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Control of mucosal polymicrobial populations by innate immunity
dc.contributor.authorMason, Katie L.en_US
dc.contributor.authorHuffnagle, Gary B.en_US
dc.date.accessioned2010-06-01T19:48:39Z
dc.date.available2010-06-01T19:48:39Z
dc.date.issued2009-09en_US
dc.identifier.citationMason, Katie L.; Huffnagle, Gary B. (2009). "Control of mucosal polymicrobial populations by innate immunity." Cellular Microbiology 11(9): 1297-1305. <http://hdl.handle.net/2027.42/72943>en_US
dc.identifier.issn1462-5814en_US
dc.identifier.issn1462-5822en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/72943
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=19558617&dopt=citationen_US
dc.description.abstractThe gastrointestinal tract carries out the complex process of localizing the polymicrobial populations of the indigenous microbiota to the lumenal side of the GI mucosa while absorbing nutrients from the lumen and preventing damage to the mucosa. This process is accomplished through a combination of physical, innate and adaptive host defences and a ‘strategic alliance’ with members of the microbiota. To cope with the constant exposure to a diverse microbial community, the GI tract, through the actions of a number of specialized cells in the epithelium and lamina propria, has layers of humoral, physical and cellular defences that limit attachment, invasion and dissemination of the indigenous microbiota. However, the role of the microbiota in this dynamic balance is vital and serves as another level of ‘innate’ defence. We are just beginning to understand how bacterial metabolites aid in the control of potential pathogens within the microbiota and limit inflammatory responses to the microbiota, concepts that will impact our understanding of the biological effects of antibiotics, diet and probiotics on mucosal inflammatory responses.en_US
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dc.format.extent3109 bytes
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dc.publisherBlackwell Publishing Ltden_US
dc.rights© 2009 Blackwell Publishing Ltden_US
dc.titleControl of mucosal polymicrobial populations by innate immunityen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI, USA.en_US
dc.contributor.affiliationotherPulmonary Division, Department of Internal Medicine anden_US
dc.identifier.pmid19558617en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/72943/1/j.1462-5822.2009.01347.x.pdf
dc.identifier.doi10.1111/j.1462-5822.2009.01347.xen_US
dc.identifier.sourceCellular Microbiologyen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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