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Regulation of DNA synthesis in bacteria: analysis of the Bates/Kleckner licensing/initiation-mass model for cell cycle control

dc.contributor.authorCooper, Stephenen_US
dc.date.accessioned2010-06-01T19:07:16Z
dc.date.available2010-06-01T19:07:16Z
dc.date.issued2006-10en_US
dc.identifier.citationCooper, Stephen (2006). "Regulation of DNA synthesis in bacteria: analysis of the Bates/Kleckner licensing/initiation-mass model for cell cycle control." Molecular Microbiology 62(2): 303-307. <http://hdl.handle.net/2027.42/72308>en_US
dc.identifier.issn0950-382Xen_US
dc.identifier.issn1365-2958en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/72308
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=17020574&dopt=citationen_US
dc.description.abstractBates and Kleckner have recently proposed that bacterial cell division is a licensing agent for a subsequent initiation of DNA replication. They also propose that initiation mass for DNA replication is not constant. These two proposals do not take into account older data showing that initiation of DNA replication can occur prior to the division event. This critical analysis is derived from measurements of DNA replication during the division cycle in cells growing at different, and more rapid, growth rates. Furthermore, mutants impaired in division can initiate DNA synthesis. The data presented by Bates and Kleckner do not support the proposal that initiation mass is variable, and the proposed pattern of DNA replication during the division cycle of the K12 cells analysed is not consistent with prior data on the pattern of DNA replication during the division cycle.en_US
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dc.publisherBlackwell Publishing Ltden_US
dc.rights© 2006 The Author; Journal compilation © 2006 Blackwell Publishing Ltden_US
dc.titleRegulation of DNA synthesis in bacteria: analysis of the Bates/Kleckner licensing/initiation-mass model for cell cycle controlen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelMicrobiology and Immunologyen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.identifier.pmid17020574en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/72308/1/j.1365-2958.2006.05342.x.pdf
dc.identifier.doi10.1111/j.1365-2958.2006.05342.xen_US
dc.identifier.sourceMolecular Microbiologyen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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