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THE EFFECT OF PROPRANOLOL ON PLASMA RENIN ACTIVITY AND BLOOD PRESSURE IN MILD ESSENTIAL HYPERTENSION
dc.contributor.authorHansson, Lennarten_US
dc.contributor.authorZweifler, Andrew J.en_US
dc.date.accessioned2010-06-01T20:12:11Z
dc.date.available2010-06-01T20:12:11Z
dc.date.issued1974-01-12en_US
dc.identifier.citationHansson, Lennart; Zweifler, Andrew J. (1974). "THE EFFECT OF PROPRANOLOL ON PLASMA RENIN ACTIVITY AND BLOOD PRESSURE IN MILD ESSENTIAL HYPERTENSION." Acta Medica Scandinavica 195(1-6): 397-401. <http://hdl.handle.net/2027.42/73325>en_US
dc.identifier.issn0001-6101en_US
dc.identifier.issn0954-6820en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/73325
dc.description.abstractFourteen male patients with mild to moderate essential hypertension have been studied with regard to plasma renin activity (PRA) after acute and prolonged Β-adrenergic blockade with propranolol. Initial PRA was determined after four weeks of placebo treatment. Before propranolol was given PRA rose in response to 10 min of 45° head-up tilt from 151.7 ng/100 ml/h to 248.7 ng/100 ml/h ( p <0.01). After acute administration of propranolol 0.22 mg/kg b.wt. i.v. and following repeated tilt for 10 min PRA only rose to 204.7 ng/100 ml/h (n.s.). Following four weeks of oral propranolol treatment at 160–320 mg daily PRA after tilt was 39.0 ng/100 ml/h. Thus a significant reduction of PRA had taken place ( p < 0.005) to a level constituting only 15% of the initial PRA after tilt. The reduction of blood pressure (BP) after four weeks of propranolol treatment was also significant. Diastolic BP was reduced by 19 mmHg( p < 0.001). The changes in BP and tilted PRA were not significantly correlated ( r =0.449, p <0.10). These results indicate that propranolol causes a marked reduction of PRA in addition to its hypotensive effect. However, this does not necessarily imply that there is a direct causal relationship between the effect of propranolol on PRA and its effect on BP.en_US
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dc.publisherBlackwell Publishing Ltden_US
dc.rights1974 Association for the Publication of the Journal of Internal Medicineen_US
dc.titleTHE EFFECT OF PROPRANOLOL ON PLASMA RENIN ACTIVITY AND BLOOD PRESSURE IN MILD ESSENTIAL HYPERTENSIONen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelMedicine (General)en_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Internal Medicine, Hypertension Section, University of Michigan Medical Center, Ann Arbor, Michigan, USAen_US
dc.identifier.pmid4598059en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/73325/1/j.0954-6820.1974.tb08159.x.pdf
dc.identifier.doi10.1111/j.0954-6820.1974.tb08159.xen_US
dc.identifier.sourceActa Medica Scandinavicaen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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