies for vascular diseases

dc.contributor.authorStephan, Dominique J.en_US
dc.contributor.authorNabel, Elizabeth G.en_US
dc.date.accessioned2010-06-01T18:38:32Z
dc.date.available2010-06-01T18:38:32Z
dc.date.issued1997-03-04en_US
dc.identifier.citationStephan, D.; Nabel, EG (1997). "Gene and other biological therapies for vascular diseases." Fundamental & Clinical Pharmacology 11(2): 97-110. <http://hdl.handle.net/2027.42/71843>en_US
dc.identifier.issn0767-3981en_US
dc.identifier.issn1472-8206en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/71843
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=9107554&dopt=citationen_US
dc.description.abstractGene transfer and antisense therapy offer novel approaches to the study and treatment of vascular diseases. The localized nature of vascular diseases like restenosis has made the application of genetic material an attractive therapeutic option. Viral and nonviral vectors have been developed to facilitate the entry of foreign DNA or RNA into cells. Vector improvement and production, demonstration of vector safety and demonstration of therapeutic efficacy are among the main present challenges. Various strategies have already been shown to be successful in preventing restenosis in animal models and include: the transfer of the herpes simplex virus thymidine kinase associated with ganciclovir; transfection of the cell cycle regulatory genes encoding for the active form of retinoblastoma gene product (Rb) or the cyclin-dependant kinase inhibitor p21, and antisense therapy. Therapeutic angiogenesis using gene transfer is a new strategy for the treatment of severe limb ischemia. Transfection of DNA encoding for the vascular endothelial growth factor has resulted in increasing collateral flow in animal models of peripheral ischemia. This approach is currently being investigated in a clinical trial in patients with distal ischemia. Other potential targets for genetic treatment in cardiovascular diseases include thrombosis, extracellular matrix synthesis and lipid metabolism.en_US
dc.format.extent1632556 bytes
dc.format.extent3109 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherBlackwell Publishing Ltden_US
dc.rights1997 SociÉtÉ FranÇaise de Pharmacologie et de ThÉrapeutiqueen_US
dc.subject.otherGene Transferen_US
dc.subject.otherGene Expressionen_US
dc.subject.otherGene Vectorsen_US
dc.subject.otherAntisense Oligonucleotidesen_US
dc.subject.otherRestenosisen_US
dc.subject.otherAngiogenesisen_US
dc.titleGene and other biological therapies for vascular diseasesen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelPharmacy and Pharmacologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Internal Medicine and Physiology, Cardiovascular Research Center, University of Michigan, Ann Arbor, MI, USAen_US
dc.contributor.affiliationotherService d'Hypertension et des Maladies Vasculaires, Institut de Pharmacologie et de MÉdecine ExpÉrimentale, FacultÉ de MÉdecine, CHRU Strasbourg, Strasbourg 67000 Franceen_US
dc.identifier.pmid9107554en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/71843/1/j.1472-8206.1997.tb00175.x.pdf
dc.identifier.doi10.1111/j.1472-8206.1997.tb00175.xen_US
dc.identifier.sourceFundamental & Clinical Pharmacologyen_US
dc.identifier.citedreferenceBarr E., Carroll J., Kalynych A. et al. Efficient catheter-mediated gene transfer into the heart using replication-defective adenovirus. Gene Ther 1994; 1: 51 – 8.en_US
