Role of protein kinase C in functional selectivity for desensitization at the µ-opioid receptor: from pharmacological curiosity to therapeutic potential
dc.contributor.author | Ingram, Susan L. | en_US |
dc.contributor.author | Traynor, John R. | en_US |
dc.date.accessioned | 2010-06-01T19:13:44Z | |
dc.date.available | 2010-06-01T19:13:44Z | |
dc.date.issued | 2009-09 | en_US |
dc.identifier.citation | Ingram, Susan L; Traynor, John R (2009). "Role of protein kinase C in functional selectivity for desensitization at the µ-opioid receptor: from pharmacological curiosity to therapeutic potential." British Journal of Pharmacology 158(1 Themed Issue: GPCR ): 154-156. <http://hdl.handle.net/2027.42/72412> | en_US |
dc.identifier.issn | 0007-1188 | en_US |
dc.identifier.issn | 1476-5381 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/72412 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=19719778&dopt=citation | en_US |
dc.format.extent | 121235 bytes | |
dc.format.extent | 3109 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Blackwell Publishing Ltd | en_US |
dc.rights | Journal compilation © 2009 The British Pharmacological Society | en_US |
dc.subject.other | Morphine | en_US |
dc.subject.other | µ-Opioid Receptor | en_US |
dc.subject.other | PKC | en_US |
dc.subject.other | Opioid | en_US |
dc.subject.other | Opiate | en_US |
dc.subject.other | Desensitization | en_US |
dc.subject.other | Tolerance | en_US |
dc.subject.other | G Protein-coupled Receptor Kinase (GRK) | en_US |
dc.subject.other | DAMGO | en_US |
dc.subject.other | G Protein | en_US |
dc.title | Role of protein kinase C in functional selectivity for desensitization at the µ-opioid receptor: from pharmacological curiosity to therapeutic potential | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Pharmacy and Pharmacology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pharmacology and Substance Abuse Research Center, University of Michigan, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationother | Department of Psychology, Washington State University Vancouver, Vancouver, WA, USA, and | en_US |
dc.identifier.pmid | 19719778 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/72412/1/j.1476-5381.2009.00198.x.pdf | |
dc.identifier.doi | 10.1111/j.1476-5381.2009.00198.x | en_US |
dc.identifier.source | British Journal of Pharmacology | en_US |
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dc.identifier.citedreference | Clark MJ, Furman CA, Gilson TD, Traynor JR ( 2006 ). Comparison of the relative efficacy and potency of µ-opioid agonists to activate Gα i/o proteins containing a pertussis toxin-insensitive mutation. J Pharmacol Exp Ther 317: 858 – 864. | en_US |
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dc.identifier.citedreference | Lodowski DT, Pitcher JA, Capel WD, Lefkowitz RJ, Tesmer JJ ( 2003 ). Keeping G proteins at bay: a complex between G protein-coupled receptor kinase 2 and Gβγ. Science 300: 1256 – 1262. | en_US |
dc.identifier.citedreference | Singh P, Wang B, Maeda T, Palczewski K, Tesmer JJ ( 2008 ). Structures of rhodopsin kinase in different ligand states reveal key elements involved in G protein-coupled receptor kinase activation. J Biol Chem 283: 14053 – 14062. | en_US |
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dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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