Associations between apolipoprotein E phenotype, glucose metabolism and cognitive function in men. An explorative study in a population sample
dc.contributor.author | Helkala, E. L. | en_US |
dc.contributor.author | Lakka, T. A. (Timo A.) | en_US |
dc.contributor.author | Vanhanen, M. | en_US |
dc.contributor.author | Tuomainen, T. P. | en_US |
dc.contributor.author | Ehnholm, Christian | en_US |
dc.contributor.author | Kaplan, George A. | en_US |
dc.contributor.author | Salonen, Jukka T. | en_US |
dc.date.accessioned | 2010-06-01T19:46:23Z | |
dc.date.available | 2010-06-01T19:46:23Z | |
dc.date.issued | 2001-12 | en_US |
dc.identifier.citation | Helkala, E-L.; Lakka, T.; Vanhanen, M.; Tuomainen, T-P.; Ehnholm, C.; Kaplan, G.A.; Salonen, J.T. (2001). "Associations between apolipoprotein E phenotype, glucose metabolism and cognitive function in men. An explorative study in a population sample." Diabetic Medicine 18(12): 991-997. <http://hdl.handle.net/2027.42/72906> | en_US |
dc.identifier.issn | 0742-3071 | en_US |
dc.identifier.issn | 1464-5491 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/72906 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=11903399&dopt=citation | en_US |
dc.description.abstract | Aims To investigate the associations of the apolipoprotein E phenotype (apoE) and disturbed glucose metabolism with cognitive function in a random population sample. Methods A cross-sectional study was conducted, in which 528 men aged 54 or 60 years were recruited randomly from a larger population-based sample of 1516 men. A subject was defined as having abnormal glucose tolerance (AGT), if he had a clinical diagnosis of diabetes, with either dietary or oral antidiabetic treatment or showed impaired glucose tolerance in an oral glucose tolerance test. The subjects were divided into three groups according to apolipoprotein E phenotypes: (a) E2/4, E3/4 or E4/4 (apoE E4); (b) E 3/3 (apoE E3); and (c) E2/2 or E2/3 (apoE E2). Memory function was examined using a word-list learning with Buschke's selective reminding method and test. Executive functions were assessed with the Trail Making Test A and B. Results Those subjects with apoE E2 and abnormal glucose metabolism demonstrated the worst cognitive executive control compared to other groups. Simple cognitive speed did not differ between the groups. Conclusions The exploratory analyses revealed that subjects with apoE E2 allele and AGT had worse glycaemic control and cognitive executive control compared to other groups. Different apolipoprotein phenotypes together with impaired glucose tolerance may have different cumulative adverse effects on age-related cognitive performance. Some subgroups of subjects may be especially vulnerable to cognitive impairment. Diabet. Med. 18, 991–997 (2001) | en_US |
dc.format.extent | 116929 bytes | |
dc.format.extent | 3109 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Blackwell Science Ltd | en_US |
dc.rights | British Diabetic Association | en_US |
dc.subject.other | Cognitive Functions | en_US |
dc.subject.other | Glucose Metabolism | en_US |
dc.subject.other | Apolipoprotein E Phenotype | en_US |
dc.title | Associations between apolipoprotein E phenotype, glucose metabolism and cognitive function in men. An explorative study in a population sample | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Medicine (General) | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | †† Department of Epidemiology, University of Michigan, School of Public Health, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationother | * Department of Public Health and General Practice of University of Kuopio, Kuopio, Finland, | en_US |