dc.identifier.citedreferenceBauters C., Asahara T., Lu Z. et al. Recovery of disturbed endothelium-dependent flow in the collateral-perfused rabbit ischemic hindlimb after administration of vascular endothelial growth factor. Circulation 1995; 91: 2802 – 9.en_US
dc.identifier.citedreferenceBennet M., Anglin S., McEwan J., Jagoe R., Newby A., Evan G. Inhibition of vascular smooth muscle cell proliferation in vitro and in vivo by c-myc antisense oligonucleotides. J Clin Invest 1993; 93: 820 – 8.en_US
dc.identifier.citedreferenceBennet M., Schwartz S. Antisense therapy for angioplasty restenosis some critical considerations. Circulation 1995; 92: 1981 – 93.en_US
dc.identifier.citedreferenceBorrelli E., Heyman R., Hsi M., Evans R. Targeting of an inducible toxic phenotype in animal cells. Proc Natl Acad Sci USA 1988; 85: 7572 – 6.en_US
dc.identifier.citedreferenceBoussif O., Lezoualc'h F., Zanta MA et al. A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine. Proc Natl Acad Sci USA 1995; 92: 7297 – 301.en_US
dc.identifier.citedreferenceChang M., Barr E., Seltzer J. et al. Cytostatic gene therapy for vascular proliferative disorders with a constituvely active form of the retinoblastoma gene product. Science 1995a; 267: 518 – 22.en_US
dc.identifier.citedreferenceChang M., Ohno T., Gordon D. et al. Adenovirus-mediated transfer of the herpes simplex virus thymidine kinase gene inhibits vascular smooth muscle proliferation and neointima formation following balloon angioplasty of the rat carotid artery. Mol Med 1995b; 1: 172 – 81.en_US
dc.identifier.citedreferenceChang M., Barr E., Lu M., Barton K., Leiden J. Adenovirus-mediated over-expression of the cyclin/cyclin-dependant kinase inhibitor, p21 inhibits vascular smooth muscle cell proliferation and neointima formation in the rat carotid artery model of balloon angioplasty. J Clin Invest 1996; 96: 2260 – 8.en_US
dc.identifier.citedreferenceChen S., Wilson J., Muller D. Adenovirus-mediated gene transfer of soluble vascular cell adhesion molecule to porcine interposition vein grafts. Circulation 1994; 89: 1922 – 8.en_US
dc.identifier.citedreferenceConnolly D. Vascular permeability factor a unique regulator of blood vessel function. J Cell Biochem 1991; 47: 219 – 23.en_US
dc.identifier.citedreferenceConte M., Birinyi L., Miyata T. et al. Efficient repopulation of denuded rabbit arteries with autologous gentically modified endothelial cells. Circulation 1994; 23: 2161 – 9.en_US
dc.identifier.citedreferenceDichek D., Neville R., Zwiebel J., Freeman S., Leon M., Anderson F. Seeding of intravascular stents with gentically engineered endothelial cells. Circulation 1989; 80: 1347 – 53.en_US
dc.identifier.citedreferenceEllis S., Roubin G., Wilentz J., Douglas J., King S. Effect of 18–24 hour heparin administration for prevention of restenosis after uncomplicated coronary angioplasty. Am Heart J 1989; 117: 777 – 82.en_US
dc.identifier.citedreferenceEngelhardt J., Ye X., Doranz B., Wilson J. Ablation of E2A in recombinant adenoviruses improves transgene persistence and decreases inflammatory response in mouse liver. Proc Natl Acad Sci USA 1994; 91: 6196 – 200.en_US
dc.identifier.citedreferenceEuropean Working Group on Critical Limb Ishemia, and Ischemia. Second European consensus document on chronic critical leg ischemia. Circulation 1991; 84 ( suppl IV ): IV-1 – IV-6.en_US
dc.identifier.citedreferenceFeldman L., Steg P., Zheng L. et al. Low-efficiency of percutaneous adenovirus-mediated arterial gene transfer in the atherosclerotic rabbit. J Clin Invest 1995; 95: 2662 – 71.en_US
dc.identifier.citedreferenceFeigner P. Particulate systems and polymers for in vitro and in vivo delivery of polynucleotides. Adv Drug Delivery Rev 1990; 5: 163 – 87.en_US
