The effects of omeprazole and famotidine on mucin and PGE 2 release in the rat stomach
dc.contributor.author | Yoshimura, Kenji | en_US |
dc.contributor.author | Delbarre, S. G. | en_US |
dc.contributor.author | Kraus, E. | en_US |
dc.contributor.author | Boland, C. R. | en_US |
dc.date.accessioned | 2010-06-01T20:15:47Z | |
dc.date.available | 2010-06-01T20:15:47Z | |
dc.date.issued | 1996-02 | en_US |
dc.identifier.citation | YOSHIMURA, K.; DELBARRE, S. G.; KRAUS, E.; BOLAND, C. R. (1996). "The effects of omeprazole and famotidine on mucin and PGE 2 release in the rat stomach." Alimentary Pharmacology & Therapeutics 10(1): 111-117. <http://hdl.handle.net/2027.42/73383> | en_US |
dc.identifier.issn | 0269-2813 | en_US |
dc.identifier.issn | 1365-2036 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/73383 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8871451&dopt=citation | en_US |
dc.description.abstract | Background : Gastric antisecretory agents may inhibit the synthesis or secretion of gastric mucin during acid suppression, which would interfere with mucosal protection and limit the efficacy of the agents. Methods : Rats were dosed with famotidine, omeprazole, or buffer control for 4 weeks. Mucin synthesis, mucin histochemistry, mucin carbohydrate composition and prostaglandin E 2 (PGE 2 ) release were measured during and after drug treatment. Results : PGE 2 release was maximally inhibited after 2 weeks of omeprazole or 4 weeks of famotidine. Total glycoprotein synthesis was inhibited at all times by omeprazole, but only after the cessation of dosing with famotidine. Sulphated glycoprotein synthesis was inhibited by both drugs at 2 weeks. PGE 2 release and sulphated glycoprotein synthesis were restored to control values or more by the 5th day after the end of dosing, at which time total glycoprotein synthesis was significantly suppressed in both groups. Histologically, a reduction of PAS-positive surface mucus was observed after 2 weeks of dosing in both groups. Both famotidine and omeprazole reduced the sialic acid content during and after treatment. Conclusions : These results suggest that long-term anti-secretory therapy also affects the production of factors involved in primary gastric mucosal defence, which should be considered in the assessment of response to treatment in clinical trials. | en_US |
dc.format.extent | 711744 bytes | |
dc.format.extent | 3109 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Blackwell Publishing Ltd | en_US |
dc.rights | 1996 Blackwell Scientific Publications Ltd. | en_US |
dc.title | The effects of omeprazole and famotidine on mucin and PGE 2 release in the rat stomach | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Otolaryngology | en_US |
dc.subject.hlbsecondlevel | Pharmacy and Pharmacology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, VA Medical Centre and The University of Michigan School of Medicine Ann Arbor, Michigan, USA | en_US |
dc.identifier.pmid | 8871451 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/73383/1/j.1365-2036.1996.tb00184.x.pdf | |
dc.identifier.doi | 10.1111/j.1365-2036.1996.tb00184.x | en_US |
dc.identifier.source | Alimentary Pharmacology & Therapeutics | en_US |
dc.identifier.citedreference | Shay H. Etiology of peptic ulcer. Am J Dig Dis 1961; 6: 29 – 49. | en_US |
dc.identifier.citedreference | Yamamoto O, Okada Y, Okabe S. Effects of a proton pump inhibitor, omeprazole, on gastric secretion and gastric and duodenal ulcers or erosions in rats. Dig Dis Sci 1984; 29: 394 – 401. | en_US |
dc.identifier.citedreference | Takeuchi K, Magee DJ, Matthews CJ, Silen W. Studies of the pH gradient and thickness of frog gastric mucus gel. Gastroenterology 1983; 84: 331 – 40. | en_US |
dc.identifier.citedreference | Ryberg B, Mattsson H, Larsson H, Carlsson E. Correlation between inhibition of gastric acid secretion, plasma gastrin, and oxyntic mucosal histidine decarboxylase activity in the rat. Scand J Gastroenterol 1989; 24: 287 – 92. | en_US |
