A Second Nonsecretor Allele of the Blood Group Α(1,2)Fucosyl-transferase Gene (FUT2)
dc.contributor.author | Henry, Stephen G. | en_US |
dc.contributor.author | Mollicone, Rosella | en_US |
dc.contributor.author | Lowe, John B. | en_US |
dc.contributor.author | Samuelsson, Bo | en_US |
dc.contributor.author | Larson, Göran | en_US |
dc.date.accessioned | 2010-06-01T19:29:54Z | |
dc.date.available | 2010-06-01T19:29:54Z | |
dc.date.issued | 1996-01 | en_US |
dc.identifier.citation | Henry, Stephen; Mollicone, Rosella; Lowe, John B.; Samuelsson, Bo; Larson, GÖran (1996). "A Second Nonsecretor Allele of the Blood Group Α(1,2)Fucosyl-transferase Gene (FUT2)." Vox Sanguinis 70(1): 21-25. <http://hdl.handle.net/2027.42/72637> | en_US |
dc.identifier.issn | 0042-9007 | en_US |
dc.identifier.issn | 1423-0410 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/72637 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8928486&dopt=citation | en_US |
dc.description.abstract | While screening Le(a+b+) Polynesian DN A samples for a candidate Se w allele, a point mutation (C 571 →T) resulting in a new stop codon (Arg 191 →stop) in the Α(1,2)fucosyltransferase gene (FUT2) was identified. This point mutation resulted in the gaining of a new restriction enzyme cleavage site ( DdeI ), which allowed restriction enzyme cleavage screening of 40 selected Polynesians and 42 random Caucasians. The nonsecretor phenotype in two of the three nonsecretor Polynesians analyzed was due to homozygosity for the ‘new’ mutation, whereas the third Polynesian nonsecretor (with Caucasian ancestors) was due to homozygosity of the ‘old’ (Trp 143 →stop) mutation. The nonsecretor phenotype in all Caucasians analyzed was a consequence of homozygosity for the ‘old’ mutation. Both the new and the old nonsecretor mutations were identified in the heterozygous state in some secretor-positive Polynesians, while only the old mutation was found in the heterozygous state in Caucasians of the same phenotype. | en_US |
dc.format.extent | 498197 bytes | |
dc.format.extent | 3109 bytes | |
dc.format.mimetype | application/octet-stream | |
dc.format.mimetype | text/plain | |
dc.publisher | Blackwell Publishing Ltd | en_US |
dc.rights | 1996 Blackwell Publishing Ltd | en_US |
dc.title | A Second Nonsecretor Allele of the Blood Group Α(1,2)Fucosyl-transferase Gene (FUT2) | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Oncology and Hematology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Howard Hughes Medical Institute, University of Michigan Medical Centre, MSRBI, Ann Arbor, Mich., USA | en_US |
dc.contributor.affiliationother | Department of Clinical Chemistry and Transfusion Medicine, Goteborg University, Sahlgrenska Hospital, Goteborg, Sweden | en_US |
dc.contributor.affiliationother | INSERM U178, Villejuif, France | en_US |
dc.identifier.pmid | 8928486 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/72637/1/j.1423-0410.1996.tb00991.x.pdf | |
dc.identifier.doi | 10.1111/j.1423-0410.1996.tb00991.x | en_US |
dc.identifier.source | Vox Sanguinis | en_US |
dc.identifier.citedreference | Oriol R: ABO, Hh, Lewis and secretion: Serology, genetics and tissue distribution; in Cartron JP, Rouger P ( eds ): Blood Cell Biochemistry: Molecular Basis of Major Blood Group Antigens. New York. Plenum 1995, pp 37 – 73. | en_US |
dc.identifier.citedreference | Watkins WM: Biochemistry and genetics of the ABO. Lewis, and P blood group systems. Adv Hum Genet 1980; 10: 1 – 136. | en_US |
dc.identifier.citedreference | Henry SM, Oriol R, Samuelsson BE: Lewis his-to-blood group system and associated secretory phenotypes. Vox Sang 1995; 69: 166 – 182. | en_US |