dc.identifier.citedreferenceFeigner P., Ringold G. Cationic liposome-mediated transfection. Nature 1989; 337: 387 – 8.en_US
dc.identifier.citedreferenceFeigner P., Gadek T., Holm M. et al. Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure. Proc Natl Acad Sci USA 1987; 84: 7413 – 7.en_US
dc.identifier.citedreferenceFischman DL, Leon MB, Bairn DS et al. A randomized comparison of coronary stent placement and balloon angioplasty in the treatment of coronary artery disease. (The STRESS trial). N Engl J Med 1994; 331: 496 – 501.en_US
dc.identifier.citedreferenceFrench B., Mazur W., Ali N. et al. Percutaneous transluminal in vivo gene transfer by recombinant adenovirus in normal porcine coronary arteries, atherosclerotic arteries, and two models of coronary restenosis. Circulation 1994; 90: 2402 – 13.en_US
dc.identifier.citedreferenceGellman J., Ezekowitz M., Sarembock I. et al. Effect of lovastatin on intimal hyperplasia after balloon angioplasty: a study in an atherosclerotic hypercholesterolemic rabbit. J Am Coll Cardiol 1991; 17: 251 – 9.en_US
dc.identifier.citedreferenceGerard R., Meidel R. Adenovirus-mediated gene transfer. Trends Cardiovasc Med 1993; 3: 171 – 7.en_US
dc.identifier.citedreferenceGlagov S. Intimal hyperplasia, vascular remodeling, and the restenosis problem. Circulation 1994; 89: 2888 – 91.en_US
dc.identifier.citedreferenceGlagov S., Weisenberg E., Zarins CK, Stankunavicius R., Kolettis GJ. Compensatory enlargement of human atherosclerotic coronary arteries. N Engl J Med 1987; 316: 1371 – 5.en_US
dc.identifier.citedreferenceGrossman M., Raper S., Kozarsky K. et al. Successful ex vivo gene therapy directed to liver in a patient with familial hypercholesterolaemia. Nature Genet 1994; 6: 335 – 41.en_US
dc.identifier.citedreferenceHerz I., Gerard R. Adenovirus-mediated transfer of low density lipoprotein receptor gene acutely accelerates cholesterol clearance in normal mice. Proc Natl Acad Sci USA 1993; 90: 2812 – 6.en_US
dc.identifier.citedreferenceHorwitz M. Adenoviridae and their replication. In: Fields BN, Knipe DM et al, eds. Fundamental Virology, 2nd edn. New York: Raven Press, 1991; 772 – 804.en_US
dc.identifier.citedreferenceHuckle W., Drag M., Acker W. et al. Effects of subtype-selective and balanced angiotensin II receptor antagonists in a porcine coronary artery model of vascular restenosis. Circulation 1996; 93: 1009 – 19.en_US
dc.identifier.citedreferenceIndolfi C., Avvedimento E., Rapacciuolo A. et al. Inhibition of cellular ras prevents smooth muscle cell proliferation after vascular injury in vivo. Nature Med 1995; 1: 541 – 5.en_US
dc.identifier.citedreferenceIsner J., Walsh K., Symes J. et al. Arterial gene therapy for therapeutic angiogenesis in patients with peripheral artery disease. Circulation 1995; 91: 2687 – 92.en_US
dc.identifier.citedreferenceKass-Eisler A., Falck-Pedersen E., Alvira M. et al. Quantitative determination of adenovirus-mediated gene delivery to rat cardiac myocytes in vitro and in vivo. Proc Natl Acad Sci USA 1993; 90: 11498 – 502.en_US
dc.identifier.citedreferenceKass-Eisler A., Falck-Pedersen E., Elfenbein D., Alvira M., Buttrick P., Leinwand L. The impact of developmental stage, route of administration and the immune system on adenovirus-mediated gene transfer. Gene Ther 1994; 1: 395 – 402.en_US
dc.identifier.citedreferenceKolberg R. Gene transfer virus contaminant linked to monkeys' cancer. J NIH Res 1992; 4: 43 – 4.en_US
