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Regulatory Mechanisms of Corticotropin-Releasing Hormone and Vasopressin Gene Expression in the Hypothalamus
dc.contributor.authorItoi, K.en_US
dc.contributor.authorJiang, Y. -Q.en_US
dc.contributor.authorIwasaki, Y.en_US
dc.contributor.authorWatson, Stanley J.en_US
dc.date.accessioned2010-06-01T19:20:00Z
dc.date.available2010-06-01T19:20:00Z
dc.date.issued2004-04en_US
dc.identifier.citationItoi, K.; Jiang, Y.-Q.; Iwasaki, Y.; . Watson, S. J (2004). "Regulatory Mechanisms of Corticotropin-Releasing Hormone and Vasopressin Gene Expression in the Hypothalamus." Journal of Neuroendocrinology 16(4): 348-355. <http://hdl.handle.net/2027.42/72477>en_US
dc.identifier.issn0953-8194en_US
dc.identifier.issn1365-2826en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/72477
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=15089973&dopt=citationen_US
dc.description.abstractTuberoinfundibular corticotropin-releasing hormone (CRH) neurones are the principal regulators of the hypothalamic-pituitary-adrenal (HPA)-axis. Vasopressin is primarily a neurohypophysial hormone, produced in magnocellular neurones of the hypothalamic paraventricular and supraoptic nuclei, but parvocellular CRH neurones also coexpress vasopressin, which acts as a second ‘releasing factor’ for adrenocorticotropic hormone along with CRH. All stress inputs converge on these hypothalamic neuroendocrine neurones, and the input signals are integrated to determine the output secretion of CRH and vasopressin. Aminergic, cholinergic, GABAergic, glutamatergic and a number of peptidergic inputs have all been implicated in the regulation of CRH/vasopressin neurones. Glucocorticoids inhibit the HPA-axis activity by negative feedback. Interleukin-1 stimulates CRH and vasopressin gene expression, and is implicated in immune-neuroendocrine regulation. cAMP-response element-binding protein phosphorylation may mediate transcriptional activation of both CRH and vasopressin genes, but the roles of AP-1 and other transcription factors remain controversial. Expression profiles of the CRH and vasopressin genes are not uniform after stress exposure, and the vasopressin gene appears to be more sensitive to glucocorticoid suppression.en_US
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dc.format.extent3109 bytes
dc.format.mimetypeapplication/pdf
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dc.publisherBlackwell Science Ltden_US
dc.rights© 2004 Blackwell Publishing Ltden_US
dc.subject.otherGlucocorticoidsen_US
dc.subject.otherNeurotransmittersen_US
dc.subject.otherTranscriptionen_US
dc.subject.otherNoradrenalineen_US
dc.subject.otherStressen_US
dc.titleRegulatory Mechanisms of Corticotropin-Releasing Hormone and Vasopressin Gene Expression in the Hypothalamusen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationum§ Mental Health Research Institute, University of Michigan, Ann Arbor, MI, USA.en_US
dc.contributor.affiliationotherLaboratory of Information Biology, Graduate School of Information Sciences, Tohoku University, Sendai, Japan.en_US
dc.contributor.affiliationother† Division of Molecular Endocrinology, Graduate School of Medicine, Tohoku University, Sendai, Japan.en_US
dc.contributor.affiliationother† Department of Clinical Pathophysiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.en_US
dc.identifier.pmid15089973en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/72477/1/j.0953-8194.2004.01172.x.pdf
dc.identifier.doi10.1111/j.0953-8194.2004.01172.xen_US
dc.identifier.sourceJournal of Neuroendocrinologyen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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