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Epstein–Barr virus and post-transplant lymphoproliferative disease
dc.contributor.authorHolmes, R. D.en_US
dc.contributor.authorSokol, R. J.en_US
dc.date.accessioned2010-06-01T19:20:22Z
dc.date.available2010-06-01T19:20:22Z
dc.date.issued2002-12en_US
dc.identifier.citationHolmes, R. D.; Sokol, R. J. (2002). "Epstein–Barr virus and post-transplant lymphoproliferative disease." Pediatric Transplantation 6(6): 456-464. <http://hdl.handle.net/2027.42/72483>en_US
dc.identifier.issn1397-3142en_US
dc.identifier.issn1399-3046en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/72483
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=12453197&dopt=citationen_US
dc.description.abstractThere is convincing evidence that Epstein–Barr virus (EBV) is associated with post-transplant lymphoproliferative disease (PTLD). Primary EBV infection following transplantation occurs in as many as 90% of cases of PTLD in children and pretransplant EBV seronegativity is a recognized risk factor for developing PTLD. Other risk factors include young age at the time of transplant, the type of transplant that the recipient receives and the type and intensity of immunosuppression. The clinical presentation is often nonspecific and tissue biopsy is necessary to establish the diagnosis. There appears to be a correlation between PTLD and EBV viral load measured by polymerase chain reaction (PCR) of the peripheral blood and quantitative PCR may be a useful guide in the management of PTLD. Antiviral drugs and cytomegalovirus-immunoglobulin G may have a role in preventing PTLD. Because PTLD results from functional over-immunosuppression, the initial treatment is reduction of immunosuppression. Antiviral agents, interferon, immuno-based monoclonal therapy, cell-based therapy and chemotherapy also have a potential role in treating this disorder. At the present time there is no standardized approach to the evaluation and treatment of PTLD.en_US
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dc.format.extent3109 bytes
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dc.publisherMunksgaard International Publishersen_US
dc.publisherBlackwell Publishing Ltden_US
dc.rights2002 Blackwell Munksgaarden_US
dc.subject.otherEBVen_US
dc.subject.otherPost-transplant Lymphoproliferative Diseaseen_US
dc.subject.otherTransplantationen_US
dc.titleEpstein–Barr virus and post-transplant lymphoproliferative diseaseen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelPediatricsen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Pediatrics, University of Michigan, Ann Arbor, Michigan, USAen_US
dc.contributor.affiliationotherPediatric Liver Center and Liver Transplantation Program, Department of Pediatrics, University of Colorado Health Sciences Center and the Children's Hospital, Denver, Colorado, USAen_US
dc.identifier.pmid12453197en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/72483/1/j.1399-3046.2002.02043.x.pdf
dc.identifier.doi10.1034/j.1399-3046.2002.02043.xen_US
dc.identifier.sourcePediatric Transplantationen_US
dc.identifier.citedreferenceDror Y, Greenberg M, Taylor G, Superina R, et al. Lymphoproliferative disorders after organ transplantation in children. Transplantation 1999: 67: 990 – 998.en_US
dc.identifier.citedreferenceCollins MH, Montone KT, Leahey RL, et al. Post-transplant lymphoproliferative disease in children. Pediatr Transpl 2001: 5: 250 – 257.en_US
dc.identifier.citedreferenceAris RM, Maia DM, Neuringer IP, et al. Post-transplantation lymphoproliferative disorder in the Epstein–Barr virus naÏve lung transplant recipient. Am J Respir Crit Care Med 1996: 154: 1712 – 1717.en_US
dc.identifier.citedreferenceKowal-Vern A, Swinner L, Pyle J, et al. Characterization of postcardiac transplant lymphomas. Histology, immunophenotyping, immunohistochemistry, and gene rearrangement. Arch Pathol Lab Med 1996: 120: 41 – 48.en_US
dc.identifier.citedreferenceHo M, Jaffe R, Miller G, Breinig MK, et al. The frequency of Epstein–Barr virus infection and associated lymphoproliferative syndrome after transplantation, and its manifestations in children. Transplantation 1988: 45: 719 – 727.en_US
