Mycobacterial FurA is a negative regulator of catalase–peroxidase gene katG
dc.contributor.author | Zahrt, Thomas C. | en_US |
dc.contributor.author | Song, Jian | en_US |
dc.contributor.author | Siple, Jessica | en_US |
dc.contributor.author | Deretic, Vojo | en_US |
dc.date.accessioned | 2010-06-01T18:38:47Z | |
dc.date.available | 2010-06-01T18:38:47Z | |
dc.date.issued | 2001-03 | en_US |
dc.identifier.citation | Zahrt, Thomas C . ; Song, Jian; Siple, Jessica; Deretic, Vojo (2001). "Mycobacterial FurA is a negative regulator of catalase–peroxidase gene katG ." Molecular Microbiology 39(5): 1174-1185. <http://hdl.handle.net/2027.42/71847> | en_US |
dc.identifier.issn | 0950-382X | en_US |
dc.identifier.issn | 1365-2958 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/71847 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=11251835&dopt=citation | en_US |
dc.format.extent | 243852 bytes | |
dc.format.extent | 3109 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Blackwell Science, Ltd | en_US |
dc.rights | Blackwell Science Ltd | en_US |
dc.title | Mycobacterial FurA is a negative regulator of catalase–peroxidase gene katG | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Microbiology and Immunology | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Microbiology and Immunology, University of Michigan Medical School, Medical Science Building II, Ann Arbor, MI 48109, USA. | en_US |
dc.identifier.pmid | 11251835 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/71847/1/j.1365-2958.2001.02321.x.pdf | |
dc.identifier.doi | 10.1111/j.1365-2958.2001.02321.x | en_US |
dc.identifier.source | Molecular Microbiology | en_US |
dc.identifier.citedreference | Altuvia, S., Almiron, M., Huisman, G., Kolter, R. & Storz, G. ( 1994 ) The dps promoter is activated by OxyR during growth and by IHF and sigma S in stationary phase. Mol Microbiol 13: 265 – 272. | en_US |
dc.identifier.citedreference | Armstrong, J.A. & Hart, P.D.A. ( 1971 ) Response of cultured macrophages to Mycobacterium tuberculosis, with observations on fusion of lysosomes with phagosomes. J Exp Med 134: 713 – 740. | en_US |
dc.identifier.citedreference | Baillon, M.L., van Vliet, A.H., Ketley, J.M., Constantinidou, C. & Penn, C.W. ( 1999 ) An iron-regulated alkyl hydroperoxide reductase (AhpC) confers aerotolerance and oxidative stress resistance to the microaerophilic pathogen Campylobacter jejuni. J Bacteriol 181: 4798 – 4804. | en_US |
dc.identifier.citedreference | Banerjee, A., Dubnau, E., Quemard, A., Balasubramanian, V., Um, K.S. & Wilson, T., et al. ( 1994 ) inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis. Science 263: 227 – 230. | en_US |
dc.identifier.citedreference | Bartholomew, W.R. ( 1968 ) Multiple catalase enzymes in two species of mycobacteria. Am Rev Respir Dis 97: 710 – 712. | en_US |
dc.identifier.citedreference | Billman-Jacobe, H., Sloan, J. & Coppel, R.L. ( 1996 ) Analysis of isoniazid-resistant transposon mutants of Mycobacterium smegmatis. FEMS Microbiol Lett 144: 47 – 52. | en_US |
dc.identifier.citedreference | Bsat, N., Herbig, A., Casillas-Martinez, L., Setlow, P. & Helmann, J.D. ( 1998 ) Bacillus subtilis contains multiple Fur homologues: identification of the iron uptake (Fur) and peroxide regulon (PerR) repressors. Mol Microbiol 29: 189 – 198. | en_US |
