Gender-related differences of renal mass supply and metabolic demand after living donor kidney transplantation
dc.contributor.author | Oh, Chang-Kwon | en_US |
dc.contributor.author | Lee, Byung Mo | en_US |
dc.contributor.author | Jeon, Kyung Ock | en_US |
dc.contributor.author | Kim, Hyun Jung | en_US |
dc.contributor.author | Pelletier, Shawn J. | en_US |
dc.contributor.author | Kim, Soon Il | en_US |
dc.contributor.author | Kim, Yu Seun | en_US |
dc.date.accessioned | 2010-06-01T20:03:32Z | |
dc.date.available | 2010-06-01T20:03:32Z | |
dc.date.issued | 2006-03 | en_US |
dc.identifier.citation | Oh, Chang-Kwon; Lee, Byung Mo; Jeon, Kyung Ock; Kim, Hyun Jung; Pelletier, Shawn J . ; Kim, Soon Il; Kim, Yu Seun (2006). "Gender-related differences of renal mass supply and metabolic demand after living donor kidney transplantation." Clinical Transplantation 20(2): 163-170. <http://hdl.handle.net/2027.42/73185> | en_US |
dc.identifier.issn | 0902-0063 | en_US |
dc.identifier.issn | 1399-0012 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/73185 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=16640522&dopt=citation | en_US |
dc.description.abstract | Kidney donation from female donors to male recipients has been reported to be associated with decreased allograft survival. Whether there was a gender-related inadequacy between donor nephron supply and recipient functional demand was investigated in this study. One hundred ninety-five living donor kidney transplant recipients that had neither ischemic injury, episode of rejection, nor any complication were included. Weights and heights of both donors and recipients were recorded to calculate body surface area, lean body weight, and body mass index. The donated kidney was weighed just after cold flush, and the recipient's serum creatinine (Scr) was measured on a daily basis post-operatively. When the recipient's Scr reached the baseline, a 24-h urine was collected for the amount of proteinuria (Upr), creatinine excretion (Ucr) and creatinine clearance (Ccr) calculation. The effect of donor and recipient gender was analysed by independent sample t -test. On average, male donors and recipients were heavier and taller than females. However, the mass of kidneys donated from men and women were not statistically different. The gender-related differences in post-transplant Scr and Ucr of recipients were associated with the differences in the parameters of metabolic demands of recipients rather than with the weight of implanted kidney (renal mass supply) or with pre-operative renal functions of donors (functional supply). The early graft function is not determined by donor gender. The effect of recipient gender on the graft function depends on the metabolic demands, which are higher in male recipients. | en_US |
dc.format.extent | 121331 bytes | |
dc.format.extent | 3109 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Blackwell Publishing Inc | en_US |
dc.rights | Copyright © Blackwell Munksgaard 2006 | en_US |
dc.subject.other | Gender | en_US |
dc.subject.other | Graft Function | en_US |
dc.subject.other | Kidney Transplantation | en_US |
dc.subject.other | Nephron | en_US |
dc.title | Gender-related differences of renal mass supply and metabolic demand after living donor kidney transplantation | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Medicine (General) | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Surgery, University of Michigan, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationother | Department of Surgery, Ajou University School of Medicine, Yeongtong-Gu, Suwon, Korea , | en_US |
dc.contributor.affiliationother | Department of Surgery, Yonsei University College of Medicine, Seodaemun-Ku, Seoul, Korea and | en_US |