dc.identifier.citedreferenceMcDiarmid SV, Wallace P, Vargas J, et al. The treatment of intractable rejection with tacrolimus (FK506) in pediatric liver transplant recipients. J Pediatr Gastroenterol Nutr 1995: 20: 291 – 299.en_US
dc.identifier.citedreferenceHo M, Jaffe R, Miller G, et al. The frequency of Epstein–Barr virus infection and associated lymphoproliferative syndrome after transplantation and its manifestations in children. Transplantation 1988: 45: 719 – 727.en_US
dc.identifier.citedreferenceBaldanti F, Grossi P, Furione M, et al. High levels of Epstein–Barr virus DNA in blood of solid-organ transplant recipients and their value in predicting posttransplant lymphoproliferative disorders. J Clin Microbiol 2000: 38: 613 – 619.en_US
dc.identifier.citedreferenceRandhawa PS, Jaffee R, Demetris AJ, et al. Expression of Epstein–Barr virus-encoded small RNA (by the EBER-1 gene) in liver specimens from transplant recipients with post-transplantation lymphoproliferative disease N Eng J Med 1992: 327: 1710 – 1714.en_US
dc.identifier.citedreferenceHarris NL, Jaffe ES, Stein H, et al. A revised European-American classification of lymphoid neoplasm: A proposal from the international lymphoma study group. Blood 1994: 84: 1361 – 1392.en_US
dc.identifier.citedreferenceFingeroth JD, Weiss JJ, Telder TF, et al. Epstein–Barr virus receptor of human B lymphocytes is the C3d receptor CR2. Proc Natl Acad Sci USA 1984: 81: 4510 – 4514.en_US
dc.identifier.citedreferenceYao QY, Rowe M, Martin B, et al. The Epstein–Barr virus carrier state: Dominance of a single growth-transforming isolate in the blood and in the oropharynx of healthy virus carriers. J Gen Virol 1991: 72: 1579 – 1590.en_US
dc.identifier.citedreferenceRowe DT. Epstein–Barr virus immortalization and latency. Front Biosci 1999: 4: D346 – D371.en_US
dc.identifier.citedreferenceCohen JL. Epstein–Barr virus infection. N Engl J Med 2000: 343: 481 – 492.en_US
dc.identifier.citedreferenceFries K, Miller W, Raab-Traub N. Epstein–Barr virus latent membrane protein 1 blocks p53-mediated apoptosis through the induction of the A20 gene. J Virol 1996: 70: 8653 – 8659.en_US
dc.identifier.citedreferenceKerr BM, Lear AL, Rowe M, et al. Three transcriptionally distinct forms of Epstein–Barr virus latency in somatic cell hybrids: Cell phenotype dependence of virus promoter usage. Virology 1992: 187: 189 – 201.en_US
dc.identifier.citedreferenceHaque T, Amlot PL, Helling N, et al. Reconstitution of EBV-specific T cell immunity in solid organ transplant recipients. J Immunol 1998: 160: 6204 – 6209.en_US
dc.identifier.citedreferenceIbish C, Saulquin X, Gallot G, et al. The T cell receptoire selected in vitro against EBV. Diversity, specificity, and improved purification through early IL-2 receptor α-chain (CD25)-positive selection. J Immunol 2000: 1674: 4924 – 4932.en_US
dc.identifier.citedreferenceHopwood P, Crawford DH. The role of EBV in post-transplant malignancies: A review. J Clin Pathol 2000: 53: 248 – 254.en_US
dc.identifier.citedreferenceCen H, Williams HP, McWilliams MC, et al. Evidence for restricted Epstein–Barr virus latent gene expression and anti-EBNA antibody response in solid organ transplant recipients with posttransplant lymphoproliferative disorders. Blood 1993: 81: 1393 – 1403.en_US
dc.identifier.citedreferenceKenagy DH, Schleisinger Y, Weck K, et al. Epstein–Barr virus DNA in peripheral blood leukocytes of patients with posttransplant lymphoproliferative disease. Transplantation 1995: 60: 547 – 554.en_US
dc.identifier.citedreferenceRooney CM, Loftin SK, Holladay MS, et al. Early identification of Epstein–Barr virus-associated post-transplantation lymphoproliferative disease. Br J Haematol 1995: 89: 98 – 103.en_US
dc.identifier.citedreferenceGreen M, Cacciarelli TV, Mazariegos GV, et al. Serial measurement of Epstein–Barr viral load in peripheral blood in pediatric liver transplant recipients during treatment for posttransplant lymphoproliferative disease. Transplantation 1998: 66: 1641 – 1644.en_US
