The Immunobiology of Inductive Anti-CD40L Therapy in Transplantation: Allograft Acceptance is Not Dependent Upon the Deletion of Graft-Reactive T Cells
dc.contributor.author | Nathan, Meera J. | en_US |
dc.contributor.author | Yin, Dengping | en_US |
dc.contributor.author | Eichwald, Ernst J. | en_US |
dc.contributor.author | Bishop, D. Keith | en_US |
dc.date.accessioned | 2010-06-01T19:57:10Z | |
dc.date.available | 2010-06-01T19:57:10Z | |
dc.date.issued | 2002-04 | en_US |
dc.identifier.citation | Nathan, Meera J . ; Yin, Dengping; Eichwald, Ernst J . ; Bishop, D. Keith (2002). "The Immunobiology of Inductive Anti-CD40L Therapy in Transplantation: Allograft Acceptance is Not Dependent Upon the Deletion of Graft-Reactive T Cells." American Journal of Transplantation 2(4): 323-332. <http://hdl.handle.net/2027.42/73082> | en_US |
dc.identifier.issn | 1600-6135 | en_US |
dc.identifier.issn | 1600-6143 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/73082 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=12118853&dopt=citation | en_US |
dc.format.extent | 351058 bytes | |
dc.format.extent | 3109 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Munksgaard International Publishers | en_US |
dc.publisher | Blackwell Publishing Ltd | en_US |
dc.rights | Blackwell Munksgaard, 2002 | en_US |
dc.subject.other | Costimulation | en_US |
dc.subject.other | Graft Acceptance | en_US |
dc.subject.other | Regulatory Cells | en_US |
dc.title | The Immunobiology of Inductive Anti-CD40L Therapy in Transplantation: Allograft Acceptance is Not Dependent Upon the Deletion of Graft-Reactive T Cells | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Medicine (General) | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Microbiology and Immunology, University of Michigan School of Medicine, Ann Arbor, MI 48109; USA | en_US |
dc.contributor.affiliationother | Division of Transplantation, Department of Surgery and | en_US |
dc.contributor.affiliationother | Department of Surgery, Section of Transplantation, Rush Presbyterian St. Luke's Medical Center, Chicago, IL; USA | en_US |
dc.contributor.affiliationother | Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT 84132, USA | en_US |
dc.identifier.pmid | 12118853 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/73082/1/j.1600-6143.2002.20406.x.pdf | |
dc.identifier.doi | 10.1034/j.1600-6143.2002.20406.x | en_US |
dc.identifier.source | American Journal of Transplantation | en_US |
dc.identifier.citedreference | Schwartz RH. A cell culture model for T lymphocyte clonal anergy. Science 1990; 248: 1349 – 1356. | en_US |
dc.identifier.citedreference | Ferguson TA, Green D. T cells are just dying to accept grafts. Nat Med 1999; 5: 1231 – 1232. | en_US |
dc.identifier.citedreference | Li XC, Wells AD, Strom TB, Turka LA. The role of T cell apoptosis in transplantation tolerance. Curr Opin Immunol 2000; 12: 522 – 527. | en_US |
dc.identifier.citedreference | Grewal IS, Flavell RA. A central role of CD40 ligand in the regulation of CD4+ T-cell responses. Immunol Today 1996; 17: 410. | en_US |
dc.identifier.citedreference | Gudmundsdottir H, Turka LA. T cell costimulatory blockade: New therapies for transplant rejection. J Am Soc Nephrol 1999; 10: 1356 – 1365. | en_US |
dc.identifier.citedreference | Harlan DM, Kirk AD. The future of organ and tissue transplantation: Can T-cell costimulatory pathway modifiers revolutionize the prevention of graft rejection? JAMA 1999; 282: 1076 – 1082. | en_US |
dc.identifier.citedreference | Blair PJ, Riley JL, Harlan DM et al. CD40 ligand (CD154) triggers a short-term CD4+ T cell activation response that results in a secretion of immunomodulatory cytokines and apoptosis. J Exp Med 2000; 191: 651 – 660. | en_US |
dc.identifier.citedreference | Iwakoshi NN, Mordes JP, Markees TG, Phillips NE, Rosini AA, Greiner DL. Treatment of allograft recipients with donor-specific transfusion and anti-CD154 antibody leads to deletion of alloreactive CD8+ T cells and prolonged graft survival in a CTLA4-dependent manner. J Immunol 2000; 164: 512 – 521. | en_US |
dc.identifier.citedreference | Wells AD, Li XC, Li Y et al. Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance. Nat Med 1999; 5: 1303 – 1307. | en_US |