dc.identifier.pmid | 16640522 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/73185/1/j.1399-0012.2005.00459.x.pdf | |
dc.identifier.doi | 10.1111/j.1399-0012.2005.00459.x | en_US |
dc.identifier.source | Clinical Transplantation | en_US |
dc.identifier.citedreference | Vereerstraeten P, Wissing M, De Pauw L, Abramowicz D, Kinnaert P. Male recipients of kidneys from female donors are at increased risk of graft loss from both rejection and technical failure. Clin Transplant 1999: 13: 181. | en_US |
dc.identifier.citedreference | Zeier M, Dohler B, Opelz G, Ritz E. The effect of donor gender on graft survival. J Am Soc Nephrol 2002: 13: 2570. | en_US |
dc.identifier.citedreference | Meier-Kriesche HU, Ojo AO, Leavey SF et al. Gender differences in the risk for chronic renal allograft failure. Transplantation 2001: 71: 429. | en_US |
dc.identifier.citedreference | Matas AJ, Gillingham KJ, Humar A, Dunn DL, Sutherland DE, Najarian JS. Immunologic and nonimmunologic factors: different risks for cadaver and living donor transplantation. Transplantation 2000: 69: 54. | en_US |
dc.identifier.citedreference | Kasiske BL, Umen JA. The influence of age, sex, race and body habitus on kidney weight in humans. Arch Pathol Lab Med 1986: 110: 55. | en_US |
dc.identifier.citedreference | Brenner BM, Meyer TW, Hostetter TH. Dietary protein intake and the progressive nature of kidney disease: the role of hemodynamically mediated glomerular injury in the pathogenesis of progressive glomerular sclerosis in aging, renal ablation, and intrinsic renal disease. N Engl J Med 1982: 307: 652. | en_US |
dc.identifier.citedreference | Terasaki PI, Koyama H, Cecka JM, Gjertson DW. The hyperfiltration hypothesis in human renal transplantation. Transplantation 1994: 57: 1450. | en_US |
dc.identifier.citedreference | Kim YS, Moon JI, Kim DK, Kim SI, Park K. Ratio of donor kidney weight to recipient body weight as an index of graft function. Lancet 2001: 357: 1180. | en_US |
dc.identifier.citedreference | Zhou YC, Cecka JM. Effect of sex on kidney transplants. Clin Transplant 1989: 1: 361. | en_US |
dc.identifier.citedreference | Iguro T, Okazaki H, Sato T, Jimbo M, Oguma S. The effect of donor age and sex on cyclosporine associated nephrotoxicity. Transplant Proc 1989: 21: 1554. | en_US |
dc.identifier.citedreference | Silbiger SR, Neugarten J. The impact of gender on the progression of chronic renal disease. Am J Kidney Dis 1995: 25: 515. | en_US |
dc.identifier.citedreference | Grossman C. Possible underlying mechanisms of sexual dimorphism in the immune response, fact and hypothesis. J Steroid Biochem 1989: 34: 241. | en_US |
dc.identifier.citedreference | Enosawa S, Hirasawa K. Sex-associated differences in the survival of skin grafts in rats. Transplantation 1989: 47: 933. | en_US |
dc.identifier.citedreference | Hirasawa K, Enosawa S. Effects of sex steroid hormones on sex-associated differences in the survival time of allogeneic skin grafts in rats: evidence that testosterone enhances and estradiol reverses the immunosuppressive activity of cyclosporine. Transplantation 1990: 50: 637. | en_US |
dc.identifier.citedreference | DuBois D, DuBois EF. A formula to estimate the approximate surface area if height and weight be known. Arch Int Med 1916: 17: 863. | en_US |
dc.identifier.citedreference | Nicholson ML, Windmill DC, Horsburgh T, Harris KP. Influence of allograft size to recipient body-weight ratio on the long-term outcome of renal transplantation. Br J Surg 2000: 87: 314. | en_US |
dc.identifier.citedreference | Miles AMV, Sumrani N, John S et al. The effect of kidney size on cadaveric renal allograft outcome. Transplantation 1996: 61: 894. | en_US |
dc.identifier.citedreference | Kim SI, Kim YS, Kim MS, Moon JI, Park K. True living donor kidney weight-to-recipient body weight ratio influences posttransplant 1-year renal allograft function. Transplant Proc 1998: 30: 3120. | en_US |
