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Synovial Inflammation in Patients with Osteonecrosis of the Femoral Head
dc.contributor.authorRabquer, Bradley J.en_US
dc.contributor.authorTan, Giselle J.en_US
dc.contributor.authorShaheen, Philip J.en_US
dc.contributor.authorHaines III, G. Kennethen_US
dc.contributor.authorUrquhart, Andrew G.en_US
dc.contributor.authorKoch, Alisa E.en_US
dc.date.accessioned2010-06-01T18:40:21Z
dc.date.available2010-06-01T18:40:21Z
dc.date.issued2009-08en_US
dc.identifier.citationRabquer, Bradley J.; Tan, Giselle J.; Shaheen, Philip J.; Haines III, G. Kenneth; Urquhart, Andrew G.; Koch, Alisa E. (2009). "Synovial Inflammation in Patients with Osteonecrosis of the Femoral Head." Clinical and Translational Science 2(4): 273-278. <http://hdl.handle.net/2027.42/71872>en_US
dc.identifier.issn1752-8054en_US
dc.identifier.issn1752-8062en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/71872
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=20443906&dopt=citationen_US
dc.description.abstractMuch of the work aimed at elucidating the pathogenesis of osteonecrosis (ON) of the femoral head has focused on bone blood supply, with little attention to the surrounding synovial tissue (ST). We hypothesized that patients with ON exhibit synovial inflammation. Using immunohistological techniques, we found that a large population of patients with ON had synovial inflammation. Moreover, a population of ON patients had inflamed ST without having an inflammatory disease co-morbidity. The inflammatory infiltrate in these patients comprised primarily CD4 + T cells and CD68 + macrophages, the latter of which expressed increased levels of cellular adhesion molecules. Our results suggest the presence of a previously unrecognized population of ON patients without a diagnosed inflammatory co-morbidity and a highly inflammed synovium consisting primarily of a macrophage and CD4 + T-cell infi ltrate.en_US
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dc.format.extent3109 bytes
dc.format.mimetypeapplication/pdf
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dc.publisherBlackwell Publishing Incen_US
dc.rights© 2009 Wiley Periodicals, Inc.en_US
dc.subject.otherOsteonecrosisen_US
dc.subject.otherSynoviumen_US
dc.subject.otherInflammationen_US
dc.subject.otherMacrophageen_US
dc.subject.otherAdhesion Moleculesen_US
dc.titleSynovial Inflammation in Patients with Osteonecrosis of the Femoral Headen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelPharmacy and Pharmacologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USAen_US
dc.contributor.affiliationumDepartment of Orthopaedic Surgery, University of Michigan Medical School, Ann Arbor, MI, USAen_US
dc.contributor.affiliationotherDepartment of Pathology, Yale University, New Haven, CT, USAen_US
dc.contributor.affiliationotherDepartment of Veterans Affairs, VA Medical Service, Ann Arbor, MI, USA.en_US
dc.identifier.pmid20443906en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/71872/1/j.1752-8062.2009.00133.x.pdf
dc.identifier.doi10.1111/j.1752-8062.2009.00133.xen_US
dc.identifier.sourceClinical and Translational Scienceen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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