dc.identifier.citedreference | Graca L, Honey K, Adams E, Cobbold SP, Waldmann H. Anti-CD154 therapeutic antibodies induce infectious transplantation tolerance. J Immunol 2000; 165: 4783 – 4786. | en_US |
dc.identifier.citedreference | Corry R, Winn HJ, Russell PS. Primarily vascularized allografts of hearts in mice. The role of H-2D, H-2K, and non-H-2 antigens in rejection. Transplantation 1973; 16: 343 – 350. | en_US |
dc.identifier.citedreference | Chen Z. A technique of cervical heterotopic heart transplantation in mice. Transplantation 1991; 52: 1099 – 1101. | en_US |
dc.identifier.citedreference | Piccotti JR, Chan SY, Li K, Eichwald EJ, Bishop DK. Differential effects of IL-12 receptor blockade with IL-12 p40 homodimer on the induction of CD4+ and CD8+ IFN-γ-producing cells. J Immunol 1997; 158: 643 – 648. | en_US |
dc.identifier.citedreference | Piccotti JR, Li K, Chan SY, Eichwald EJ, Bishop DK. Alloantigen-reactive Th1 helper T lymphocyte development in IL-12 deficient mice. J Immunol 1998; 160: 1132 – 1138. | en_US |
dc.identifier.citedreference | Piccotti JR, Li K, Chan SY, Eichwald EJ, Bishop DK. Cytokine regulation of chronic cardiac allograft rejection: evidence against a role for Th1 in the disease process. Transplantation 1999; 67: 1548 – 1555. | en_US |
dc.identifier.citedreference | Bishop DK, Orosz CG. Limiting dilution analysis for alloreactive, TCGF-secreting T cells: LDA methods that discriminate between unstimulated precursor T cells and in vivo alloactivated T cells. Transplantation 1989; 47: 671 – 677. | en_US |
dc.identifier.citedreference | Glasebrook AL, Fitch FW. Alloreactive cloned T cell lines: interactions between cloned amplifier and cytolytic T cell lines. J Exp Med 1980; 151: 876 – 895. | en_US |
dc.identifier.citedreference | Orosz CG, Horstemeyer B, Zinn NE, Bishop DK. Development and evaluation of a limiting dilution analysis technique that can discriminate in vivo alloactivated cytotoxic T lymphocytes from their native precursors. Transplantation 1989; 47: 189 – 194. | en_US |
dc.identifier.citedreference | Taswell C. Limiting dilution assays for the determination of immunocompetent cell frequencies. J Immunol 1981; 126: 1614 – 1619. | en_US |
dc.identifier.citedreference | Matesic D, Lehmann PV, Heeger PS. High resolution characterization of cytokine-producing alloreactivity in naÏve and allograft-primed mice. Transplantation 1998; 65: 906 – 914. | en_US |
dc.identifier.citedreference | Bishop DK, Shelby J, Eichwald EJ. Mobilization of T lymphocytes following cardiac transplantation: evidence that CD4-positive cells are required for cytotoxic T lymphocyte activation, inflammatory endothelial development, graft infiltration, and acute allograft rejection. Transplantation 1992; 53: 849 – 857. | en_US |
dc.identifier.citedreference | Bishop DK, Li W, Chan SY, Ensley RD, Shelby J, Eichwald EJ. Helper T lymphocyte unresponsiveness to cardiac allografts following transient depletion of CD4-positive cells: implications for cellular and humoral responses. Transplantation 1994; 58: 576 – 584. | en_US |
dc.identifier.citedreference | Kawabe T, Naka T, Yoshida K et al. The immune responses in CD40-deficient mice: impaired immunoglobulin class switching and germinal center formation. Immunity 1994; 1: 167 – 178. | en_US |
dc.identifier.citedreference | Renshaw BR, Fanslow WC III, Armitage RJ et al. Humoral immune responses in CD40 ligand-deficient mice. J Exp Med 1994; 180: 1889 – 1900. | en_US |
dc.identifier.citedreference | Schmid C, Heemann U, Tilney NL. Factors contributing to the development of chronic rejection in heterotopic rat heart transplantation. Transplantation 1997; 64: 222 – 228. | en_US |
dc.identifier.citedreference | Orosz CG, Wakely E, Bergese SD et al. Prevention of murine cardiac allograft rejection with gallium nitrate: comparison with anti-CD4 monoclonal antibody. Transplantation 1996; 61: 783 – 791. | en_US |
dc.identifier.citedreference | Sayegh MH, Akalin E, Hancock WW et al. CD28-B7 blockade after alloantigenic challenge in vivo inhibits Th1 cytokines but spares Th2. J Exp Med 1995; 181: 1869 – 1874. | en_US |
dc.identifier.citedreference | Bishop DK, Wood SC, Eichwald EJ, Orosz CG. Immunobiology of allograft rejection in the absence of IFNγ: CD8+ effector cells develop independently of CD4+ cells and CD40–CD40 ligand interactions. J Immunol 2001; 166: 3248 – 3255. | en_US |
