View Item 

Show simple item record

Double-blind, placebo-controlled study to evaluate the efficacy of fish oil and low-dose UVB in the treatment of psoriasis

dc.contributor.authorGupta, A. K.en_US
dc.contributor.authorEllis, C. N.en_US
dc.contributor.authorTellner, D. C.en_US
dc.contributor.authorAnderson, T. F.en_US
dc.contributor.authorVoorhees, John J.en_US
dc.date.accessioned2010-06-01T19:54:20Z
dc.date.available2010-06-01T19:54:20Z
dc.date.issued1989-06en_US
dc.identifier.citationGUPTA, A.K.; ELLIS, C.N.; TELLNER, D.C.; ANDERSON, T.F.; VOORHEES, J.J. (1989). "Double-blind, placebo-controlled study to evaluate the efficacy of fish oil and low-dose UVB in the treatment of psoriasis." British Journal of Dermatology 120(6): 801-807. <http://hdl.handle.net/2027.42/73035>en_US
dc.identifier.issn0007-0963en_US
dc.identifier.issn1365-2133en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/73035
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2667615&dopt=citationen_US
dc.description.abstractSince eicosanoids have been implicated in the pathogenesis of psoriasis, less potent eicosanoid mediators derived from fish oil might improve psoriasis. Using a double-blind, randomized, parallel design, 18 patients with stable, plaque psoriasis received capsules of either fish oil or identical-appearing placebo olive oil for 15 weeks, with concomitant sub-erythemal UVB in weeks 3 to 11. At the conclusion of phototherapy, and 4 weeks later, patients in the fish oil group had a greater decrease in the total body surface area of psoriasis and more improvement compared to patients in the olive oil group. The improvement in the fish oil group was statistically significantly greater for all parameters compared to the change in the olive oil group. The apparent safety and general health-promoting features of fish oil could provide an ideal adjunctive therapy for psoriasis.en_US
dc.format.extent1474790 bytes
dc.format.extent3109 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherBlackwell Publishing Ltden_US
dc.rights1989 British Association of Dermatologistsen_US
dc.titleDouble-blind, placebo-controlled study to evaluate the efficacy of fish oil and low-dose UVB in the treatment of psoriasisen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelDermatologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDermatopharmacology and Photobiology Units, Department of Dermatology, University of Michigan Medical Center, Ann Arbor, and the Veterans Administration Medical Center, Ann Arbor, Michigan, U.S.Aen_US
dc.identifier.pmid2667615en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/73035/1/j.1365-2133.1989.tb01378.x.pdf
dc.identifier.doi10.1111/j.1365-2133.1989.tb01378.xen_US
dc.identifier.sourceBritish Journal of Dermatologyen_US
dc.identifier.citedreferenceVoorhees JJ. Leukotrienes and other lipoxygenase products in the pathogenesis and therapy of psoriasis and other dermatoses. Arch Dermatol 1983; 119: 541 – 7.en_US
dc.identifier.citedreferenceLokesh BR, German B, Kinsella JE. Differential effects of docosahexaenoic acid and eicosapentaenoic acid on suppression of lipoxygenase pathway in peritoneal macrophages. Biochimica et Biophysica Acta 1988; 958: 99 – 107.en_US
dc.identifier.citedreferenceZiboh VA, Cohen KA, Ellis CN et al. Effects of dietary supplementation of fish oil on neutrophil and epidermal fatty acids. Arch Dermatol 1986; 122: 1277 – 82.en_US
dc.identifier.citedreferenceAllen BR, Maurice PDL, Goodfield MW et al. The effects on psoriasis of dietary supplementation with eicosapentaenoic acid. Br J Dermatol 1985; 133: 777.en_US
dc.identifier.citedreferenceMaurice PDL, Allen BR, Barkley ASJ et al. The effects of dietary supplementation with fish oil in patients with psoriasis. Br J Dermatol 1987; 117: 599 – 606.en_US
