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Constitutive activity of the Δ -opioid receptor expressed in C6 glioma cells: identification of non-peptide Δ -inverse agonists

dc.contributor.authorNeilan, Claire L.en_US
dc.contributor.authorAkil, Hudaen_US
dc.contributor.authorWoods, James H.en_US
dc.contributor.authorTraynor, John R.en_US
dc.date.accessioned2010-06-01T19:31:14Z
dc.date.available2010-06-01T19:31:14Z
dc.date.issued1999-10en_US
dc.identifier.citationNeilan, Claire L; Akil, Huda; Woods, James H; Traynor, John R (1999). "Constitutive activity of the Δ -opioid receptor expressed in C6 glioma cells: identification of non-peptide Δ -inverse agonists." British Journal of Pharmacology 128(3): 556-562. <http://hdl.handle.net/2027.42/72658>en_US
dc.identifier.issn0007-1188en_US
dc.identifier.issn1476-5381en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/72658
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=10516632&dopt=citationen_US
dc.format.extent207367 bytes
dc.format.extent3109 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherBlackwell Publishing Ltden_US
dc.rights1999 British Pharmacological Societyen_US
dc.subject.otherConstitutive Activityen_US
dc.subject.otherInverse Agonismen_US
dc.subject.otherΔ-Opioid Receptoren_US
dc.subject.otherΜ-Opioid Receptoren_US
dc.subject.otherG-proteinen_US
dc.subject.otherPertussis Toxinen_US
dc.titleConstitutive activity of the Δ -opioid receptor expressed in C6 glioma cells: identification of non-peptide Δ -inverse agonistsen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelPharmacy and Pharmacologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumMental Health Research Institute, University of Michigan Medical School, Ann Arbor, Michigan, MI 48109-0720, USAen_US
dc.identifier.pmid10516632en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/72658/1/sj.bjp.0702816.pdf
dc.identifier.doi10.1038/sj.bjp.0702816en_US
dc.identifier.sourceBritish Journal of Pharmacologyen_US
dc.identifier.citedreferenceAPPELMANS, N., CARROLL, J.A., RANCE, M.J., SIMON, E.J. & TRAYNOR, J.R. ( 1986 ). Sodium ions increase the binding of the antagonist peptide ICI 174,864 to the delta opiate receptor. Neuropeptides, 7, 139 – 143.en_US
dc.identifier.citedreferenceCHILDERS, S.R. & SNYDER, S.H. ( 1980 ). Differential regulation by guanine nucleotides of opiate agonist and antagonist receptor interactions. J. Neurochem., 34, 583 – 593.en_US
dc.identifier.citedreferenceCHIU, T.T., YUNG, L.Y. & WONG, Y.H. ( 1996 ). Inverse agonist effect of ICI 174,864 on the cloned Δ-opioid receptor: Role of G-protein and adenylyl cyclase activation. Mol. Pharmacol., 50, 1651 – 1657.en_US
dc.identifier.citedreferenceCLARK, M.J., EMMERSON, P.J., MANSOUR, A., AKIL, H., WOODS, J.H., PORTOGHESE, P.S., REMMERS, A.E. & MEDZIHRADSKY, F. ( 1997 ). Opioid efficacy in a C6 glioma cell line stably expressing the delta opioid receptor. J. Pharmacol. Exp. Ther., 283, 501 – 510.en_US
dc.identifier.citedreferenceCOMER, S.D., BURKE, T.F., LEWIS, J.W. & WOODS, J.H. ( 1992 ). Clocinnamox: a novel, systemically active, irreversible opioid antagonist. J. Pharmacol. Exp. Ther., 262, 1051 – 1056.en_US
dc.identifier.citedreferenceCOSTA, T. & HERZ, A. ( 1989 ). Antagonists with negative intrinsic efficacy at Δ opioid receptors coupled to GTP-binding proteins. Proc. Natl. Acad. Sci., 86, 7321 – 7325.en_US
dc.identifier.citedreferenceDHAWAN, B.N., CESSELIN, R., RAGHUBIR, R., REISINE, T., BRADLEY, P.B., PORTOGHESE, P.S. & HAMON, M. ( 1996 ). International union of pharmacology. XII. Classification of opioid receptors. Pharmacol. Rev., 48, 567 – 592.en_US
dc.identifier.citedreferenceEMMERSON, P.J., CLARK, M.J., MANSOUR, A., AKIL, H., WOODS, J.H. & MEDZIHRADSKY, F. ( 1996 ). Characterisation of opioid agonist efficacy in a C6 glioma cell line expressing the mu opioid receptor. J. Pharmacol. Exp. Ther., 278, 1121 – 1127.en_US
dc.identifier.citedreferenceGEORGOUSSI, Z. & ZIOUDROU, C. ( 1993 ). Effect of delta-opioid antagonists on the functional coupling between opioid receptors and G-proteins in rat brain membranes. Biochem. Pharmacol., 45, 2405 – 2410.en_US
dc.identifier.citedreferenceKATADA, T., OINUMA, M. & UI, M. ( 1986 ). Mechanism for the inhibition of the catalytic activity of the enzyme adenylate cyclase by the guanine nucleotide binding proteins serving as the substrate of the islet activating protein, pertussis toxin. J. Biol. Chem., 261, 5215 – 5221.en_US