dc.identifier.citedreferenceKozarsky K., Wilson J. Gene therapy: adenovirus vectors. Curr Opin Gen Dev 1993; 3: 499 – 503.en_US
dc.identifier.citedreferenceLandau C., Lange R., Hillis L. Percutaneous transluminal coronary angioplasty. N Engl J Med 1994; 330: 981 – 93.en_US
dc.identifier.citedreferenceLasic D., Papahadjopoulos D. Liposomes revisited. Science 1995; 267: 1275 – 6.en_US
dc.identifier.citedreferenceLeclerc G., Gal D., Takeshita S., Nikol S., Weir L., Isner J. Percutaneous arterial gene transfer in a rabbit model. Efficiency in normal and balloon-dilated atherosclerotic arteries. J Clin Invest 1992; 90: 936 – 44.en_US
dc.identifier.citedreferenceLemarchand P., Jaffe H., Danel C. et al. Adenovirus-mediated transfer of a recombinant human a1-antitrypsin cDNA to human endothelial cells. Proc Natl Acad Sci USA 1992; 89: 6482 – 6.en_US
dc.identifier.citedreferenceLemarchand P., Jones M., Yamada I., Crystal R. In vivo gene transfer and expression in normal uninjured blood vessels using replication-deficient recombinant adenovirus vectors. Circ Res 1993; 72: 1132 – 8.en_US
dc.identifier.citedreferenceLeyden H., Gibbons G., Morishita R. et al. Gene therapy inhibiting neointimal vascular lesion: in vivo transfer of endothelial cell nitric oxide synthase gene. 1995; 92: 1137 – 41.en_US
dc.identifier.citedreferenceLynch C., Clowes M., Osborne W., Clowes A., Miller A. Long-term expression of human adenosine deaminase in vascular smooth muscle cells of rats: a model of gene therapy. Proc Natl Acad Sci USA 1992; 89: 1138 – 42.en_US
dc.identifier.citedreferenceMERCATOR Study Group. Does the new angiotensin converting enzyme inhibitor cilazapril prevent restenosis after percutaneous transluminal coronary angioplasty? Results of the mercator study: a multicenter, randomized double-blind placebo controlled trial. Circulation 1992; 86: 100 – 10.en_US
dc.identifier.citedreferenceMorishita R., Gibbons G., Ellison K. et al. Single intraluminal delivery of antisense cdc2 kinase and proliferating-cell nuclear antigen oligonucleotides results in chronic inhibition of neointimal hyperplasia. Proc Natl Acad Sci USA 1993a; 90: 8474 – 8.en_US
dc.identifier.citedreferenceMorishita R., Gibbons G., Kaneda Y., Ogihara T., Dzau V. Novel and effective gene transfer technique for study of vascular renin angiotensin system. J Clin Invest 1993b; 91: 2580 – 5.en_US
dc.identifier.citedreferenceMorishita R., Gibbons G., Ellison K. et al. Intimal hyperplasia after vascular injury is inhibited by antisense cdk 2 kinase oligonucleotides. J Clin Invest 1994; 93: 1458 – 64.en_US
dc.identifier.citedreferenceMuhlhauser J., Merrill M., Pili R. et al. VEGF 165 expressed by a replication-deficient recombinant adenovirus vector induces angiogenesis in vivo. Circ Res 1995; 77: 1077 – 86.en_US
dc.identifier.citedreferenceMuller D., Ellis S., Topol E. Colchicine and antineoplastic therapy for the prevention of restenosis after percutaneous coronary interventions. J Am Coll Cardiol 1991; 17 ( Suppl B ): 126B – 31B.en_US
dc.identifier.citedreferenceNabel E., Plautz G., Boyce F., Stanley J., Nabel G. Recombinant gene expression in vivo within endothelial cells of the arterial wall. Science 1989; 244: 1342 – 4.en_US
dc.identifier.citedreferenceNabel E., Plautz G., Nabel G. Site-specific gene expression in vivo by direct gene transfer into the arterial wall. Science 1990; 249: 1285 – 8.en_US
dc.identifier.citedreferenceNabel E., Gordon D., Yang Z. et al. Gene transfer in vivo with DNA-liposome complexes: lack of autoimmunity and gonadal localization. Hum Gene Ther 1992a; 3: 649 – 56.en_US