dc.identifier.citedreferenceBittiner SB, Tucker WFG, Bleehen SS. Fish oil in psoriasis—a double-blind randomized placebo-controlled trial. Br J Dermatol 1987; 117: 25 – 6.en_US
dc.identifier.citedreferenceBjorneboe A, Smith AK, Bjornboe G-EA et al. Effect of dietary supplementation with n-3 fatty acids on clinical manifestations of psoriasis. Br J Dermatol 1988; 118: 77 – 83.en_US
dc.identifier.citedreferenceBittiner SB, Tucker WFG, Cartwright I et al. A double-blind, randomized, placebo-controlled trial of fish oil in psoriasis. Lancet 1988; i: 378 – 80.en_US
dc.identifier.citedreferenceBjorneboe A, Soyland E, Bjorneboe G-EA et al. Effect of dietary supplementation with eicosapentaenoic acid in the treatment of atopic dermatitis. Br J Dermatol 1987; 117: 463 – 9.en_US
dc.identifier.citedreferenceSaynor R, Verel D, Gillott T. The long-term effect of dietary supplementation with fish lipid concentrate on serum lipids, bleeding time, platelets and angina. Atherosclerosis 1984; 50: 3 – 10.en_US
dc.identifier.citedreferenceKnapp HR, Reilly AG, Alessandrini P et al. In vivo indexes of platelet and vascular function during fish-oil administration in patients with atherosclerosis. N Eng J Med 1986; 314: 937 – 42.en_US
dc.identifier.citedreferenceSchacky CV. Prophylaxis of atherosclerosis with marine omega-3 fatty acids. Ann Intern Med 1987; 107: 890 – 9.en_US
dc.identifier.citedreferencePhillipson BE, Rothrock DW, Connor WE et al. Reduction of plasma lipids, lipoproteins, and apoproteins by dietary fish oils in patients with hypertriglyceridemia. New Eng J Med 1985; 312: 1210 – 6.en_US
dc.identifier.citedreferenceHerold PM, Kinsella JE. Fish oil consumption and decreased risk of cardiovascular disease: a comparison of findings from animal and human feeding trials. Am J Clin Nutr 1986; 43: 566 – 98.en_US
dc.identifier.citedreferenceSaynar R. Effects of w3 fatty acids on serum lipids. Lancet 1984; ii: 692 – 3.en_US
dc.identifier.citedreferenceSanders TAB, Roshanai F. The influence of different types of w3 polyunsaturated fatty acids on blood lipids and platelet function in healthy volunteers. Clinical Science 1983; 64: 91 – 9.en_US
dc.identifier.citedreferenceMarsden JR. Reduction of retinoid hyperlipidemia with Max-EPA. Br J Dermatol 1987; 116: 450.en_US
dc.identifier.citedreferenceMarsden JR. Effect of dietary fish oil on hyperlipidemia due to isotretinoin and etretinate. Human Toxicol 1987; 6: 219 – 222.en_US
dc.identifier.citedreferenceLowe NJ, Borok ME, Ashley JM et al. Fish oil consumption reduces hypertriglyceridemia in psoriatic patients receiving etretinate therapy. Arch Dermatol 1988; 124: 177.en_US
dc.identifier.citedreferenceGoodnight SH Jr, Harris WS, Connor WE. The effect of dietary w3 fatty acids on platelet composition and function in man: A prospective, controlled study. Blood 1981; 58: 880 – 5.en_US
dc.identifier.citedreferenceTerano T, Hirai A, Hamazaki T et al. Effect of oral administration of highly purified eicosapentaenoic acid on platelet function, blood viscosity and red cell deformity in healthy human subjects. Atherosclerosis 1983; 46: 321 – 31.en_US
dc.identifier.citedreferenceSiess W, Schrer B, Bohlig B et al. Platelet membrane fatty acids. Platelet aggregation and thromboxane formation during a mackerel diet. Lancet 1980; i: 441 – 4.en_US
dc.identifier.citedreferenceKromhout D, Bosschieter EB, Coulander C de L. The inverse relation between fish consumption and 20 year old mortality from coronary heart diesease. New Eng J Med 1985; 312: 1205 – 9.en_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


Files in this item

Name:
j.1365-2133.1989.tb01378.x.pdf
Size:
1.406MB
Format:
PDF
View/Open

Show simple item record

Remediation of Harmful Language

The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.

Accessibility

If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.