dc.identifier.citedreferenceRowe DT, Qu L, Reyes J, et al. Use of quantitative competitive PCR to measure Epstein–Barr virus genome load in the peripheral blood of pediatric transplant patients with lymphoproliferative disorders. J Clin Microbiol 1997: 35: 1612 – 1615.en_US
dc.identifier.citedreferenceRowe DT, Webber S, Schauer EM, et al. Epstein–Barr virus load monitoring: Its role in the prevention and management of post-transplant lymphoproliferative disease. Transpl Infect Dis 2001: 3: 79 – 87.en_US
dc.identifier.citedreferenceOrii T, Ohkohchi N, Koyamada N, et al. Usefulness of quantitative real-time polymerase chain reaction with Epstein–Barr virus infection after liver transplantation. Clin Transpl 2000: 14: 308 – 317.en_US
dc.identifier.citedreferenceKimura H, Morita M, Yabuta Y, et al. Quantitative analysis of Epstein–Barr virus load by using real-time PCR assay. J Clin Microbiol 1999: 37: 132 – 136.en_US
dc.identifier.citedreferenceWitte D, Groen P, Bucuvalas J, et al. New method for determination of EBV viral load in transplant recipients. Am J Transplant 2001: S1: 204.en_US
dc.identifier.citedreferenceQu L, Green M, Webber S, et al. Epstein–Barr virus gene expression in the peripheral blood of transplant recipients with persistent circulating viral loads. J Infect Dis 2000: 182: 10013 – 11021.en_US
dc.identifier.citedreferenceRowe D, Niedobitek G, Young L. EBV gene expression in posttransplant lymphoproliferative disorders. Springer Semin Immunopathol 1998: 20: 389 – 403.en_US
dc.identifier.citedreferenceCox KL, Lawrence-Miyasaki LS, Garcia-Kennedy R, et al. An increased incidence of Epstein–Barr virus infection and lymphoproliferative disorder in young children on FK506 after liver transplantation. Transplantation 1995: 59: 524 – 529.en_US
dc.identifier.citedreferenceStarzl TE, Nalesnik M, Porter KA, et al. Reversibility of lymphomas and lymphoproliferative lesions developing under cyclosporin-steroid therapy. Lancet 1984: 1: 583 – 587.en_US
dc.identifier.citedreferenceReding R, Wallemacq PE, Lamy ME, et al. Conversion from cyclosporine to FK506 for salvage of immunocompromised pediatric liver allografts. Efficacy, toxicity, and dose regimen in 23 children. Transplantation 1994: 57: 93 – 100.en_US
dc.identifier.citedreferenceShapiro R, Nalesnik M, McCauly J, et al. Posttransplant lymphoproliferative disorders in adult and pediatric renal transplant patients receiving tacrolimus-based immunosuppression. Transplantation 1999: 68: 1851 – 1854.en_US
dc.identifier.citedreferenceSwinnen LJ, Costanzo-Nordin MR, Fisher SG, et al. Increased incidence of lymphoproliferative disorder after immunosuppression with the monoclonal antibody OKT3 in cardiac-transplant recipients. N Eng J Med 1990: 323: 1723 – 1728.en_US
dc.identifier.citedreferenceManez R, Breinig MC, Linden P, et al. Posttransplant lymphoproliferative disease in primary Epstein–Barr virus infection after liver transplantation: The role of cytomegalovirus disease. J Infect Dis 1997: 176: 1462 – 1467.en_US
dc.identifier.citedreferenceNewell KA, Alonso EM, Kelly SM, et al. Association between liver transplantation for Langerhans cell histiocytosis, rejection, and development of posttransplant lymphoproliferative disease in children. J Pediatr 1997: 131: 98 – 104.en_US
dc.identifier.citedreferenceEgeler RM, Neglia JP, Puccetti DM, et al. Association of Langerhans' cell histiocytosis with malignant neoplasms. Cancer 1993: 71: 865 – 873.en_US
dc.identifier.citedreferencePickhardt PJ, Siegel MJ, Hayashi RJ, Kelly M. Posttransplantation lymphoproliferative disorder in children: Clinical, histopathologic, and imaging features. Radiology 2000: 217: 16 – 25.en_US
dc.identifier.citedreferenceYounes BS, Ament M, McDiarmid SV, et al. The involvement of the gastrointestinal tract in posttransplant lymphoproliferative disease in pediatric liver transplantation. J Pediatr Gastroenterol Nutr 1999: 28: 380 – 385.en_US
dc.identifier.citedreferenceNalesnik MA, Jaffee R, Starzl TE, et al. The pathology of posttransplant lymphoproliferative disorders occurring in the setting of cyclosporine A-prednisone immunosuppression. Am J Pathol 1988: 133: 173 – 192.en_US
