Open pilot study of gabapentin versus trazodone to treat insomnia in alcoholic outpatients
dc.contributor.author | Karam-Hage, Maher A. | en_US |
dc.contributor.author | Brower, Kirk J. | en_US |
dc.date.accessioned | 2010-06-01T20:04:12Z | |
dc.date.available | 2010-06-01T20:04:12Z | |
dc.date.issued | 2003-10 | en_US |
dc.identifier.citation | Karam-Hage, Maher; Brower, Kirk J. (2003). "Open pilot study of gabapentin versus trazodone to treat insomnia in alcoholic outpatients." Psychiatry and Clinical Neurosciences 57(5): 542-544. <http://hdl.handle.net/2027.42/73196> | en_US |
dc.identifier.issn | 1323-1316 | en_US |
dc.identifier.issn | 1440-1819 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/73196 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=12950711&dopt=citation | en_US |
dc.description.abstract | Alcohol-dependent outpatients with persisting insomnia were treated with either gabapentin or trazodone. Patients were assessed at baseline and after 4–6 weeks on medication using the Sleep Problems Questionnaire (SPQ). Of 55 cases initially treated, 9% dropped out due to morning drowsiness. Of the remaining 50 cases, 34 were treated with gabapentin (mean dose ± SD = 888 ± 418 mg) at bedtime and 16 were treated with trazodone (105 ± 57 mg) at bedtime. Both groups improved significantly on the SPQ but the gabapentin group improved significantly more than the trazodone group. Controlled studies are warranted to replicate these findings. | en_US |
dc.format.extent | 57869 bytes | |
dc.format.extent | 3109 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Blackwell Science Pty | en_US |
dc.rights | Blackwell Publishing Ltd 2003 | en_US |
dc.subject.other | Alcoholism | en_US |
dc.subject.other | Drug Therapy | en_US |
dc.subject.other | Gabapentin | en_US |
dc.subject.other | Insomnia | en_US |
dc.subject.other | Trazodone | en_US |
dc.title | Open pilot study of gabapentin versus trazodone to treat insomnia in alcoholic outpatients | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Psychiatry | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Psychiatry, University of Michigan Medical School, Ann Arbor, Michigan, USA | en_US |
dc.identifier.pmid | 12950711 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/73196/1/j.1440-1819.2003.01161.x.pdf | |
dc.identifier.doi | 10.1046/j.1440-1819.2003.01161.x | en_US |
dc.identifier.source | Psychiatry and Clinical Neurosciences | en_US |
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dc.identifier.citedreference | Mashiko H, Niwa S, Kumashiro H et al. Effect of trazodone in a single dose before bedtime for sleep disorders accompanied by a depressive state: Dose-finding study with no concomitant use of hypnotic agent. Psychiatry Clin. Neurosci. 1999; 53: 193 – 194. | en_US |
dc.identifier.citedreference | Yamadera H, Suzuki H, Nakamura S, Endo S. Effects of trazodone on polysomnography, blood concentration and core body temperature in healthy volunteers. Psychiatry Clin. Neurosci. 1999; 53: 189 – 191. | en_US |
dc.identifier.citedreference | Bonnet U, Banger M, Leweke FM, Maschke M, Kowalski T, Gastpar M. Treatment of alcohol withdrawal syndrome with gabapentin. Pharmacopsychiatry 1999; 32: 107 – 109. | en_US |
dc.identifier.citedreference | Taylor CP. Gabapentin: mechanisms of action. In: Levy RH, Mattson RH, Meldrum BS, Perucca E (eds). Antiepileptic Drugs, 5th edn. Lippincott Williams & Wilkins, Philadelphia, PA, 2002; 321 – 334. | en_US |
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dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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