dc.identifier.citedreference | Chan, J. & Kaufmann, S.H.E. ( 1994 ) Immune mechanisms of protection. In Tuberculosis: Pathogenesis, Protection and Control. Bloom, B.R. (ed. ). Washington, DC: American Society for Microbiology Press, pp. 389 – 415. | en_US |
dc.identifier.citedreference | Chan, J., Fan, X.D., Hunter, S.W., Brennan, P.J. & Bloom, B.R. ( 1991 ) Lipoarabinomannan, a possible virulence factor involved in persistence of Mycobacterium tuberculosis within macrophages. Infect Immun 59: 1755 – 1761. | en_US |
dc.identifier.citedreference | Chen, L., Xie, Q.W. & Nathan, C. ( 1998 ) Alkyl hydroperoxide reductase subunit C (AhpC) protects bacterial and human cells against reactive nitrogen intermediates. Mol Cell 1: 795 – 805. | en_US |
dc.identifier.citedreference | Christman, M.F., Morgan, R.W., Jacobson, F.S. & Ames, B.N. ( 1985 ) Positive control of a regulon for defenses against oxidative stress and some heat-shock proteins in Salmonella typhimurium. Cell 41: 753 – 762. | en_US |
dc.identifier.citedreference | Christman, M.F., Storz, G. & Ames, B.N. ( 1989 ) OxyR, a positive regulator of hydrogen peroxide-inducible genes in Escherichia coli and Salmonella typhimurium, is homologous to a family of bacterial regulatory proteins. Proc Natl Acad Sci USA 86: 3484 – 3488. | en_US |
dc.identifier.citedreference | Clemens, D.L. & Horwitz, M.A. ( 1995 ) Characterization of the Mycobacterium tuberculosis phagosome and evidence that phagosomal maturation is inhibited. J Exp Med 181: 257 – 270. | en_US |
dc.identifier.citedreference | Cooper, A.M., Segal, B.H., Frank, A.A., Holland, S.M. & Orme, I.M. ( 2000 ) Transient loss of resistance to pulmonary tuberculosis in p47 phox–/– mice. Infect Immun 68: 1231 – 1234. | en_US |
dc.identifier.citedreference | Curcic, R., Dhandayuthapani, S. & Deretic, V. ( 1994 ) Gene expression in mycobacteria: transcriptional fusions based on xylE and analysis of the promoter region of the response regulator mtrA from Mycobacterium tuberculosis. Mol Microbiol 13: 1057 – 1064. | en_US |
dc.identifier.citedreference | Dannenberg, A.M., Jr, & Rook, G.A. ( 1994 ) Pathogenesis of pulmonary tuberculosis: an interplay of tissue-damaging and macrophage-activating immune responses-dual mechanisms that control bacillary multiplication. In Tuberculosis: Pathogenesis, Protection, and Control. Bloom, B.R. (ed.). Washington, DC: American Society for Microbiology Press, pp. 459 – 483. | en_US |
dc.identifier.citedreference | Deretic, V. & Fratti, R.A. ( 1999 ) Mycobacterium tuberculosis phagosome. Mol Microbiol 31: 1603 – 1609. | en_US |
dc.identifier.citedreference | Deretic, V., Philipp, W., Dhandayuthapani, S., Mudd, M.H., Curcic, R. & Garbe, T., et al. ( 1995 ) Mycobacterium tuberculosis is a natural mutant with an inactivated oxidative-stress regulatory gene: implications for sensitivity to isoniazid. Mol Microbiol 17: 889 – 900. | en_US |
dc.identifier.citedreference | Deretic, V., Pagan-Ramos, E., Zhang, Y., Dhandayuthapani, S. & Via, L.E. ( 1996 ) The extreme sensitivity of Mycobacterium tuberculosis to the front-line antituberculosis drug isoniazid. Nature Biotechnol 14: 1557 – 1561. | en_US |
