The epidemiology and natural history of Crohn’s disease in population-based patient cohorts from North America: a systematic review
dc.contributor.author | Loftus, Edward V. | en_US |
dc.contributor.author | Schoenfeld, Philip S. | en_US |
dc.contributor.author | Sandborn, W. J. | en_US |
dc.date.accessioned | 2010-06-01T18:50:13Z | |
dc.date.available | 2010-06-01T18:50:13Z | |
dc.date.issued | 2002-01-07 | en_US |
dc.identifier.citation | Loftus, E. V.; Schoenfeld, P.; Sandborn, W. J. (2002). "The epidemiology and natural history of Crohn’s disease in population-based patient cohorts from North America: a systematic review." Alimentary Pharmacology & Therapeutics 16(1): 51-60. <http://hdl.handle.net/2027.42/72031> | en_US |
dc.identifier.issn | 0269-2813 | en_US |
dc.identifier.issn | 1365-2036 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/72031 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=11856078&dopt=citation | en_US |
dc.description.abstract | To quantify, through systematic review, the epidemiology and natural history of Crohn’s disease in North America. Methods: The selected articles contained: (i) population-based samples of patients followed from the time of diagnosis; and (ii) objective diagnostic criteria for disease. Studies on the natural history of Crohn’s disease also contained sufficient follow-up. Data collection and analysis: For prevalence studies, data on the incidence, prevalence, gender and age at diagnosis were extracted. For natural history studies, data on the disease activity, use of medications and surgery were extracted. Main results: The prevalence of Crohn’s disease in North America ranges from 26.0 to 198.5 cases per 100 000 persons. The incidence rates range from 3.1 to 14.6 cases per 100 000 person-years. Most patients have a chronic intermittent disease course, while 13% have an unremitting disease course and 10% have a prolonged remission. Less than half require corticosteroids at any point. During any given year, approximately 10% are treated with corticosteroids and 30% are treated with 5-aminosalicylates. Up to 57% of patients require at least one surgical resection. Conclusions: Between 400 000 and 600 000 patients in North America have Crohn’s disease, and the natural history is marked by frequent exacerbations requiring treatment with corticosteroids, 5-aminosalicylate products and surgery. | en_US |
dc.format.extent | 261025 bytes | |
dc.format.extent | 3109 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Blackwell Science Ltd | en_US |
dc.rights | Blackwell Science Ltd | en_US |
dc.title | The epidemiology and natural history of Crohn’s disease in population-based patient cohorts from North America: a systematic review | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Otolaryngology | en_US |
dc.subject.hlbsecondlevel | Pharmacy and Pharmacology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Division of Gastroenterology, University of Michigan School of Medicine and VA Center for Excellence in Health Services Research, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationother | Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA, | en_US |
dc.identifier.pmid | 11856078 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/72031/1/j.1365-2036.2002.01140.x.pdf | |
dc.identifier.doi | 10.1046/j.1365-2036.2002.01140.x | en_US |
dc.identifier.source | Alimentary Pharmacology & Therapeutics | en_US |
dc.identifier.citedreference | Hanauer SB. Inflammatory bowel disease [published erratum appears in N Engl J Med 1996; 335 (2): 143]. N Engl J Med 1996; 334: 841 – 48. | en_US |
dc.identifier.citedreference | Logan RF. Inflammatory bowel disease incidence: up, down or unchanged? Gut 1998; 42: 309 – 11. | en_US |
dc.identifier.citedreference | Binder V, Hendriksen C, Kreiner S. Prognosis in Crohn’s disease – based on results from a regional patient group from the county of Copenhagen. Gut 1985; 26: 146 – 50. | en_US |
dc.identifier.citedreference | Munkholm P, Langholz E, Davidsen M, Binder V. Intestinal cancer risk and mortality in patients with Crohn’s disease. Gastroenterology 1993; 105: 1716 – 23. | en_US |
dc.identifier.citedreference | Munkholm P, Langholz E, Davidsen M, Binder V. Frequency of glucocorticoid resistance and dependency in Crohn’s disease. Gut 1994; 35: 360 – 2. | en_US |
