Intragastric acidification reduces the occurrence of false-negative urea breath test results in patients taking a proton pump inhibitor
dc.contributor.author | Chey, William D. | en_US |
dc.contributor.author | Chathadi, K. V. | en_US |
dc.contributor.author | Montague, J. | en_US |
dc.contributor.author | Ahmed, F. | en_US |
dc.contributor.author | Murthy, U. K. | en_US |
dc.date.accessioned | 2010-06-01T18:46:28Z | |
dc.date.available | 2010-06-01T18:46:28Z | |
dc.date.issued | 2001-04 | en_US |
dc.identifier.citation | Chey, W.D . ; Chathadi, K.V . ; Montague, J . ; Ahmed, F . ; Murthy, U . (2001). "Intragastric acidification reduces the occurrence of false-negative urea breath test results in patients taking a proton pump inhibitor." The American Journal of Gastroenterology 96(4): 1028-1032. <http://hdl.handle.net/2027.42/71971> | en_US |
dc.identifier.issn | 0002-9270 | en_US |
dc.identifier.issn | 1572-0241 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/71971 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=11316142&dopt=citation | en_US |
dc.description.abstract | The aim of this study was to investigate whether reducing intragastric pH, at the time of urea ingestion, decreases the likelihood of false-negative (FN) urea breath test (UBT) results in patients taking a proton pump inhibitor (PPI). Methods : Patients with active Helicobacter pylori infection underwent a baseline 14 C-UBT (UBT-1) followed by treatment with lansoprazole 30 mg/day for 14 to 16 days. On day 13, patients returned for a repeat standard UBT (UBT-2). Between days 14 to 16, patients underwent a modified UBT (UBT-3), which included consuming 200 ml of 0.1 N citrate solution 30 min before and at the time of 14 C-urea administration. Breath samples were collected 10 and 15 min after 14 C-urea ingestion. Mean 14 CO 2 excretion and the number of FN and equivocal UBT results were compared for the three UBTs. Results : A total of 20 patients completed the study. Lansoprazole caused a significant decrease in mean breath 14 CO 2 excretion (disintegrations per minute) between UBT-1 (2.96 ± 0.23) and UBT-2 (2.08 ± 0.52, p < 0.05 ). Lansoprazole caused six (30%) FN and eight (40%) equivocal UBT-2 results. Mean breath 14 CO 2 excretion for UBT-3 (677 ± 514) was greater than for UBT-2 (234 ± 327, p = 0.001 ). UBT-3 caused only two (10%) FN and three (15%) equivocal results. The 15-min breath sample caused fewer FN and equivocal results than the 10-min sample for both UBT-2 and UBT-3. Conclusions : Giving citrate before and at the time of 14 C-urea administration increases mean breath 14 CO 2 excretion and decreases FN and equivocal UBT results in patients taking a PPI. These observations suggest that it may be possible to design a UBT protocol that will remain accurate in the face of PPI therapy. | en_US |
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dc.format.extent | 3109 bytes | |
dc.format.mimetype | application/octet-stream | |
dc.format.mimetype | text/plain | |
dc.publisher | Blackwell Publishing Ltd | en_US |
dc.rights | 2001 by Am. Coll. of Gastroenterology | en_US |
dc.title | Intragastric acidification reduces the occurrence of false-negative urea breath test results in patients taking a proton pump inhibitor | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | University of Michigan Health System, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationother | Syracuse Veterans Administration Medical Center, Syracuse, New York, USA | en_US |
dc.identifier.pmid | 11316142 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/71971/1/j.1572-0241.2001.03687.x.pdf | |
dc.identifier.doi | 10.1111/j.1572-0241.2001.03687.x | en_US |
dc.identifier.source | The American Journal of Gastroenterology | en_US |
dc.identifier.citedreference | Talley N.J., Axon A., Bytzer P., et al. Management of uninvestigated and functional dyspepsia: A working party report for the World Congress of Gastroenterology 1998. Aliment Pharm Ther 1999; 13: 1135 – 1148. | en_US |
dc.identifier.citedreference | Talley N.J., Silverstien M.D., Agreus L., et al. AGA technical review: Evaluation of dyspepsia. Gastroenterology 1998; 114: 579 – 581. | en_US |
dc.identifier.citedreference | Lassen A.T., Pederson F.M., Bytzer P., et al. H. pylori test and treat or prompt endoscopy for dyspeptic patients in primary care. A randomized, controlled trial of two management strategies: One year follow-up. Gastroenterology 1998; 114: A196 ( abstract ). | en_US |