dc.contributor.affiliationother | † Research Institute of Public Health, University of Kuopio and | en_US |
dc.contributor.affiliationother | † Research Institute of Exercise Medicine, Kuopio, | en_US |
dc.contributor.affiliationother | § Department of Neurology, University Hospital and University of Kuopio, Kuopio, Finland, | en_US |
dc.contributor.affiliationother | ** National Public Health Institute, Helsinki, Finland, | en_US |
dc.identifier.pmid | 11903399 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/72906/1/j.0742-3071.2001.00588.x.pdf | |
dc.identifier.doi | 10.1046/j.0742-3071.2001.00588.x | en_US |
dc.identifier.source | Diabetic Medicine | en_US |
dc.identifier.citedreference | Corder EH, Saunders AM, Strittmacher WJ, Schmechel DE, Gaskell PC, Small GW et al. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 1993; 261: 921 – 923. | en_US |
dc.identifier.citedreference | Kuusisto J, Koivisto K, Kervinen K, MykkÄnen L, Helkala E-L, Vanhanen M et al. Association of apolipoprotein E phenotypes with late onset alzheimer's disease: population based study. Br Med J 1994; 309: 636 – 638. | en_US |
dc.identifier.citedreference | Reed T, Carmelli D, Swan GE, Breitner JCS, Welsh KA, Jarvik GP et al. Lower cognitive performance in normal older adult male twins carrying the apolipoprotein E ε4 allele. Arch Neurol 1994; 51: 1189 – 1192. | en_US |
dc.identifier.citedreference | Bondi MW, Salmon DP, Monsch AU, Galalsko D, Butters N, Klauber MR et al. Episodic memory changes are associated with the ApoE-ε4 allele in nondemented older adults. Neurology 1995; 45: 2203 – 2206. | en_US |
dc.identifier.citedreference | Yaffe K, Cauley J, Sands L, Browner W, Apolipoprotein E phenotype and cognitive decline in a prospective study of elderly community women. Arch Neurol 1997; 54: 1110 – 1114. | en_US |
dc.identifier.citedreference | Louhija J, Miettinen HE, Kontula K, Tikkanen MJ, Miettinen TA, Tilvis RS. Aging and genetic variation of plasma apolipoproteins. Relative loss of the apolipoprotein e4 phenotype in centenarians. Arterioscler Tromb 1994; 14: 1084 – 1089. | en_US |
dc.identifier.citedreference | Helkala E-L, Koivisto K, HÄnninen T, Vanhanen M, Kervinen K, Kuusisto J et al. The association of apolipoprotein E polymorphism with cognitive performance: population based study. Neurosci Lett 1995; 191: 141 – 144. | en_US |
dc.identifier.citedreference | Helkala E-L, Koivisto K, HÄnninen T, Vanhanen M, Kervinen K, Kuusisto J et al. Memory functions in human subjects with different apolioprotein E phenotypes during a 3-year population-based follow-up study. Neurosci Lett 1996; 204: 177 – 180. | en_US |
dc.identifier.citedreference | U'Ren R, Riddle MC, Lezak MD, Bennington-Davis M. The mental efficiency of the elderly person with type II diabetes mellitus. J Am Geriatric Soc 1990; 38: 505 – 510. | en_US |
dc.identifier.citedreference | Tun PA, Nathan DM, Perlmuter LC. Cognitive and affective disorders in elderly diabetics. Clin Geriatr Med 1990; 6: 731 – 746. | en_US |
dc.identifier.citedreference | Helkala E-L, Niskanen L, ViinamÄki H, Partanen J, Uusitupa M. Short-term and long-term memory in elderly patients with NIDDM. Diabetes Care 1995; 18: 681 – 685. | en_US |
dc.identifier.citedreference | Strachan MWJ, Deary IJ, Ewing FME, Frier BM. Is type II diabetes associated with an increased risk of cognitive dysfunction? Diabetes Care 1997; 20: 438 – 445. | en_US |