dc.identifier.citedreference | Kim YS, Kim MS, Han DS et al. Evidence that the ratio of donor kidney weight to recipient body weight, donor age, and episodes of acute rejection correlate independently with live-donor graft function. Transplantation 2002: 74: 280. | en_US |
dc.identifier.citedreference | Moon IS, Kim YG, Park JH et al. Influence of donor kidney size on immediate renal function (1 month) in kidney transplantation. Transplant Proc 1998: 30: 3666. | en_US |
dc.identifier.citedreference | Pourmand G, Taheri M, Mehrsai AR, Nourijelyani K. Impact of donor nephron mass on outcomes in renal transplantation. Transplant Proc 2001: 33: 2828. | en_US |
dc.identifier.citedreference | Pirsch JD, Armbrust MJ, Knechtle SJ et al. Obesity as a risk factor following renal transplantation. Transplantation 1995: 59: 631. | en_US |
dc.identifier.citedreference | Meier-Kriesche HU, Vaghela M, Thambuganipalle R, Friedman G, Jacobs M, Kaplan B. The effect of body mass index on long-term renal allograft survival. Transplantation 1999: 68: 1294. | en_US |
dc.identifier.citedreference | Eschwege P, Trifa M, Randrianjohany A et al. Effects of donor and recipient weight differences on serum creatinine levels in renal transplantation. Transplant Proc 1995: 27: 2456. | en_US |
dc.identifier.citedreference | Gaston RS, Hudson SL, Julian BA et al. Impact of donor/recipient size matching on outcomes in renal transplantation. Transplantation 1996: 61: 383. | en_US |
dc.identifier.citedreference | Dinkel E, Ertel M, Dittrich M, Peters H, Berres M, Schulte-Wissermann H. Kidney size in childhood: sonographic growth charts for kidney length and volume. Pediatr Radiol 1983: 15: 38. | en_US |
dc.identifier.citedreference | Han BK, Babcock DS. Sonographic measurements and appearance of normal kidneys in children. Am J Roentgenol 1985: 145: 611. | en_US |
dc.identifier.citedreference | Karn MN. Radiographic measurements of kidney section area. Ann Hum Genet 1962: 25: 379. | en_US |
dc.identifier.citedreference | Emamian SA, Nielsen MB, Pedersen JF, Ytte L. Kidney dimensions at sonography: correlation with age, sex, and habitus in 665 adult volunteers. Am J Roentgenol 1993: 160: 83. | en_US |
dc.identifier.citedreference | Rasmussen SN, Haase L, Kjeldsen H, Hancke S. Determination of renal volume by ultrasound scanning. J Clin Ultrasound 1978: 6: 160. | en_US |
dc.identifier.citedreference | Bunke M, Marx MA, Abul-Ezz S, Almquist G, Barone G, Ketel B. The poor accuracy of indirect measurements of cadaveric donor kidney weights. Clin Transplant 1999: 13: 253. | en_US |
dc.identifier.citedreference | Neugarten J, Kasiske B, Silbiger SR, Nyengaard JR. Effects of sex on renal structure. Nephron 2002: 90: 139. | en_US |
dc.identifier.citedreference | de la Grandmaison GL, Clairand I, Durigon M. Organ weight in 684 adult autopsies: new tables for a Caucasoid population. Forensic Sci Int 2001: 119: 149. | en_US |
dc.identifier.citedreference | Wald H. The weight of normal adult human kidneys and its variability. Arch Pathol 1937: 23: 493. | en_US |
dc.identifier.citedreference | Boyd E. Normal variability in weight of the adult human liver and spleen. Arch Pathol 1933: 16: 350. | en_US |
dc.identifier.citedreference | Paivansalo MJ, Merikanto J, Savolainen MJ et al. Effect of hypertension, diabetes and other cardiovascular risk factors on kidney size in middle-aged adults. Clin Nephrol 1998: 50: 161. | en_US |
dc.identifier.citedreference | Valdes F, Pita S, Alonso A et al. The effect of donor gender on renal allograft survival and influence of donor age on posttransplant graft outcome and patient survival. Transplant Proc 1997: 29: 3371. | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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