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Connective Tissue Growth Factor Promotes Fibrosis Downstream of TGFΒ and IL-6 in Chronic Cardiac Allograft Rejection
dc.contributor.authorBooth, Adam J.en_US
dc.contributor.authorCsencsits-Smith, K.en_US
dc.contributor.authorWood, S. C.en_US
dc.contributor.authorLu, G.en_US
dc.contributor.authorLipson, K. E.en_US
dc.contributor.authorBishop, D. Keithen_US
dc.date.accessioned2010-06-01T19:26:01Z
dc.date.available2010-06-01T19:26:01Z
dc.date.issued2010-02en_US
dc.identifier.citationBooth, A. J.; Csencsits-Smith, K.; Wood, S. C.; Lu, G.; Lipson, K. E.; Bishop, D. K. (2010). "Connective Tissue Growth Factor Promotes Fibrosis Downstream of TGFΒ and IL-6 in Chronic Cardiac Allograft Rejection." American Journal of Transplantation 10(2): 220-230. <http://hdl.handle.net/2027.42/72574>en_US
dc.identifier.issn1600-6135en_US
dc.identifier.issn1600-6143en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/72574
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=19788504&dopt=citationen_US
dc.format.extent534146 bytes
dc.format.extent3109 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherBlackwell Publishing Incen_US
dc.rights© 2010 American Society of Transplantation and the American Society of Transplant Surgeonsen_US
dc.subject.otherChronic Rejectionen_US
dc.subject.otherCTGFen_US
dc.subject.otherFibrosisen_US
dc.subject.otherIL-6en_US
dc.subject.otherTGFΒen_US
dc.titleConnective Tissue Growth Factor Promotes Fibrosis Downstream of TGFΒ and IL-6 in Chronic Cardiac Allograft Rejectionen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelMedicine (General)en_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Surgery, University of Michigan Medical Center, Ann Arbor, MIen_US
dc.contributor.affiliationotherGraduate Program in Immunologyen_US
dc.contributor.affiliationotherDepartment of Pathology and Laboratory Medicine, University of Texas Health Science Center at Houston, Houston, TXen_US
dc.contributor.affiliationotherFibroGen Inc., San Francisco, CAen_US
dc.identifier.pmid19788504en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/72574/1/j.1600-6143.2009.02826.x.pdf
dc.identifier.doi10.1111/j.1600-6143.2009.02826.xen_US
dc.identifier.sourceAmerican Journal of Transplantationen_US
dc.identifier.citedreferenceOrosz CG, Pelletier RP. Chronic remodeling pathology in grafts. Curr Opin Immunol 1997; 9: 676 – 680.en_US
dc.identifier.citedreferencePaul LC. Current knowledge of the pathogenesis of chronic allograft dysfunction. Transplant Proc 1999; 31: 1793 – 1795.en_US
dc.identifier.citedreferenceWaaga AM, Gasser M, Laskowski I, Tilney NL. Mechanisms of chronic rejection. Curr Opin Immunol 2000; 12: 517 – 521.en_US
dc.identifier.citedreferenceWomer KL, Vella JP, Sayegh MH. Chronic allograft dysfunction: Mechanisms and new approaches to therapy. Semin Nephrol 2000; 20: 126 – 147.en_US
dc.identifier.citedreferenceWeiss MJ, Madsen JC, Rosengard BR, Allan JS. Mechanisms of chronic rejection in cardiothoracic transplantation. Front Biosci 2008; 13: 2980 – 2988.en_US
dc.identifier.citedreferenceMehra MR. Contemporary concepts in prevention and treatment of cardiac allograft vasculopathy. Am J Transplant 2006; 6: 1248 – 1256.en_US
dc.identifier.citedreferenceValantine H. Cardiac allograft vasculopathy after heart transplantation: Risk factors and management. J Heart Lung Transplant 2004; 23 ( 5 Suppl ): S187 – S193.en_US
