Mycobacterial 65-kD heat shock protein induces release of proinflammatory cytokines from human monocytic cells
dc.contributor.author | Friedland, Jon S. | en_US |
dc.contributor.author | Shattock, R. J. | en_US |
dc.contributor.author | Remick, Daniel G. | en_US |
dc.contributor.author | Griffin, G. E. | en_US |
dc.date.accessioned | 2010-06-01T19:47:03Z | |
dc.date.available | 2010-06-01T19:47:03Z | |
dc.date.issued | 1993-01 | en_US |
dc.identifier.citation | FRIEDLAND, J. S.; SHATTOCK, R.; REMICK, D. G.; GRIFFIN, G. E. (1993). "Mycobacterial 65-kD heat shock protein induces release of proinflammatory cytokines from human monocytic cells." Clinical & Experimental Immunology 91(1): 58-62. <http://hdl.handle.net/2027.42/72917> | en_US |
dc.identifier.issn | 0009-9104 | en_US |
dc.identifier.issn | 1365-2249 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/72917 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8419086&dopt=citation | en_US |
dc.description.abstract | Monocytes having phagocytosed mycobacteria are known to present the bacterial 65-kD heat shock protein (hsp) on their cell surface to ΑΒ and ΓΔ T lymphocytes. Cytotoxic CD4 + cells may then lyse monocytes expressing mycobacterial 65-kD hsp. However, it is not known whether 65-kD hsp directly stimulates monocyte functions other than antigen presentation. This study has demonstrated that following extraction of bacterial lipopolysaccharide, purified recombinant mycobacterial 65-kD hsp may directly activate THP-1 cells, a human monocytic line, to accumulate mRNA for and secrete tumour necrosis factor (TNF), a cytokine important in granuloma formation, the characteristic host immune response to mycobacterial infection. TNF gene expression and secretion following stimulation by hsp was dose-dependent and abolished by heat-induced proteolysis. Subsequently, THP-1 cells secreted IL-6 and IL-8, cytokines involved in recruitment and differentiation of T lymphocytes. The data indicate that secretion of proinflammatory cytokines from monocytes activated by mycobacterial 65-kD hsp may be important in the host immune response and in the development of antigen-specific T cell-mediated immunity. | en_US |
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dc.format.extent | 3109 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Blackwell Publishing Ltd | en_US |
dc.rights | 1993 Blackwell Science Ltd, Oxford | en_US |
dc.subject.other | Heat Shock Protein | en_US |
dc.subject.other | Cytokines | en_US |
dc.subject.other | Monocytes | en_US |
dc.title | Mycobacterial 65-kD heat shock protein induces release of proinflammatory cytokines from human monocytic cells | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Microbiology and Immunology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | * Department of Pathology, University of Michigan Medical School, Ann Arbor, MI. USA | en_US |
dc.contributor.affiliationother | Division of Communicable Diseases, St George's Hospital Medical School, London, UK | en_US |
dc.identifier.pmid | 8419086 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/72917/1/j.1365-2249.1993.tb03354.x.pdf | |
dc.identifier.doi | 10.1111/j.1365-2249.1993.tb03354.x | en_US |
dc.identifier.source | Clinical & Experimental Immunology | en_US |
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dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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