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Lhx3, a LIM domain transcription factor, is regulated by Pou4f3 in the auditory but not in the vestibular system
dc.contributor.authorHertzano, Ronnaen_US
dc.contributor.authorDror, Amiel A.en_US
dc.contributor.authorMontcouquiol, Mireilleen_US
dc.contributor.authorAhmed, Zubair M.en_US
dc.contributor.authorEllsworth, Buffyen_US
dc.contributor.authorCamper, Sally A.en_US
dc.contributor.authorFriedman, Thomas B.en_US
dc.contributor.authorKelley, Matthew W.en_US
dc.contributor.authorAvraham, Karen B.en_US
dc.date.accessioned2010-06-01T18:49:28Z
dc.date.available2010-06-01T18:49:28Z
dc.date.issued2007-02en_US
dc.identifier.citationHertzano, Ronna; Dror, Amiel A.; Montcouquiol, Mireille; Ahmed, Zubair M.; Ellsworth, Buffy; Camper, Sally; Friedman, Thomas B.; Kelley, Matthew W.; Avraham, Karen B. (2007). "Lhx3, a LIM domain transcription factor, is regulated by Pou4f3 in the auditory but not in the vestibular system." European Journal of Neuroscience 25(4): 999-1005. <http://hdl.handle.net/2027.42/72019>en_US
dc.identifier.issn0953-816Xen_US
dc.identifier.issn1460-9568en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/72019
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=17331196&dopt=citationen_US
dc.description.abstractA dominant mutation of the gene encoding the POU4F3 transcription factor underlies human non-syndromic progressive hearing loss DFNA15. Using oligonucleotide microarrays to generate expression profiles of inner ears of Pou4f3 ddl/ ddl mutant and wild-type mice, we have identified and validated Lhx3, a LIM domain transcription factor, as an in vivo target gene regulated by Pou4f3. Lhx3 is a hair cell-specific gene expressed in all hair cells of the auditory and vestibular system as early as embryonic day 16. The level of Lhx3 mRNA is greatly reduced in the inner ears of embryonic Pou4f3 mutant mice. Our data also show that the expression of Lhx3 is regulated differently in auditory and vestibular hair cells. This is the first example of a hair cell-specific gene expressed both in auditory and in vestibular hair cells, with differential regulation of expression in these two closely related systems.en_US
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dc.format.extent3109 bytes
dc.format.mimetypeapplication/pdf
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dc.publisherBlackwell Publishing Ltden_US
dc.rightsThe Authors (2007). Journal Compilation Federation of European Neuroscience Societies and Blackwell Publishing Ltden_US
dc.subject.otherCochleaen_US
dc.subject.otherInner Earen_US
dc.subject.otherHair Cellen_US
dc.subject.otherGfi1en_US
dc.subject.otherDeafnessen_US
dc.subject.otherMouseen_US
dc.titleLhx3, a LIM domain transcription factor, is regulated by Pou4f3 in the auditory but not in the vestibular systemen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Human Genetics, University of Michigan Medical School, Ann Arbor, MI, 48109, USAen_US
dc.contributor.affiliationotherDepartment of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israelen_US
dc.contributor.affiliationotherSection on Developmental Neuroscience, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892, USAen_US
dc.contributor.affiliationotherLaboratory of Development Neurosciences - Avenir Team, Centre de Recherche INSERM Francois Magendie, Universite Bordeaux II, 33077 Bordeaux Cedex, Franceen_US
dc.contributor.affiliationotherSection on Human Genetics, Laboratory of Molecular Genetics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Rockville, MD 20850, USAen_US
dc.identifier.pmid17331196en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/72019/1/j.1460-9568.2007.05332.x.pdf
dc.identifier.doi10.1111/j.1460-9568.2007.05332.xen_US
dc.identifier.sourceEuropean Journal of Neuroscienceen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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