dc.identifier.citedreference | Deretic, V., Song, J. & Pagan-Ramos, E. ( 1997 ) Loss of oxyR in Mycobacterium tuberculosis. Trends Microbiol 5: 367 – 372. | en_US |
dc.identifier.citedreference | Dhandayuthapani, S., Zhang, Y., Mudd, M.H. & Deretic, V. ( 1996 ) Oxidative stress response and its role in sensitivity to isoniazid in mycobacteria: characterization and inducibility of ahpC by peroxides in Mycobacterium smegmatis and lack of expression in M. aurum and M. tuberculosis. J Bacteriol 178: 3641 – 3649. | en_US |
dc.identifier.citedreference | Dubrac, S. & Touati, D. ( 2000 ) Fur positive regulation of iron superoxide dismutase in Escherichia coli: functional analysis of the sodB promoter. J Bacteriol 182: 3802 – 3808. | en_US |
dc.identifier.citedreference | Dussurget, O., Rodriguez, M. & Smith, I. ( 1996 ) An ideR mutant of Mycobacterium smegmatis has derepressed siderophore production and an altered oxidative-stress response. Mol Microbiol 22: 535 – 544. | en_US |
dc.identifier.citedreference | Eiglmeier, K., Fsihi, H., Heym, B. & Cole, S.T. ( 1997 ) On the catalase-peroxidase gene, katG, of Mycobacterium leprae and the implications for treatment of leprosy with isoniazid. FEMS Microbiol Lett 149: 273 – 278. | en_US |
dc.identifier.citedreference | Falkinham, J.O., III ( 1996 ) Epidemiology of infection by nontuberculous mycobacteria. Clin Microbiol Rev 9: 177 – 215. | en_US |
dc.identifier.citedreference | Hahn, J.S., Oh, S.Y. & Roe, J.H. ( 2000 ) Regulation of the furA and catC operon, encoding a ferric uptake regulator homologue and catalase-peroxidase, respectively in Streptomyces coelicolor A3(2). J Bacteriol 182: 3767 – 3774. | en_US |
dc.identifier.citedreference | Hassett, D.J., Howell, M.L., Ochsner, U.A., Vasil, M.L., Johnson, Z. & Dean, G.E. ( 1997 ) An operon containing fumC and sodA encoding fumarase C and manganese superoxide dismutase is controlled by the ferric uptake regulator in Pseudomonas aeruginosa: fur mutants produce elevated alginate levels. J Bacteriol 179: 1452 – 1459. | en_US |
dc.identifier.citedreference | Heym, B., Zhang, Y., Poulet, S., Young, D. & Cole, S.T. ( 1993 ) Characterization of the katG gene encoding a catalase-peroxidase required for the isoniazid susceptibility of Mycobacterium tuberculosis. J Bacteriol 175: 4255 – 4259. | en_US |
dc.identifier.citedreference | Heym, B., Alzari, P.M., Honore, N. & Cole, S.T. ( 1995 ) Missense mutations in the catalase-peroxidase gene, katG, are associated with isoniazid resistance in Mycobacterium tuberculosis. Mol Microbiol 15: 235 – 245. | en_US |
dc.identifier.citedreference | Heym, B., Stavropoulos, E., Honore, N., Domenech, P., Saint-Joanis, B. & Wilson, T.M., et al. ( 1997 ) Effects of overexpression of the alkyl hydroperoxide reductase AhpC on the virulence and isoniazid resistance of Mycobacterium tuberculosis. Infect Immun 65: 1395 – 1401. | en_US |
dc.identifier.citedreference | Jacobs, W.R., Jr, Kalpana, G.V., Cirillo, J.D., Pascopella, L., Snapper, S.B. & Udani, R.A., et al. ( 1991 ) Genetic systems for mycobacteria. Methods Enzymol 204: 537 – 555. | en_US |
