C-Telopeptide Pyridinoline Cross-Links: Sensitive Indicators of Periodontal Tissue Destruction
dc.contributor.author | Giannobile, William V. | en_US |
dc.date.accessioned | 2010-06-01T19:27:30Z | |
dc.date.available | 2010-06-01T19:27:30Z | |
dc.date.issued | 1999-06 | en_US |
dc.identifier.citation | GIANNOBILE, WILLIAM V. (1999). "C-Telopeptide Pyridinoline Cross-Links: Sensitive Indicators of Periodontal Tissue Destruction." Annals of the New York Academy of Sciences 878(1 INHIBITION OF MATRIX METALLOPROTEINASES THERAPEUTIC APPLICATIONS ): 404-412. <http://hdl.handle.net/2027.42/72598> | en_US |
dc.identifier.issn | 0077-8923 | en_US |
dc.identifier.issn | 1749-6632 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/72598 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=10415744&dopt=citation | en_US |
dc.description.abstract | C-telopeptides and related pyridinoline cross-links of bone Type I collagen are sensitive markers of bone resorption in osteolytic diseases such as osteoporosis and osteoarthritis. We have studied the release of C-telopeptide pyridinoline crosslinks of Type I collagen as measures of bone destruction in periodontal disease. Studies in preclinical animal models and humans have demonstrated the relationship between radiographic bone loss and crevicular fluid C-telopeptide levels. We have recently found that C-telopeptide levels correlate strongly with microbial pathogens associated with periodontitis and around endosseous dental implants. Host-modulation of bone-related collagen breakdown has been shown by studies in humans demonstrating that MMP inhibition blocks tissue destruction and release of C-telopeptides in patients with active periodontal disease. | en_US |
dc.format.extent | 676161 bytes | |
dc.format.extent | 3109 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Blackwell Publishing Ltd | en_US |
dc.rights | New York Academy of Sciences 1999 | en_US |
dc.title | C-Telopeptide Pyridinoline Cross-Links: Sensitive Indicators of Periodontal Tissue Destruction | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Science (General) | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Periodontics/Prevention/Geriatrics, University of Michigan, 1011 North University Avenue, Ann Arbor, Michigan 48109-1078, USA | en_US |
dc.identifier.pmid | 10415744 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/72598/1/j.1749-6632.1999.tb07698.x.pdf | |
dc.identifier.doi | 10.1111/j.1749-6632.1999.tb07698.x | en_US |
dc.identifier.source | Annals of the New York Academy of Sciences | en_US |
dc.identifier.citedreference | Socransky, S.S. & A.D. Haffajee. 1997. The nature of periodontal diseases. Ann. Periodontol. 2: 3 – 10. | en_US |
dc.identifier.citedreference | Armitage, G.C. 1996. Periodontal diseases: diagnosis. Ann. Periodontol. 1: 37 – 215. | en_US |
dc.identifier.citedreference | Calvo, M.S., D.R. Eyre & C.M. Gundberg. 1996. Molecular basis and clinical application of biologic markers of bone turnover. Endocrine Rev. 17: 333 – 368. | en_US |
dc.identifier.citedreference | Delmas, P.D., A. Schlemmer, E. Gineyts, B. Riis & C. Christiansen. 1991. Urinary excretion of pyridinoline crosslinks correlates with bone turnover measured on iliac crest biopsy in patients with vertebral osteoporosis. J. Bone Mineral Res. 6: 639 – 644. | en_US |
dc.identifier.citedreference | 5 Eastell, R., L. Hampton, A. Colwell, J.R. Green, A.M.A. Assiri, R. Hesp & R.G.G. Russell. 1990. Urinary collagen crosslinks are highly correlated with radioisotopic measurements of bone resorption. In Osteoporosis. C. Christiansen & K. Overgaard, Eds.: 469-470. Osteopress ApS. Copenhagen. | en_US |
dc.identifier.citedreference | Eastell, R., S.P. Robins, T. Colwell, A.M.A. Assiri, B.L. Riggs & R.G.G. Russell, 1993. Evaluation of bone turnover in type I osteoporosis using biochemical markers specific for both bone formation and bone resorption. Osteoporosis Int. 3: 255 – 260. | en_US |
dc.identifier.citedreference | Black, D., M. Marabani, R.D. Sturrock & S.P. Robins. 1989. Urinary excretion of the hydroxypyridinium cross links of collagen in patients with rheumatoid arthritis. Ann. Rheum. Dis. 48: 641 – 644. | en_US |
