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Global Expression Profiles in Human Normal and Aneurysmal Abdominal Aorta Based on Two Distinct Whole Genome Microarray Platforms
dc.contributor.authorLenk, Guy M.en_US
dc.contributor.authorTromp, Gerarden_US
dc.contributor.authorSkunca, Magdalenaen_US
dc.contributor.authorGatalica, Zoranen_US
dc.contributor.authorBerguer, Ramonen_US
dc.contributor.authorKuivaniemi, Helenaen_US
dc.date.accessioned2010-06-01T18:50:39Z
dc.date.available2010-06-01T18:50:39Z
dc.date.issued2006-11en_US
dc.identifier.citationLENK, GUY M . ; TROMP, GERARD; SKUNCA, MAGDALENA; GATALICA, ZORAN; BERGUER, RAMON; KUIVANIEMI, HELENA (2006). "Global Expression Profiles in Human Normal and Aneurysmal Abdominal Aorta Based on Two Distinct Whole Genome Microarray Platforms." Annals of the New York Academy of Sciences 1085(1 The Abdominal Aortic Aneurysm: Genetics, Pathophysiology, and Molecular Biology ): 360-362. <http://hdl.handle.net/2027.42/72038>en_US
dc.identifier.issn0077-8923en_US
dc.identifier.issn1749-6632en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/72038
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=17182956&dopt=citationen_US
dc.description.abstractAbdominal aortic aneurysms (AAA) are the thirteenth cause of death in the United States. The etiology of the disease is yet largely unknown, although several environmental risk factors (e.g., smoking) have been identified and the search for finding genetic risk factors has been initiated. The purpose of our study was to gain insight into the pathobiology of AAA by determining which genes are expressed in the abdominal aorta under either the diseased or normal states, thereby generating the whole-genome-wide expression profiles for these conditions .en_US
dc.format.extent113632 bytes
dc.format.extent3109 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherBlackwell Publishing Incen_US
dc.rights2006 New York Academy of Sciencesen_US
dc.subject.otherAbdominal Aortic Aneurysmen_US
dc.subject.otherGene Expressionen_US
dc.subject.otherGenomicsen_US
dc.subject.otherPathway Analysisen_US
dc.subject.otherGene Ontologyen_US
dc.titleGlobal Expression Profiles in Human Normal and Aneurysmal Abdominal Aorta Based on Two Distinct Whole Genome Microarray Platformsen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelScience (General)en_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Surgery, University of Michigan, Ann Arbor, MI, USAen_US
dc.contributor.affiliationotherCenter for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI, USAen_US
dc.contributor.affiliationotherDepartment of Surgery, Wayne State University School of Medicine, Detroit, MI, USAen_US
dc.contributor.affiliationotherDepartment of Pathology, Creighton University School of Medicine, Omaha, NE, USAen_US
dc.identifier.pmid17182956en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/72038/1/annals.1383.041.pdf
dc.identifier.doi10.1196/annals.1383.041en_US
dc.identifier.sourceAnnals of the New York Academy of Sciencesen_US
dc.identifier.citedreferenceErnst, C.B. 1993. Abdominal aortic aneurysms. N. Engl. J. Med. 328: 1167 1172.en_US
dc.identifier.citedreferenceLederle, F.A., G.R. Johnson, S.E. Wilson, et al. 2000. The aneurysm detection and management study screening program: validation cohort and final results. Aneurysm Detection and Management Veterans Affairs Cooperative Study Investigators. Arch. Intern. Med. 160: 1425 1430.en_US
dc.identifier.citedreferenceShibamura, H., J.M. Olson, C. van Vlijmen-Van Keulen, et al. 2004. Genome scan for familial abdominal aortic aneurysm using sex and family history as covariates suggests genetic heterogeneity and identifies linkage to chromosome 19q13. Circulation 109: 2103 2108.en_US
dc.identifier.citedreferenceMi, H., B. Lazareva-Ulitsky, R. Loo, et al. 2005. The PANTHER database of protein families, subfamilies, functions and pathways. Nucleic Acids Res. 33: D284 D288.en_US
dc.identifier.citedreferenceIrizarry, E., K.M. Newman, R.H. Gandhi, et al. 1993. Demonstration of interstitial collagenase in abdominal aortic aneurysm disease. J. Surg. Res. 54: 571 574.en_US
dc.identifier.citedreferenceNewman, K.M., Y. Ogata, A.M. Malon, et al. 1994. Identification of matrix metalloproteinases 3 (stromelysin-1) and 9 (gelatinase B) in abdominal aortic aneurysm. Arterioscler. Thromb. Vasc. Biol. 14: 1315 1320.en_US
dc.identifier.citedreferencePearce, W.H., I. Sweis, J.S. Yao, et al. 1992. Interleukin-1 beta and tumor necrosis factor-alpha release in normal and diseased human infrarenal aortas. J. Vasc. Surg. 16: 784 789.en_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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