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CXCL12 overexpression and secretion by aging fibroblasts enhance human prostate epithelial proliferation in vitro
dc.contributor.authorBegley, Lesa A.en_US
dc.contributor.authorMonteleon, Christineen_US
dc.contributor.authorShah, Rajal B.en_US
dc.contributor.authorMacDonald, James W.en_US
dc.contributor.authorMacoska, Jill A.en_US
dc.date.accessioned2010-06-01T20:14:06Z
dc.date.available2010-06-01T20:14:06Z
dc.date.issued2005-12en_US
dc.identifier.citationBegley, Lesa; Monteleon, Christine; Shah, Rajal B.; MacDonald, James W.; Macoska, Jill A. (2005). "CXCL12 overexpression and secretion by aging fibroblasts enhance human prostate epithelial proliferation in vitro ." Aging Cell 4(6): 291-298. <http://hdl.handle.net/2027.42/73356>en_US
dc.identifier.issn1474-9718en_US
dc.identifier.issn1474-9726en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/73356
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=16300481&dopt=citationen_US
dc.description.abstractThe direct relationship between the aging process and the incidence and prevalence of both benign prostatic hyperplasia (BPH) and prostate cancer (PCa) implies that certain risk factors associated with the development of both diseases increase with the aging process. In particular, both diseases share an overly proliferative phenotype, suggesting that mechanisms that normally act to suppress cellular proliferation are disrupted or rendered dysfunctional as a consequence of the aging process. We propose that one such mechanism involves changes in the prostate microenvironment, which ‘evolves’ during the aging process and disrupts paracrine interactions between epithelial and associated stromal fibroblasts. We show that stromal fibroblasts isolated from the prostates of men 63–81 years of age at the time of surgery express and secrete higher levels of the CXCL12 chemokine compared with those isolated from younger men, and stimulate CXCR4-mediated signaling pathways that induce cellular proliferation. These studies represent an important first step towards a mechanistic elucidation of the role of aging in the etiology of benign and malignant prostatic diseases.en_US
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dc.format.extent3109 bytes
dc.format.mimetypeapplication/pdf
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dc.publisherBlackwell Science Ltden_US
dc.rights© 2005 The Authors Journal compilationen_US
dc.subject.otherAgingen_US
dc.subject.otherCXCL12en_US
dc.subject.otherParacrineen_US
dc.subject.otherProliferationen_US
dc.subject.otherProstateen_US
dc.titleCXCL12 overexpression and secretion by aging fibroblasts enhance human prostate epithelial proliferation in vitroen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumthe Comprehensive Cancer Center, The University of Michigan, Ann Arbor, MI, USAen_US
dc.contributor.affiliationotherDepartments of Urology, anden_US
dc.contributor.affiliationotherPathology anden_US
dc.identifier.pmid16300481en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/73356/1/j.1474-9726.2005.00173.x.pdf
dc.identifier.doi10.1111/j.1474-9726.2005.00173.xen_US
dc.identifier.sourceAging Cellen_US
dc.identifier.citedreferenceArenas MI, Romo E, Royuela M, Ruiz A, Fraile B, Sanchez-Chapado M, Paniagua R ( 2001 ) Morphometric evaluation of the human prostate. Int. J. Andrology 24, 37 – 47.en_US
