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Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice

dc.contributor.authorStrong, Randyen_US
dc.contributor.authorMiller, Richard A.en_US
dc.contributor.authorAstle, Clinton M.en_US
dc.contributor.authorFloyd, Robert A.en_US
dc.contributor.authorFlurkey, Kevin en_US
dc.contributor.authorHensley, Kenneth L.en_US
dc.contributor.authorJavors, Martin A.en_US
dc.contributor.authorLeeuwenburgh, Christiaan en_US
dc.contributor.authorNelson, James F.en_US
dc.contributor.authorOngini, Ennio en_US
dc.contributor.authorNadon, Nancy L.en_US
dc.contributor.authorWarner, Huber R.en_US
dc.contributor.authorHarrison, David E.en_US
dc.date.accessioned2010-06-01T18:55:32Z
dc.date.available2010-06-01T18:55:32Z
dc.date.issued2008-10en_US
dc.identifier.citationStrong, Randy ; Miller, Richard A. ; Astle, Clinton M. ; Floyd, Robert A. ; Flurkey, Kevin ; Hensley, Kenneth L. ; Javors, Martin A. ; Leeuwenburgh, Christiaan ; Nelson, James F. ; Ongini, Ennio ; Nadon, Nancy L. ; Warner, Huber R. ; Harrison, David E.  (2008). "Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice." Aging Cell 7(5): 641-650. <http://hdl.handle.net/2027.42/72117>en_US
dc.identifier.issn1474-9718en_US
dc.identifier.issn1474-9726en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/72117
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=18631321&dopt=citationen_US
dc.description.abstractThe National Institute on Aging's Interventions Testing Program was established to evaluate agents that are purported to increase lifespan and delay the appearance of age-related disease in genetically heterogeneous mice. Up to five compounds are added to the study each year and each compound is tested at three test sites (The Jackson Laboratory, University of Michigan, and University of Texas Health Science Center at San Antonio). Mice in the first cohort were exposed to one of four agents: aspirin, nitroflurbiprofen, 4-OH-Α-phenyl-N-tert-butyl nitrone, or nordihydroguaiaretic acid (NDGA). Sample size was sufficient to detect a 10% difference in lifespan in either sex, with 80% power, using data from two of the three sites. Pooling data from all three sites, a log-rank test showed that both NDGA ( p  = 0.0006) and aspirin ( p  = 0.01) led to increased lifespan of male mice. Comparison of the proportion of live mice at the age of 90% mortality was used as a surrogate for measurement of maximum lifespan; neither NDGA ( p  = 0.12) nor aspirin ( p  = 0.16) had a significant effect in this test. Measures of blood levels of NDGA or aspirin and its salicylic acid metabolite suggest that the observed lack of effects of NDGA or aspirin on lifespan in females could be related to gender differences in drug disposition or metabolism. Further studies are warranted to find whether NDGA or aspirin, over a range of doses, might prove to postpone death and various age-related outcomes reproducibly in mice.en_US
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dc.publisherBlackwell Publishing Ltden_US
dc.rightsJournal compilation © 2008 Blackwell Publishing Ltd/The Anatomical Society of Great Britain and Irelanden_US
dc.subject.otherAgingen_US
dc.subject.otherAspirinen_US
dc.subject.otherLongevityen_US
dc.subject.otherMiceen_US
dc.subject.otherNordihydroguaiaretic Aciden_US