dc.identifier.citedreference | Larsen CP, Elwood ET, Alexander DZ et al. Long-term acceptance of skin and allografts after blocking CD40 and CD28 pathways. Nature 1996; 381: 434 – 438. | en_US |
dc.identifier.citedreference | Markees TG, Phillips NE, Noelle RJ et al. Prolonged survival of mouse skin allografts in recipients treated with donor splenocytes and antibody to CD40 ligand. Transplantation 1997; 64: 329 – 335. | en_US |
dc.identifier.citedreference | Bumgardner GL, Li J, Heininger M, Orosz CG. Costimulation pathways in host immune responses to allogeneic hepatocytes. Transplantation 1998; 66: 1841 – 1845. | en_US |
dc.identifier.citedreference | Kirk AD, Burkly LC, Batty DS et al. Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in non-human primates. Nat Med 1999; 5: 686 – 693. | en_US |
dc.identifier.citedreference | Sun H, Subbotin V, Chen C et al. Prevention of chronic rejection in mouse aortic allografts by combined treatment with CTLA4-Ig and anti-CD40 ligand monoclonal antibody. Transplantation 1997; 64: 1838 – 1856. | en_US |
dc.identifier.citedreference | Lu L, Li W, Fu F et al. Blockade of the CD40-CD40 ligand pathway potentiates the capacity of donor-derived dendritic cell progenitors to induce long-term cardiac allograft survival. Transplantation 1997; 64: 1808 – 1815. | en_US |
dc.identifier.citedreference | Vriens PW, Nisco SJ, Hoyt EG et al. Tissue-specific differences in the establishment of tolerance: tolerogenic effects of lung allografts in rats. Transplantation 1994; 57: 1795 – 1798. | en_US |
dc.identifier.citedreference | Fedoseyeva EV, Zhang F, Orr PL, Levin D, Buncke HJ, Benichou G. De novo autoimmunity to cardiac myosin after heart transplantation and its contribution to the rejection process. J Immunol 1999; 162: 6836 – 6842. | en_US |
dc.identifier.citedreference | Warraich RS, Pomerance A, Stanley A, Banner NR, Dunn MJ, Yacoub MH. Cardiac myosin autoantibodies and acute rejection after heart transplantation in patients with dilated cardiomyopathy. Transplantation 2000; 69: 1609 – 1617. | en_US |
dc.identifier.citedreference | Fuchimoto Y, Gleit AL, Huang CA et al. Skin-specific alloantigens in miniature swine. Transplantation 2001; 72: 122 – 126. | en_US |
dc.identifier.citedreference | Zhou P, Seder RA. CD40 ligand is not essential for induction of type 1 cytokine responses or protective immunity after primary or secondary infection with histoplasma capsulatum. J Exp Med 1998; 8: 1315 – 1324. | en_US |
dc.identifier.citedreference | Stuber E, Strober W, Neurath M. Blocking the CD40L–CD40 interactions in vivo specifically prevents the priming of T helper 1 cells through the inhibition of interleukin 12 secretion. J Exp Med 1996; 2: 693 – 698. | en_US |
dc.identifier.citedreference | Shimizu K, SchÖnbeck U, Mach F, Libby P, Mitchell PN. Host CD40 ligand deficiency induces long-term allograft survival and donor-specific tolerance in mouse cardiac transplantation but does not prevent graft arteriosclerosis. J Immunol 2000; 165: 3506 – 3518. | en_US |
dc.identifier.citedreference | Lutgens EL, Gorelik MJ, Daemen AP et al. Requirement for CD154 in the progression of atherosclerosis. Nat Med 1999; 5: 1313 – 1316. | en_US |
dc.identifier.citedreference | Piccotti JR, Chan SY, VanBuskirk AM, Eichwald EJ, Bishop DK. Are Th2 helper T lymphocytes beneficial, deleterious, or irrelevant in promoting allograft survival? Transplantation 1997; 63: 619 – 624. | en_US |
dc.identifier.citedreference | Fowler S, Powrie F. Control of immune pathology by IL-10-secreting regulatory T cells. Springer Semin Immunopathol 1999; 21: 287 – 294. | en_US |
dc.identifier.citedreference | Letterio JJ, Roberts AB. Regulation of immune responses by TGF-β. Annu Rev Immunol 1998; 16: 137 – 161. | en_US |
dc.identifier.citedreference | Cottrez F, Hurst SD, Coffman RL, Grouz H. T regulatory cells 1 inhibit a Th2-specific response in vivo. J Immunol 2000; 165: 4848 – 4853. | en_US |
dc.identifier.citedreference | Bickertsaff AA, VanBuskirk AM, Wakely E, Orosz CG. Transforming growth factor-beta and interleukin 10 subvert alloreactive delayed hypersensitivity in cardiac allograft acceptor mice. Transplantation 2000; 69: 1517 – 1520. | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.