The induction of behavioural sensitization is associated with cocaine-induced structural plasticity in the core (but not shell) of the nucleus accumbens
dc.contributor.author | Li, Yilin | en_US |
dc.contributor.author | Acerbo, Martin J. | en_US |
dc.contributor.author | Robinson, Terry E. | en_US |
dc.date.accessioned | 2010-06-01T20:25:05Z | |
dc.date.available | 2010-06-01T20:25:05Z | |
dc.date.issued | 2004-09 | en_US |
dc.identifier.citation | Li, Yilin; Acerbo, Martin J.; Robinson, Terry E. (2004). "The induction of behavioural sensitization is associated with cocaine-induced structural plasticity in the core (but not shell) of the nucleus accumbens." European Journal of Neuroscience 20(6): 1647-1654. <http://hdl.handle.net/2027.42/73532> | en_US |
dc.identifier.issn | 0953-816X | en_US |
dc.identifier.issn | 1460-9568 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/73532 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=15355332&dopt=citation | en_US |
dc.description.abstract | Repeated exposure to cocaine increases the density of dendritic spines on medium spiny neurons in the nucleus accumbens (Acb) and pyramidal cells in the medial prefrontal cortex (mPFC). To determine if this is associated with the development of psychomotor sensitization, rats were given daily i.p. injections of 15 mg/kg of cocaine (or saline) for 8 days, either in their home cage (which failed to induce significant psychomotor sensitization) or in a distinct and relatively novel test cage (which induced robust psychomotor sensitization). Their brains were obtained 2 weeks after the last injection and processed for Golgi–Cox staining. In the Acb core (AcbC) cocaine treatment increased spine density only in the group that developed psychomotor sensitization (i.e. in the Novel but not Home group), and there was a significant positive correlation between the degree of psychomotor sensitization and spine density. In the Acb shell (AcbS) cocaine increased spine density to the same extent in both groups; i.e. independent of psychomotor sensitization. In the mPFC cocaine increased spine density in both groups, but to a significantly greater extent in the Novel group. Furthermore, when rats were treated at Home with a higher dose of cocaine (30 mg/kg), cocaine now induced psychomotor sensitization in this context, and also increased spine density in the AcbC. Thus, the context in which cocaine is experienced influences its ability to reorganize patterns of synaptic connectivity in the Acb and mPFC, and the induction of psychomotor sensitization is associated with structural plasticity in the AcbC and mPFC, but not the AcbS. | en_US |
dc.format.extent | 220452 bytes | |
dc.format.extent | 3109 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Blackwell Science Ltd | en_US |
dc.rights | 2004 Federation of European Neuroscience Societies | en_US |
dc.subject.other | Cocaine | en_US |
dc.subject.other | Dendrites | en_US |
dc.subject.other | Dendritic Spines | en_US |
dc.subject.other | Frontal Cortex | en_US |
dc.subject.other | Rat | en_US |
dc.subject.other | Synaptic Plasticity | en_US |
dc.title | The induction of behavioural sensitization is associated with cocaine-induced structural plasticity in the core (but not shell) of the nucleus accumbens | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.identifier.pmid | 15355332 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/73532/1/j.1460-9568.2004.03612.x.pdf | |
dc.identifier.doi | 10.1111/j.1460-9568.2004.03612.x | en_US |