dc.titleNordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male miceen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Pathology, University of Michigan, Ann Arbor, MI 48109, USAen_US
dc.contributor.affiliationumGeriatrics Center, University of Michigan, Ann Arbor, MI 48109-5796, USAen_US
dc.contributor.affiliationotherGeriatric Research, Education and Clinical Center and Research Service, South Texas Veterans Health Care System, San Antonio, TX 78229, USAen_US
dc.contributor.affiliationotherDepartment of Pharmacology, University of Texas Health Science Center at San Antonio, TX 78229-3900, USAen_US
dc.contributor.affiliationotherBarshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, TX 78245, USAen_US
dc.contributor.affiliationotherAnn Arbor VA Medical Center, Ann Arbor, MI 48109-2200, USAen_US
dc.contributor.affiliationotherThe Jackson Laboratory, Bar Harbor, ME 04609, USAen_US
dc.contributor.affiliationotherOklahoma Medical Research Foundation, Oklahoma City, OK 73104, USAen_US
dc.contributor.affiliationotherDepartment of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USAen_US
dc.contributor.affiliationotherDepartment of Psychiatry, University of Texas Health Science Center at San Antonio, TX 78229, USAen_US
dc.contributor.affiliationotherDepartment of Aging and Geriatrics, University of Florida, Gainesville, FL 32610, USAen_US
dc.contributor.affiliationotherDepartment of Physiology, University of Texas Health Science Center at San Antonio, TX 78229-3900, USAen_US
dc.contributor.affiliationotherBarshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, TX 78229, USAen_US
dc.contributor.affiliationotherNicox Research Institute, Milan, Italyen_US
dc.contributor.affiliationotherBiology of Aging Program, National Institute on Aging, Bethesda, MD 20892, USAen_US
dc.contributor.affiliationotherUniversity of Minnesota, College of Biological Sciences, St. Paul, MN 55108, USAen_US
dc.identifier.pmid18631321en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/72117/1/j.1474-9726.2008.00414.x.pdf
dc.identifier.doi10.1111/j.1474-9726.2008.00414.xen_US
dc.identifier.sourceAging Cellen_US
dc.identifier.citedreferenceAgÜero-Torres H, Viitanen M, Fratiglioni L, Louhija J ( 2001 ) The effect of low-dose daily aspirin intake on survival in the Finnish centenarians cohort. J. Am. Geriatr. Soc. 49, 1578 – 1580.en_US
dc.identifier.citedreferenceArcher JR, Harrison DE ( 1996 ) L-deprenyl treatment in aged mice slightly increases life spans, and greatly reduces fecundity by aged males. J. Gerontol. A Biol. Sci. Med. Sci. 51, B448 – B453.en_US
dc.identifier.citedreferenceBrunelli S, Sciorati C, D’Antona G, Innocenzi A, Covarello D, Galvez BG, Perrotta C, Monopoli A, Sanvito F, Bottinelli R, Ongini E, Cossu G, Clementi E ( 2007 ) Nitric oxide release combined with nonsteroidal antiinflammatory activity prevents muscular dystrophy pathology and enhances stem cell therapy. Proc. Natl Acad. Sci. USA 104, 264 – 269.en_US
dc.identifier.citedreferenceBuu-Hoi NP, Ratsimamanga AR ( 1959 ) [Retarding action of nordihydroguiaiaretic acid on aging in the rat.] C R Seances Soc Biol Fil 153, 1180 – 1182.en_US
dc.identifier.citedreferenceChan AT, Giovannucci EL, Meyerhardt JA, Schernhammer ES, Wu K, Fuchs CS ( 2008 ) Aspirin dose and duration of use and risk of colorectal cancer in men. Gastroenterology 134, 21 – 28.en_US
dc.identifier.citedreferenceFloyd RA ( 1990 ) Role of oxygen free radicals in carcinogenesis and brain ischemia. FASEB J. 4, 2587 – 2597.en_US