dc.identifier.citedreferenceCsencsits K, Wood SC, Lu G et al. Transforming growth factor beta-induced connective tissue growth factor and chronic allograft rejection. Am J Transplant 2006; 6 ( 5 Pt 1 ): 959 – 966.en_US
dc.identifier.citedreferenceJain S, Furness PN, Nicholson ML. The role of transforming growth factor beta in chronic renal allograft nephropathy. Transplantation 2000; 69: 1759 – 1766.en_US
dc.identifier.citedreferenceLi MO, Wan YY, Sanjabi S, Robertson AK, Flavell RA. Transforming growth factor-beta regulation of immune responses. Annu Rev Immunol 2006; 24: 99 – 146.en_US
dc.identifier.citedreferenceBlobe GC, Schiemann WP, Lodish HF. Role of transforming growth factor beta in human disease. N Engl J Med 2000; 342: 1350 – 1358.en_US
dc.identifier.citedreferenceWood KJ, Sakaguchi S. Regulatory T cells in transplantation tolerance. Nat Rev Immunol 2003; 3: 199 – 210.en_US
dc.identifier.citedreferenceYong Z, Chang L, Mei YX, Yi L. Role and mechanisms of CD4+CD25+ regulatory T cells in the induction and maintenance of transplantation tolerance. Transpl Immunol 2007; 17: 120 – 129.en_US
dc.identifier.citedreferenceWalsh PT, Taylor DK, Turka LA. Tregs and transplantation tolerance. J Clin Invest 2004; 114: 1398 – 1403.en_US
dc.identifier.citedreferenceBrattain MG, Markowitz SD, Willson JK. The type II transforming growth factor-beta receptor as a tumor-suppressor gene. Curr Opin Oncol 1996; 8: 49 – 53.en_US
dc.identifier.citedreferenceLeask A, Abraham DJ. The role of connective tissue growth factor, a multifunctional matricellular protein, in fibroblast biology. Biochem Cell Biol 2003; 81: 355 – 363.en_US
dc.identifier.citedreferenceChen MM, Lam A, Abraham JA, Schreiner GF, Joly AH. CTGF expression is induced by TGF-beta in cardiac fibroblasts and cardiac myocytes: A potential role in heart fibrosis. J Mol Cell Cardiol 2000; 32: 1805 – 1819.en_US
dc.identifier.citedreferencede Winter P, Leoni P, Abraham D. Connective tissue growth factor: Structure-function relationships of a mosaic, multifunctional protein. Growth Factors 2008; 26: 80 – 91.en_US
dc.identifier.citedreferenceBonniaud P, Martin G, Margetts PJ et al. Connective tissue growth factor is crucial to inducing a profibrotic environment in “fibrosis-resistant” BALB/c mouse lungs. Am J Respir Cell Mol Biol 2004; 31: 510 – 516.en_US
dc.identifier.citedreferenceCheng O, Thuillier R, Sampson E et al. Connective tissue growth factor is a biomarker and mediator of kidney allograft fibrosis. Am J Transplant 2006; 6: 2292 – 2306.en_US
dc.identifier.citedreferenceYuan YC, Xia ZK, Mu JJ, Zhang QC, Yin BL. Increased connective tissue growth factor expression in a rat model of chronic heart allograft rejection. J Formos Med Assoc 2009; 108: 240 – 246.en_US
dc.identifier.citedreferenceDaniels A, van Bilsen M, Goldschmeding R, Van Der Vusse GJ, van Nieuwenhoven FA. Connective tissue growth factor and cardiac fibrosis. Acta Physiol (Oxf) 2009; 195: 321 – 338.en_US
dc.identifier.citedreferenceMannon RB. Therapeutic targets in the treatment of allograft fibrosis. Am J Transplant 2006; 6 ( 5 Pt 1 ): 867 – 875.en_US
dc.identifier.citedreferenceCsencsits K, Wood SC, Lu G, Bishop DK. Transforming growth factor-beta1 gene transfer is associated with the development of regulatory cells. Am J Transplant 2005; 5: 2378 – 2384.en_US
dc.identifier.citedreferenceGuo X, Wang XF. Signaling cross-talk between TGF-beta/BMP and other pathways. Cell Res 2009; 19: 71 – 88.en_US
