Cross-regulatory role of interferon-gamma (IFN-Γ), IL-4 and IL-10 in schistosome egg granuloma formation: in vivo regulation of Th activity and inflammation
dc.contributor.author | Chensue, Stephen W. | en_US |
dc.contributor.author | Warmington, K. S. | en_US |
dc.contributor.author | Ruth, J. | en_US |
dc.contributor.author | Lincoln, Pamela M. | en_US |
dc.contributor.author | Kunkel, Steven L | en_US |
dc.date.accessioned | 2010-06-01T20:12:08Z | |
dc.date.available | 2010-06-01T20:12:08Z | |
dc.date.issued | 1994-12 | en_US |
dc.identifier.citation | CHENSUE, S. W.; WARMINGTON, K. S.; RUTH, J.; LINCOLN, P. M.; KUNKEL, S. L. (1994). "Cross-regulatory role of interferon-gamma (IFN-Γ), IL-4 and IL-10 in schistosome egg granuloma formation: in vivo regulation of Th activity and inflammation." Clinical & Experimental Immunology 98(3): 395-400. <http://hdl.handle.net/2027.42/73324> | en_US |
dc.identifier.issn | 0009-9104 | en_US |
dc.identifier.issn | 1365-2249 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/73324 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7994903&dopt=citation | en_US |
dc.description.abstract | This study examined the relationship ofIL-4, IL-10 and IFN-Γ with regard to the local granuloma (GR) and draining lymph node (LN) response to Schistosoma mansoni eggs. Synchronized GR were induced in naive and schistosome-infected mice at the vigorous (8 weeks) and late chronic (20 weeks) stages. In LN cultures, IL-10 and IFN production peaked on day 4 and was greatest for 8 week-infected mice. All GR cultures contained IFN, but compared with naive mice IL-10 production was accelerated at 8 weeks and abrogated at 20 weeks, consistent with expansion and abatement of Th2 activity, Cytokine neutralization was performed in egg-challenged, naive mice that were adoptively sensitized with lymphoid cells from 8 week-infected donors. GR size, GR macrophage tumour necrosis factor (TNF) production and egg antigen-elicited IL-2, IL-4, IL-5, IL-10 and IFN were examined on day 4 of GR formation, Anti-IFN augmented GR area by 40%, increased local IL-4 and IL-10, but decreased IFN and TNF production. In corresponding LN cultures, IFN decreased by about 50%, while IL-2, IL-4, IL-IO and lL-5 increased by nearly two-, four-, five- and six-fold, respectively, Anti-IL-10 did not affect GR size or GR cytokines, but increased IFN levels in LN cultures four-fold and decreased IL-2, IL-4, lL-5 and IL-10. Anti-IL-4 abrogated GR area by 40%, along with a reduction in local IL-4 and TNF production. In LN, IL-4 depletion reduced IL-4 and IL-5 by 60–70% and increased IFN levels. These results support the notion of a cross-regulatory network in which IFN inhibits Th2 and IL-10 inhibits ThI cells. IL-4 fosters Th2 cell differentiation in LN, but also performs a critical recruitment function in the eosinophil-rich schistosome egg-induced GR, whereas IFN contributes to enhanced GR macrophage function. | en_US |
dc.format.extent | 3232293 bytes | |
dc.format.extent | 3109 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Blackwell Publishing Ltd | en_US |
dc.rights | 1994 Blackwell Science Ltd, Oxford | en_US |
dc.subject.other | Granulomas | en_US |
dc.subject.other | T Helper Cells | en_US |
dc.subject.other | Schistosoma Mansoni | en_US |
dc.subject.other | IL-4 | en_US |
dc.subject.other | IL-10 | en_US |
dc.subject.other | Interferon-gamma | en_US |
dc.subject.other | Cross-regulation | en_US |
dc.title | Cross-regulatory role of interferon-gamma (IFN-Γ), IL-4 and IL-10 in schistosome egg granuloma formation: in vivo regulation of Th activity and inflammation | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Microbiology and Immunology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | † Department of Pathology, University of Michigan Hospitals, MI, USA | en_US |
dc.contributor.affiliationum | † Department of Epidemiology, University of Michigan. Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationother | * Department of Pathology, Veterans Affairs Medical Centre, MI, USA | en_US |
dc.identifier.pmid | 7994903 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/73324/1/j.1365-2249.1994.tb05503.x.pdf | |