dc.identifier.citedreference | Lee, H.S., Lee, Y.S., Kim, H.S., Choi, J.Y., Hassan, H.M. & Chung, M.H. ( 1998 ) Mechanism of regulation of 8-hydroxyguanine endonuclease by oxidative stress: roles of FNR, ArcA, and Fur. Free Radical Biol Med 24: 1193 – 1201. | en_US |
dc.identifier.citedreference | Lei, B., Wei, C.J. & Tu, S.C. ( 2000 ) Action mechanism of antitubercular isoniazid. Activation by Mycobacterium tuberculosis KatG, isolation, and characterization of inhA inhibitor. J Biol Chem 275: 2520 – 2526. | en_US |
dc.identifier.citedreference | Li, Z., Kelley, C., Collins, F., Rouse, D. & Morris, S. ( 1998 ) Expression of katG in Mycobacterium tuberculosis is associated with its growth and persistence in mice and guinea pigs. J Infect Dis 177: 1030 – 1035. | en_US |
dc.identifier.citedreference | Manca, C., Paul, S., Barry, C.E., III, Freedman, V.H. & Kaplan, G. ( 1999 ) Mycobacterium tuberculosis catalase and peroxidase activities and resistance to oxidative killing in human monocytes in vitro. Infect Immun 67: 74 – 79. | en_US |
dc.identifier.citedreference | Mdluli, K., Slayden, R.A., Zhu, Y., Ramaswamy, S., Pan, X. & Mead, D., et al. ( 1998 ) Inhibition of a Mycobacterium tuberculosis beta-ketoacyl ACP synthase by isoniazid. Science 280: 1607 – 1610. | en_US |
dc.identifier.citedreference | Middlebrook, G. & Cohn, M.L. ( 1953 ) Some observations on the pathogenicity of isoniazid-resistant variants of tubercle bacilli. Science 118: 297 – 299. | en_US |
dc.identifier.citedreference | Mitchison, D.A., Selkon, J.B. & Lloyd, J. ( 1963 ) Virulence in the guinea pig, susceptibility to hydrogen peroxide, and catalase activity of isoniazid-sensitive tubercle bacilli from South Indian and British patients. J Pathol Bacteriol 86: 377 – 386. | en_US |
dc.identifier.citedreference | Morse, W.C., Weiser, O.L., Kuhns, D.M., Fusillo, M., Dail, M.C. & Evans, J.R. ( 1954 ) Study of the virulence of isoniazid-resistant tubercle bacilli in guinea pigs and mice. Am Rev Tuberc 69: 464 – 468. | en_US |
dc.identifier.citedreference | Musser, J.M. ( 1995 ) Antimicrobial agent resistance in mycobacteria: molecular genetic insights. Clin Microbiol Rev 8: 496 – 514. | en_US |
dc.identifier.citedreference | Mustafa, T., Phyu, S., Nilsen, R., Bjune, G. & Jonsson, R. ( 1999 ) Increased expression of Fas ligand on Mycobacterium tuberculosis infected macrophages: a potential novel mechanism of immune evasion by Mycobacterium tuberculosis Inflammation 23: 507 – 521. | en_US |
dc.identifier.citedreference | Nakata, N., Matsuoka, M., Kashiwabara, Y., Okada, N. & Sasakawa, C. ( 1997 ) Nucleotide sequence of the Mycobacterium leprae katG region. J Bacteriol 179: 3053 – 3057. | en_US |
dc.identifier.citedreference | Niederhoffer, E.C., Naranjo, C.M., Bradley, K.L. & Fee, J.A. ( 1990 ) Control of Escherichia coli superoxide dismutase ( sodA and sodB ) genes by the ferric uptake regulation ( fur ) locus. J Bacteriol 172: 1930 – 1938. | en_US |
dc.identifier.citedreference | Pagan-Ramos, E., Song, J., McFalone, M., Mudd, M.H. & Deretic, V. ( 1998 ) Oxidative stress response and characterization of the oxyR-ahpC and furA-katG loci in Mycobacterium marinum. J Bacteriol 180: 4856 – 4864. | en_US |