dc.identifier.citedreferenceDiaz JA, Booth AJ, Lu G, Wood SC, Pinsky DJ, Bishop DK. Critical role for IL-6 in hypertrophy and fibrosis in chronic cardiac allograft rejection. Am J Transplant 2009; 9: 1773 – 1783.en_US
dc.identifier.citedreferenceBettelli E, Carrier Y, Gao W et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 2006; 441: 235 – 238.en_US
dc.identifier.citedreferenceChen RH, Chang MC, Su YH, Tsai YT, Kuo ML. Interleukin-6 inhibits transforming growth factor-beta-induced apoptosis through the phosphatidylinositol 3-kinase/Akt and signal transducers and activators of transcription 3 pathways. J Biol Chem 1999; 274: 23013 – 23019.en_US
dc.identifier.citedreferenceZhang XL, Topley N, Ito T, Phillips A. Interleukin-6 regulation of transforming growth factor (TGF)-beta receptor compartmentalization and turnover enhances TGF-beta1 signaling. J Biol Chem 2005; 280: 12239 – 12245.en_US
dc.identifier.citedreferenceCorry RJ, Winn HJ, Russell PS. Primarily vascularized allografts of hearts in mice. The role of H-2D, H-2K, and non-H-2 antigens in rejection. Transplantation 1973; 16: 343 – 350.en_US
dc.identifier.citedreferenceBurrell BE, Csencsits K, Lu G, Grabauskiene S, Bishop DK. CD8+ Th17 mediate costimulation blockade-resistant allograft rejection in T-bet-deficient mice. J Immunol 2008; 181: 3906 – 3914.en_US
dc.identifier.citedreferenceAikawa T, Gunn J, Spong SM, Klaus SJ, Korc M. Connective tissue growth factor-specific antibody attenuates tumor growth, metastasis, and angiogenesis in an orthotopic mouse model of pancreatic cancer. Mol Cancer Ther 2006; 5: 1108 – 1116.en_US
dc.identifier.citedreferenceDornhofer N, Spong S, Bennewith K et al. Connective tissue growth factor-specific monoclonal antibody therapy inhibits pancreatic tumor growth and metastasis. Cancer Res 2006; 66: 5816 – 5827.en_US
dc.identifier.citedreferenceChan SY, Goodman RE, Szmuszkovicz JR, Roessler B, Eichwald EJ, Bishop DK. DNA-liposome versus adenoviral mediated gene transfer of transforming growth factor beta1 in vascularized cardiac allografts: Differential sensitivity of CD4+ and CD8+ T cells to transforming growth factor beta1. Transplantation 2000; 70: 1292 – 1301.en_US
dc.identifier.citedreferenceChan SY, Li K, Piccotti JR et al. Tissue-specific consequences of the anti-adenoviral immune response: Implications for cardiac transplants. Nat Med 1999; 5: 1143 – 1149.en_US
dc.identifier.citedreferenceHaberberger TC, Kupfer K, Murphy JE. Profiling of genes which are differentially expressed in mouse liver in response to adenoviral vectors and delivered genes. Gene Ther 2000; 7: 903 – 909.en_US
dc.identifier.citedreferenceBurrell BE, Lu G, Li XC, Bishop DK. OX40 costimulation prevents allograft acceptance induced by CD40-CD40L blockade. J Immunol 2009; 182: 379 – 390.en_US
dc.identifier.citedreferenceNozato T, Ito H, Tamamori M et al. G1 cyclins are involved in the mechanism of cardiac myocyte hypertrophy induced by angiotensin II. Jpn Circ J 2000; 64: 595 – 601.en_US
dc.identifier.citedreferenceBishop DK, Li W, Chan SY, Ensley RD, Shelby J, Eichwald EJ. Helper T lymphocyte unresponsiveness to cardiac allografts following transient depletion of CD4-positive cells. Implications for cellular and humoral responses. Transplantation 1994; 58: 576 – 584.en_US
dc.identifier.citedreferencePiccotti JR, Li K, Chan SY, Eichwald EJ, Bishop DK. Cytokine regulation of chronic cardiac allograft rejection: Evidence against a role for Th1 in the disease process. Transplantation 1999; 67: 1548 – 1555.en_US