dc.identifier.doi | 10.1111/j.1365-2249.1994.tb05503.x | en_US |
dc.identifier.source | Clinical & Experimental Immunology | en_US |
dc.identifier.citedreference | Mossmann TRH, Cherwinski H, Bond MW et al. Two types of murine helper T cell clones. I. Definition accordmg to profiles of lymphokine activities and secreted proteins. J Immunol 1986; 136: 2348 – 57. | en_US |
dc.identifier.citedreference | Sadick MD, Heinzel FP, Holaday BJ et al. Cure of murine leishmaniasis with anti-interieukin 4 monoclonal antibody. Evidence for a T cell dependent, interferon-Γ independent mechanism. J Exp Med 1990; 171: 115 – 27. | en_US |
dc.identifier.citedreference | Scott P. IFN-Γ modulates the early development of Th1 and Th2 responses in a murine model of cutaneous leishmaniasis. J Immunol 1991; 147: 3149 – 55. | en_US |
dc.identifier.citedreference | Chatelain R, Varkila K, Coffman RL. IL-4 induces a Th2 response in Leishmania major -infected mice. J Immunol 1992; 148: 1182 – 7. | en_US |
dc.identifier.citedreference | Yamamura M, Uyemura K, Deans RJ et al. Defining protective responses to pathogens: cytokine profiles in leprosy lesions. Science 1991; 254: 277 – 9. | en_US |
dc.identifier.citedreference | Haanen JA, de Waal Malefyt R, Res PC et al. Selection of a human T helper type 1-tike cell subset by mycobacteria. J Exp Med 1991; 174: 583 – 92. | en_US |
dc.identifier.citedreference | Mosmann TR. Role of a new cytokine. interleukin-10, in the cross-regulation of T helper cells. Ann NY Acad Sci 1991; 628: 337 – 44. | en_US |
dc.identifier.citedreference | Mosmann TR, Moore KW. The role of IL-10 in crossregulation of Th1 and Th2 responses. Immunol Today 1991; 12: A49 – 53. | en_US |
dc.identifier.citedreference | Street NE, Schutnacher JH, Fong TAT et al. Heterogeneity of mouse helper T cells. Evidence from bulk cultures and limiting dilution cloning for precursors of Th1 and Th2 cells. J Immunol. 1990; 144: 1629 – 39. | en_US |
dc.identifier.citedreference | Grzych J, Pearce E, Cheever A et al. Egg deposition is the major stimulus for the production of the Th2 cytokines in murine schistosomiasis mansoni. J Immunol 1991; 146: 1322 – 7. | en_US |
dc.identifier.citedreference | Chensue SW, Terebuh PD, Warmington KS et al. Role of IL-4 and IFN-Γ in Schistosoma mansoni egg-induced hypersensitivity granulotna fotination. Orchestration, relative contribution, and relationship to macrophage function. J Immunol 1992; 148: 900 – 6. | en_US |
dc.identifier.citedreference | Chensue SW, Terebuh P, Kunkel SL. Gamma-interferon suppresses schistosome egg granuloma formation: possible role of natural killer cells. FASEB J 1990; 4: A344. | en_US |
dc.identifier.citedreference | Lukacs NW, Boros DL. Lymphokine regulation of granuloma formation in murine schistosomiasis mansoni. Clin Immunol Immunopathol 1993; 68: 57 – 63. | en_US |
dc.identifier.citedreference | Sher A, Fiorentino D, Caspar P et al. Production of IL-10 by CD4 + T lymphocytes correlates with down-regulation of Th1 cytokine synthesis in helminth infection. J Immunol 1991; 147; 2713 – 6. | en_US |
dc.identifier.citedreference | Coker CM, von Lichtenberg F. A revised method for the isolation of Schistosoma mansoni eggs for biologic experimentation. Proc Soc Biol Med 1956; 92; 780 – 2. | en_US |
dc.identifier.citedreference | Fiorentino DF, Zlotiiik A, Viera P et al. IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells. J Immunol 1991; 146: 3444 – 51. | en_US |
dc.identifier.citedreference | Tada H, Shiho O, Kuroshima K et al. An improved colorimetric assay for inlerleukin-2. J Immunol Methods 1986; 93: 157 – 65. | en_US |
dc.identifier.citedreference | Hui-Li J, Ohara J, Watyson C et al. Derivation of a T cell line that is highly responsive to IL-4 and lL-2 (CT.4R) and of a IL-2 hyporesponsive mutant of that line (CT.4S). J Immunol 1989; 142: 800 – 7. | en_US |
dc.identifier.citedreference | Schumacher JH, O'Garra A, Shrader B et al. The characterization of four monoclonal antibodies specific for mouse IL-5 and the development of mouse and human IL-5 enzyme-linked immunoabsorbentassays. J Immunol 1988; 141: 576 – 81. | en_US |