dc.identifier.citedreferenceFloyd RA, Kotake Y, Hensley K, Nakae D, Konishi Y ( 2002 ) Reactive oxygen species in choline deficiency induced carcinogenesis and nitrone inhibition. Mol. Cell. Biochem. 234–235, 195 – 203.en_US
dc.identifier.citedreferenceFlurkey K, Brandvain Y, Klebanov S, Austad SN, Miller RA, Yuan R, Harrison DE ( 2007 ) PohnB6F1: a cross of wild and domestic mice that is a new model of extended female reproductive life span. J. Gerontol. A Biol. Sci. Med. Sci. 62, 1187 – 1198.en_US
dc.identifier.citedreferenceFlurkey K, Papaconstantinou J, Miller RA, Harrison DE ( 2001 ) Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production. Proc. Natl Acad. Sci. USA 98, 6736 – 6741.en_US
dc.identifier.citedreferenceHarper A, Kerr DJ, Gescher A, Chipman JK ( 1999 ) Antioxidant effects of isoflavonoids and lignans, and protection against DNA oxidation. Free Radic. Res. 31, 149 – 160.en_US
dc.identifier.citedreferenceHoferova Z, Soucek K, Hofmanova J, Hofer M, Chramostova K, Fedorocko P, Kozubik A ( 2004 ) In vitro proliferation of fibrosarcoma cells depends on intact functions of lipoxygenases and cytochrome P-450-monooxygenase. Cancer Invest. 22, 234 – 247.en_US
dc.identifier.citedreferenceHolloszy JO ( 1993 ) Exercise increases average longevity of female rats despite increased food intake and no growth retardation. J. Gerontol. 48, B97 – B100.en_US
dc.identifier.citedreferenceJacobs EJ, Rodriguez C, Mondul AM, Connell CJ, Henley SJ, Calle EE, Thun MJ ( 2005 ) A large cohort study of aspirin and other nonsteroidal anti-inflammatory drugs and prostate cancer incidence. J. Natl Cancer Inst. 97, 975 – 980.en_US
dc.identifier.citedreferenceJohnson TW, Anderson KE, Lazovich D, Folsom AR ( 2002 ) Association of aspirin and nonsteroidal anti-inflammatory drug use with breast cancer. Cancer Epidemiol. Biomarkers Prev. 11, 1586 – 1591.en_US
dc.identifier.citedreferenceLi BH, Ma XF, Wang Y, Tian WX ( 2005 ) Structure-activity relationship of polyphenols that inhibit Fatty Acid synthase. J. Biochem. (Tokyo) 138, 679 – 685.en_US
dc.identifier.citedreferenceLim SS, Gaziano TA, Gakidou E, Reddy KS, Farzadfar F, Lozano R, Rodgers A ( 2007 ) Prevention of cardiovascular disease in high-risk individuals in low-income and middle-income countries: health effects and costs. Lancet 370, 2054 – 2062.en_US
dc.identifier.citedreferenceManev H, Uz T, Sugaya K, Qu T ( 2000 ) Putative role of neuronal 5-lipoxygenase in an aging brain. FASEB J. 14, 1464 – 1469.en_US
dc.identifier.citedreferenceMcDonald RW, Bunjobpon W, Liu T, Fessler S, Pardo OE, Freer IK, Glaser M, Seckl MJ, Robins DJ ( 2001 ) Synthesis and anticancer activity of nordihydroguaiaretic acid (NDGA) and analogues. Anticancer Drug Des. 16, 261 – 270.en_US
dc.identifier.citedreferenceMiller RA ( 2001 ) Genetics of increased longevity and retarded aging in mice. In Handbook of the Biology of Aging ( Masoro EJ, Austad SN, eds) San Diego, CA: Academic Press, pp. 369 – 395.en_US
dc.identifier.citedreferenceMiller RA ( 2002 ) Extending life: scientific prospects and political obstacles. Milbank Q. 80, 155 – 174.en_US
dc.identifier.citedreferenceMiller RA, Harrison DE, Astle CM, Floyd RA, Flurkey K, Hensley KL, Javors MA, Leeuwenburgh C, Nelson JF, Ongini E, Nadon NL, Warner HR, Strong R ( 2007 ) An aging interventions testing program: study design and interim report. Aging Cell 6, 565 – 575.en_US
