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Open pilot study of gabapentin versus trazodone to treat insomnia in alcoholic outpatients

dc.contributor.authorKaram-Hage, Maher A.en_US
dc.contributor.authorBrower, Kirk J.en_US
dc.date.accessioned2010-06-01T20:04:12Z
dc.date.available2010-06-01T20:04:12Z
dc.date.issued2003-10en_US
dc.identifier.citationKaram-Hage, Maher; Brower, Kirk J. (2003). "Open pilot study of gabapentin versus trazodone to treat insomnia in alcoholic outpatients." Psychiatry and Clinical Neurosciences 57(5): 542-544. <http://hdl.handle.net/2027.42/73196>en_US
dc.identifier.issn1323-1316en_US
dc.identifier.issn1440-1819en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/73196
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=12950711&dopt=citationen_US
dc.description.abstractAlcohol-dependent outpatients with persisting insomnia were treated with either gabapentin or trazodone. Patients were assessed at baseline and after 4–6 weeks on medication using the Sleep Problems Questionnaire (SPQ). Of 55 cases initially treated, 9% dropped out due to morning drowsiness. Of the remaining 50 cases, 34 were treated with gabapentin (mean dose ± SD = 888 ± 418 mg) at bedtime and 16 were treated with trazodone (105 ± 57 mg) at bedtime. Both groups improved significantly on the SPQ but the gabapentin group improved significantly more than the trazodone group. Controlled studies are warranted to replicate these findings.en_US
dc.format.extent57869 bytes
dc.format.extent3109 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherBlackwell Science Ptyen_US
dc.rightsBlackwell Publishing Ltd 2003en_US
dc.subject.otherAlcoholismen_US
dc.subject.otherDrug Therapyen_US
dc.subject.otherGabapentinen_US
dc.subject.otherInsomniaen_US
dc.subject.otherTrazodoneen_US
dc.titleOpen pilot study of gabapentin versus trazodone to treat insomnia in alcoholic outpatientsen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbsecondlevelPsychiatryen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Psychiatry, University of Michigan Medical School, Ann Arbor, Michigan, USAen_US
dc.identifier.pmid12950711en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/73196/1/j.1440-1819.2003.01161.x.pdf
dc.identifier.doi10.1046/j.1440-1819.2003.01161.xen_US
dc.identifier.sourcePsychiatry and Clinical Neurosciencesen_US
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dc.identifier.citedreferenceYamadera H, Suzuki H, Nakamura S, Endo S. Effects of trazodone on polysomnography, blood concentration and core body temperature in healthy volunteers. Psychiatry Clin. Neurosci. 1999; 53: 189 – 191.en_US
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dc.identifier.citedreferenceTaylor CP. Gabapentin: mechanisms of action. In: Levy RH, Mattson RH, Meldrum BS, Perucca E (eds). Antiepileptic Drugs, 5th edn. Lippincott Williams & Wilkins, Philadelphia, PA, 2002; 321 – 334.en_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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