dc.identifier.source | European Journal of Neuroscience | en_US |
dc.identifier.citedreference | Badiani, A., Browman, K. E. & Robinson, T. E. ( 1995 ) Influence of novel versus home environments on sensitization to the psychomotor stimulant effects of cocaine and amphetamine. Brain Res., 674, 291 – 298. | en_US |
dc.identifier.citedreference | Badiani, A., Oates, M. M., Day, H. E. W., Watson, S. J., Akil, H. & Robinson, T. E. ( 1998 ) Amphetamine-induced behavior, dopamine release, and c-fos mRNA expression: modulation by environmental novelty. J. Neurosci., 18, 10579 – 10593. | en_US |
dc.identifier.citedreference | Badiani, A., Oates, M. M., Day, H. E. W., Watson, S. J., Akil, H. & Robinson, T. E. ( 1999 ) Environmental modulation of amphetamine-induced c-fos expression in D1 versus D2 striatal neurons. Behav. Brain Res., 103, 203 – 209. | en_US |
dc.identifier.citedreference | de Borchgrave, R., Rawlins, J. N., Dickinson, A. & Balleine, B. W. ( 2002 ) Effects of cytotoxic nucleus accumbens lesions on instrumental conditioning in rats. Exp. Brain Res., 144, 50 – 68. | en_US |
dc.identifier.citedreference | Browman, K. E., Badiani, A. & Robinson, T. E. ( 1998a ) The influence of environment on the induction of sensitization to the psychomotor activating effects of intravenous cocaine in rats is dose-dependent. Psychopharmacology, 137, 90 – 98. | en_US |
dc.identifier.citedreference | Browman, K. E., Badiani, A. & Robinson, T. E. ( 1998b ) Modulatory effect of environmental stimuli on the susceptibility to amphetamine sensitization: a dose-effect study in rats. J. Pharmacol. Exp. Ther., 287, 1007 – 1014. | en_US |
dc.identifier.citedreference | Cadoni, C. & Di Chiara, G. ( 1999 ) Reciprocal changes in dopamine responsiveness in the nucleus accumbens shell and core and in the dorsal caudate-putamen in rats sensitized to morphine. Neuroscience, 90, 447 – 455. | en_US |
dc.identifier.citedreference | Cadoni, C. & Di Chiara, G. ( 2000 ) Differential changes in accumbens shell and core dopamine in behavioral sensitization to nicotine. Eur. J. Pharmacol., 387, R23 – R25. | en_US |
dc.identifier.citedreference | Cadoni, C., Solinas, M. & Di Chiara, G. ( 2000 ) Psychostimulant sensitization: differential changes in accumbal shell and core dopamine. Eur. J. Pharmacol., 388, 69 – 76. | en_US |
dc.identifier.citedreference | Cardinal, R. N., Parkinson, J. A., Hall, J. & Everitt, B. J. ( 2002 ) Emotion and motivation: the role of the amygdala, ventral striatum, and prefrontal cortex. Neurosci. Biobehav Rev., 26, 321 – 352. | en_US |
dc.identifier.citedreference | Corbit, L. H., Muir, J. L. & Balleine, B. W. ( 2001 ) The role of the nucleus accumbens in instrumental conditioning: Evidence of a functional dissociation between accumbens core and shell. J. Neurosci., 21, 3251 – 3260. | en_US |
dc.identifier.citedreference | Crombag, H. S., Badiani, A. & Robinson, T. E. ( 1996 ) Signalled versus unsignalled intravenous amphetamine: large differences in the acute psychomotor response and sensitization. Brain Res., 722, 227 – 231. | en_US |
dc.identifier.citedreference | Day, H. E. W., Badiani, A., Uslaner, J., Oates, M. M., Vittoz, N. M., Robinson, T. E., Watson, S. J. & Akil, H. ( 2001 ) Environmental novelty differentially affects amphetamine-induced c-fos mRNA expression in subregions of the bed nucleus of the stria terminalis and amygdala. J. Neurosci., 21, 732 – 740. | en_US |