dc.identifier.citedreferenceCsencsits K, Burrell BE, Lu G, Eichwald EJ, Stahl GL, Bishop DK. The classical complement pathway in transplantation: Unanticipated protective effects of C1q and role in inductive antibody therapy. Am J Transplant 2008; 8: 1622 – 1630.en_US
dc.identifier.citedreferenceBonniaud P, Margetts PJ, Kolb M et al. Adenoviral gene transfer of connective tissue growth factor in the lung induces transient fibrosis. Am J Respir Crit Care Med 2003; 168: 770 – 778.en_US
dc.identifier.citedreferenceGrotendorst GR, Okochi H, Hayashi N. A novel transforming growth factor beta response element controls the expression of the connective tissue growth factor gene. Cell Growth Differ 1996; 7: 469 – 480.en_US
dc.identifier.citedreferenceFrazier K, Williams S, Kothapalli D, Klapper H, Grotendorst GR. Stimulation of fibroblast cell growth, matrix production, and granulation tissue formation by connective tissue growth factor. J Invest Dermatol 1996; 107: 404 – 411.en_US
dc.identifier.citedreferenceMori T, Kawara S, Shinozaki M et al. Role and interaction of connective tissue growth factor with transforming growth factor-beta in persistent fibrosis: A mouse fibrosis model. J Cell Physiol 1999; 181: 153 – 159.en_US
dc.identifier.citedreferenceBurlingham WJ, Love RB, Jankowska-Gan E et al. IL-17-dependent cellular immunity to collagen type V predisposes to obliterative bronchiolitis in human lung transplants. J Clin Invest 2007; 117: 3498 – 3506.en_US
dc.identifier.citedreferenceYuan X, Paez-Cortez J, Schmitt-Knosalla I et al. A novel role of CD4 Th17 cells in mediating cardiac allograft rejection and vasculopathy. J Exp Med 2008; 205: 3133 – 3144.en_US
dc.identifier.citedreferenceHayata N, Fujio Y, Yamamoto Y et al. Connective tissue growth factor induces cardiac hypertrophy through Akt signaling. Biochem Biophys Res Commun 2008; 370: 274 – 278.en_US
dc.identifier.citedreferenceMatsui Y, Sadoshima J. Rapid upregulation of CTGF in cardiac myocytes by hypertrophic stimuli: Implication for cardiac fibrosis and hypertrophy. J Mol Cell Cardiol 2004; 37: 477 – 481.en_US
dc.identifier.citedreferenceCaron KM, James LR, Kim HS et al. Cardiac hypertrophy and sudden death in mice with a genetically clamped renin transgene. Proc Natl Acad Sci USA 2004; 101: 3106 – 3111.en_US
dc.identifier.citedreferenceFredj S, Bescond J, Louault C, Potreau D. Interactions between cardiac cells enhance cardiomyocyte hypertrophy and increase fibroblast proliferation. J Cell Physiol 2005; 202: 891 – 899.en_US
dc.identifier.citedreferenceBabic AM, Chen CC, Lau LF. Fisp12/mouse connective tissue growth factor mediates endothelial cell adhesion and migration through integrin alphavbeta3, promotes endothelial cell survival, and induces angiogenesis in vivo. Mol Cell Biol 1999; 19: 2958 – 2966.en_US
dc.identifier.citedreferenceBall DK, Rachfal AW, Kemper SA, Brigstock DR. The heparin-binding 10 kDa fragment of connective tissue growth factor (CTGF) containing module 4 alone stimulates cell adhesion. J Endocrinol 2003; 176: R1 – R7.en_US
dc.identifier.citedreferenceChen CC, Chen N, Lau LF. The angiogenic factors Cyr61 and connective tissue growth factor induce adhesive signaling in primary human skin fibroblasts. J Biol Chem 2001; 276: 10443 – 10452.en_US
dc.identifier.citedreferenceChen Y, Abraham DJ, Shi-Wen X et al. CCN2 (connective tissue growth factor) promotes fibroblast adhesion to fibronectin. Mol Biol Cell 2004; 15: 5635 – 5646.en_US
