The Role of a Bioengineered Artificial Kidney in Renal Failure
dc.contributor.author | Fissell, William H. | en_US |
dc.contributor.author | Kimball, Jason | en_US |
dc.contributor.author | Mackay, Sherrill M. | en_US |
dc.contributor.author | Funke, Angela J. | en_US |
dc.contributor.author | Humes, H. David | en_US |
dc.date.accessioned | 2010-06-01T18:47:59Z | |
dc.date.available | 2010-06-01T18:47:59Z | |
dc.date.issued | 2001-11 | en_US |
dc.identifier.citation | FISSELL, WILLIAM H.; KIMBALL, JASON; MACKAY, SHERRILL M.; FUNKE, ANGELA; HUMES, H. DAVID (2001). "The Role of a Bioengineered Artificial Kidney in Renal Failure." Annals of the New York Academy of Sciences 944(1 BIOARTIFICIAL ORGANS III: TISSUE SOURCING, IMMUNOISOLATION, AND CLINICAL TRIALS ): 284-295. <http://hdl.handle.net/2027.42/71995> | en_US |
dc.identifier.issn | 0077-8923 | en_US |
dc.identifier.issn | 1749-6632 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/71995 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=11797678&dopt=citation | en_US |
dc.description.abstract | Renal failure continues to carry substantial burden of morbidity and mortality in both acute and chronic forms, despite advances in transplantation and dialysis. There is evidence to suggest that the kidney has metabolic, endocrine, and immune effects transcending its filtration functions, even beyond secretion of renin and erythropoietin. Our laboratory has developed experience in the tissue culture of renal parenchymal cells, and has now been able to demonstrate the metabolic activity of these cells in an extracorporeal circuit recapitulating glomerulotubular anatomy. We have observed active transport of sodium, glucose, and glutathione. We describe the design and initial preclinical testing of the bioartificial kidney, as well as future directions of our research. | en_US |
dc.format.extent | 492334 bytes | |
dc.format.extent | 3109 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Blackwell Publishing Ltd | en_US |
dc.rights | 2001 by the New York Academy of Sciences | en_US |
dc.subject.other | Bioengineering | en_US |
dc.subject.other | Artificial Kidney | en_US |
dc.subject.other | Renal Failure | en_US |
dc.title | The Role of a Bioengineered Artificial Kidney in Renal Failure | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Science (General) | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Departments of Internal Medicine, VA Medical Center and University of Michigan, Ann Arbor, Michigan, USA | en_US |
dc.identifier.pmid | 11797678 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/71995/1/j.1749-6632.2001.tb03841.x.pdf | |
dc.identifier.doi | 10.1111/j.1749-6632.2001.tb03841.x | en_US |
dc.identifier.source | Annals of the New York Academy of Sciences | en_US |
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dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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