dc.identifier.citedreference | Pique JM, Leung FW, Tan HW, Livingston E, Scremin OU, Guth PH. Gastric mucosal blood tlow response to stimulation and inhibition of gastric acid secretion. Gastroenterology 1988; 95: 642 – 50. | en_US |
dc.identifier.citedreference | Goso K, Ishihara K, Ohara S, Kakei M, Hotta K. Characterization of sulfated glycoconjugates in human gastric mucosa. Digestion 1985; 31: 205 – 12. | en_US |
dc.identifier.citedreference | Golden MP, Thebert P. Inhibition by methylpredonisolone of zymosan-induced leukotriene synthesis in alveolar macrophages. Am Rev Respir Dis 1987; 135: 1020 – 6. | en_US |
dc.identifier.citedreference | Seidler U, Sewing, K-Fr. Ca 2+ -dependent and -independent secretagogue action on gastric mucus secretion in rabbit mucosal explants. Am J Physiol 1989; 256; G739 – 46. | en_US |
dc.identifier.citedreference | Boland CR, Deshmukh GD. The carbohydrate composition of mucin in colonic cancer. Gastroenterology 1990; 98: 1170 – 7. | en_US |
dc.identifier.citedreference | Johansen AA. Staining methods and histochemistry of normal gastric mucin. Acta Pathol Microbiol Scand 1970; 212 ( Suppl. ): 57 – 67. | en_US |
dc.identifier.citedreference | 11 Danish omeprazole study group. Relapse of gastric ulcers after healing with omeprazole and cimetidine. Scand J Gastroenterol 1989; 24: 557 – 60. | en_US |
dc.identifier.citedreference | Baker R, Jaffe BM, Reed JD, Shaw B, Venables CW. Endogenous prostaglandins and gastric secretion in the cat. J Physiol 1978; 278: 451 – 60. | en_US |
dc.identifier.citedreference | Yoshimura K, Delbarre SG, Kraus ER, Shimakura S, Scheiman JM, Boland CR. The effect of histamine and receptor antagonists on PGE 2 release by explants and isolated cells from rabbit stomach. Gastroenterology 1991; 100: A190 ( Abstract ). | en_US |
dc.identifier.citedreference | Ryberg B, Bishop AE, Bloom SR, et al. Omeprazole and ranitidine, antisecretagogues with different modes of action, are equally effective in causing hyperplasia of enterochromaffin-like cells in rat stomach. Reg Peptides 1989; 25: 235 – 46. | en_US |
dc.identifier.citedreference | Helander HF, Mattsson H, Elm G, Ottosson S. Structure and function of rat parietal cells during treatment with omeprazole, SSCH28080, SCH32651, or ranitidine. Scand J Gastroenterol 1990; 25: 799 – 809. | en_US |
dc.identifier.citedreference | Pearson J, Allen A, Venables C. Gastric mucus. Isolation and polymeric structure of the undegraded glycoprotein: its breakdown by pepsin. Gastroenterology 1980; 78: 709 – 15. | en_US |
dc.identifier.citedreference | Mikuni-Takagaki Y, Hotta K. Characterization of peptic inhibitory activity associated with sulfated glycoprotein isolated from gastric mucosa. Biochiin Biophys Acta 1979; 584: 288 – 97. | en_US |
dc.identifier.citedreference | Kim YS, Bella, A Jr, Whitehead JS, Isaacs R, Remer L. Studies on the binding of arnylopectin sulfate with gastric mucin. Gastroenterology 1975; 69: 138 – 45. | en_US |
dc.identifier.citedreference | Slomiany BL, Sarosiek J, Slomiany A. Role of carbohydrates in the viscosity and permeability of gastric mncin to hydrogenion. Biochem Biophys Res Com 1987; 142: 783 – 90. | en_US |
dc.identifier.citedreference | Vianello F, Dirnario F, Vio A, et al. The effect of full-dose farnotidine therapy on mucus and pepsin concentrations. Current Therap Res 1990; 48: 91 – 5. | en_US |
dc.identifier.citedreference | Cook GC. Infective gastroenteritis and its relationship to reduced gastric acidity. Scand J Gastroenterol 1985; 20 ( Suppl. ): 17 – 22. | en_US |
dc.identifier.citedreference | Allen A, Starkey BJ. Neuraminidase in pig gastric mucus. Biochim Biophys Acta 1974; 338: 364 – 8. | en_US |
dc.identifier.citedreference | Ohara S, Mnrayama N, Kuwata H, Ishihara K, Hotta K. Effects of omeprazole on rat gastric mucus glycoproteins with acetylsalicylic acid-induced gastric damage. Arch Int Pharmacodyn 1988; 296: 192 – 201. | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.