dc.identifier.citedreference | De Vries, T. J., Schoffelmeer, A. N., Binnekade, R., Mulder, A. H. & Vanderschuren, L. J. ( 1998 ) Drug-induced reinstatement of heroin- and cocaine-seeking behaviour following long-term extinction is associated with expression of behavioural sensitization. Eur. J. Neurosci., 10, 3565 – 3571. | en_US |
dc.identifier.citedreference | De Vries, T. J., Schoffelmeer, A. N., Binnekade, R., Raaso, H. & Vanderschuren, L. J. ( 2002 ) Relapse to cocaine- and heroin-seeking behavior mediated by dopamine D2 receptors is time-dependent and associated with behavioral sensitization. Neuropsychopharmacology, 26, 18 – 26. | en_US |
dc.identifier.citedreference | Di Ciano, P., Cardinal, R. N., Cowell, R. A., Little, S. J. & Everitt, B. J. ( 2001 ) Differential involvement of NMDA, AMPA/kainate, and dopamine receptors in the nucleus accumbens core in the acquisition and performance of pavlovian approach behavior. J. Neurosci., 21, 9471 – 9477. | en_US |
dc.identifier.citedreference | Everitt, B. L., Cardinal, R. N., Hall, J., Parkinson, J. A. & Robbins, T. W. ( 2000 ) Differential involvement of amygdala subsystems in appetitive conditioning and drug addiction. In Aggleton, J. P., (ed.) The Amygdala: a Functional Analysis. Oxford University Press, New York, pp. 353 – 390. | en_US |
dc.identifier.citedreference | Gibb, R. & Kolb, B. ( 1998 ) A method for vibratome sectioning of Golgi-Cox stained whole rat brain. J. Neurosci. Meth., 79, 1 – 4. | en_US |
dc.identifier.citedreference | Goldman-Rakic, P. S., Lidow, M. S., Smiley, J. F. & Williams, M. S. ( 1992 ) The anatomy of dopamine in monkey and human prefrontal cortex. J. Neural Transm., 36, 163 – 177. | en_US |
dc.identifier.citedreference | Greenough, W. T., Withers, G. S. & Wallace, C. S. ( 1990 ) Morphological changes in the nervous system arising from behavioral experience: what is the evidence that they are involved in learning and memory?. In Squire, L. R. & Lindenlaub, E. (eds), The Biology of Memory, Symposia Medica Hoechst. F. K. Schattauder Verlag, New York, pp. 159 – 185. | en_US |
dc.identifier.citedreference | Groenewegen, H. J., Berendse, H. W., Meredith, G. E., Haber, S. N., Voorn, P., Wolters, J. G. & Lohman, A. H. M. ( 1991 ) Functional anatomy of the ventral, limbic system-innervated striatum. In Willner, P. & Scheel-KrÜger, J. (eds), The Mesolimbic Dopamine System: from Motivation to Action. John Wiley & Sons, New York, pp. 19 – 59. | en_US |
dc.identifier.citedreference | Hall, J., Parkinson, J. A., Connor, T. M., Dickinson, A. & Everitt, B. J. ( 2001 ) Involvement of the central nucleus of the amygdala and nucleus accumbens core in mediating Pavlovian influences on instrumental behaviour. Eur. J. Neurosci., 13, 1984 – 1992. | en_US |
dc.identifier.citedreference | Harmer, C. J. & Phillips, G. D. ( 1998 ) Enhanced appetitive conditioning following repeated pretreatment with d- amphetamine. Behav. Pharmacol., 9, 299 – 308. | en_US |
dc.identifier.citedreference | Harmer, C. J. & Phillips, G. D. ( 1999 ) Enhanced dopamine efflux in the amygdala by a predictive, but not a non- predictive, stimulus: facilitation by prior repeated d-amphetamine. Neuroscience, 90, 119 – 130. | en_US |
dc.identifier.citedreference | HÉdou, G., Jongen-Relo, A. L., Murphy, C. A., Heidbreder, C. A. & Feldon, J. ( 2002 ) Sensitized Fos expression in subterritories of the rat medial prefrontal cortex and nucleus accumbens following amphetamine sensitization as revealed by stereology. Brain Res., 950, 165 – 179. | en_US |