dc.identifier.citedreferenceSandlund JT, Downing JR, Crist WM. Non-Hodgkin's lymphoma in childhood. N Engl J Med 1996: 334: 1238 – 1248.en_US
dc.identifier.citedreferenceRiddler SA, Breining MC, McKnight JLC. Increased levels of circulating Epstein–Barr virus infected lymphocytes and decreased EBV nuclear antigen antibody responses are associated with the development of posttransplant lymphoproliferative disease in solid organ transplant recipients. Blood 1994: 84: 972 – 984.en_US
dc.identifier.citedreferenceBroughton S, McClay JE, Murray A, et al. The effectiveness of tonsillectomy in diagnosing lymphoproliferative disease in pediatric patients after liver transplantation. Arch Otolaryngol Head Neck Surg 2000: 126: 1444 – 1447.en_US
dc.identifier.citedreferenceLones MA, Mishalani S, Shintaku IP, et al. Changes in tonsils and adenoids in children with posttransplant lymphoproliferative disorder: Report of cases with early involvement of Waldeyer's ring. Hum Pathol 1995: 26: 525 – 530.en_US
dc.identifier.citedreferenceLin JC, Smith MC, Pagano JS. Prolonged inhibitory effect of 9-(1,3-dihydroxy-2-propoxymethyl) guanine against replication of Epstein–Barr virus. J Virol 1984: 50: 50 – 55.en_US
dc.identifier.citedreferenceCrumpacker CS. Ganciclovir. N Engl J Med 1996: 335: 721 – 729.en_US
dc.identifier.citedreferenceYao QY, Ogan P, Rowe M, et al. Epstein–Barr virus-infected B cells persist in the circulation of acyclovir-treated virus carriers. Int J Cancer 1989: 43: 67 – 71.en_US
dc.identifier.citedreferenceGreen M, Kaufman M, Wilson J, Ryes J. Comparison of intravenous ganciclovir followed by oral acyclovir with intravenous ganciclovir alone for prevention of cytomegalovus and Epstein–Barr virus disease after liver transplantation in children. Clin Infect Dis 1997: 25: 1344 – 1349.en_US
dc.identifier.citedreferenceDavis CL, Harrison KL, McVicar JP, et al. Antiviral prophylaxis and the Epstein–Barr virus-related post-transplant lymphoproliferative disorder. Clin Transpl 1995: 9: 53 – 59.en_US
dc.identifier.citedreferenceHart GD, Paya CV. Prophylaxis for CMV should now replace pre-emptive therapy in solid organ transplantation. Rev Med Virol 2001: 11: 73 – 81.en_US
dc.identifier.citedreferenceManez R, Brenig MC, Linden P, et al. Posttransplant lymphoproliferative disease in primary Epstein–Barr virus infection after liver transplantation: the role of cytomegalovirus disease. J Infect Dis 1997: 176: 1462 – 1467.en_US
dc.identifier.citedreferenceRinaldo CR. Immune suppression by herpesviruses. Annu Rev Med 1990: 41: 331 – 338.en_US
dc.identifier.citedreferenceGraczyk MJ, Paraskevas S, Gruessner RWG, Coad JE. Post-transplant lymphoma after abdominal organ transplantation: An association with cytomegalovirus. Am J Transplant 2001: S1: 402.en_US
dc.identifier.citedreferencePenn I. The role of immunosuppression in lymphoma formation. Springer Semin Immunopathol 1998: 20: 343 – 355.en_US
dc.identifier.citedreferenceBenkerrow M, Durandy A, Fischer A. Therapy for transplant-related lymphoproliferative diseases. Hematol Oncol Clin North Am 1993: 7: 467 – 475.en_US
dc.identifier.citedreferenceDavis CL. The antiviral prophylaxis of post-transplant lymphoproliferative disorder. Semin Immunopathol 1998: 20: 437 – 453.en_US
dc.identifier.citedreferenceLin JC, Smith MC, Pagano JS. Prolonged inhibitory effect of 9-(1,3-dihydroxy-2-propoxymethyl) guanine against replication of Epstein–Barr virus. J Virol 1984: 50: 50 – 55.en_US
dc.identifier.citedreferenceHanto DW, Fizzera G, Gajl-Peczalska KJ, et al. Acyclovir therapy of Epstein–Barr virus-induced posttransplant lymphoproliferative diseases. Transplant Proc 1985: 17: 89 – 92.en_US
dc.identifier.citedreferencePaya CV, Fung JJ, Nalesnik MA, et al. Epstein–Barr virus induces post transplant lymphoproliferative disorders. Transplantation 1999: 68: 1517 – 1525.en_US
dc.identifier.citedreferenceKane RE, Bunchman TE, Vogler C, Brems JJ. Treatment of a B-cell lymphoproliferative disorder in a liver transplant patient with interferon alfa and gamma globulin: a case report. Clin Transpl 1992: 6: 164 – 168.en_US