dc.identifier.citedreference | Curry RC, Kiener PA, Spitalny GL. A sensitive immunochemical assay for biologically active Mu IFN-gamma. J Immunol Methods 1987; 104; 137 – 42. | en_US |
dc.identifier.citedreference | Chensue SW, Warmington KS, Hershey SD et al. Evolving T cell responses in murine schistosomiaisis. Th2 cells mediate secondary granulomatous hypersensitivity and are regulated by CD8 + cells in vivo. J Immunol 1993; 151: 1391 – 400. | en_US |
dc.identifier.citedreference | Vella A, Pearce EJ. CD4 + Th2 response induced by Schistosoma mansoni eggs develops rapidly, through an early, transient. Th0-like state. J Immunol 1992; 148: 2283 – 90. | en_US |
dc.identifier.citedreference | Henderson GS, Lu X, McCurley TL, Colley DG. In vivo molecular analysis of lymphokines involved in the murine immune response during Schistosoma mansoni infection. II. Quantification of IL-4 mRNA, IFN-Γ mRNA, and IL-2 mRNA in the granulomatous livers, mcsenteric, lymph nodes and spleens during the course of modulation. J Immunol 1992; 148: 2261 – 9. | en_US |
dc.identifier.citedreference | Bradley LM, Duncan DD, Yoshimoto K, Swain SL. Memory effectors; a potent, IL-4-secreting helper T cell population that develops in vivo after restimulation with antigen. J Immunol 1993; 150: 3119 – 30. | en_US |
dc.identifier.citedreference | Silva JS, Morrisey PJ, Grabstetn KH et al. Interlcukin-10 and interferon gamma regulation of experimental Tryponosoma cruzi infection. J Exp Med 1992; 175: 169 – 74. | en_US |
dc.identifier.citedreference | Sieling PA, Abrams JS, Yamamura M el al. Immunosuppressive roles for IL-10 and IL-4 in human infection. In vitro modulation of T cell responses in leprosy. J Immunol 1993; 150: 5501 – 10. | en_US |
dc.identifier.citedreference | Gajewski TK, Joyce J, Fitch FW. Anti-proliferative effect of IFN-Γ in immune regulation. L IFN-Γ inhibits the proliferation of Th2 but not Th1 murine helper T lymphocyte clones. J Immunol 1989; 140: 4245 – 52. | en_US |
dc.identifier.citedreference | Hsieh C-S, Heimberger AB, Gold JS et al. Differential regulation of T helper phenotype development by IL-4 and IL-10 in a ab-TCR transgcnic system. Proc Natl Acad Sci USA 1992; 89; 6065 – 9. | en_US |
dc.identifier.citedreference | Swain SL, Weinberg AD, English M, Huston G. IL-4 directs the development of Th2-like helper effectors. J Immunol 1990; 145: 3796 – 806. | en_US |
dc.identifier.citedreference | Le Gros G, Ben-Sasson SZ, Seder R et al. Generation of interleukin 4 (IL-4)-producing ceils in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4 producing cells. J Exp Med 1990; 172: 921 – 9. | en_US |
dc.identifier.citedreference | Seder RA, Paul WE. Acquisition of lymphokine-producing phenotype by CD4 + T cells. Annu Rev Immunol 1994; 12: 635 – 73. | en_US |
dc.identifier.citedreference | Muller KM, Jaunin F, Masouye I et al. Th2 cells mediate IL-4 dependent local tissue inflammation. J Immunol 1993; 150: 5576 – 83. | en_US |
dc.identifier.citedreference | Dieli F, Asherson GL, Romanno GC et al. IL-4 is essential for the systemic transfer of delayed hypersensitivity by T cell lines: role of Γ/Δ cells. J Immunol 1994; 152: 2698 – 704. | en_US |
dc.identifier.citedreference | Hart PH, Vitti GF, Burgess DR et al. Potential anti-inflammatory effects of interleukin 4: suppression of human monocyte tumour necrosis factor a. interleukin I, and prostaglandin E2. Proc Natl Acad Sci USA 1989; 86; 1303 – 7. | en_US |
dc.identifier.citedreference | Masinovsky B, Urdal D, Gallitin WM. IL-4 acts synergistically with IL-1Β to promote lymphocyte adhesion lo microvascular endothelium by induction of vascular cell adhesion molecule-l. J Immunol 1990; 145: 2886 – 95. | en_US |
dc.identifier.citedreference | Rollins BJ, Pober JS. Interleukin-4 induces the synthesis and secretion of MCP-I/JE by human endothelial cells. Am J Pathol 1991; 138: 1315 – 9. | en_US |
dc.identifier.citedreference | Farrar MA, Schreiber RD. The molecular cell biology of interferongamma and its receptor. Annu Rev immunol 1993; 11: 571 – 611. | en_US |
dc.identifier.citedreference | Essner R, Rhoades K, McBride WH et al. IL-4 down-regulates IL-1 and TNF gene expression in human monocytes. J Immunol 1989; 142: 3857 – 61. | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.