dc.identifier.citedreferenceGao R, Brigstock DR. Connective tissue growth factor (CCN2) induces adhesion of rat activated hepatic stellate cells by binding of its C-terminal domain to integrin alpha(v)beta(3) and heparan sulfate proteoglycan. J Biol Chem 2004; 279: 8848 – 8855.en_US
dc.identifier.citedreferenceHoshijima M, Hattori T, Inoue M et al. CT domain of CCN2/CTGF directly interacts with fibronectin and enhances cell adhesion of chondrocytes through integrin alpha5beta1. FEBS Lett 2006; 580: 1376 – 1382.en_US
dc.identifier.citedreferenceNishida T, Kawaki H, Baxter RM, Deyoung RA, Takigawa M, Lyons KM. CCN2 (Connective Tissue Growth Factor) is essential for extracellular matrix production and integrin signaling in chondrocytes. J Cell Commun Signal 2007; 1: 45 – 58.en_US
dc.identifier.citedreferenceGao R, Brigstock DR. A novel integrin alpha5beta1 binding domain in module 4 of connective tissue growth factor (CCN2/CTGF) promotes adhesion and migration of activated pancreatic stellate cells. Gut 2006; 55: 856 – 862.en_US
dc.identifier.citedreferenceHeng EC, Huang Y, Black SA Jr, Trackman PC. CCN2, connective tissue growth factor, stimulates collagen deposition by gingival fibroblasts via module 3 and alpha6- and beta1 integrins. J Cell Biochem 2006; 98: 409 – 420.en_US
dc.identifier.citedreferenceJedsadayanmata A, Chen CC, Kireeva ML, Lau LF, Lam SC. Activation-dependent adhesion of human platelets to Cyr61 and Fisp12/mouse connective tissue growth factor is mediated through integrin alpha(IIb)beta(3). J Biol Chem 1999; 274: 24321 – 24327.en_US
dc.identifier.citedreferenceWu SH, Lu C, Dong L, Chen ZQ. Signal transduction involved in CTGF-induced production of chemokines in mesangial cells. Growth Factors 2008; 26: 192 – 200.en_US
dc.identifier.citedreferenceZhao XM, Frist WH, Yeoh TK, Miller GG. Expression of cytokine genes in human cardiac allografts: Correlation of IL-6 and transforming growth factor-beta (TGF-beta) with histological rejection. Clin Exp Immunol 1993; 93: 448 – 451.en_US
dc.identifier.citedreferenceLetterio JJ, Roberts AB. Regulation of immune responses by TGF-beta. Annu Rev Immunol 1998; 16: 137 – 161.en_US
dc.identifier.citedreferencePrud’homme GJ, Piccirillo CA. The inhibitory effects of transforming growth factor-beta-1 (TGF-beta1) in autoimmune diseases. J Autoimmun 2000; 14: 23 – 42.en_US
dc.identifier.citedreferenceWahl SM. Transforming growth factor beta: The good, the bad, and the ugly. J Exp Med 1994; 180: 1587 – 1590.en_US
dc.identifier.citedreferenceMassague J, Blain SW, Lo RS. TGFbeta signaling in growth control, cancer, and heritable disorders. Cell 2000; 103: 295 – 309.en_US
dc.identifier.citedreferenceFu S, Zhang N, Yopp AC et al. TGF-beta induces Foxp3 +T-regulatory cells from CD4+ CD25− precursors. Am J Transplant 2004; 4: 1614 – 1627.en_US
dc.identifier.citedreferenceChen W, Jin W, Hardegen N et al. Conversion of peripheral CD4+CD25− naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med 2003; 198: 1875 – 1886.en_US
dc.identifier.citedreferenceZheng SG, Gray JD, Ohtsuka K, Yamagiwa S, Horwitz DA. Generation ex vivo of TGF-beta-producing regulatory T cells from CD4+CD25− precursors. J Immunol 2002; 169: 4183 – 4189.en_US
dc.identifier.citedreferenceMarin V, Montero-Julian FA, Gres S et al. The IL-6-soluble IL-6Ralpha autocrine loop of endothelial activation as an intermediate between acute and chronic inflammation: An experimental model involving thrombin. J Immunol 2001; 167: 3435 – 3442.en_US