dc.identifier.citedreference | Kelly RJ, Ernst LK, Larsen RD, Bryand JG, Robinson JS. Lowe JB: Molecular basis for H blood group deficiency in Bombay (O h ) and parabonibay individuals. Proc Natl Acad Sci USA 1994; 91: 5843 – 5847. | en_US |
dc.identifier.citedreference | Kumazaki T, Yoshida A: Biochemical evidence that secretor gene. Se, is a structural gene encoding a specific fucosyltransferase. Proc Natl Acad Sci USA 1984; 81: 4193 – 4197. | en_US |
dc.identifier.citedreference | Le Pendu J, Cartron JP, Lemieux RU, Oriol R: The presence of at least two different H-blood-group-related ΒDGal Α-2- L -fucosyltransferases in human serum and the genetics of blood group H substances. Am J Hum Genet 1985; 37: 749 – 760. | en_US |
dc.identifier.citedreference | Oriol R, Danilovs J, Hawkins BR: A new genetic model proposing that the Se gene is a structural gene closely linked to the H gene. Am J Hum Genet 1981; 33: 421 – 431. | en_US |
dc.identifier.citedreference | Sarnesto A, KÖhlin T, Hindsgaul O, Thurin J, Blaszczyk-Thurin M: Purification of the secre-tor-type Β-galactoside Α1–2-fucosyltransferase from human serum. J Biol Chem 1992; 267: 2737 – 2744. | en_US |
dc.identifier.citedreference | Kelly RJ, Rouquier S, Giorgi D, Lennon GG, Lowe JB: Sequence and expression of a candidate for the human secretor blood group Α(1,2) fucosyltransferase gene (FUT2): Homozygosity for an enzyme-inactivating nonsense mutation commonly correlates with the non-secretor phenotype. J Biol Chem 1995; 270: 464 – 4649. | en_US |
dc.identifier.citedreference | Broadberry RE, Lin-Chu M: The Lewis blood group system among Chinese in Taiwan. Hum Heredl 1991; 41: 290 – 294. | en_US |
dc.identifier.citedreference | Vos GH, Comley P: Red cell and saliva studies for the evaluation of ABH and Lewis factors among the Caucasians and Aboriginal populations of Western Australia. Acta Genet 1967; 17: 495 – 510. | en_US |
dc.identifier.citedreference | Henry SM, Benny AG, Woodfield DG: Investigation of Polynesian Lewis phenotypes: Evidence of a weak secretor phenotype. Vos Sang 1990; 58: 61 – 66. | en_US |
dc.identifier.citedreference | Henry SM, Oriol R, Samuelsson BE: Detection and characterisation of Lewis antigens in plasma of Lewis-negative individuals: Evidence of chain extension as a result of reduced fucosyltransferase competition. Vox Sang 1994; 67: 387 – 396. | en_US |
dc.identifier.citedreference | Henry SM, Samuelsson BE, Oriol R: Immunochemical and immunohistological expression of Lewis histo-blood group antigens in small intestine including individuals of the Le(a+b+) and Le(a-b-) nonsecretor phenotypes. Glycoconj J 1994; 11: 600 – 607. | en_US |
dc.identifier.citedreference | Henry SM, Oriol R, Samuelsson BE: Expression of Lewis histo-blood group glycolipids in the plasma of individuals of Le(a+b+) and partial secretor phenotype. Glycoconj J 1994; 11: 593 – 599. | en_US |
dc.identifier.citedreference | Elmgren A, Borjeson C, Svensson L, Rydberg L, Larson G: DNA sequencing and screening for point mutations in the human Lewis (FUT3) gene enables molecular genotyping of the human Lewis blood group system. Vox Sang 1995; in press. | en_US |
dc.identifier.citedreference | Mollison PL, Engelfriet CP, Contreras M: Blood Transfusion in Clinical Medicine. Oxford, Blackwell Scientific, 1993, pp 149 – 205. | en_US |
dc.identifier.citedreference | Miller SA, Dykes DD, Polesky HF: A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 1988; 16: 1215. | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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