An Osteoblast-dependent Mechanism Contributes to the Leptin Regulation of Insulin Secretion
dc.contributor.author | Hinoi, Eiichi | en_US |
dc.contributor.author | Gao, Nan | en_US |
dc.contributor.author | Jung, Dae Young | en_US |
dc.contributor.author | Yadav, Vijay | en_US |
dc.contributor.author | Yoshizawa, Tatsuya | en_US |
dc.contributor.author | Kajimura, Daisuke | en_US |
dc.contributor.author | Myers, Jr. , Martin G. | en_US |
dc.contributor.author | Chua, Jr. , Streamson C. | en_US |
dc.contributor.author | Wang, Qin | en_US |
dc.contributor.author | Kim, Jason K. | en_US |
dc.contributor.author | Kaestner, Klaus H. | en_US |
dc.contributor.author | Karsenty, Gerard | en_US |
dc.date.accessioned | 2010-06-01T19:31:26Z | |
dc.date.available | 2010-06-01T19:31:26Z | |
dc.date.issued | 2009-09 | en_US |
dc.identifier.citation | Hinoi, Eiichi; Gao, Nan; Jung, Dae Young; Yadav, Vijay; Yoshizawa, Tatsuya; Kajimura, Daisuke; Myers, Jr., Martin G.; Chua, Jr., Streamson C.; Wang, Qin; Kim, Jason K.; Kaestner, Klaus H.; Karsenty, Gerard (2009). "An Osteoblast-dependent Mechanism Contributes to the Leptin Regulation of Insulin Secretion." Annals of the New York Academy of Sciences 1173(s1 S1 Integrative Physiology ): E20-E30. <http://hdl.handle.net/2027.42/72661> | en_US |
dc.identifier.issn | 0077-8923 | en_US |
dc.identifier.issn | 1749-6632 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/72661 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=19751411&dopt=citation | en_US |
dc.format.extent | 815209 bytes | |
dc.format.extent | 182037 bytes | |
dc.format.extent | 3109 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Blackwell Publishing Inc | en_US |
dc.rights | © 2009 The New York Academy of Sciences | en_US |
dc.subject.other | Leptin | en_US |
dc.subject.other | Osteoblast | en_US |
dc.subject.other | Osteocalcin | en_US |
dc.title | An Osteoblast-dependent Mechanism Contributes to the Leptin Regulation of Insulin Secretion | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Science (General) | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Internal Medicine and Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationother | Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, New York, USA | en_US |
dc.contributor.affiliationother | Department of Genetics, University of Pennsylvania, Philadelphia, Pennsylvania, USA | en_US |
dc.contributor.affiliationother | Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA | en_US |
dc.contributor.affiliationother | Department of Medicine and Neuroscience, Albert Einstein College of Medicine, Bronx, New York, USA | en_US |
dc.contributor.affiliationother | Department of Physiology and Biophysics, University of Alabama at Birmingham, Birmingham, Alabama, USA | en_US |
dc.identifier.pmid | 19751411 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/72661/1/j.1749-6632.2009.05061.x.pdf | |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/72661/2/NYAS_5061_sm_SuppMat.pdf | |
dc.identifier.doi | 10.1111/j.1749-6632.2009.05061.x | en_US |
dc.identifier.source | Annals of the New York Academy of Sciences | en_US |
dc.identifier.citedreference | Morioka, T., E. Asilmaz, J. Hu, et al. 2007. Disruption of leptin receptor expression in the pancreas directly affects beta cell growth and function in mice. J. Clin. Invest. 117: 2860 – 2868. | en_US |
dc.identifier.citedreference | Covey, S.D., R.D. Wideman, C. McDonald, et al. 2006. The pancreatic beta cell is a key site for mediating the effects of leptin on glucose homeostasis. Cell Metab. 4: 291 – 302. | en_US |
dc.identifier.citedreference | Kieffer, T.J. & J.F. Habener. 2000. The adipoinsular axis: effects of leptin on pancreatic beta-cells. Am. J. Physiol. Endocrinol. Metab. 278: E1 – E14. | en_US |
dc.identifier.citedreference | Spiegelman, B.M. & J.S. Flier. 1996. Adipogenesis and obesity: rounding out the big picture. Cell 87: 377 – 389. | en_US |
