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Intracellular innate resistance to bacterial pathogens
dc.contributor.authorRadtke, Andrea Lynnen_US
dc.contributor.authorO'Riordan, Mary X. D.en_US
dc.date.accessioned2010-06-01T18:43:06Z
dc.date.available2010-06-01T18:43:06Z
dc.date.issued2006-11en_US
dc.identifier.citationRadtke, Andrea L.; O'Riordan, Mary X. D. (2006). "Intracellular innate resistance to bacterial pathogens." Cellular Microbiology 8(11): 1720-1729. <http://hdl.handle.net/2027.42/71916>en_US
dc.identifier.issn1462-5814en_US
dc.identifier.issn1462-5822en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/71916
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=16939532&dopt=citationen_US
dc.description.abstractMammalian innate immunity stimulates antigen-specific immune responses and acts to control infection prior to the onset of adaptive immunity. Some bacterial pathogens replicate within the host cell and are therefore sheltered from some protective aspects of innate immunity such as complement. Here we focus on mechanisms of innate intracellular resistance encountered by bacterial pathogens and how some bacteria can evade destruction by the innate immune system. Major strategies of intracellular antibacterial defence include pathogen compartmentalization and iron limitation. Compartmentalization of pathogens within the host endocytic pathway is critical for generating high local concentrations of antimicrobial molecules, such as reactive oxygen species, and regulating concentrations of divalent cations that are essential for microbial growth. Cytosolic sensing, autophagy, sequestration of essential nutrients and membrane attack by antimicrobial peptides are also discussed.en_US
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dc.publisherBlackwell Publishing Ltden_US
dc.rights© 2006 The Authors; Journal compilation © 2006 Blackwell Publishing Ltden_US
dc.titleIntracellular innate resistance to bacterial pathogensen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.identifier.pmid16939532en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/71916/1/j.1462-5822.2006.00795.x.pdf
dc.identifier.doi10.1111/j.1462-5822.2006.00795.xen_US
dc.identifier.sourceCellular Microbiologyen_US
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