dc.identifier.citedreferenceMiquel J, Fleming J, Economos AC ( 1982 ) Antioxidants, metabolic rate and aging in Drosophila. Arch. Gerontol. Geriatr. 1, 159 – 165.en_US
dc.identifier.citedreferenceMitchell JA, Akarasereenont P, Thiemermann C, Flower RJ, Vane JR ( 1993 ) Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. Proc. Natl. Acad. Sci. USA. 90, 11693 – 11697.en_US
dc.identifier.citedreferenceNakae D, Kishida H, Enami T, Konishi Y, Hensley KL, Floyd RA, Kotake Y ( 2003 ) Effects of phenyl N-tert-butyl nitrone and its derivatives on the early phase of hepatocarcinogenesis in rats fed a choline-deficient, L-amino acid-defined diet. Cancer Sci. 94, 26 – 31.en_US
dc.identifier.citedreferenceNony PA, Kennett SB, Glasgow WC, Olden K, Roberts JD ( 2005 ) 15S-Lipoxygenase-2 mediates arachidonic acid-stimulated adhesion of human breast carcinoma cells through the activation of TAK1, MKK6, and p38 MAPK. J. Bio1. Chem. 280, 31413 – 31419.en_US
dc.identifier.citedreferenceOlshansky SJ, Carnes BA, Cassel C ( 1990 ) In search of Methuselah: estimating the upper limits to human longevity. Science 250, 634 – 640.en_US
dc.identifier.citedreferenceOlshansky SJ, Perry D, Miller RA, Butler RN ( 2006 ) In pursuit of the longevity dividend. Scientist 20, 28 – 35.en_US
dc.identifier.citedreferenceOngini E, Bolla M ( 2006 ) Nitric-oxide based nonsteroidal anti-inflammatory agents. Drug Discov Today Ther Strateg 3, 395 – 400.en_US
dc.identifier.citedreferencePark Y, Pariza MW ( 2001 ) Lipoxygenase inhibitors inhibit heparin-releasable lipoprotein lipase activity in 3T3-L1 adipocytes and enhance body fat reduction in mice by conjugated linoleic acid. Biochim. Biophys. Acta. 1534, 27 – 33.en_US
dc.identifier.citedreferencePeters LL, Robledo RF, Bult CJ, Churchill GA, Paigen BJ, Svenson KL ( 2007 ) The mouse as a model for human biology: a resource guide for complex trait analysis. Nat. Rev. Genet. 8, 58 – 69.en_US
dc.identifier.citedreferencePetkov PM, Graber JH, Churchill GA, DiPetrillo K, King BL, Paigen K ( 2007 ) Evidence of a large-scale functional organization of mammalian chromosomes. PLoS Biol. 5, e127.en_US
dc.identifier.citedreferenceQu T, Manev R, Manev H ( 2001 ) 5-Lipoxygenase (5-LOX) promoter polymorphism in patients with early-onset and late-onset Alzheimer's disease. J. Neuropsychiatry Clin. Neurosci. 13, 304 – 305.en_US
dc.identifier.citedreferenceReed MJ, Meszaros K, Entes LJ, Claypool MD, Pinkett JG, Brignetti D, Luo J, Khandwala A, Reaven GM ( 1999 ) Effect of masoprocol on carbohydrate and lipid metabolism in a rat model of type II diabetes. Diabetologia 42, 102 – 106.en_US
dc.identifier.citedreferenceRichie JP Jr, Mills BJ, Lang CA ( 1986 ) Dietary nordihydroguaiaretic acid increases the life span of the mosquito. Proc. Soc. Exp. Biol. Med. 183, 81 – 85.en_US
dc.identifier.citedreferenceSchneider EL, Miller RA ( 1998 ) Anti-aging interventions. In Brockelhurst's Textbook of Geriatric Medicine ( Tallis R, Fillit H, Brockelhurst JC, eds). New York: Churchill Livingstone, pp. 193 – 199.en_US
dc.identifier.citedreferenceSchneider EL, Reed JD Jr ( 1985 ) Life extension. New Engl. J. Med. 312, 1159 – 1168.en_US
dc.identifier.citedreferenceShi X, Min D, Zigang D, Fei C, Jiangping Y, Suwei W, Stephen S, Leonard Vince C, Val V ( 1999 ) Antioxidant properties of aspirin: characterization of the ability of aspirin to inhibit silica-induced lipid peroxidation, DNA damage, NF-κB activation, and TNF-Α production. Mol. Cell. Biochem. 199, 93 – 102.en_US
