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‘Accelerated aging’: a primrose path to insight?
dc.contributor.authorMiller, Richard A.en_US
dc.date.accessioned2010-06-01T19:56:09Z
dc.date.available2010-06-01T19:56:09Z
dc.date.issued2004-04en_US
dc.identifier.citationMiller, Richard A. (2004). "‘Accelerated aging’: a primrose path to insight?." Aging Cell 3(2): 47-51. <http://hdl.handle.net/2027.42/73065>en_US
dc.identifier.issn1474-9718en_US
dc.identifier.issn1474-9726en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/73065
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=15038817&dopt=citationen_US
dc.description.abstractOrganism envy afflicts most researchers who work on aging in mice; how frustrating it is to see the worm and fly biologists nail down milestone after milestone, citation after citation! Surely genetic trickery can produce mice that age in a comparable jiffy? Alas, our near-total ignorance of what times the aging process makes it hard to guess what genes to tweak, if indeed aging can be mimicked a presto . Building a case that a given short-lived mutant ages quickly is a steep and thorny path, requiring more than just plucking a symptom here and there from a list of things that sometimes go wrong in old people or old mice. The hallmark of aging is that a lot goes wrong more or less at the same time, in 2-year-old mice, 10-year-old dogs and 70-year-old people. Finding ways to damage one or two systems in a 6-week or 6-month-old mouse is not too hard to do, but the implications of such studies for improved understanding of aging per se are at best indirect and at worst imaginary and distracting.en_US
dc.format.extent111292 bytes
dc.format.extent3109 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherBlackwell Publishing, Ltd.en_US
dc.rights© Blackwell Publishing Ltd/Anatomical Society of Great Britain and Ireland 2004en_US
dc.subject.otherSegmental Agingen_US
dc.subject.otherSkepticismen_US
dc.subject.otherLongevityen_US
dc.subject.otherMouse Modelsen_US
dc.subject.otherMutantsen_US
dc.subject.otherPathologyen_US
dc.title‘Accelerated aging’: a primrose path to insight?en_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Pathology and Geriatrics Center, University of Michigan, Ann Arbor VA Medical Center, Ann Arbor, MI 48103, USAen_US
dc.identifier.pmid15038817en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/73065/1/j.1474-9728.2004.00081.x.pdf
dc.identifier.doi10.1111/j.1474-9728.2004.00081.xen_US
dc.identifier.sourceAging Cellen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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