dc.identifier.citedreferenceLAUGWITZ, K.-L., OFFERMANS, S., SPICHER, K. & SCHULTZ, G. ( 1993 ). Μ and Δ opioid receptors differentially couple to G protein subtypes in membranes of human neuroblastoma SH-SY5Y cells. Neuron, 10, 233 – 242.en_US
dc.identifier.citedreferenceLEFF, P. ( 1995 ). The two-state model of receptor activation. Trends Pharmacol. Sci., 16, 89 – 97.en_US
dc.identifier.citedreferenceLEFKOWITZ, R.J., COTECCHIA, S., SAMAMA, P. & COSTA, T. ( 1993 ). Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins. Trends Pharmacol. Sci., 14, 203 – 207.en_US
dc.identifier.citedreferenceMALMBERG, A., MIKAELS, A. & MOHELL, N. ( 1998 ). Agonist and inverse agonist activity at the dopamine D3 receptor measured by guanosine 5′-[Γ-thio]triphosphate[ 35 S] binding. J. Pharmacol. Exp. Ther., 285, 119 – 126.en_US
dc.identifier.citedreferenceMENG, F., HOVERSTEN, M., THOMPSON, R.C., TAYLOR, L., WATSON, S.J. & AKIL, H. ( 1995 ). A chimeric study of the molecular basis of affinity and selectivity of the Κ and the Δ opioid receptors: potential role of extracellular domains. J. Biol. Chem., 270, 12730 – 12736.en_US
dc.identifier.citedreferenceMERKOURIS, M., MULLANEY, I., GEORGOUSSI, Z. & MILLIGAN, G. ( 1997 ). Regulation of spontaneous activity of the Δ-opioid receptor: Studies of inverse agonism in intact cells. J. Neurochem., 69, 2115 – 2122.en_US
dc.identifier.citedreferenceMULLANEY, I., CARR, C. & MILLIGAN, G. ( 1996 ). Analysis of inverse agonism at the Δ opioid receptor after expression in Rat 1 fibroblasts. Biochem. J., 315, 227 – 234.en_US
dc.identifier.citedreferenceNEILAN, C.L., VIVIAN, J.A., WOODS, J.H. & TRAYNOR, J.R. ( 1998 ). Constitutive activity at opioid receptors expressed in C6 glioma cells. Society for Neuroscience Abstracts, 24, 2053.en_US
dc.identifier.citedreferencePASTERNAK, G., SNOWMAN, A.M. & SNYDER, S. ( 1975 ). Selective enhancement of [ 3 H]opiate agonist binding by divalent cations. Mol. Pharm., 11, 735 – 744.en_US
dc.identifier.citedreferencePORTOGHESE, P.S., SULTANA, M., NAGASE, H. & TAKEMORI, A.E. ( 1992 ). A highly selective Δ 1 -opioid receptor antagonist: 7-benzylidenenaltrexone. Eur. J. Pharmacol., 218, 195 – 196.en_US
dc.identifier.citedreferenceSHAW, J.S., MILLER, L., TURNBULL, M.J., GORMLEY, J.J. & MORLEY, J.S. ( 1982 ). Selective antagonists at the opiate delta-receptor. Life. Sci., 31, 1259 – 1262.en_US
dc.identifier.citedreferenceSOFUOGLU, M., PORTOGHESE, P.S. & TAKEMORI, A.E. ( 1991 ). Differential antagonism of delta opioid agonists by naltrindole and its benzofuran analog (NTB) in mice: Evidence for delta opioid receptor subtypes. J. Pharmacol. Exp. Ther., 257, 676 – 680.en_US
dc.identifier.citedreferenceSTICKLE, D. & BARBER, R. ( 1992 ). The encounter coupling model for Β-adrenergic receptor/GTP binding protein interaction in the S49 cell. Calculation of the encounter frequency. Biochem. Pharmacol., 43, 2015 – 2028.en_US
dc.identifier.citedreferenceSZEKERES, P. & TRAYNOR, J.R. ( 1997 ). Delta opioid modulation of the binding of guanosine-5′-O-(3-[ 35 S]thio)triphosphate to NG108-15 cell membranes: characterization of agonist and inverse agonist effects. J. Pharmacol. Exp. Ther., 283, 1276 – 1284.en_US
dc.identifier.citedreferenceTHOMPSON, R.C., MANSOUR, A., AKIL, H. & WATSON, S.J. ( 1993 ). Cloning and pharmacological characterization of a rat Μ-opioid receptor. Neuron, 11, 903 – 913.en_US
dc.identifier.citedreferenceTRAYNOR, J.R. & NAHORSKI, S.R. ( 1995 ). Modulation by Μ-opioid agonists of guanosine-5′-O-(3-[ 35 S]thio)triphosphate binding to membranes from human neuroblastoma SH-SY5Y cells. Mol. Pharmacol., 47, 848 – 854.en_US
dc.identifier.citedreferenceTRAYNOR, J.R. & WOOD, M.S. ( 1989 ). [ 3 H]Diprenorphine binding to kappa sites in guinea-pig and rat brain: evidence for apparent heterogeneity. J. Neurochem., 53, 173 – 178.en_US
dc.identifier.citedreferenceWANG, Z., BILSKY, E.J., PORRECA, F. & SADEE, W. ( 1994 ). Constitutive mu opioid receptor activation as a regulatory mechanism underlying narcotic tolerance and dependence. Life Sci., 50, 339 – 350.en_US
dc.identifier.citedreferenceZERNIG, G., BROADBEAR, J., BRINE, G.A., LEWIS, J.W. & WOODS, J.H. ( 1995 ). Opioid agonist effects on mouse writhing after irreversible mu receptor blockade with clocinnamox. Exp. Clin. Psychopharm., 3, 323 – 329.en_US
dc.identifier.citedreferenceZERNIG, G., BURKE, T., LEWIS, J.W. & WOODS, J.H. ( 1996 ). Mechanism of clocinnamox blockade of opioid receptors: Evidence from in vitro and ex vivo binding and behavioral assays. J. Pharmacol. Exp. Ther., 279, 23 – 31.en_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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