dc.identifier.citedreferenceShishido Y, Furushiro M, Hashimoto S, Yokokura T ( 2001 ) Effect of nordihydroguaiaretic acid on behavioral impairment and neuronal cell death after forebrain ischemia. Pharmacol. Biochem. Behav. 69, 469 – 474.en_US
dc.identifier.citedreferenceSmith JW, Al-Khamees O, Costall B, Naylor RJ, Smythe JW ( 2002 ) Chronic aspirin ingestion improves spatial learning in adult and aged rats. Pharmacol. Biochem. Behav. 71, 233 – 238.en_US
dc.identifier.citedreferenceStark LA, Reid K, Sansom OJ, Din FV, Guichard S, Mayer I, Jodrell DI, Clarke AR, Dunlop MG ( 2007 ) Aspirin activates the NF-κB signalling pathway and induces apoptosis in intestinal neoplasia in two in vivo models of human colorectal cancer. Carcinogenesis 28, 968 – 976.en_US
dc.identifier.citedreferenceSvenson KL, Von SR, Magnani PA, Suetin HR, Paigen B, Naggert JK, Li R, Churchill GA, Peters LL ( 2007 ) Multiple trait measurements in 43 inbred mouse strains capture the phenotypic diversity characteristic of human populations. J. Appl. Physiol. 102, 2369 – 2378.en_US
dc.identifier.citedreferenceTuttle RS, Yager J, Northrup N ( 1988 ) Age and the antihypertensive effect of aspirin in rats. Br. J. Pharmacol. 94, 755 – 758.en_US
dc.identifier.citedreferenceVane SJ ( 2000 ) Aspirin and other anti-inflammatory drugs. Thorax 55, 3S – 9.en_US
dc.identifier.citedreferenceWang C, Li Q, Redden DT, Weindruch R, Allison DB ( 2004 ) Statistical methods for testing effects on ‘maximum lifespan’. Mech. Ageing Dev. 125, 629 – 632.en_US
dc.identifier.citedreferenceWarner HR, Ingram D, Miller RA, Nadon NL, Richardson AG ( 2000 ) Program for testing biological interventions to promote healthy aging. Mech. Ageing Dev. 115, 199 – 207.en_US
dc.identifier.citedreferenceWeissmann G ( 1991 ) Aspirin. Sci. Am. 264, 84 – 90.en_US
dc.identifier.citedreferenceWest M, Mhatre M, Ceballos A, Floyd RA, Grammas P, Gabbita SP, Hamdheydari L, Mai T, Mou S, Pye QN, Stewart C, West S, Williamson KS, Zemlan F, Hensley K ( 2004 ) The arachidonic acid 5-lipoxygenase inhibitor nordihydroguaiaretic acid inhibits tumor necrosis factor alpha activation of microglia and extends survival of G93A-SOD1 transgenic mice. J. Neurochem. 91, 133 – 143.en_US
dc.identifier.citedreferenceWood JG, Rogina B, Lavu S, Howitz K, Helfand SL, Tatar M, Sinclair D ( 2004 ) Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature 430, 686 – 689 ( erratum appears in Nature, 2004; 431(7004): 107).en_US
dc.identifier.citedreferenceYerman T, Gan WQ, Sin DD ( 2007 ) The influence of gender on the effects of aspirin in preventing myocardial infarction. BMC Med. 5, 29 – 35.en_US
dc.identifier.citedreferenceYoungren JF, Gable K, Penaranda C, Maddux BA, Zavodovskaya M, Lobo M, Campbell M, Kerner J, Goldfine ID ( 2005 ) Nordihydroguaiaretic acid (NDGA) inhibits the IGF-1 and c-erbB2/HER2/neu receptors and suppresses growth in breast cancer cells. Breast Cancer Res. Treat. 94, 37 – 46.en_US
dc.identifier.citedreferenceZhao Q, Pahlmark K, Smith ML, Siesjo BK ( 1994 ) Delayed treatment with the spin trap alpha-phenyl-N-tert-butyl nitrone (PBN) reduces infarct size following transient middle cerebral artery occlusion in rats. Acta Physiol. Scand. 152, 349 – 350.en_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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