dc.identifier.citedreferenceBegley L, Keeney D, Beheshti B, Squire JA, Kant R, Chaib H, MacDonald JW, Rhim J, Macoska JA ( 2005 ) Concordant copy number and transcriptional activity of genes mapping to derivative chromosomes 8 during cellular immortalization in vitro. Genes Chromosomes Cancer in press, Epub Oct 18, 2005.en_US
dc.identifier.citedreferenceBerges RR, Vukanovic J, Epstein JI, CarMichel M, Cisek L, Johnson DE, Veltri RW, Walsh PC, Isaacs JT ( 1995 ) Implication of cell kinetic changes during the progression of human prostatic cancer. Clin. Cancer Res. 1, 473 – 480.en_US
dc.identifier.citedreferenceChaib H, Rubin MA, Mucci NR, Li L, Taylor JMG, Day M, Rhim JS, Macoska JA ( 2001 ) Activated in prostate cancer: a PDZ domain-containing protein highly expressed in human primary prostate tumors. Cancer Res. 61, 2390 – 2394.en_US
dc.identifier.citedreferenceChen Y, Stamatoyannopoulos G, Song CZ ( 2003 ) Down-regulation of CXCR4 by inducible small interfering RNA inhibits breast cancer cell invasion in vitro. Cancer Res. 63, 4801 – 4804.en_US
dc.identifier.citedreferenceColombel M, Vacherot F, Diez SG, Fontaine E, Buttyan R, Chopin D ( 1998 ) Zonal variation of apoptosis and proliferation in the normal prostate and in benign prostatic hyperplasia. Br. J. Urol. 82, 380 – 385.en_US
dc.identifier.citedreferenceCunha GR, Hayward SW, Dahiya R, Foster BA ( 1996 ) Smooth muscle–epithelial interactions in normal and neoplastic prostatic development. Acta Anat. 155, 63 – 72.en_US
dc.identifier.citedreferenceFernandis AZ, Prasad A, Band H, Klosel R, Ganju RK ( 2004 ) Regulation of CXCR4-mediated chemotaxis and chemoinvasion of breast cancer cells. Oncogene 23, 157 – 167.en_US
dc.identifier.citedreferenceFoster BA, Kaplan PJ, Greenberg NM ( 1998–99 ) Peptide growth factors and prostate cancer: new models, new opportunities. Cancer Metastasis Rev 17, 317 – 324.en_US
dc.identifier.citedreferenceHayward SW, Haughney PC, Rosen MA, Greulich KM, Weier HU, Dahiya R, Cunha GR ( 1998 ) Interactions between adult human prostatic epithelium and rat urogenital sinus mesenchyme in a tissue recombination model. Differentiation 63, 131 – 140.en_US
dc.identifier.citedreferenceLapteva N, Yang AG, Sanders DE, Strube RW, Chen SY ( 2005 ) CXCR4 knockdown by small interfering RNA abrogates breast tumor growth in vivo. Cancer Gene Ther. 12, 84 – 89.en_US
dc.identifier.citedreferenceMacoska JA, Paris P, Collins C, Andaya A, Beheshti B, Chaib H, Kant R, Begley L, MacDonald JW, Squire JA ( 2004 ) Evolution of 8p loss in transformed human prostate epithelial cells. Cancer Genet. Cytogenet. 154, 36 – 43.en_US
dc.identifier.citedreferenceMeigs JB, Mohr B, Barry MJ, Collins MM, McKinlay JB ( 2001 ) Risk factors for clinical benign prostatic hyperplasia in a community-based population of healthy aging men. J. Clin. Epidemiol. 54, 935 – 944.en_US
dc.identifier.citedreferenceMerz VW, Miller GJ, Krebs T, Timme TL, Kadmon D, Park SH, Egawa S, Scardino PT, Thompson TL ( 1991 ) Elevated transforming growth factor-beta 1 and beta 3 mRNA levels are associated with ras + myc-induced carcinomas in reconstituted mouse prostate: evidence for a paracrine role during progression. Mol. Endocrinol. 5, 503 – 513.en_US
dc.identifier.citedreferenceMochizuki H, Matsubara A, Teishima J, Mutaguchi K, Yasumoto H, Dahiya R, Usui T, Kamiya K ( 2004 ) Interaction of ligand-receptor system between stromal-cell-derived factor-1 and CXC chemokine receptor 4 in human prostate cancer: a possible predictor of metastasis. Biochem. Biophys. Res. Commun. 320, 656 – 663.en_US
dc.identifier.citedreferenceMoser B, Loetscher P ( 2001 ) Lymphocyte traffic control by chemokines. Nature Immunol. 2, 123 – 128.en_US