dc.identifier.citedreference | Kalmijn S, Feskens EJ, Launer LJ, Kromhout D. Cerebrovascular disease, the apolipoprotein e4 allele, and cognitive decline in a community-based study of elderly men. Stroke 1996; 27: 2230 – 2235. | en_US |
dc.identifier.citedreference | Hofman A, Ott A, Breteles MMB, Bots ML, Slooter AJC, vanHarskamp F et al. Atherosclerosis, apolipoprotein-E and the prevalence of dementia and Alzheimer's disease in the Rotterdam study. Lancet 1997; 349: 151 – 154. | en_US |
dc.identifier.citedreference | Salonen JT. Is there a continuing need for longitudinal epidemiological research? The Kuopio Ischaemic heart disease risk factor study. Ann Clin Res 1988; 20: 46 – 50. | en_US |
dc.identifier.citedreference | 16 World Health Organization. Diabetes Mellitus. Report of a WHO Study Group. Technical Report Ser No. 727, World Health Org, Geneva 1985. | en_US |
dc.identifier.citedreference | Ehnholm C, Lukka M, Kuusi T, NikkilÄ E, Uterman G, Apolipoprotein E polymorphism in the Finnish population: gene frequencies and relation to lipoprotein concentration. J Lipid Res 1986; 27: 227 – 235. | en_US |
dc.identifier.citedreference | Buschke H & Fuld PS. Evaluating storage, retention, and retrieval in disordered memory and learning. Neurology 1974; 24: 1019 – 1025. | en_US |
dc.identifier.citedreference | Reitan RM. Validity of the Trail Making test as an indicator of organic brain damage. Percept Motor Skills 1958; 8: 271 – 276. | en_US |
dc.identifier.citedreference | Kuusisto J, Koivisto K, MykkÄnen L, Helkala E-L, Vanhanen M, HÄnninen T. Association between features of the insulin resistance syndrome and Alzheimer's disease independently of apolipoprotein e4 phenotype: cross sectional population based study. BMJ 1997; 315: 1045 – 1048. | en_US |
dc.identifier.citedreference | Craft S, Peskind E, Schwartz MW, Schellenberg GD, Raskind M, Porte D. Cerebrospinal fluid and plasma insulin levels in Alzheimer's disease: relationship to severity of dementia and apolipoprotein E phenotype. Neurology 1998; 50: 164 – 168. | en_US |
dc.identifier.citedreference | Elias PK, Elias MF, D'Agostino RB, Cupples LA, Wilson PW, Silberhatz H et al. NIDDM and blood pressure as risk factors for poor cognitive performance. The Framingham Study. Diabetes Care 1997; 20: 1388 – 1395. | en_US |
dc.identifier.citedreference | Scott RD, Kritz-Silverstein D, Barret-Connor E, Wiederholt WC. The association of non-insulin-dependent diabetes mellitus and cognitive function in an older cohort. J Am Geriatr Soc 1998; 46: 1217 – 1222. | en_US |
dc.identifier.citedreference | Vanhanen M, Koivisto K, Kuusisto J, MykkÄnen L, Helkala E-L, HÄnninen T et al. Cognitive function in an elderly population with persistent impaired glucose tolerance. Diabetes Care 1998; 21: 398 – 402. | en_US |
dc.identifier.citedreference | Kalmijm S, Feskens EJM, Launer LJ, Kromhout D. Glucose intolerance, hyperinsulinemia and cognitive function in a general population of elderly men. Diabetologia 1995; 38: 1096 – 1102. | en_US |
dc.identifier.citedreference | Leibson CL, Rocca WA, Hanson VA, Cha R, Kokmen E, O'Brian PC et al. Risk of dementia among persons with diabetes mellitus: a population-based cohort study. Am J Epidemiol 1997; 145: 301 – 308. | en_US |
dc.identifier.citedreference | Ott A, Stolk RP, van Harskamp F, Pols HAP, Hofman A, Breteler MMB. Diabetes mellitus and risk of dementia in a elderly population. The Rotterdam Study. Neurol 1999; 53: 1907 – 09. | en_US |
dc.identifier.citedreference | Perlmuter LC, Hakami MK, Hodgson-Harrington C, Ginsberg J, Katz J, Singer DE et al. Decreased cognitive function in aging non-insulin-dependent diabetic patients. Am J Med 1984; 77: 1043 – 1048. | en_US |