dc.identifier.citedreference | Heaney A., Collins J.S.A., Watson R.G.P., et al. A prospective randomized trial of a “test and treat” policy versus endoscopy based management in young Helicobacter pylori positive patients with ulcer-like dyspepsia, referred to a hospital clinic. Gut 1999; 45: 186 – 190. | en_US |
dc.identifier.citedreference | Cutler A.F., Havstad S., Ma C.K., et al. Accuracy of invasive and noninvasive tests to diagnose Helicobacter pylori infection. Gastroenterology 1995; 109: 136 – 141. | en_US |
dc.identifier.citedreference | Vaira D., Malfertheiner P., Megraud F., et al. Diagnosis of Helicobacter pylori infection with a new non-invasive antigen-based assay. HpSA European Study Group. Lancet 1999; 354: 30 – 33. | en_US |
dc.identifier.citedreference | Brown K.E., Peura D.A.. Diagnosis of Helicobacter pylori infection. Gastroenterol Clin N Am 1993; 22: 105 – 115. | en_US |
dc.identifier.citedreference | Chey W.D., Spybrook M., Carpenter S., et al. Prolonged effect of omeprazole on the 14 C-urea breath test. Am J Gastroenterol 1996; 91: 89 – 92. | en_US |
dc.identifier.citedreference | Chey W.D., Woods M., Scheiman J.M., et al. Lansoprazole and ranitidine affect the accuracy of the 14C-urea breath test by a pH dependent mechanism. Am J Gastroenterol 1997; 92: 446 – 450. | en_US |
dc.identifier.citedreference | Laine L., Estrada R., Trujillo M., et al. Effect of proton pump inhibitor therapy on diagnostic testing for Helicobacter pylori. Ann Intern Med 1998; 129: 547 – 550. | en_US |
dc.identifier.citedreference | Lew E.A., Pisegna J.R., Ohning G.V., et al. Intragastric pH titration affects the accuracy of 13C-urea breath test in the diagnosis of Helicobacter pylori. Gastroenterology 1999; 116: A235 ( abstract ). | en_US |
dc.identifier.citedreference | Leodolter A., Dominguez-Munoz E., von Arnim U., et al. Validity of a modified 13 C-urea breath test for pre- and posttreatment diagnosis of Helicobacter pylori infection in the routine clinical setting. Am J Gastroenterol 1999; 94: 2100 – 2104. | en_US |
dc.identifier.citedreference | Bravo L.E., Realpe J.L., Campo C., et al. Effects of acid suppression and bismuth medications on the performance of diagnostic tests for Helicobacter pylori infection. Am J Gastroenterol 1999; 94: 2380 – 2383. | en_US |
dc.identifier.citedreference | Iwahi T., Satoh H., Nakao M., et al. Lansoprazole, a novel benzimidazole proton pump inhibitor, and its related compounds have selective activity against Helicobacter pylori. Antimicrob Agents Chemother 1991; 35: 490 – 496. | en_US |
dc.identifier.citedreference | McGowan C.C., Cover T.L., Blaser M.J.. The proton pump inhibitor omeprazole inhibits acid survival of Helicobacter pylori by a urease-independent mechanism. Gastroenterology 1994; 107: 738 – 743. | en_US |
dc.identifier.citedreference | Sharma B.K., Santana I.A., Wood E.C., et al. Intragastric bacterial activity and nitrosation before, during, and after treatment with omeprazole. Br Med J 1984; 289: 717 – 719. | en_US |
dc.identifier.citedreference | Meyer-Rosenberg K., Scott D.R., Rex D., et al. The effect of environmental pH on the proton motive force of Helicobacter pylori. Gastroenterology 1996; 111: 886 – 900. | en_US |
dc.identifier.citedreference | Scott D.R., Weeks D., Hong C., et al. The role of internal urease in acid resistance of Helicobacter pylori. Gastroenterology 1998; 114: 58 – 70. | en_US |
dc.identifier.citedreference | Rektorschek M., Weeks D., Sachs G., et al. Influence of pH on metabolism and urease activity of Helicobacter pylori. Gastroenterology 1998; 115: 628 – 641. | en_US |
dc.identifier.citedreference | Tsuda M., Karita M., Morshed M.G., et al. A urease-negative mutant of Helicobacter pylori constructed by allelic exchange mutagenesis lacks the ability to colonize the nude mouse stomach. Infect Immun 1994; 62: 3586 – 3589. | en_US |
dc.identifier.citedreference | Logan R.P.H., Walker M.M., Misiewicz J.J., et al. Changes in the intragastric distribution of Helicobacter pylori during treatment with omeprazole. Gut 1995; 36: 12 – 16. | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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