dc.identifier.citedreference | Pancholi, P., Mirza, A., Bhardwaj, N. & Steinman, R.M. ( 1993 ) Sequestration from immune CD4+ T cells of mycobacteria growing in human macrophages. Science 260: 984 – 986. | en_US |
dc.identifier.citedreference | Patzer, S.I. & Hantke, K. ( 1998 ) The ZnuABC high-affinity zinc uptake system and its regulator Zur in Escherichia coli. Mol Microbiol 28: 1199 – 1210. | en_US |
dc.identifier.citedreference | Rogall, T., Wolters, J., Flohr, T. & Bottger, E.C. ( 1990 ) Towards a phylogeny and definition of species at the molecular level within the genus Mycobacterium. Int J Syst Bacteriol 40: 323 – 330. | en_US |
dc.identifier.citedreference | Rosner, J.L. ( 1993 ) Susceptibilities of oxyR regulon mutants of Escherichia coli and Salmonella typhimurium to isoniazid. Antimicrob Agents Chemother 37: 2251 – 2253. | en_US |
dc.identifier.citedreference | Rouse, D.A. & Morris, S.L. ( 1995 ) Molecular mechanisms of isoniazid resistance in Mycobacterium tuberculosis and Mycobacterium bovis. Infect Immun 63: 1427 – 1433. | en_US |
dc.identifier.citedreference | Russell, D.G. ( 1995 ) Mycobacterium and Leishmania: stowaways in the endosomal network. Trends Cell Biol 5: 125 – 128. | en_US |
dc.identifier.citedreference | Sherman, D.R., Sabo, P.J., Hickey, M.J., Arain, T.M., Mahairas, G.G. & Yuan, Y., et al. ( 1995 ) Disparate responses to oxidative stress in saprophytic and pathogenic mycobacteria. Proc Natl Acad Sci USA 92: 6625 – 6629. | en_US |
dc.identifier.citedreference | Shoeb, H.A., Bowman, B.U., Jr, Ottolenghi, A.C. & Merola, A.J. ( 1985 ) Peroxidase-mediated oxidation of isoniazid. Antimicrob Agents Chemother 27: 399 – 403. | en_US |
dc.identifier.citedreference | Snapper, S.B., Melton, R.E., Mustafa, S., Kieser, T. & Jacobs, W.R., Jr ( 1990 ) Isolation and characterization of efficient plasmid transformation mutants of Mycobacterium smegmatis. Mol Microbiol 4: 1911 – 1919. | en_US |
dc.identifier.citedreference | Stenger, S., Niazi, K.R. & Modlin, R.L. ( 1998 ) Down-regulation of CD1 on antigen-presenting cells by infection with Mycobacterium tuberculosis. J Immunol 161: 3582 – 3588. | en_US |
dc.identifier.citedreference | Storz, G. & Altuvia, S. ( 1994 ) OxyR regulon. Methods Enzymol 234: 217 – 223. | en_US |
dc.identifier.citedreference | Storz, G. & Imlay, J.A. ( 1999 ) Oxidative stress. Curr Opin Microbiol 2: 188 – 194. | en_US |
dc.identifier.citedreference | Stover, C.K., de la Cruz, V.F., Fuerst, T.R., Burlein, J.E., Benson, L.A. & Bennett, L.T., et al. ( 1991 ) New use of BCG for recombinant vaccines. Nature 351: 456 – 460. | en_US |
dc.identifier.citedreference | Tardat, B. & Touati, D. ( 1993 ) Iron and oxygen regulation of Escherichia coli MnSOD expression: competition between the global regulators Fur and ArcA for binding to DNA. Mol Microbiol 9: 53 – 63. | en_US |
dc.identifier.citedreference | Tartaglia, L.A., Storz, G. & Ames, B.N. ( 1989 ) Identification and molecular analysis of oxyR -regulated promoters important for the bacterial adaptation to oxidative stress. J Mol Biol 210: 709 – 719. | en_US |
dc.identifier.citedreference | van Vliet, A.H.M., Wooldridge, K.G. & Ketley, J.M. ( 1998 ) Iron-responsive gene regulation in a Campylobacter jejuni fur mutant. J Bacteriol 180: 5291 – 5298. | en_US |
