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The role of Xmsx-2 in the anterior-posterior patterning of the mesoderm in Xenopus laevis
dc.contributor.authorGong, Siew-Gingen_US
dc.contributor.authorKiba, Atsushien_US
dc.date.accessioned2010-06-01T20:14:18Z
dc.date.available2010-06-01T20:14:18Z
dc.date.issued1999-11en_US
dc.identifier.citationGong, S.-G . ; Kiba, Atsushi (1999). "The role of Xmsx-2 in the anterior-posterior patterning of the mesoderm in Xenopus laevis ." Differentiation 65(3): 131-140. <http://hdl.handle.net/2027.42/73359>en_US
dc.identifier.issn0301-4681en_US
dc.identifier.issn1432-0436en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/73359
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=10631810&dopt=citationen_US
dc.description.abstractMany molecules are involved in defining mesodermal patterning of the Xenopus embryo. In this paper, evidence is provided that a member of the msx family of genes, the Xmsx-2 gene, is involved in anterior-posterior patterning of the mesoderm. A comparison of its sequence to another previously cloned msx-2 Xenopus homolog, Xhox-7.1’ [45] showed that they are closely related. The Xmsx-2 gene is first expressed at midgastrulation predominantly in the dorsal part of the embryo. It showed a complex pattern of spatial expression, consistent with a role in patterning of the anterior-posterior axis. This inference is confirmed by gain-of-function experiments in which overexpressed msx-2 mRNA in developing Xenopus embryos resulted in embryos lacking anterior structures. Analysis of markers in mutant embryos showed that genes involved in ventral-posterior patterning such as Xhox-3 , Xwnt-8 , and Xvent-1 were upregulated, confirming the posteriorized nature of the embryos. We believe that the Xmsx-2 gene is involved in refining the patterning of the anterior-posterior part of the dorsal mesoderm after the initial signals determining the dorsal or ventral nature of the mesoderm have been specified.en_US
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dc.format.extent3109 bytes
dc.format.mimetypeapplication/pdf
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dc.publisherBlackwell Publishing Ltden_US
dc.rightsSpringer-Verlag Berlin Heidelberg 1999en_US
dc.titleThe role of Xmsx-2 in the anterior-posterior patterning of the mesoderm in Xenopus laevisen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelOncology and Hematologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Orthodontics and Pediatric Dentistry, School of Dentistry, University of Michigan, 1011 N. University Avenue, Ann Arbor, MI 48109-1078, USA e-mail: sggong@umich.edu Tel.: (734)647-4318, Fax:(734)763-8100en_US
dc.identifier.pmid10631810en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/73359/1/j.1432-0436.1999.6530131.x.pdf
dc.identifier.doi10.1046/j.1432-0436.1999.6530131.xen_US
dc.identifier.sourceDifferentiationen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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