dc.identifier.citedreference | Horger, B. A., Shelton, K. & Schenk, S. ( 1990 ) Preexposure sensitizes rats to the rewarding effects of cocaine. Pharm. Biochem. Behav., 37, 707 – 711. | en_US |
dc.identifier.citedreference | Ito, R., Dalley, J. W., Howes, S. R., Robbins, T. W. & Everitt, B. J. ( 2000 ) Dissociation in conditioned dopamine release in the nucleus accumbens core and shell in response to cocaine cues and during cocaine-seeking behavior in rats. J. Neurosci., 20, 7489 – 7495. | en_US |
dc.identifier.citedreference | Ito, R., Robbins, T. W. & Everitt, B. J. ( 2004 ) Differential control over cocaine-seeking behavior by nucleus accumbens core and shell. Nature Neurosci., 7, 389 – 397. | en_US |
dc.identifier.citedreference | Kalivas, P. W. ( 2004 ) Glutamate systems in cocaine addiction. Curr. Opin. Pharmacol., 4, 23 – 29. | en_US |
dc.identifier.citedreference | Kalivas, P. W. & McFarland, K. ( 2003 ) Brain circuitry and the reinstatement of cocaine-seeking behavior. Psychopharmacology (Berlin), 168, 44 – 56. | en_US |
dc.identifier.citedreference | Kolb, B., Forgie, M., Gibb, R., Gorny, G. & Rowntree, S. ( 1998 ) Age, experience and the changing brain. Neurosci. Biobehav. Rev., 22, 143 – 159. | en_US |
dc.identifier.citedreference | Lett., B. T. ( 1989 ) Repeated exposures intensify rather than diminish the rewarding effects of amphetamine, morphine, and cocaine. Psychopharmacology (Berlin), 98, 357 – 362. | en_US |
dc.identifier.citedreference | Li, Y., Kolb, B. & Robinson, T. E. ( 2003 ) The location of persistent amphetamine-induced changes in the density of dendritic spines on medium spiny neurons in the nucleus accumbens and caudate-putamen. Neuropsychopharmacology, 238, 1082 – 1085. | en_US |
dc.identifier.citedreference | Lorrain, D. S., Arnold, G. M. & Vezina, P. ( 2000 ) Previous exposure to amphetamine increases incentive to obtain the drug: long-lasting effects revealed by the progressive ratio schedule. Behav. Brain Res., 107, 9 – 19. | en_US |
dc.identifier.citedreference | McFarland, K. & Kalivas, P. W. ( 2001 ) The circuitry mediating cocaine-induced reinstatement of drug-seeking behavior. J. Neurosci., 21, 8655 – 8663. | en_US |
dc.identifier.citedreference | Mead, A. N., Crombag, H. S. & Rocha, B. A. ( 2004 ) Sensitization of psychomotor stimulation and conditioned reward in mice: differential modulation by contextual learning. Neuropsychopharmacology, 29, 249 – 258. | en_US |
dc.identifier.citedreference | Mendrek, A., Blaha, C. D. & Phillips, A. G. ( 1998 ) Pre-exposure of rats to amphetamine sensitizes self-administration of this drug under a progressive ratio schedule. Psychopharmacology, 135, 416 – 422. | en_US |
dc.identifier.citedreference | Parkinson, J. A., Olmstead, M. C., Burns, L. H., Robbins, T. W. & Everitt, B. J. ( 1999 ) Dissociation in effects of lesions of the nucleus accumbens core and shell on appetitive pavlovian approach behavior and the potentiation of conditioned reinforcement and locomotor activity by d-amphetamine. J. Neurosci., 19, 2401 – 2411. | en_US |
dc.identifier.citedreference | Piazza, P. V., DeminiÈre, J. M., Le Moal, M. & Simon, H. ( 1989 ) Factors that predict individual vulnerability to amphetamine self-administration. Science, 245, 1511 – 1513. | en_US |
dc.identifier.citedreference | Piazza, P. V., Deroche, V., Rouge-Pont, F. & Le Moal, M. ( 1998 ) Behavioral and biological factors associated with individual vulnerability to psychostimulant abuse. NIDA Res. Monogr., 169, 105 – 133. | en_US |