dc.identifier.citedreferenceHurst SM, Wilkinson TS, McLoughlin RM et al. Il-6 and its soluble receptor orchestrate a temporal switch in the pattern of leukocyte recruitment seen during acute inflammation. Immunity 2001; 14: 705 – 714.en_US
dc.identifier.citedreferenceVenkatachalam K, Mummidi S, Cortez DM, Prabhu SD, Valente AJ, Chandrasekar B. Resveratrol inhibits high glucose-induced PI3K/Akt/ERK-dependent interleukin-17 expression in primary mouse cardiac fibroblasts. Am J Physiol Heart Circ Physiol 2008; 294: H2078 – H2087.en_US
dc.identifier.citedreferenceJones SA. Directing transition from innate to acquired immunity: Defining a role for IL-6. J Immunol 2005; 175: 3463 – 3468.en_US
dc.identifier.citedreferenceWeissenbach M, Clahsen T, Weber C et al. Interleukin-6 is a direct mediator of T cell migration. Eur J Immunol 2004; 34: 2895 – 2906.en_US
dc.identifier.citedreferenceShi-wen X, Stanton LA, Kennedy L et al. CCN2 is necessary for adhesive responses to transforming growth factor-beta1 in embryonic fibroblasts. J Biol Chem 2006; 281: 10715 – 10726.en_US
dc.identifier.citedreferenceQi W, Chen X, Polhill TS et al. TGF-beta1 induces IL-8 and MCP-1 through a connective tissue growth factor-independent pathway. Am J Physiol Renal Physiol 2006; 290: F703 – F709.en_US
dc.identifier.citedreferenceIkawa Y, Ng PS, Endo K et al. Neutralizing monoclonal antibody to human connective tissue growth factor ameliorates transforming growth factor-beta-induced mouse fibrosis. J Cell Physiol 2008; 216: 680 – 687.en_US
dc.identifier.citedreferenceRaichlin E, Villarraga HR, Chandrasekaran K et al. Cardiac allograft remodeling after heart transplantation is associated with increased graft vasculopathy and mortality. Am J Transplant 2009; 9: 132 – 139.en_US
dc.identifier.citedreferenceTorre-Amione G. Cardiac allograft hypertrophy: A new target for therapy, a surrogate marker for survival? Am J Transplant 2009; 9: 7 – 8.en_US
dc.identifier.citedreferenceNishida T, Kubota S, Fukunaga T et al. CTGF/Hcs24, hypertrophic chondrocyte-specific gene product, interacts with perlecan in regulating the proliferation and differentiation of chondrocytes. J Cell Physiol 2003; 196: 265 – 275.en_US
dc.identifier.citedreferenceDuisters RF, Tijsen AJ, Schroen B et al. miR-133 and miR-30 regulate connective tissue growth factor: Implications for a role of microRNAs in myocardial matrix remodeling. Circ Res 2009; 104: 170 – 178, 176p following 178.en_US
dc.identifier.citedreferenceLiu W, Feng W, Wang F et al. Osteoprotegerin/RANK/RANKL axis in cardiac remodeling due to immuno-inflammatory myocardial disease. Exp Mol Pathol 2008; 84: 213 – 217.en_US
dc.identifier.citedreferenceOkada H, Kikuta T, Inoue T et al. Dexamethasone induces connective tissue growth factor expression in renal tubular epithelial cells in a mouse strain-specific manner. Am J Pathol 2006; 168: 737 – 747.en_US
dc.identifier.citedreferenceHolmes A, Abraham DJ, Sa S, Shiwen X, Black CM, Leask A. CTGF and SMADs, maintenance of scleroderma phenotype is independent of SMAD signaling. J Biol Chem 2001; 276: 10594 – 10601.en_US
dc.identifier.citedreferenceYoshimura A, Naka T, Kubo M. SOCS proteins, cytokine signalling and immune regulation. Nat Rev Immunol 2007; 7: 454 – 465.en_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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