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RELEVANCE OF VASCULAR STRUCTURAL AND SMOOTH MUSCLE SENSITIVITY CHANGES IN HYPERTENSION
dc.contributor.authorBohr, David F.en_US
dc.contributor.authorBerecek, Kathleen H.en_US
dc.date.accessioned2010-06-01T18:54:21Z
dc.date.available2010-06-01T18:54:21Z
dc.date.issued1976-08en_US
dc.identifier.citationBohr, David F.; Berecek, Kathleen H. (1976). "RELEVANCE OF VASCULAR STRUCTURAL AND SMOOTH MUSCLE SENSITIVITY CHANGES IN HYPERTENSION." Internal Medicine Journal 6(4): 26-34. <http://hdl.handle.net/2027.42/72098>en_US
dc.identifier.issn1444-0903en_US
dc.identifier.issn1445-5994en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/72098
dc.description.abstractThis is a mini-review of the vascular changes that occur in experimental hypertension. Augmented vascular resistance and reactivity appear to be due to an increase both in wall thickness and in vascular smooth muscle sensitivity. The increase in wall thickness is an adaptive change that is secondary to the increase in arterial pressure; the altered smooth muscle sensitivity occurs in the absence of an increase in arterial pressure and hence may initiate the increase in vascular resistance and reactivity of experimental hypertension. Studies of subcellular function indicate that changes in smooth muscle sensitivity may be caused by an increase in cell membrane permeability and an altered handling of calcium by its subcellular sequestering system. This review was supported by U.S. Public Health Service grant HL-03756 from the National Heart and Lung Institute. K.H. Berecek is a predoctoral fellow supported by NIH grant PHS-4620.en_US
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dc.format.mimetypeapplication/pdf
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dc.publisherBlackwell Publishing Ltden_US
dc.rights1976 Published on behalf of the Adult Medicine Division of the Royal Australasian College of Physiciansen_US
dc.titleRELEVANCE OF VASCULAR STRUCTURAL AND SMOOTH MUSCLE SENSITIVITY CHANGES IN HYPERTENSIONen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelInternal Medicine and Specialtiesen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Physiology, University of Michigan, Ann Arbor, Michigan 48109en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/72098/1/j.1445-5994.1976.tb03320.x.pdf
dc.identifier.doi10.1111/j.1445-5994.1976.tb03320.xen_US
dc.identifier.sourceInternal Medicine Journalen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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