dc.identifier.citedreference | Pierce, R. C., Bell, K., Duffy, P. & Kalivas, P. W. ( 1996 ) Repeated cocaine augments excitatory amino acid transmission in the nucleus accumbens only in rats having developed behavioral sensitization. J. Neurosci., 16, 1550 – 1560. | en_US |
dc.identifier.citedreference | Pierce, R. C. & Kalivas, P. W. ( 1995 ) Amphetamine produces sensitized increases in locomotion and extracellular dopamine preferentially in the nucleus accumbens shell of rats administered repeated cocaine. J. Pharmacol. Exp. Ther., 275, 1019 – 1029. | en_US |
dc.identifier.citedreference | Pierce, R. C. & Kalivas, P. W. ( 1997 ) A circuitry model of the expression of behavioral sensitization to amphetamine-like psychostimulants. Brain Res. Rev., 25, 192 – 216. | en_US |
dc.identifier.citedreference | Pierre, P. J. & Vezina, P. ( 1998 ) D1 dopamine receptor blockade prevents the facilitation of amphetamine self-administration induced by prior exposure to the drug. Psychopharmacology (Berlin), 138, 159 – 166. | en_US |
dc.identifier.citedreference | Robinson, T. E. & Becker, J. B. ( 1986 ) Enduring changes in brain and behavior produced by chronic amphetamine administration: a review and evaluation of animal models of amphetamine psychosis. Brain Res. Rev., 11, 157 – 198. | en_US |
dc.identifier.citedreference | Robinson, T. E. & Berridge, K. C. ( 1993 ) The neural basis of drug craving: an incentive-sensitization theory of addiction. Brain Res. Rev., 18, 247 – 291. | en_US |
dc.identifier.citedreference | Robinson, T. E. & Berridge, K. C. ( 2000 ) The psychology and neurobiology of addiction: an incentive-sensitization view. Addiction, 95, S91 – S117. | en_US |
dc.identifier.citedreference | Robinson, T. E. & Berridge, K. C. ( 2003 ) Addiction. Annu. Rev. Psychol, 54, 25 – 53. | en_US |
dc.identifier.citedreference | Robinson, T. E., Gorny, G., Mitton, E. & Kolb, B. ( 2001 ) Cocaine self-administration alters the morphology of dendrites and dendritic spines in the nucleus accumbens and neocortex. Synapse, 39, 257 – 266. | en_US |
dc.identifier.citedreference | Robinson, T. E., Jurson, P. A., Bennett, J. A. & Bentgen, K. M. ( 1988 ) Persistent sensitization of dopamine neurotransmission in ventral striatum (nucleus accumbens) produced by past experience with (+)-amphetamine: a microdialysis study in freely moving rats. Brain Res., 462, 211 – 222. | en_US |
dc.identifier.citedreference | Robinson, T. E. & Kolb, B. ( 1997 ) Persistent structural modifications in nucleus accumbens and prefrontal cortex neurons produced by previous experience with amphetamine. J. Neurosci., 17, 8491 – 8497. | en_US |
dc.identifier.citedreference | Robinson, T. E. & Kolb, B. ( 1999 ) Alterations in the morphology of dendrites and dendritic spines in the nucleus accumbens and prefrontal cortex following repeated treatment with amphetamine or cocaine. Eur. J. Neurosci., 11, 1598 – 1604. | en_US |
dc.identifier.citedreference | Segal, D. S. & Mandell, A. J. ( 1974 ) Long-term administration of d-amphetamine: progressive augmentation of motor activity and stereotypy. Pharmacol. Biochem. Behav., 2, 249 – 255. | en_US |
dc.identifier.citedreference | Sesack, S. R. & Pickel, V. M. ( 1990 ) In the rat medial nucleus accumbens, hippocampal and catecholaminergic terminals converge on spiny neurons and are in apposition to each other. Brain Res., 527, 266 – 279. | en_US |
dc.identifier.citedreference | Smith, A. D. & Bolam, J. P. ( 1990 ) The neural network of the basal ganglia as revealed by the study of synaptic connections of identified neurons. Trends Neurosci., 13, 259 – 265. | en_US |