dc.identifier.citedreference | Munkholm P, Langholz E, Davidsen M, Binder V. Disease activity courses in a regional cohort of Crohn’s disease patients. Scand J Gastroenterol 1995; 30: 699 – 706. | en_US |
dc.identifier.citedreference | Agrez MV, Valente RM, Pierce W, Melton LJ III, van Heerden JA, Beart RW. Surgical history of Crohn’s disease in a well-defined population. Mayo Clin Proc 1982; 57: 747 – 52. | en_US |
dc.identifier.citedreference | Silverstein MD, Loftus EV, Sandborn WJ, et al. Clinical course and costs of care for Crohn’s disease: Markov model analysis of a population-based cohort. Gastroenterology 1999; 117: 49 – 57. | en_US |
dc.identifier.citedreference | Faubion WA, Loftus EV, Harmsen WS, Zinsmeister AR, Sandborn WJ. The natural history of corticosteroid therapy for inflammatory bowel disease: a population-based study of corticosteroid dependence. Gastroenterology 2001; 121: 255 – 260. | en_US |
dc.identifier.citedreference | Laupacis A, Wells G, Richardson WS, Tugwell P. Users’ guides to the medical literature. V. How to use an article about prognosis. Evidence-Based Medicine Working Group. J Am Med Assoc 1994; 272: 234 – 7. | en_US |
dc.identifier.citedreference | Sedlack RE, Nobrega FT, Kurland LT, Sauer WG. Inflammatory colon disease in Rochester, Minnesota, 1935–1964. Gastroenterology 1972; 62: 935 – 41. | en_US |
dc.identifier.citedreference | Sedlack RE, Whisnant J, Elveback LR, Kurland LT. Incidence of Crohn’s disease in Olmsted County, Minnesota, 1935–1975. Am J Epidemiol 1980; 112: 759 – 63. | en_US |
dc.identifier.citedreference | Gollop JH, Phillips SF, Melton LJ III, Zinsmeister AR. Epidemiologic aspects of Crohn’s disease: a population based study in Olmsted County, Minnesota, 1943–1982. Gut 1988; 29: 49 – 56. | en_US |
dc.identifier.citedreference | Loftus EV Jr, Silverstein MD, Sandborn WJ, Tremaine WJ, Harmsen WS, Zinsmeister AR. Crohn’s disease in Olmsted County, Minnesota, 1940–1993: incidence, prevalence, and survival [published erratum appears in Gastroenterology 1999; 116 (6): 1507] [see comments]. Gastroenterology 1998; 114: 1161 – 68. | en_US |
dc.identifier.citedreference | Monk M, Mendeloff AI, Siegel CI, Lilienfeld A. An epidemiological study of ulcerative colitis and regional enteritis among adults in Baltimore I. Hospital incidence and prevalence 1960–1963. Gastroenterology 1967; 53: 198 – 210. | en_US |
dc.identifier.citedreference | Calkins BM, Lilienfeld AM, Garland CF, Mendeloff AI. Trends in incidence rates of ulcerative colitis and Crohn’s disease. Dig Dis Sci 1984; 29: 913 – 20. | en_US |
dc.identifier.citedreference | Nunes GC & Ahlquist RE. Increasing incidence of Crohn’s disease. Am J Surg 1983; 145: 578 – 81. | en_US |
dc.identifier.citedreference | Hiatt RA & Kaufman L. Epidemiology of inflammatory bowel disease in a defined northern California population. West J Med 1988; 149: 541 – 6. | en_US |
dc.identifier.citedreference | Bernstein CN, Blanchard JF, Rawsthorne P, Wajda A. Epidemiology of Crohn’s disease and ulcerative colitis in a central Canadian province: a population-based study. Am J Epidemiol 1999; 149: 916 – 24. | en_US |
dc.identifier.citedreference | Kurata JH, Kantor-Fish S, Frankl H, Godby P, Vadheim CM. Crohn’s disease among ethnic groups in a large health maintenance organization. Gastroenterology 1992; 102: 1940 – 8. | en_US |
dc.identifier.citedreference | Pinchbeck BR, Kirdeikis J, Thomson AB. Inflammatory bowel disease in northern Alberta. An epidemiologic study. J Clin Gastroenterol 1988; 10: 505 – 15. | en_US |
dc.identifier.citedreference | Stowe SP, Redmond SR, Stormont JM, et al. An epidemiologic study of inflammatory bowel disease in Rochester, New York. Hospital incidence. Gastroenterology 1990; 98: 104 – 10. | en_US |
dc.identifier.citedreference | Nordenholtz KE, Stowe SP, Stormont JM, et al. The cause of death in inflammatory bowel disease: a comparison of death certificates and hospital charts in Rochester, New York. Am J Gastroenterol 1995; 90: 927 – 32. | en_US |
dc.identifier.citedreference | Garland CF, Lilienfeld AM, Mendeloff AI, Markowitz JA, Terrell KB, Garland FC. Incidence rates of ulcerative colitis and Crohn’s disease in fifteen areas of the United States. Gastroenterology 1981; 81: 1115 – 24. | en_US |
dc.identifier.citedreference | Ogunbi SO, Ransom JA, Sullivan K, Schoen BT, Gold BD. Inflammatory bowel disease in African–American children living in Georgia. J Pediatr 1998; 133: 103 – 7. | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.