dc.identifier.citedreference | Jagusch W, Cramon DYV, Renner R, Hepp KD. Cognitive function and metabolic state in elderly diabetic patients. Diabetes Nutr Metab 1992; 5: 265 – 274. | en_US |
dc.identifier.citedreference | Worrall G, Moulton N, Briffett E. Effect of type II diabetes mellitus on cognitive function. J Fam Pract 1993; 36: 639 – 643. | en_US |
dc.identifier.citedreference | Lowe LP, Tranel DT, Wallace RB, Welty TK, Type II diabetes and cognitive function. Diabetes Care 1994; 17: 891 – 896. | en_US |
dc.identifier.citedreference | Ryu N & Chin K. Decreased brain function in patients with non-insulin-dependent diabetes mellitus (in Japanese). No Shinkei 1995; 47: 543 – 548. | en_US |
dc.identifier.citedreference | Meneilly GS & Hill A. Alterations in glucose metabolism in patients with Alzheimer's disease. J Am Geriatr Soc 1993; 41: 710 – 714. | en_US |
dc.identifier.citedreference | Reaven GM, Thompson LW, Nahum D, Haskins E. Relationship between hyperglycemia and cognitive function in older NIDDM patients. Diabetes Care 1990; 13: 16 – 21. | en_US |
dc.identifier.citedreference | Mooradian AD, Perryman K, Fitten J, Kavonian GD, Morley JRE. Cortical function in elderly non-insulin dependent diabetic patients. Behavioral and electrophysiologic studies. Arch Intern Med 1988; 148: 2369 – 2372. | en_US |
dc.identifier.citedreference | Meuter F, Thomas W, GrÜneklee D, Gries FA, Lohmann R. Psychometric evaluation of performance in diabetes mellitus. Horm Metab Res 1980; 9: 9 – 17. | en_US |
dc.identifier.citedreference | Sasaki N, Fukatsu R, Tsuzuki K, Hayashi Y, Yoshida T, Fujii N. Advanced glycation end products in Alzheimer's disease and other neurodegenerative diseases. Am J Pathol 1998; 153: 1149 – 1150. | en_US |
dc.identifier.citedreference | Messier C & Gagnon M. Glucose regulation and cognitive functions: relation to Alzheimer's disease and diabetes. Behav Brain Res 1996; 75: 1 – 11. | en_US |
dc.identifier.citedreference | Gregg EW, Yaffe K, Cauley JA, Rolka DB, Blackwell TL, Nrayan KM et al. Is diabetes associated with cognitive impairment and cognitive decline among older women? Study Osteoporotic Fractures Res Group. Arch Intern Med 2000; 160: 174 – 180. | en_US |
dc.identifier.citedreference | Croxson SC & Jagger C. Diabetes and cognitive impairment: a community-based study of elderly subjects. Age Ageing 1995; 24: 421 – 424. | en_US |
dc.identifier.citedreference | Stolk RP, Breteler MMB, Ott A, Pols HAP, Lamberts SWJ, Grobbee DE et al. Insulin and cognitive function in an elderly population. Diabetes Care 1997; 20: 792 – 794. | en_US |
dc.identifier.citedreference | Craft S, Asthana S, Schellenberg G, Baker L, Cherrier M, Boyt AA et al. Insulin effects on glucose metabolism, memory, and plasma amyloid precursor protein in Alzheimer's disease differ according to apolipoprotein-E phenotype. Ann N Y Acad Sci 2000; 903: 222 – 228. | en_US |
dc.identifier.citedreference | DeCarli C, Reed T, Miller BL, Wolf PA, Swan GE, Carmelli D. Impact of apolipoprotein E epsilon4 and vascular disease on brain morphology in men from the. NHLBI twin study. Stroke 1999; 30: 1548 – 1553. | en_US |
dc.identifier.citedreference | Nordoy A, Bonaa KH, Sandset PM, Hansen JB, Nilsen H. Relationship between apolipoprotein E polymorphism, postprandial hyperlipemia and hemostatic variables in patients with combined hyperlipemia. Nutr Metab Cardiovasc Dis 2000; 10: 15 – 23. | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.