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Role of protein kinase C in functional selectivity for desensitization at the µ-opioid receptor: from pharmacological curiosity to therapeutic potential
dc.contributor.authorIngram, Susan L.en_US
dc.contributor.authorTraynor, John R.en_US
dc.date.accessioned2010-06-01T19:13:44Z
dc.date.available2010-06-01T19:13:44Z
dc.date.issued2009-09en_US
dc.identifier.citationIngram, Susan L; Traynor, John R (2009). "Role of protein kinase C in functional selectivity for desensitization at the µ-opioid receptor: from pharmacological curiosity to therapeutic potential." British Journal of Pharmacology 158(1 Themed Issue: GPCR ): 154-156. <http://hdl.handle.net/2027.42/72412>en_US
dc.identifier.issn0007-1188en_US
dc.identifier.issn1476-5381en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/72412
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=19719778&dopt=citationen_US
dc.format.extent121235 bytes
dc.format.extent3109 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherBlackwell Publishing Ltden_US
dc.rightsJournal compilation © 2009 The British Pharmacological Societyen_US
dc.subject.otherMorphineen_US
dc.subject.otherµ-Opioid Receptoren_US
dc.subject.otherPKCen_US
dc.subject.otherOpioiden_US
dc.subject.otherOpiateen_US
dc.subject.otherDesensitizationen_US
dc.subject.otherToleranceen_US
dc.subject.otherG Protein-coupled Receptor Kinase (GRK)en_US
dc.subject.otherDAMGOen_US
dc.subject.otherG Proteinen_US
dc.titleRole of protein kinase C in functional selectivity for desensitization at the µ-opioid receptor: from pharmacological curiosity to therapeutic potentialen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelPharmacy and Pharmacologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Pharmacology and Substance Abuse Research Center, University of Michigan, Ann Arbor, MI, USAen_US
dc.contributor.affiliationotherDepartment of Psychology, Washington State University Vancouver, Vancouver, WA, USA, anden_US
dc.identifier.pmid19719778en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/72412/1/j.1476-5381.2009.00198.x.pdf
dc.identifier.doi10.1111/j.1476-5381.2009.00198.xen_US
dc.identifier.sourceBritish Journal of Pharmacologyen_US
dc.identifier.citedreferenceBailey CP, Oldfield S, Llorente J, Caunt CJ, Teschemacher AG, Roberts L et al. ( 2009 ). Role of PKCα and G-protein-coupled receptor kinase 2 in agonist-selective desensitization of µ-opioid receptors in mature brain neurons. Br J Pharmacol 158: 157 – 164.en_US
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dc.identifier.citedreferenceClark MJ, Furman CA, Gilson TD, Traynor JR ( 2006 ). Comparison of the relative efficacy and potency of µ-opioid agonists to activate Gα i/o proteins containing a pertussis toxin-insensitive mutation. J Pharmacol Exp Ther 317: 858 – 864.en_US
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dc.identifier.citedreferenceLodowski DT, Pitcher JA, Capel WD, Lefkowitz RJ, Tesmer JJ ( 2003 ). Keeping G proteins at bay: a complex between G protein-coupled receptor kinase 2 and Gβγ. Science 300: 1256 – 1262.en_US
dc.identifier.citedreferenceSingh P, Wang B, Maeda T, Palczewski K, Tesmer JJ ( 2008 ). Structures of rhodopsin kinase in different ligand states reveal key elements involved in G protein-coupled receptor kinase activation. J Biol Chem 283: 14053 – 14062.en_US
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dc.identifier.citedreferenceUrban JD, Clarke WP, von Zastrow M, Nichols DE, Kobilka B, Weinstein H et al. ( 2007 ). Functional selectivity and classical concepts of quantitative pharmacology. J Pharmacol Exp Ther 320: 1 – 13.en_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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