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CXCL12 overexpression and secretion by aging fibroblasts enhance human prostate epithelial proliferation in vitro

dc.contributor.authorBegley, Lesa A.en_US
dc.contributor.authorMonteleon, Christineen_US
dc.contributor.authorShah, Rajal B.en_US
dc.contributor.authorMacDonald, James W.en_US
dc.contributor.authorMacoska, Jill A.en_US
dc.date.accessioned2010-06-01T20:14:06Z
dc.date.available2010-06-01T20:14:06Z
dc.date.issued2005-12en_US
dc.identifier.citationBegley, Lesa; Monteleon, Christine; Shah, Rajal B.; MacDonald, James W.; Macoska, Jill A. (2005). "CXCL12 overexpression and secretion by aging fibroblasts enhance human prostate epithelial proliferation in vitro ." Aging Cell 4(6): 291-298. <http://hdl.handle.net/2027.42/73356>en_US
dc.identifier.issn1474-9718en_US
dc.identifier.issn1474-9726en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/73356
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=16300481&dopt=citationen_US
dc.description.abstractThe direct relationship between the aging process and the incidence and prevalence of both benign prostatic hyperplasia (BPH) and prostate cancer (PCa) implies that certain risk factors associated with the development of both diseases increase with the aging process. In particular, both diseases share an overly proliferative phenotype, suggesting that mechanisms that normally act to suppress cellular proliferation are disrupted or rendered dysfunctional as a consequence of the aging process. We propose that one such mechanism involves changes in the prostate microenvironment, which ‘evolves’ during the aging process and disrupts paracrine interactions between epithelial and associated stromal fibroblasts. We show that stromal fibroblasts isolated from the prostates of men 63–81 years of age at the time of surgery express and secrete higher levels of the CXCL12 chemokine compared with those isolated from younger men, and stimulate CXCR4-mediated signaling pathways that induce cellular proliferation. These studies represent an important first step towards a mechanistic elucidation of the role of aging in the etiology of benign and malignant prostatic diseases.en_US
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dc.format.extent3109 bytes
dc.format.mimetypeapplication/pdf
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dc.publisherBlackwell Science Ltden_US
dc.rights© 2005 The Authors Journal compilationen_US
dc.subject.otherAgingen_US
dc.subject.otherCXCL12en_US
dc.subject.otherParacrineen_US
dc.subject.otherProliferationen_US
dc.subject.otherProstateen_US
dc.titleCXCL12 overexpression and secretion by aging fibroblasts enhance human prostate epithelial proliferation in vitroen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumthe Comprehensive Cancer Center, The University of Michigan, Ann Arbor, MI, USAen_US
dc.contributor.affiliationotherDepartments of Urology, anden_US
dc.contributor.affiliationotherPathology anden_US
dc.identifier.pmid16300481en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/73356/1/j.1474-9726.2005.00173.x.pdf
dc.identifier.doi10.1111/j.1474-9726.2005.00173.xen_US
dc.identifier.sourceAging Cellen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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