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Re-engineering the Functions of a Terminally Differentiated Epithelial Cell in Vivo
dc.contributor.authorBaum, Bruce J.en_US
dc.contributor.authorWang, Songlinen_US
dc.contributor.authorCukierman, Ednaen_US
dc.contributor.authorDelporte, Christineen_US
dc.contributor.authorKagami, Hideakien_US
dc.contributor.authorMarmary, Yitzhaken_US
dc.contributor.authorFox, Philip C.en_US
dc.contributor.authorMooney, David J.en_US
dc.contributor.authorYamada, Kenneth M.en_US
dc.date.accessioned2010-06-01T18:54:32Z
dc.date.available2010-06-01T18:54:32Z
dc.date.issued1999-06en_US
dc.identifier.citationBAUM, BRUCE J.; WANG, SONGLIN; CUKIERMAN, EDNA; DELPORTE, CHRISTINE; KAGAMI, HIDEAKI; MARMARY, YITZHAK; FOX, PHILIP C.; MOONEY, DAVID J.; YAMADA, KENNETH M. (1999). "Re-engineering the Functions of a Terminally Differentiated Epithelial Cell in Vivo ." Annals of the New York Academy of Sciences 875(1 BIOARTIFICIAL ORGANS II: TECHNOLOGY, MEDICINE, AND MATERIALS ): 294-300. <http://hdl.handle.net/2027.42/72101>en_US
dc.identifier.issn0077-8923en_US
dc.identifier.issn1749-6632en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/72101
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=10415576&dopt=citationen_US
dc.description.abstractBecause of their easy access, and important role in oral homeostasis, mammalian salivary glands provide a unique site for addressing key issues and problems in tissue engineering. This manuscript reviews studies by us in three major directions involving re-engineering functions of salivary epithelial cells. Using adenoviral-mediated gene transfer in vivo , we show approaches to i) repair damaged, hypofunctional glands and ii) redesign secretory functions to include endocrine as well as exocrine pathways. The third series of studies show our general approach to develop an artificial salivary gland for clinical situations in which all glandular tissue has been lost.en_US
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dc.publisherBlackwell Publishing Ltden_US
dc.rightsNew York Academy of Sciences 1999en_US
dc.titleRe-engineering the Functions of a Terminally Differentiated Epithelial Cell in Vivoen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelScience (General)en_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Chemical Engineering, University of Michigan, Ann Arbor, Michigan 48109-2136, USAen_US
dc.contributor.affiliationotherGene Therapy and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USAen_US
dc.contributor.affiliationotherCraniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USAen_US
dc.identifier.pmid10415576en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/72101/1/j.1749-6632.1999.tb08512.x.pdf
dc.identifier.doi10.1111/j.1749-6632.1999.tb08512.xen_US
dc.identifier.sourceAnnals of the New York Academy of Sciencesen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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