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Retinal nerve fiber layer abnormalities in Alzheimer's disease
dc.contributor.authorHedges, Thomas R.en_US
dc.contributor.authorGalves, Rosalba Perezen_US
dc.contributor.authorSpeigelman, Donnaen_US
dc.contributor.authorBarbas, Nancy R.en_US
dc.contributor.authorPeli, Elien_US
dc.contributor.authorYardley, Christine J.en_US
dc.date.accessioned2010-06-01T20:07:59Z
dc.date.available2010-06-01T20:07:59Z
dc.date.issued1996-06en_US
dc.identifier.citationHedges, Thomas R.; Galves, Rosalba Perez; Speigelman, Donna; Barbas, Nancy R.; Peli, Eli; Yardley, Christine J. (1996). "Retinal nerve fiber layer abnormalities in Alzheimer's disease." Acta Ophthalmologica Scandinavica 74(3): 271-275. <http://hdl.handle.net/2027.42/73257>en_US
dc.identifier.issn1395-3907en_US
dc.identifier.issn1600-0420en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/73257
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8828725&dopt=citationen_US
dc.description.abstractRetinal nerve fiber layer (RNFL) photographs from 26 patients with Alzheimer's disease and 23 normal, age-matched, control subjects were reviewed for quality and abnormalities by two observers. A higher proportion of Alzheimer's patients showed RNFL abnormalities when compared to control subjects. There was some disagreement between the two observers regarding quality and frequency of abnormalities, reflecting suboptimal quality of the photographs obtained in patients with advanced Alzheimer's disease. Although these findings add to the clinical and histopathological evidence that ganglion cell degeneration occurs in Alzheimer's disease, the difficulty in obtaining and evaluating retinal nerve fiber layer photographs, especially in advanced cases, may limit the clinical usefulness of retinal nerve fiber layer analysis in such patients.en_US
dc.format.extent779791 bytes
dc.format.extent3109 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherBlackwell Publishing Ltden_US
dc.rights1996 Institution Acta Ophthalmologica Scandinavicaen_US
dc.subject.otherAlzheimer's Diseaseen_US
dc.subject.otherRetinal Nerve Fiber Layeren_US
dc.subject.otherOptic Neuropathyen_US
dc.subject.otherAgingen_US
dc.subject.otherVisionen_US
dc.titleRetinal nerve fiber layer abnormalities in Alzheimer's diseaseen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelOphthalmologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumUniversity of Michigan Medical Center, Department of Neurology, Ann Arbor, Michiganen_US
dc.contributor.affiliationotherDepartment of Ophthalmology, Tufts University, New England Medical Center, Boston, Massachusettsen_US
dc.contributor.affiliationotherDepartment of Neurology, Tufts University, New England Medical Center, Boston, Massachusettsen_US
dc.contributor.affiliationotherCenter for Studies of Sensory Impairment, Aging and Metabolism, Hospital de Ojos y Oidos ‘Dr. Roldolfo Robles V.’, Guatemala City, Guatemalaen_US
dc.contributor.affiliationotherDepartment of Epidemiology, Harvard School of Public Health, Boston, Massachusettsen_US
dc.identifier.pmid8828725en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/73257/1/j.1600-0420.1996.tb00090.x.pdf
dc.identifier.doi10.1111/j.1600-0420.1996.tb00090.xen_US
dc.identifier.sourceActa Ophthalmologica Scandinavicaen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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