dc.identifier.citedreference | Stewart, J. & Badiani, A. ( 1993 ) Tolerance and sensitization to the behavioral effects of drugs. Behav. Pharmacol., 4, 289 – 312. | en_US |
dc.identifier.citedreference | Taylor, J. R. & Horger, B. A. ( 1999 ) Enhanced responding for conditioned reward produced by intra-accumbens amphetamine is potentiated after cocaine sensitization. Psychopharmacology, 142, 31 – 40. | en_US |
dc.identifier.citedreference | Taylor, J. R. & Jentsch, J. D. ( 2001 ) Repeated intermittent administration of psychomotor stimulant drugs alters the acquisition of Pavlovian approach behavior in rats: differential effects of cocaine, d-amphetamine and 3,4-methylenedioxymethamphetamine (‘Ecstasy’). Biol. Psychiatry, 50, 137 – 143. | en_US |
dc.identifier.citedreference | Todtenkopf, M. S., Mihalakopoulos, A. & Stellar, J. R. ( 2002 ) Withdrawal duration differentially affects c-fos expression in the medial prefrontal cortex and discrete subregions of the nucleus accumbens in cocaine-sensitized rats. Neuroscience, 114, 1061 – 1069. | en_US |
dc.identifier.citedreference | Uslaner, J. M., Crombag, H. S., Ferguson, S. M. & Robinson, T. E. ( 2003a ) Cocaine-induced psychomotor activity is associated with its ability to induce c-fos mRNA expression in the subthalamic nucleus: effects of dose and repeated treatment. Eur. J. Neurosci., 17, 2180 – 2186. | en_US |
dc.identifier.citedreference | Uslaner, J. M., Norton, C. S., Watson, S. J., Akil, H. & Robinson, T. E. ( 2003b ) Amphetamine-induced c-fos mRNA expression in the caudate-putamen and subthalamic nucleus: interactions between dose, environment, and neuronal phenotype. J. Neurochem., 85, 105 – 114. | en_US |
dc.identifier.citedreference | Vanderschuren, L. J. & Kalivas, P. W. ( 2000 ) Alterations in dopaminergic and glutamatergic transmission in the induction and expression of behavioral sensitization: a critical review of preclinical studies. Psychopharmacology, 151, 99 – 120. | en_US |
dc.identifier.citedreference | Vezina, P. ( 2004 ) Sensitization of midbrain dopamine neuron reactivity and the self-administration of psychomotor stimulant drugs. Neurosci. Biobehav. Rev., 27, 827 – 839. | en_US |
dc.identifier.citedreference | White, F. J. & Kalivas, P. W. ( 1998 ) Neuroadaptations involved in amphetamine and cocaine addiction. Drug Alcohol Depend., 51, 141 – 153. | en_US |
dc.identifier.citedreference | Wolf, M. E. ( 1998 ) The role of excitatory amino acids in behavioral sensitization to psychomotor stimulants. Prog. Neurobiol., 54, 679 – 720. | en_US |
dc.identifier.citedreference | Wolf, M. E., White, F. J. & Hu, X. T. ( 1994 ) MK-801 prevents alterations in the mesoaccumbens dopamine system associated with behavioral sensitization to amphetamine. J. Neurosci., 14, 1735 – 1745. | en_US |
dc.identifier.citedreference | Woolley, C. S. ( 1998 ) Estrogen-mediated structural and functional synaptic plasticity in the female rat hippocampus. Horm. Behav., 34, 140 – 148. | en_US |
dc.identifier.citedreference | Wyvell, C. L. & Berridge, K. C. ( 2001 ) Incentive sensitization by previous amphetamine exposure: increased cue- triggered ‘wanting’ for sucrose reward. J. Neurosci., 21, 7831 – 7840. | en_US |
dc.identifier.citedreference | Zahm, D. S. ( 2000 ) An integrative neuroanatomical perspective on some subcortical substrates of adaptive responding with emphasis on the nucleus accumbens. Neurosci. Biobehav. Rev., 24, 85 – 105. | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.