A major role for intestinal epithelial nucleotide oligomerization domain 1 (NOD1) in eliciting host bactericidal immune responses to Campylobacter jejuni
dc.contributor.author | Zilbauer, Matthias | en_US |
dc.contributor.author | Dorrell, Nick | en_US |
dc.contributor.author | Elmi, Abdi | en_US |
dc.contributor.author | Lindley, Keith J. | en_US |
dc.contributor.author | Schüller, Stephanie | en_US |
dc.contributor.author | Jones, Hannah E. | en_US |
dc.contributor.author | Klein, Nigel J. | en_US |
dc.contributor.author | Núňez, Gabriel | en_US |
dc.contributor.author | Wren, Brendan W. | en_US |
dc.contributor.author | Bajaj-Elliott, Mona | en_US |
dc.date.accessioned | 2010-06-01T18:52:40Z | |
dc.date.available | 2010-06-01T18:52:40Z | |
dc.date.issued | 2007-10 | en_US |
dc.identifier.citation | Zilbauer, Matthias; Dorrell, Nick; Elmi, Abdi; Lindley, Keith J.; SchÜller, Stephanie; Jones, Hannah E.; Klein, Nigel J.; NÚňez, Gabriel; Wren, Brendan W.; Bajaj-Elliott, Mona (2007). "A major role for intestinal epithelial nucleotide oligomerization domain 1 (NOD1) in eliciting host bactericidal immune responses to Campylobacter jejuni ." Cellular Microbiology 9(10): 2404-2416. <http://hdl.handle.net/2027.42/72071> | en_US |
dc.identifier.issn | 1462-5814 | en_US |
dc.identifier.issn | 1462-5822 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/72071 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=17521327&dopt=citation | en_US |
dc.description.abstract | Campylobacter jejuni is the foremost cause of bacterial-induced diarrhoeal disease worldwide. Although it is well established that C. jejuni infection of intestinal epithelia triggers host innate immune responses, the mechanism(s) involved remain poorly defined. Innate immunity can be initiated by families of structurally related pattern-recognition receptors (PRRs) that recognize specific microbial signature motifs. Here, we demonstrated maximal induction of epithelial innate responses during infection with live C . jejuni cells. In contrast when intestinal epithelial cells (IECs) were exposed to paraformaldehyde-fixed bacteria, host responses were minimal and a marked reduction in the number of intracellular bacteria was noted in parallel. These findings suggested a role for intracellular host– C. jejuni interactions in eliciting early innate immunity. We therefore investigated the potential involvement of a family of intracellular, cytoplasmic PRRs, the nucleotide-binding oligomerization domain (NOD) proteins in C. jejuni recognition. We identified NOD1, but not NOD2, as a major PRR for C. jejuni in IEC. We also found that targeting intestinal epithelial NOD1 with small interfering RNA resulted in an increase in number of intracellular C. jejuni , thus highlighting a critical role for NOD1-mediated antimicrobial defence mechanism(s) in combating this infection at the gastrointestinal mucosal surface. | en_US |
dc.format.extent | 573428 bytes | |
dc.format.extent | 3109 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Blackwell Publishing Ltd | en_US |
dc.rights | © 2007 The Authors; Journal compilation © 2007 Blackwell Publishing Ltd | en_US |
dc.title | A major role for intestinal epithelial nucleotide oligomerization domain 1 (NOD1) in eliciting host bactericidal immune responses to Campylobacter jejuni | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pathology and Comprehensive Cancer Centre, University of Michigan Medical School, Ann Arbor, MI, USA. | en_US |
dc.contributor.affiliationother | Infectious Diseases and Microbiology Unit, Institute of Child Health, 30 Guilford St, London WC1N 1EH, UK. | en_US |
dc.contributor.affiliationother | Department of Infectious and Tropical Diseases, Keppel Street, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK. | en_US |
dc.contributor.affiliationother | Department of Gastroenterology, Institute of Child Health and Great Ormond Street Hospital, 30 Guilford St, London WC1N 1EH, UK. | en_US |
dc.contributor.affiliationother | Centre for Paediatric Gastroenterology, Royal Free and University College Medical School, Rowland Hill St, London NW3 2PF, UK. | en_US |
dc.identifier.pmid | 17521327 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/72071/1/j.1462-5822.2007.00969.x.pdf | |
dc.identifier.doi | 10.1111/j.1462-5822.2007.00969.x | en_US |
dc.identifier.source | Cellular Microbiology | en_US |
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dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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