dc.identifier.citedreference | van Vliet, A.H., Baillon, M.L., Penn, C.W. & Ketley, J.M. ( 1999 ) Campylobacter jejuni contains two fur homologs: characterization of iron-responsive regulation of peroxide stress defense genes by the PerR repressor. J Bacteriol 181: 6371 – 6376. | en_US |
dc.identifier.citedreference | Wayne, L.G. & Diaz, G.A. ( 1986 ) A double staining method for differentiating between two classes of mycobacterial catalase in polyacrylamide electrophoresis gels. Anal Biochem 157: 89 – 92. | en_US |
dc.identifier.citedreference | Wengenack, N.L., Todorovic, S., Yu, L. & Rusnak, F. ( 1998 ) Evidence for differential binding of isoniazid by Mycobacterium tuberculosis KatG and the isoniazid-resistant mutant KatG (S315T). Biochemistry 37: 15825 – 15834. | en_US |
dc.identifier.citedreference | Wilson, T.M., de Lisle, G.W. & Collins, D.M. ( 1995 ) Effect of inhA and katG on isoniazid resistance and virulence of Mycobacterium bovis. Mol Microbiol 15: 1009 – 1015. | en_US |
dc.identifier.citedreference | Wilson, T., de Lisle, G.W., Marcinkeviciene, J.A., Blanchard, J.S. & Collins, D.M. ( 1998 ) Antisense RNA to ahpC, an oxidative stress defense gene involved in isoniazid resistance, indicates that AhpC of Mycobacterium bovis has virulence properties. Microbiology 144: 2687 – 2695. | en_US |
dc.identifier.citedreference | Wong, D.K., Lee, B.Y., Horwitz, M.A. & Gibson, B.W. ( 1999 ) Identification of fur, aconitase, and other proteins expressed by Mycobacterium tuberculosis under conditions of low and high concentrations of iron by combined two-dimensional gel electrophoresis and mass spectrometry. Infect Immun 67: 327 – 336. | en_US |
dc.identifier.citedreference | Yu, K., Mitchell, C., Xing, Y., Magliozzo, R.S., Bloom, B.R. & Chan, J. ( 1999 ) Toxicity of nitrogen oxides and related oxidants on mycobacteria: M. tuberculosis is resistant to peroxynitrite anion. Tuberc Lung Dis 79: 191 – 198. | en_US |
dc.identifier.citedreference | Yuan, Y., Lee, R.E., Besra, G.S., Belisle, J.T. & Barry, C.E., III ( 1995 ) Identification of a gene involved in the biosynthesis of cyclopropanated mycolic acids in Mycobacterium tuberculosis. Proc Natl Acad Sci USA 92: 6630 – 6634. | en_US |
dc.identifier.citedreference | Zhang, Y., Heym, B., Allen, B., Young, D. & Cole, S. ( 1992 ) The catalase-peroxidase gene and isoniazid resistance of Mycobacterium tuberculosis. Nature 358: 591 – 593. | en_US |
dc.identifier.citedreference | Zhang, Y., Dhandayuthapani, S. & Deretic, V. ( 1996 ) Molecular basis for the exquisite sensitivity of Mycobacterium tuberculosis to isoniazid. Proc Natl Acad Sci USA 93: 13212 – 13216. | en_US |
dc.identifier.citedreference | Zheng, M., Doan, B., Schneider, T.D. & Storz, G. ( 1999 ) OxyR and SoxRS regulation of fur. J Bacteriol 181: 4639 – 4643. | en_US |
dc.identifier.citedreference | Zou, P., Borovok, I., Ortiz de Orue Lucana, D., Muller, D. & Schrempf, H. ( 1999 ) The mycelium-associated Streptomyces reticuli catalase-peroxidase, its gene and regulation by FurS. Microbiology 145: 549 – 559. | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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