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Co-ordinate expression of virulence genes by ToxR in Vibrio cholerae

dc.contributor.authorDiRita, Victor J.en_US
dc.date.accessioned2010-06-01T19:37:03Z
dc.date.available2010-06-01T19:37:03Z
dc.date.issued1992-02en_US
dc.identifier.citationDiRita, Victor J. (1992). "Co-ordinate expression of virulence genes by ToxR in Vibrio cholerae ." Molecular Microbiology 6(4): 451-458. <http://hdl.handle.net/2027.42/72753>en_US
dc.identifier.issn0950-382Xen_US
dc.identifier.issn1365-2958en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/72753
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1560773&dopt=citationen_US
dc.description.abstractEvolution of complex regulatory pathways that control virulence factor expression in pathogenic bacteria indicates the importance to these organisms of being able to distinguish time and place. In the human intestinal pathogen Vibrio cholerae , control over many virulence genes identified to date is the responsibility of the ToxR protein. ToxR, in conjunction with a second regulatory protein called ToxS, directly activates the genes encoding the cholera toxin; other ToxR regulated genes are not activated directly by ToxR. For some of these genes, ToxR manifests its control through another activator called ToxT. Expression of toxT , which encodes a member of the AraC family of bacterial transcriptional activators, is ToxR dependent and is modulated by in vitro growth conditions that modulate expression of the ToxR virulence regulon. Thus, as in other regulatory circuits, co-ordinate expression of several genes in V. cholerae results from the activity of a cascading system of regulatory factors.en_US
dc.format.extent3567334 bytes
dc.format.extent3109 bytes
dc.format.mimetypeapplication/pdf
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dc.publisherBlackwell Publishing Ltden_US
dc.rights1992 Blackwell Publishingen_US
dc.titleCo-ordinate expression of virulence genes by ToxR in Vibrio choleraeen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelMicrobiology and Immunologyen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumUnit for Laboratory Animal Medicine and Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan 48109-0614, USA.en_US
dc.identifier.pmid1560773en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/72753/1/j.1365-2958.1992.tb01489.x.pdf
dc.identifier.doi10.1111/j.1365-2958.1992.tb01489.xen_US
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