dc.identifier.citedreference | Uebelhart, D., E. Gineyts, M.-C. Chapuy & P.D. Delmas. 1990. Urinary excretion of pyridinium crosslinks: a new marker of bone resorption in metabolic bone disease. Bone Mineral 8: 87 – 96. | en_US |
dc.identifier.citedreference | Kylmala, T., T.L. Tammela, L. Risteli, J. Risteli, M. Kontturi & I. Elomaa. 1995. Type I collagen degradation product (ICTP) gives information about the nature of bone metastases and has prognostic value in prostate cancer. Br. J. Cancer 71: 1061 – 1064. | en_US |
dc.identifier.citedreference | Garnero, P., W.J. Shih, E. Gineyts, D.B. Karpf & P.D. Delmas. 1994. Comparison of new biochemical markers of bone turnover in late postmenopausal osteoporotic women in response to alendronate treatment. J. Endocrinol. Metab. 79: 1693 – 1700. | en_US |
dc.identifier.citedreference | Yasumizu, T., K. Hoshi, S. Iijima & A. Asaka. 1998. Serum concentration of the pyridinoline cross-linked carboxyterminal telopeptide of type I collagen (ICTP) is a useful indicator of decline and recovery of bone mineral density in lumbar spine: analysis in Japanese postmenopausal women with or without hormone replacement. Endocrine Journal 45: 45 – 51. | en_US |
dc.identifier.citedreference | 12 Cimasoni, G. 1983. Crevicular Fluid Updated. Karger. Basel. | en_US |
dc.identifier.citedreference | Lamster, I.B. 1997. Evaluation of components of gingival crevicular fluid as diagnostic tests. Ann. Periodontol. 2: 123 – 37. | en_US |
dc.identifier.citedreference | Giannobile, W.V. 1997. Crevicular fluid biomarkers of oral bone loss. Curr. Opinion Periodontol. 4: 19 – 30. | en_US |
dc.identifier.citedreference | Talonpoika, J.T. & M.M. HÄmÄlÄinen. 1994. Type I carboxyterminal telopeptide in human gingival crevicular fluid in different clinical conditions and after periodontal treatment. J. Clin. Periodontol. 21: 21 – 34. | en_US |
dc.identifier.citedreference | Giannobile, W.V., S.E. Lynch, R.G. Denmark, D.W. Paquette, J.P. Fiorellini & R.C. Williams. 1995. Crevicular fluid osteocalcin and pyridinoline cross-linked carboxyterminal telopeptide of type I collagen (ICTP) as markers of rapid bone turnover in periodontitis. J. Clin. Periodontol. 22: 904 – 910. | en_US |
dc.identifier.citedreference | Shibutani, T., Y. Murahashi, E. Tsukada, Y. Iwayama & J.N.M. Heersche. 1997. Experimentally induced periodontitis in beagle dogs causes rapid increases in osteoclastic resorption of alveolar bone. J. Periodontol. 68: 385 – 391. | en_US |
dc.identifier.citedreference | Socransky, S.S., A.D. Haffajee, M.A. Cugini, C. Smith & R.L. Kent Jr. 1998. Microbial complexes in subgingival plaque. J. Clin. Periodontol. 25: 134 – 144. | en_US |
dc.identifier.citedreference | Palys, M.D., A.D. Haffajee, S.S. Socransky & W.V. Giannobile. 1998. Relationship between C-telopeptide pyridinoline cross-links (ICTP) and putative periodontal pathogens in periodontitis. J. Clin. Periodontol. 25: 865 – 871. | en_US |
dc.identifier.citedreference | Fiorellini, J.P., G. Martuscelli & H.P. Weber. 1998. Longitudinal studies on implant systems. Periodontology 2000 17: 125 – 131. | en_US |
dc.identifier.citedreference | Oringer, R.J., M.D. Palys, A. Iranmanesh, J.P. Fiorellini, A.D. Haffajee, S.S. Socransky & W.V. Giannobile. 1998. C-telopeptide pyridinoline cross-links (ICTP) and periodontal pathogens associated with endosseous oral implants. Clin. Oral Implants Res. 9: 365 – 373. | en_US |
dc.identifier.citedreference | Ryan, M.E., S. Ramamurthy & L.M. Golub. 1996. Matrix metalloproteinases and their inhibition in periodontal treatment. Curr. Opinion Periodontol. 3: 85 – 96. | en_US |
dc.identifier.citedreference | Weinberg, M.A. & M. Bral. 1998. Tetracycline and its analogues: A therapeutic paradigm in periodontal diseases. Crit. Rev. Oral Biol. Med. 9: 322 – 332. | en_US |
dc.identifier.citedreference | Golub, L. M., H.M. Lee, R.A. Greenwald, M.E. Ryan, T. Sorsa, T. Salo & W.V. Giannobile. 1997. A matrix metalloproteinase inhibitor reduces bone-type collagen degradation fragments and specific collagenases in gingival crevicular fluid during adult periodontitis. Inflamm. Res. 46: 310 – 319. | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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