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HEMODYNAMIC EFFECTS OF ACUTE AND PROLONGED Β-ADRENERGIC BLOCKADE IN ESSENTIAL HYPERTENSION

dc.contributor.authorHansson, Lennarten_US
dc.contributor.authorZweifler, Andrew J.en_US
dc.contributor.authorJulius, Stevoen_US
dc.contributor.authorHunyor, Stephen N.en_US
dc.date.accessioned2010-06-01T19:14:45Z
dc.date.available2010-06-01T19:14:45Z
dc.date.issued1974-01-12en_US
dc.identifier.citationHansson, Lennart; Zweifler, Andrew J.; Julius, Stevo; Hunyor, Stephen N. (1974). "HEMODYNAMIC EFFECTS OF ACUTE AND PROLONGED Β-ADRENERGIC BLOCKADE IN ESSENTIAL HYPERTENSION." Acta Medica Scandinavica 196(1-6): 27-34. <http://hdl.handle.net/2027.42/72428>en_US
dc.identifier.issn0001-6101en_US
dc.identifier.issn0954-6820en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/72428
dc.description.abstractHemodynamic studies have been performed in 15 male patients with mild to moderately severe essential hypertension. Studies were made after four weeks of placebo treatment and again after acute i.v. administration of propranolol (0.22 mg/kg) and after four weeks of oral propranolol therapy (160–320 mg daily). After acute Β-adrenergic blockade a significant reduction of cardiac index (Qi) occurred, while total peripheral resistance (TPR) increased significantly, resulting in unaltered BP. After four weeks of oral propranolol the Qi remained significantly reduced, but TPR was readjusted towards the initial level, resulting in a reduction of BP in most patients. Major reductions of stimulated plasma renin activity were seen, but these were not correlated to the changes of BP, Qi or TPR. Studies of the baroreceptor reflex by means of i.v. administration of angiotensin suggested a change towards increased sensitivity, although this change did not achieve statistical significance.en_US
dc.format.extent560875 bytes
dc.format.extent3109 bytes
dc.format.mimetypeapplication/pdf
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dc.publisherBlackwell Publishing Ltden_US
dc.rights1974 Association for the Publication of the Journal of Internal Medicineen_US
dc.titleHEMODYNAMIC EFFECTS OF ACUTE AND PROLONGED Β-ADRENERGIC BLOCKADE IN ESSENTIAL HYPERTENSIONen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelMedicine (General)en_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumthe Department of Internal Medicine, Hypertension Section, University of Michigan Medical Center, Ann Arbor, Michigan, USAen_US
dc.identifier.pmid4370849en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/72428/1/j.0954-6820.1974.tb00962.x.pdf
dc.identifier.doi10.1111/j.0954-6820.1974.tb00962.xen_US
dc.identifier.sourceActa Medica Scandinavicaen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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