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Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice
dc.contributor.authorStrong, Randyen_US
dc.contributor.authorMiller, Richard A.en_US
dc.contributor.authorAstle, Clinton M.en_US
dc.contributor.authorFloyd, Robert A.en_US
dc.contributor.authorFlurkey, Kevin en_US
dc.contributor.authorHensley, Kenneth L.en_US
dc.contributor.authorJavors, Martin A.en_US
dc.contributor.authorLeeuwenburgh, Christiaan en_US
dc.contributor.authorNelson, James F.en_US
dc.contributor.authorOngini, Ennio en_US
dc.contributor.authorNadon, Nancy L.en_US
dc.contributor.authorWarner, Huber R.en_US
dc.contributor.authorHarrison, David E.en_US
dc.date.accessioned2010-06-01T18:55:32Z
dc.date.available2010-06-01T18:55:32Z
dc.date.issued2008-10en_US
dc.identifier.citationStrong, Randy ; Miller, Richard A. ; Astle, Clinton M. ; Floyd, Robert A. ; Flurkey, Kevin ; Hensley, Kenneth L. ; Javors, Martin A. ; Leeuwenburgh, Christiaan ; Nelson, James F. ; Ongini, Ennio ; Nadon, Nancy L. ; Warner, Huber R. ; Harrison, David E.  (2008). "Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice." Aging Cell 7(5): 641-650. <http://hdl.handle.net/2027.42/72117>en_US
dc.identifier.issn1474-9718en_US
dc.identifier.issn1474-9726en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/72117
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=18631321&dopt=citationen_US
dc.description.abstractThe National Institute on Aging's Interventions Testing Program was established to evaluate agents that are purported to increase lifespan and delay the appearance of age-related disease in genetically heterogeneous mice. Up to five compounds are added to the study each year and each compound is tested at three test sites (The Jackson Laboratory, University of Michigan, and University of Texas Health Science Center at San Antonio). Mice in the first cohort were exposed to one of four agents: aspirin, nitroflurbiprofen, 4-OH-Α-phenyl-N-tert-butyl nitrone, or nordihydroguaiaretic acid (NDGA). Sample size was sufficient to detect a 10% difference in lifespan in either sex, with 80% power, using data from two of the three sites. Pooling data from all three sites, a log-rank test showed that both NDGA ( p  = 0.0006) and aspirin ( p  = 0.01) led to increased lifespan of male mice. Comparison of the proportion of live mice at the age of 90% mortality was used as a surrogate for measurement of maximum lifespan; neither NDGA ( p  = 0.12) nor aspirin ( p  = 0.16) had a significant effect in this test. Measures of blood levels of NDGA or aspirin and its salicylic acid metabolite suggest that the observed lack of effects of NDGA or aspirin on lifespan in females could be related to gender differences in drug disposition or metabolism. Further studies are warranted to find whether NDGA or aspirin, over a range of doses, might prove to postpone death and various age-related outcomes reproducibly in mice.en_US
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dc.publisherBlackwell Publishing Ltden_US
dc.rightsJournal compilation © 2008 Blackwell Publishing Ltd/The Anatomical Society of Great Britain and Irelanden_US
dc.subject.otherAgingen_US
dc.subject.otherAspirinen_US
dc.subject.otherLongevityen_US
dc.subject.otherMiceen_US
dc.subject.otherNordihydroguaiaretic Aciden_US
dc.titleNordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male miceen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Pathology, University of Michigan, Ann Arbor, MI 48109, USAen_US
dc.contributor.affiliationumGeriatrics Center, University of Michigan, Ann Arbor, MI 48109-5796, USAen_US
dc.contributor.affiliationotherGeriatric Research, Education and Clinical Center and Research Service, South Texas Veterans Health Care System, San Antonio, TX 78229, USAen_US
dc.contributor.affiliationotherDepartment of Pharmacology, University of Texas Health Science Center at San Antonio, TX 78229-3900, USAen_US
dc.contributor.affiliationotherBarshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, TX 78245, USAen_US
dc.contributor.affiliationotherAnn Arbor VA Medical Center, Ann Arbor, MI 48109-2200, USAen_US
dc.contributor.affiliationotherThe Jackson Laboratory, Bar Harbor, ME 04609, USAen_US
dc.contributor.affiliationotherOklahoma Medical Research Foundation, Oklahoma City, OK 73104, USAen_US
dc.contributor.affiliationotherDepartment of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USAen_US
dc.contributor.affiliationotherDepartment of Psychiatry, University of Texas Health Science Center at San Antonio, TX 78229, USAen_US
dc.contributor.affiliationotherDepartment of Aging and Geriatrics, University of Florida, Gainesville, FL 32610, USAen_US
dc.contributor.affiliationotherDepartment of Physiology, University of Texas Health Science Center at San Antonio, TX 78229-3900, USAen_US
dc.contributor.affiliationotherBarshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, TX 78229, USAen_US
dc.contributor.affiliationotherNicox Research Institute, Milan, Italyen_US
dc.contributor.affiliationotherBiology of Aging Program, National Institute on Aging, Bethesda, MD 20892, USAen_US
dc.contributor.affiliationotherUniversity of Minnesota, College of Biological Sciences, St. Paul, MN 55108, USAen_US
dc.identifier.pmid18631321en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/72117/1/j.1474-9726.2008.00414.x.pdf
dc.identifier.doi10.1111/j.1474-9726.2008.00414.xen_US
dc.identifier.sourceAging Cellen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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