dc.identifier.citedreferenceNabel E., Plautz G., Nabel G. Transduction of a foreign histocompatibility gene into the arterial wall. Proc Natl Acad Sci USA 1992b; 89: 5157 – 61.en_US
dc.identifier.citedreferenceNabel E., Shum L., Pompili V. et al. Direct transfer of transforming growth factor beta 1 gene into arteries stimulates fibro-cellular hyperplasia. Proc Natl Acad Sci USA 1993a; 90: 10759 – 63.en_US
dc.identifier.citedreferenceNabel E., Yang Z., Liptay S. et al. Recombinant platelet-derived growth factor B gene expression in porcine arteries induces intimal hyperplasia in vivo. J Clin Invest 1993b; 1993: 1822 – 9.en_US
dc.identifier.citedreferenceNabel E., Yang Z., Plautz G. et al. Recombinant fibroblast growth factor-1 promotes intimal hyperplasia and angiogenesis. Nature 1993c; 362: 844 – 6.en_US
dc.identifier.citedreferenceNabel E., Pompili V., Plautz G., Nabel G. Gene transfer and vascular disease. Cardiovasc Res 1994; 28: 445 – 55.en_US
dc.identifier.citedreferenceNabel E., Nabel G. Complex models for the study of gene function in cardiovascular biology. Annu Rev Physiol 1994; 56: 741 – 61.en_US
dc.identifier.citedreferenceNakajima M., Hutchinson H., Fujinaga M. et al. The angiotensin II type 2 (AT2) receptor antagonizes the growth effects of the AT1 receptor: gain-of-function study using gene transfer. Proc Natl Acad Sci USA 1995; 92: 10663 – 7.en_US
dc.identifier.citedreferenceNewman K., Dunn P., Owens J. et al. Adenovirus-mediated gene transfer into normal rabbit arteries results in prolonged vascular cell activation, inflammation, and neointimal hyperplasia. J Clin Invest 1995; 96: 2955 – 65.en_US
dc.identifier.citedreferenceOhno T., Gordon D., San H. et al. Gene therapy for vascular smooth muscle cell proliferation after arterial injury. Science 1994; 265: 781 – 4.en_US
dc.identifier.citedreferencePrince G., Porter D., Jenson A., Horswood R., Chanock R., Ginsberg H. Pathogenesis of adenovirus type 5 pnemonia in cotton rats ( Sigmodon hipsidus ). J Virol 1993; 67: 101 – 11.en_US
dc.identifier.citedreferenceRade J., Schulick A., Virmani R., Dichek D. Local adenoviral-mediated expression of recombinant hirudin reduces neointima after arterial injury. Nature Med 1996; 2: 293 – 8.en_US
dc.identifier.citedreferenceRiessen R., Rahimizadeh H., Blessing E., Takeshita S., Barry J., Isner J. Arterial gene transfer using pure DNA applied directly to a hydrogel-coated angioplasty balloon. Hum Gene Ther 1993; 4: 749 – 58.en_US
dc.identifier.citedreferenceRoss R. The pathogenesis of atherosclerosis: a perspective for the 1990's. Nature 1993; 362: 801 – 9.en_US
dc.identifier.citedreferenceSahni R., Maniet A., Voci G., Banka V. Prevention of restenosis after successful coronary angioplasty. Am Heart J 1991; 121: 1600 – 8.en_US
dc.identifier.citedreferenceSan H., Yang Z., Pompili V. et al. Safety and toxicity of a novel cationic lipid formulation of human gene therapy. Hum Gene Ther 1993; 4: 781 – 8.en_US
dc.identifier.citedreferenceSchulick A., Newman K., Virmani R., Dichek D. In vivo gene transfer into injured carotid arteries. Circulation 1995; 91: 2407 – 14.en_US
dc.identifier.citedreferenceSchwartz R., Holmes D., Topol E. The restenosis paradigm revisited: an alternative proposal for cellular mechanisms. J Am Coll Cardiol 1992; 20: 1284 – 93.en_US
dc.identifier.citedreferenceSerruys PW, de Jaegere P., Kiemeneij C. et al. A comparison of balloon expandable stent implantation with balloon angioplasty in patients with coronary artery disease. (The Benestent study). N Engl J Med 1994; 331: 489 – 95.en_US
