Topical tretinoin: its use in daily practice to reverse photoageing
dc.contributor.author | Goldfarb, Michael T. | en_US |
dc.contributor.author | Ellis, C. N. | en_US |
dc.contributor.author | Voorhees, John J. | en_US |
dc.date.accessioned | 2010-06-01T19:31:48Z | |
dc.date.available | 2010-06-01T19:31:48Z | |
dc.date.issued | 1990-04 | en_US |
dc.identifier.citation | GOLDFARB, M. T.; ELLIS, C. N.; VOORHEES, J. J. (1990). "Topical tretinoin: its use in daily practice to reverse photoageing." British Journal of Dermatology 122(): 87-91. <http://hdl.handle.net/2027.42/72667> | en_US |
dc.identifier.issn | 0007-0963 | en_US |
dc.identifier.issn | 1365-2133 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/72667 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2186791&dopt=citation | en_US |
dc.description.abstract | The effect of 0.1% tretinoin cream for the treatment of photoageing was studied in a double-blind, placebo-controlled trial. All patients applied tretinoin cream to one forearm and the vehicle cream to the other, and half of the patients also applied tretinoin cream to the face and the other half used the vehicle cream. Tretinoin treatment produced an improvement in the signs of extrinsic ageing conipared with the vehicle-treated areas. Fine wrinkling was improved most, although coarse wrinkling, brown spots, tactile roughness and overall skin colour also showed clear improvement. The majority of lentigines and sun-induced freckles showed some reduction in coloration with extended treatment. It is important when using tretinoin that the treatment procedure is carefully explained to the patients and that they are warned about a retinoid reaction. It should be stressed that improvement is gradual and that regular application of the cream must continue even after improvement has been achieved. Patients should be assured that there is no evidence of carcinogenicity in humans. Although no teratogenic effects of tretinoin have been reported when applied topically, it is not advisable to use the cream when trying to conceive or when pregnant. | en_US |
dc.format.extent | 368854 bytes | |
dc.format.extent | 3109 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Blackwell Publishing Ltd | en_US |
dc.rights | 1990 British Association of Dermatologists | en_US |
dc.title | Topical tretinoin: its use in daily practice to reverse photoageing | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Dermatology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Dermatopharmacology Unit, Department of Dermatology, University of Michigan Medical Center, Ann Arbor, Michigan, U.S.A. | en_US |
dc.identifier.pmid | 2186791 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/72667/1/j.1365-2133.1990.tb16131.x.pdf | |
dc.identifier.doi | 10.1111/j.1365-2133.1990.tb16131.x | en_US |
dc.identifier.source | British Journal of Dermatology | en_US |
dc.identifier.citedreference | Kligman AM, Grove GL, Hirose R, Leyden JJ. Topical tretinoin for photoaged sink. J Am Acad Dermatol 1986; 15: 836 – 59. | en_US |
dc.identifier.citedreference | Weiss JS, Ellis CN, Headington JT et al. Topical tretinoin improves photoaged skin: a double-blind, vehicle-controlled study. J Am Med Assoc 1988; 259: 527 – 32. | en_US |
dc.identifier.citedreference | Connor MJ, Lowe NJ. Retinoid stimulation of epidermal cell growth in vivo. In: Retinoids ( Saurat J, ed ). Basel: S Kruger, 1985; 198 – 201. | en_US |
dc.identifier.citedreference | Elias PM. Epidermal effect of retinoids: supramolecular observations and clinical implications. J Am Acad Dermatol 1986; 15: 797 – 809. | en_US |
dc.identifier.citedreference | Eichner R. Epidermal effects of retinoids: in vitro studies. J Am Acad Dermatot 1986; 15: 789 – 97. | en_US |
dc.identifier.citedreference | Zelickson AS, Mottaz JH, Weiss JS et al. Topical tretinoin in photoaging: an ultrastructural study. J Cutan Aging Cosmetic Dermatot 1988; 1: 41 – 7. | en_US |
dc.identifier.citedreference | Petkovick M, Brand NJ, Drust A et al. A human retinoic acid receptor which belongs to the family of nuclear receptors. Nature 1987; 330: 444 – 50. | en_US |
dc.identifier.citedreference | Kligman LH. Effects of all-trans-retinoic acid on the dermis of hairless mice. J Am Acad Dermatol 1986; 15: 779 – 85. | en_US |
dc.identifier.citedreference | Ellis CN, Weiss JS, Hamilton TA et al. Sustained improvement with prolonged topical tretinoin (retinoic acid) for photoaged skin. J Am Acad Dermatol ( in press ). | en_US |
dc.identifier.citedreference | Epstein JH. Chemicals and photocarcinogenesis. Aust J Dermatol 1977; 18: 57 – 61. | en_US |
dc.identifier.citedreference | Epstein JH. All-lrani-retinoic acid and cutaneous cancers. J Am Acad Dermatol 1986; 15: 772 – 8. | en_US |
dc.identifier.citedreference | Peck GL. Topical tretinoin in actinic keratosis and basal cell carcinoma. J Am Acad Dermatol 1986; 15: 829 – 35. | en_US |
dc.identifier.citedreference | Meyskens FL. Role of topical tretinoin in melanoma and dysplastic nevi. J Am Acad Dermatol 1986; 15: 822 – 5. | en_US |
dc.identifier.citedreference | Chaing TC. Gas chomatographic-mass spectrometric assay for low levels of retinoic acid in human blood. J Chromatogr 1980; 182: 335 – 40. | en_US |
dc.identifier.citedreference | Kligman AM. Is topical tretinoin teratogenic ? J Am Med Assoc 1988; 259: 2918. | en_US |
dc.identifier.citedreference | 16 FDA and teratogenic potential of Retin-A. Scrip 1989; no. 1374: 5 – 17. | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.