dc.identifier.citedreferenceNagasawa T, Kikutani H, Kishimoto T ( 1994 ) Molecular cloning and structure of a pre-B-cell growth-stimulating factor. Proc. Natl Acad. Sci. USA 91, 2305 – 2309.en_US
dc.identifier.citedreferenceNeuhouser ML, Kristal AR, Penson DF ( 2004 ) Steroid hormones and hormone-related genetic and lifestyle characteristics as risk factors for benign prostatic hyperplasia: review of epidemiologic literature. Urology 64, 201 – 211.en_US
dc.identifier.citedreferenceOlumi AF, Grossfeld GD, Hayward SW, Carroll PR, Tlsty TD, Cunha GR ( 1996 ) Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium. Cancer Res. 59, 5002 – 5011.en_US
dc.identifier.citedreferenceOlumi AF, Dazin P, Tlsty TD ( 1998 ) A novel coculture technique demonstrates that normal human prostatic fibroblasts contribute to tumor formation of LNCaP cells by retarding cell death. Cancer Res. 58, 4525 – 4530.en_US
dc.identifier.citedreferenceSignoret N, Oldridge J, Pelchen-Matthews A, Klasse PJ, Tran T, Brass LF, Rosenkilde MM, Schwartz TW, Holmes W, Dallas W, Luther MA, Wells TN, Hoxie JA, Marsh M ( 1997 ) Phorbol esters and SDF-1 induce rapid endocytosis and down modulation of the chemokine receptor CXCR4. J. Cell Biol. 139, 651 – 664.en_US
dc.identifier.citedreferenceSingh S, Singh UP, Grizzle WE, Lillard JW Jr ( 2004 ) CXCL12–CXCR4 interactions modulate prostate cancer cell migration, metalloproteinase expression and invasion. Lab. Invest 84, 1666 – 1676.en_US
dc.identifier.citedreferenceSong Z, Wu X, Powell WC, Cardiff RD, Cohen MB, Tin RT, Matusik RJ, Miller GJ, Roy-Burman P ( 2002 ) Fibroblast growth factor 8 isoform B overexpression in prostate epithelium: a new mouse model for prostatic intraepithelial neoplasia. Cancer Res. 62, 5096 – 5105.en_US
dc.identifier.citedreferenceSpano JP, Andre F, Morat L, Sabatier L, Besse B, Combadiere C, Deterre P, Martin A, Azorin J, Valeyre D, Khayat D, Le Chevalier T, Soria JC ( 2004 ) Chemokine receptor CXCR4 and early-stage non-small cell lung cancer: pattern of expression and correlation with outcome. Ann. Oncol. 15, 613 – 617.en_US
dc.identifier.citedreferenceTaichman RS, Cooper C, Keller ET, Pienta KJ, Taichman NS, McCauley LK ( 2002 ) Use of the stromal cell-derived factor-1/CXCR4 pathway in prostate cancer metastasis to bone. Cancer Res. 62, 1832 – 1837.en_US
dc.identifier.citedreferenceThompson TC, Southgate J, Kitchener G, Land H ( 1989 ) Multistage carcinogenesis induced by ras and myc oncogenes in a reconstituted organ. Cell 56, 917 – 930.en_US
dc.identifier.citedreferenceVerhamme KM, Dieleman JP, Bleumink GS, van der Lei J, Sturkenboom MC, Artibani W, Begaud B, Berges R, Borkowski A, Chappel CR, Costello A, Dobronski P, Farmer RD, Jimenez Cruz F, Jonas U, MacRae K, Pientka L, Rutten FF, van Schayck CP, Speakman MJ, Sturkenboom MC, Tiellac P, Tubaro A, Vallencien G, Vela Navarrete R, Triumph Pan European Expert Panel ( 2002 ) Incidence and prevalence of lower urinary tract symptoms suggestive of benign prostatic hyperplasia in primary care – the Triumph project. Eur. Urol. 42, 323 – 328.en_US
dc.identifier.citedreferenceZhang Y, Foudi A, Geay JF, Berthebaud M, Buet D, Jarrier P, Jalil A, Vainchenker W, Louache F ( 2004 ) Intracellular localization and constitutive endocytosis of CXCR4 in human CD34+ hematopoietic progenitor cells. Stem Cells 22, 1015 – 1029.en_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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