Retinoic acid induces expression of PA-FABP (psoriasis-associated fatty acid-binding protein) gene in human skin in vivo but not in cultured skin cells
dc.contributor.author | Larsen, Frederik Grønhøj | en_US |
dc.contributor.author | Voorhees, John J. | en_US |
dc.contributor.author | Åström, Anders | en_US |
dc.date.accessioned | 2010-06-01T19:48:21Z | |
dc.date.available | 2010-06-01T19:48:21Z | |
dc.date.issued | 1994-10 | en_US |
dc.identifier.citation | Larsen, Frederik GrØnhØj; Voorhees, John J.; ÅstrÖm, Anders (1994). "Retinoic acid induces expression of PA-FABP (psoriasis-associated fatty acid-binding protein) gene in human skin in vivo but not in cultured skin cells." Experimental Dermatology 3(5): 212-218. <http://hdl.handle.net/2027.42/72938> | en_US |
dc.identifier.issn | 0906-6705 | en_US |
dc.identifier.issn | 1600-0625 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/72938 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7881766&dopt=citation | en_US |
dc.description.abstract | : PA-FABP (psoriasis-associated fatty acid binding protein) is a new member of a group of low-molecular-weight proteins that are highly up regulated in psoriatic skin and that share similarity to fatty acid-binding proteins. In this study we demonstrate that PA-FABP transcripts are expressed in human skin in vivo and that topical application of 0.05% retinoic acid (RA) cream results in a rapid induction of PA-FABP transcripts following treatment for 16 hours and persists at increasing levels after 48 and 96 h of RA treatment. The PA-FABP mRNA response to RA was reduced by approximately 50% when patients concurrently were treated with RA and 0.025% clobelasol propionate (CLO) for 48 and 96 h, whereas treatment with CLO alone resulted in PA-FABP transcript levels not significantly different from vehicle-treated skin. When comparing the effects of a well-known irritant, sodium lauryl sulfate (SLS), to those of RA and its vehicle, 0.05% RA cream but not 2% SLS in RA vehicle caused PA-FABP mRNA induction after 16 h. SLS treatment of human skin for 96 h caused a slight increase in PA-FABP transcripts, but markedly less than that observed in response to RA treatment. Incubation of cultured human keratinocytes or skin fibroblasts with RA for up to 48 h did not significantly induce PA-FABP transcripts. Expression of PA-FABP message in keratinocytes was observed to be induced by calcium and fetal calf serum (FCS), while tetra-decanoyl phorbol acetate (TPA) caused little or no induction. Taken together, the marked inducibility of the PA-FABP gene is compatible with the possibility that this gene might be important in RA-mediated regulation of human skin growth and differentiation. | en_US |
dc.format.extent | 599703 bytes | |
dc.format.extent | 3109 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Blackwell Publishing Ltd | en_US |
dc.rights | Munksgaard 1994 | en_US |
dc.subject.other | Retinoic Acid | en_US |
dc.subject.other | Gene Regulation | en_US |
dc.subject.other | Fibroblasts | en_US |
dc.subject.other | Keratinocytes | en_US |
dc.title | Retinoic acid induces expression of PA-FABP (psoriasis-associated fatty acid-binding protein) gene in human skin in vivo but not in cultured skin cells | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Dentistry | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Dermatology, University of Michigan, Ann Arbor, Michigan, U.S.A. | en_US |
dc.identifier.pmid | 7881766 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/72938/1/j.1600-0625.1994.tb00279.x.pdf | |
dc.identifier.doi | 10.1111/j.1600-0625.1994.tb00279.x | en_US |
dc.identifier.source | Experimental Dermatology | en_US |
dc.identifier.citedreference | Glatz J F, York M M, Cistola D P, van der Vusse G J Cytoplasmic fatty acid binding protein: Significance for in- traeellular transport of fatty acids and putative role on signal transduction pathways. Prostaglandins Leukol Essent Fatty Acids 1993: 48: 33 – 41. | en_US |
dc.identifier.citedreference | Dennis E A, Rhee S G, Billah M M, Hannum Y A Role of phospholipase in generating lipid second messengers in signal transduction. FASEB 1991: 5: 2068 – 2077. | en_US |
dc.identifier.citedreference | James G Olson E N Fatty acylated proteins as components of intracellular signaling pathways. Biochemistry 1990: 29: 2623 – 2634. | en_US |
dc.identifier.citedreference | Chan C-C, Duhamel L Ford-Hutchison A. Leukotriene B4 and 12-hydroxyeicosatetraenoic acid stimulate epidermal proliferation in vivo in the guinea pig. J Invest Dermatol 1985: 85: 333 – 334. | en_US |
dc.identifier.citedreference | Madsen P Rasmussen H H, Leffers H. et al. Molecular cloning, occurrence, and expression of a novel partially secreted protein “psoriasin” that is highly up-regulated in psoriatic skin. J Invest Dermatol 1991: 97: 701 – 712. | en_US |
dc.identifier.citedreference | Celis J E, Madsen P Rasmussen H H. et al. A comprehensive two-dimensional gel protein database of non-cultured unfractionated human epidermal keralinocytes: towards an integrated approach to the study of cell proliferation, differentiation and skin diseases.. Electrophoresis 1991: 12: 802 – 872. | en_US |
dc.identifier.citedreference | Madsen P Rasmussen H H, Leffers H, Honore B Cells J E:. Molecular cloning and expressing of a novel keratinocyte protein (psoriasis-associated fatty acid-binding protein [PA-FABP]) that is highly up-regulated in psoriatic skin and that shares similarity to fatty acid-binding proteins. J Invest Dermatol 1992: 99: 299 – 305. | en_US |