dc.identifier.citedreferenceShi Y., Fard A., Vermani P., Zalewski A. Transgene expression in the coronary circulation: transcatheter gene delivery. Gene Ther 1994; 1: 408 – 14.en_US
dc.identifier.citedreferenceSimari R., San H., Rekhter M. et al. Regulation of cellular proliferation and intimal formation following balloon injury in atherosclerotic rabbit arteries. J Clin Invest 1996; 98: 218 – 39.en_US
dc.identifier.citedreferenceSimons M., Edelman E., DeKeyser J., Langer R., Rosenberg R. Antisense c-myb oligonucleotides inhibit intimal arterial smooth muscle cell accumulation in vivo. Nature 1992; 359: 67 – 70.en_US
dc.identifier.citedreferenceSmith K., Galloway K., Kennel W., Ogilvie K., Radatus B. A new nucleoside analog, 9-[[2-hydroxy-1-(hydroxymethyl) ethoxyl]methyl]guanine, highly active in vitro against herpes simplex virus types 1 and 2. Antimicrob Agents Chemother 1982; 22: 55 – 61.en_US
dc.identifier.citedreferenceSteg P., Feldman L., Scoazec J. et al. Arterial gene transfer to rabbit endothelial and smooth muscle cells using percutaneous delivery of an adenoviral vector. Circulation 1994; 90: 1648 – 56.en_US
dc.identifier.citedreferenceStephan D., Yang ZY, San H. et al. A new cationic liposome DNA complex enhances the efficiency of arterial gene transfer in vivo. Hum Gene Ther 1996; 7: 1803 – 12.en_US
dc.identifier.citedreferenceStewart M., Plautz G., Buono L. et al. Gene transfer in vivo with DNA-liposome complexes: safety and acute toxicity in mice. Hum Gene Ther 1992; 3: 267 – 75.en_US
dc.identifier.citedreferenceTakeshita S., Pu L., Stein L. et al. Intramuscular administration of vascular endothelial growth factor induces dose-dependant collateral artery augmentation in a rabbit model of chronic limb ischemia. Circulation 1994; 90: II-228 – 34.en_US
dc.identifier.citedreferenceThornton M., Gruntzig A., Hollman J., King S., Douglas J. Coumadin and aspirin in prevention of recurrence after transluminal coronary angioplasty: a randomized trial. Circulation 1984; 69: 721 – 7.en_US
dc.identifier.citedreferenceVilla A., Guzman L., Poptic E. et al. Effects of antisense c-myb oligonucleotides on vascular smooth muscle cell proliferation and response to vessel wall injury. Circ Res 1995; 76: 505 – 13.en_US
dc.identifier.citedreferenceWagner R. Gene inhibition using antisense oligodeoxynucleotides. Nature 1994; 372: 333 – 5.en_US
dc.identifier.citedreferenceWilson J. Adenoviruses as gene-delivery vehicles. N Engl J Med 1996; 334: 1185 – 7.en_US
dc.identifier.citedreferenceWilson J., Birinyi L., Salomon R., Libby P., Callow A., Mulligan R. Implantation of vascular grafts lined with genetically modified endothelial cells. Science 1989; 244: 1344 – 6.en_US
dc.identifier.citedreferenceYang Y., Nunes F., Berencsi K., Gonczol E., Engelhardt J., Wilson J. Inactivation of E2A in recombinant adenoviruses improves the prospect for gene therapy in cystic fibrosis. Nature Genet 1994; 7: 362 – 9.en_US
dc.identifier.citedreferenceYang ZY, Simari R., Perkins N. et al. Role of the p21 cyclin-dependant kinase inhibitor in limiting intimal cell proliferation in response to arterial injury. Proc Natl Acad Sci USA 1996; 93: 7905 – 10.en_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


Files in this item

Name:
j.1472-8206.1997.tb00175.x.pdf
Size:
1.556MB
Format:
PDF
View/Open

Show simple item record

Remediation of Harmful Language

The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.

Accessibility

If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.