dc.identifier.citedreferenceO'Brien S, Bernert RA, Logon JI, Lien YHH. Remission of posttransplant lymphoproliferative disorder after interferon alpha therapy. J Am Soc Nephrol 1997: 8: 1483 – 1490.en_US
dc.identifier.citedreferenceDavis CL, Wood BL, Sabath DE, et al. Interferon-α treatment of posttransplant lymphoproliferative disorder in recipients of solid organ transplants. Transplantation 1998: 66: 1770 – 1779.en_US
dc.identifier.citedreferenceGreen M, Michaels MG, Webber SA, et al. The management of Epstein–Barr associated post-transplant lymphoproliferative disorder in pediatric solid-organ transplant recipients. Pediatr Transpl 1999: 3: 271 – 281.en_US
dc.identifier.citedreferenceMilpied N, Vasseur B, Parquet N, et al. Humanized anti-CD20 monoclonal antibody (Rituximab) in post transplant B-lymphoproliferative disorder: A retrospective analysis on 32 patients. Ann Oncol 2000: 1: 113 – 116.en_US
dc.identifier.citedreferenceWebber SA, Fine RN, McGhee WM, et al. Anti-CD20 monoclonal antibody (Rituximab) for pediatric post-transplant lymphoproliferative disorders: a prelimary multicenter experience. Am J Transplant 2001: S1: 469.en_US
dc.identifier.citedreferenceSerinet M, Jacquemin E, Habes D, et al. Anti-CD20 monoclonal antibody (Rituximab) treatment for Epstein–Barr virus-associated, B-cell lymphoproliferative disease in pediatric liver transplant recipients. J Pediatr Gastroenterol Nutr 2002: 34: 389 – 393.en_US
dc.identifier.citedreferenceFischer A, Blanche S, Lebidois J, et al. Anti-B-cell monoclonal antibodies in the treatment of severe B–cell lymphoproliferative syndrome following bone marrow and organ transplantation. N Engl J Med 1991: 324: 1451 – 1456.en_US
dc.identifier.citedreferenceGross TG. Treatment of Epstein–Barr virus-associated posttransplant lymphoproliferative disorders. J Pediatr Hematol Oncol 2001: 23: 7 – 9.en_US
dc.identifier.citedreferenceHeslop HE, Brenner MK, Rooney CM. Donor T cells to treat EBV-associated lymphoma. N Engl J Med 1994: 331: 679 – 680.en_US
dc.identifier.citedreferenceHeslop HE, Brenner MK, Rooney CM, et al. Clinical protocol: Administration of neomycin resistant gene marked EBV specific CTL to recipients of mismatched-related or phenotypically similar unrelated donor marrow grafts. Hum Gene Ther 1994: 5: 381 – 397.en_US
dc.identifier.citedreferenceKhanna R, Bell S, Sherritt M, et al. Activation and adoptive transfer of Epstein–Barr virus-specific cytotoxic T cells in solid organ transplant patients with posttransplant lymphoproliferative disease. Proc Natl Acad Sci USA 1999: 96: 10391 – 10396.en_US
dc.identifier.citedreferenceSmets F, Vajro P, Cornu G, et al. Indications and results of chemotherapy in children with posttransplant lymphoproliferative disease after liver transplantation. Transplantation 2001: 69: 9982 – 9984.en_US
dc.identifier.citedreferenceHayashi RJ, Kraus MD, Patel AL, et al. Posttransplant lymphoproliferative disease in children; correlation of histology to clinical behavior. J Pediatr Hematol Oncol 2001: 23: 14 – 18.en_US
dc.identifier.citedreferenceGross TG, Hinrichs SH, Winner J, et al. Treatment of post-transplant lymphoproliferative disease (PTLD) following solid organ transplantation with low-dose chemotherapy. Ann Oncol 1998: 9: 339 – 340.en_US
dc.identifier.citedreferenceStephan JL, Le Deist F, Blanche S, et al. Treatment of central nervous system B lymphoproliferative disease by local infusion of a B cell specific monoclonal antibody. Transplantation 1992: 54: 246 – 249.en_US
dc.identifier.citedreferenceDotti G, Fiocchi R, Motto T, et al. Epstein–Barr virus negative lymphoproliferative disorders in long term survivors of heart, kidney and liver transplant. Transplantation 2000: 69: 827 – 833.en_US
dc.identifier.citedreferenceHanto DW, Gajl-Peczalska KJ, Fizzera G, et al. Epstein–Barr virus (EBV) induced polyclonal and monoclonal B-cell lymphoproliferative diseases occurring after renal transplantation. Clinical, pathologic, and virologic findings and implications for therapy Ann Surg 1983: 198: 356 – 369.en_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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