dc.identifier.citedreference | Weiss J S, Ellis C N, Headington J T, Tincoff T, Hamilton T A, Voorhees J J Topical tretinoin improves photoaged skin. A double-blind vehicle controlled study. JAMA 1988: 259: 527 – 532. | en_US |
dc.identifier.citedreference | Fisher G J, Esmann J Griffiths C E M. et al. Cellular, immunologic and biochemical characterization of topical retinoic acid-treated human skin. J Invest Dermatol 1991: 96: 699 – 707. | en_US |
dc.identifier.citedreference | Elder J T, Cromie M A, Griffiths C E M, Chambon P Voorhees J J Stimulus-selective induction of CRABP mRNA: A marker for retinoic acid action in human skin. J Invest Dermatol 1993: 100: 356 – 359. | en_US |
dc.identifier.citedreference | Voorhees J J, Duell E A, Bass L J, Powell J A, Harrell E R Decreased cyclic AMP in the epidermis of lesions of psoriasis. Arch Dermatol 1972: 105: 695 – 701. | en_US |
dc.identifier.citedreference | Harper R A, Grove G. Human skin fibroblasts derived from papillary and reticular dermis: differences in growth potential in vitro. Science 1979: 204: 526 – 527. | en_US |
dc.identifier.citedreference | AstrÖm A, Tavakkol A Pettersson U Cromie M Elder J T, Voorhees J J Molecular cloning of two human cellular retinoic acid-binding proteins (CRABP). J Biol Chem 1991: 266: 17662 – 17666. | en_US |
dc.identifier.citedreference | Elder J T, Fisher G J, Zhang Q Y, et al. Retinoic acid receptor gene expression in human skin. J Invest Dermatol 1991: 96: 425 – 433. | en_US |
dc.identifier.citedreference | Bass N M Function and regulation of hepatic and intestinal fatty acid binding proteins. Chem Phys Lipids 1985: 38: 95 – 114. | en_US |
dc.identifier.citedreference | Kaikaus R M, Bass N M, Ockner R K Functions of fatty acid-binding proteins. Experientia 1990: 46: 617 – 630. | en_US |
dc.identifier.citedreference | Schurer N Y, Bass N M, Jin S Manning J A, Pillai S Williams M L. High-affinity fatty acid-binding activity in epidermis and cultured keratinocytes is attributable to high- molecular-weight and not low-molecular-weight fatty acid- binding proteins. J Invest Dermatol 1993: 100: 82 – 86. | en_US |
dc.identifier.citedreference | Siegenthaler G Hotz R Chatellard-Gruaz D, Jaconi S, Granhej Larsen Saurat J H et al. Characterization and expression of a novel human fatty acid-binding protein: The epidermal type (E-FABP). Biochem Biophys Res Comm 1993: 190: 482 – 487. | en_US |
dc.identifier.citedreference | Pilelta P Saurat J-H. Cellular retinoic acid-binding proteins (CRABP). Exp Dermatol 1993: 2: 191 – 195. | en_US |
dc.identifier.citedreference | Piletta P Jaconi S Siegenlhaler G Didierjean L Saurat J- H. Topical glucocorticosteroids modulate the expression of CRABP I and CRABP II in human skin differently. Exp Dermatol 1994: 3: 23 – 28. | en_US |
dc.identifier.citedreference | Elder J T, Astrom A, Pettersson U et al. Differential regulation of retinoic acid receptors and binding proteins in human skin. J Invest Dermatol 1992: 98: 673 – 679. | en_US |
dc.identifier.citedreference | Griffiths C E M, Finkel L J, Tranfaglia M G, Hamilton T A, Voorhees J J An in vivo experimental model for effects of topical retinoic acid in human skin. Br J Dermatol 1993: 129: 389 – 394. | en_US |
dc.identifier.citedreference | Lesnik R H, Mezick J A, Capetola R Kligman L H Topical all-trans-retinoic acid prevents corticosteroid-induced skin atrophy without abrogating the anti-inflammatory effect. J Am Acad Dermatol 1989: 21: 186 – 190. | en_US |
dc.identifier.citedreference | De Laccharriere O Escofficr C Gracia A M, et al. Reversal effects of topical retinoic acid on the skin of kidney transplant recipients under systemic corticotherapy. J Invest Dermatol 1990: 95: 516 – 522. | en_US |
dc.identifier.citedreference | Fuchs E Green H Regulation of terminal differentiation of cultured keratinocytes by vitamin A. Cell 1981: 25: 617 – 625. | en_US |
dc.identifier.citedreference | Green H Watt F. Regulalion by vitamin A of envelope cross-linking in cultured keratinocytes derived from different human epithelia. Mol Cell Biol 1982: 2: 1115 – 1117. | en_US |
dc.identifier.citedreference | Jetten A M, George M A, Nervi C Boone L R, Rearick J I Increased cholesterol sulfate and cholesterol sul-fotransferase activity in relation to the mulli-step process of differentiation in human keratinocytes. J Invest Dermatol 1989: 92: 203 – 209. | en_US |
dc.identifier.citedreference | Brod J Bavelier E Justine P Weerlieim A Ponec M. Acyl-ceramides and lanosterol-lipid markers of terminal differentiation in cultured human keratinocytes: modulating effect of retinoic acid. In Vitro Cell Dev Biol 1991: 27A: 163 – 168. | en_US |
dc.identifier.citedreference | Pillai S Bikle D D, Mancianti M L, Cline P Hincenbergs M Calcium regulation of growth and differentiation of normal human keratinocytes: modulation of differentiation competence by stages of growth and extracellular calcium. J Cell Physiol 1990: 143: 294 – 302. | en_US |
dc.identifier.citedreference | Bass N M The cellular fatty acid binding proteins: Aspects of structure, regulation, and function. Int Rev Cyt 1988: 111: 143 – 184. | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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