dc.identifier.citedreference | Pelleymounter, M.A., M.J. Cullen, M.B. Baker, et al. 1995. Effects of the obese gene product on body weight regulation in ob/ob mice. Science 269: 540 – 543. | en_US |
dc.identifier.citedreference | Moitra, J., M.M. Mason, M. Olive, et al. 1998. Life without white fat: a transgenic mouse. Genes Dev. 12: 3168 – 3181. | en_US |
dc.identifier.citedreference | Farooqi, I.S., G. Matarese, G.M. Lord, et al. 2002. Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency. J. Clin. Invest. 110: 1093 – 1103. | en_US |
dc.identifier.citedreference | Grupe, A., B. Hultgren, A. Ryan, et al. 1995. Transgenic knockouts reveal a critical requirement for pancreatic beta cell glucokinase in maintaining glucose homeostasis. Cell 83: 69 – 78. | en_US |
dc.identifier.citedreference | Rane, S.G., P. Dubus, R.V. Mettus, et al. 1999. Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia. Nat. Genet. 22: 44 – 52. | en_US |
dc.identifier.citedreference | BjÖrnholm, M., H. MÜnzberg, R.L. Leshan, et al. 2007. Mice lacking inhibitory leptin receptor signals are lean with normal endocrine function. J. Clin. Invest. 117: 1354 – 1360. | en_US |
dc.identifier.citedreference | Hummel, K.P., M.M. Dickie & D.L. Coleman. 1966. Diabetes, a new mutation in the mouse. Science 153: 1127 – 1128. | en_US |
dc.identifier.citedreference | van de Wall, E. et al. 2008. Collective and individual functions of leptin receptor modulated neurons controlling metabolism and ingestion. Endocrinology 149: 1773 – 1785. | en_US |
dc.identifier.citedreference | Takeda, S., F. Elefteriou, R. Levasseur, et al. 2002. Leptin regulates bone formation via the sympathetic nervous system. Cell 111: 305 – 317. | en_US |
dc.identifier.citedreference | Satoh, N., Y. Ogawa, G. Katsuura, et al. 1999. Sympathetic activation of leptin via the ventromedial hypothalamus: leptin-induced increase in catecholamine secretion. Diabetes 48: 1787 – 1793. | en_US |
dc.identifier.citedreference | Berthoud, H.R. & B. Jeanrenaud. 1979. Acute hyperinsulinemia and its reversal by vagotomy after lesions of the ventromedial hypothalamus in anesthetized rats. Endocrinology 105: 146 – 151. | en_US |
dc.identifier.citedreference | Lee, N.K., H. Sowa, E. Hinoi, et al. 2007. Endocrine regulation of energy metabolism by the skeleton. Cell 130: 456 – 469. | en_US |
dc.identifier.citedreference | Ferron, M.F., E. Hinoi, G. Karsenty & P. Ducy. 2008. Osteocalcin differentially regulates beta cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice. Proc. Natl. Acad. Sci. USA 105: 5266 – 5270. | en_US |
dc.identifier.citedreference | Yang, X., K. Matsuda, P. Bialek, et al. 2004. ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology; implication for Coffin-Lowry Syndrome. Cell 117: 387 – 398. | en_US |
dc.identifier.citedreference | Hay, C.W. & K. Docherty. 2006. Comparative analysis of insulin gene promoters: implications for diabetes research. Diabetes 55: 3201 – 3213. | en_US |
dc.identifier.citedreference | Mayr, B. & M. Montminy. 2001. Transcriptional regulation by the phosphorylation-dependent factor CREB. Nat. Rev. Mol. Cell Biol. 2: 599 – 609. | en_US |
dc.identifier.citedreference | Kim, H.I., J.Y. Cha, S.Y. Kim, et al. 2002. Peroxisomal proliferator-activated receptor-gamma upregulates glucokinase gene expression in beta-cells. Diabetes 51: 676 – 685. | en_US |
dc.identifier.citedreference | Friedman, J.M. & J.L. Halaas. 1998. Leptin and the regulation of body weight in mammals. Nature 395: 763 – 770. | en_US |
dc.identifier.citedreference | Elmquist, J.K., E. Maratos-Flier, C.B. Saper & J.S. Flier. 1998. Unraveling the central nervous system pathways underlying responses to leptin. Nat. Neurosci. 1: 445 – 450. | en_US |
dc.identifier.citedreference | Karsenty, G. 2006. Convergence between bone and energy homeostases: leptin regulation of bone mass. Cell Metab. 4: 341 – 348. | en_US |
dc.identifier.citedreference | Rosen, C.J. 2008. Bone remodeling, energy metabolism, and the molecular clock. Cell Metab. 7: 7 – 10. | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.