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Activation of Protein Kinase C Modulates Light Responses in Horizontal Cells of the Turtle Retina
dc.contributor.authorAkopian, Abramen_US
dc.contributor.authorMcReynolds, John S.en_US
dc.contributor.authorWeiler, Retoen_US
dc.date.accessioned2010-06-01T20:30:32Z
dc.date.available2010-06-01T20:30:32Z
dc.date.issued1992-08en_US
dc.identifier.citationAkopian, Abram; McReynolds, John; Weiler, Reto (1992). "Activation of Protein Kinase C Modulates Light Responses in Horizontal Cells of the Turtle Retina." European Journal of Neuroscience 4(8): 745-749. <http://hdl.handle.net/2027.42/73620>en_US
dc.identifier.issn0953-816Xen_US
dc.identifier.issn1460-9568en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/73620
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=12106318&dopt=citationen_US
dc.description.abstractThe effect of phorbol esters on the light-evoked responses of horizontal cells were studied in the turtle eyecup preparation. Phorbol esters caused a reduction in receptive field size and a significant decrease in the amplitude of responses to annular and full-field illumination; however, they caused only minor changes in responses to small spots in the receptive field centre. The dark membrane potential was not affected. The results suggest that phorbol esters may affect both coupling resistance and membrane resistance in horizontal cells. The effects of phorbol esters were blocked by the protein kinase C inhibitor staurosporine, and inactive phorbol ester had no effect, making it very likely that the phorbol ester effects were mediated through activation of protein kinase C. The above effects of the phorbol esters were considerably reduced by the dopamine antagonists haloperidol and fluphenazine, suggesting that they were in part mediated by release of dopamine.en_US
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dc.format.extent3109 bytes
dc.format.mimetypeapplication/pdf
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dc.publisherBlackwell Publishing Ltden_US
dc.rights1992 European Neuroscience Associationen_US
dc.subject.otherReceptive Field Sizeen_US
dc.subject.otherPhorbol Esteren_US
dc.subject.otherDopamineen_US
dc.subject.otherGap Junctionsen_US
dc.titleActivation of Protein Kinase C Modulates Light Responses in Horizontal Cells of the Turtle Retinaen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Physiology, University of Michigan, Ann Arbor, Ml 48109, USAen_US
dc.contributor.affiliationotherDepartment of Neurobiology, University of Oldenburg, PO Box 2503, 2900 Oldenburg, FRGen_US
dc.identifier.pmid12106318en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/73620/1/j.1460-9568.1992.tb00183.x.pdf
dc.identifier.doi10.1111/j.1460-9568.1992.tb00183.xen_US
dc.identifier.sourceEuropean Journal of Neuroscienceen_US
dc.identifier.citedreferenceAsamoto, M., Oyamada, M., El-Aoumari, A., Gros, D. and Yamasaki, H. ( 1991 ) Molecular mechanisms of TPA-mediated inhibition of gap-junctional intercellular communication: evidence for action on the assembly or function but not the expression of connexin 43 in rat liver epithelial cells. Mol. Carcinogenesis., 4, 322 – 327.en_US
dc.identifier.citedreferenceCuenca, N., Fernandez, E. and Kolb, H. ( 1990 ) Distribution of immunoreactivity to protein kinase C in the turtle retina. Brain Res., 532, 278 – 287.en_US
dc.identifier.citedreferenceDeVries, S. H. and Schwartz, E. H. ( 1989 ) Modulation of an electrical synapse between solitary pairs of catfish horizontal cells by dopamine and second messengers. J. Physiol. (Lond.), 414, 351 – 375.en_US
dc.identifier.citedreferenceDong, C.-J. and McReynolds, J. S. ( 1991 ) The relationship between light, dopamine release and horizontal cell coupling in the mudpuppy retina. J. Physiol. (Lond.), 440, 291 – 309.en_US
dc.identifier.citedreferenceGreferath, U., GrÜnert, U. and WÄssle, H. ( 1990 ) Rod bipolars in the mammalian retina show protein kinase C-like immunoreactivity. J. Comp. Neurol, 301, 433 – 442.en_US
dc.identifier.citedreferenceJanssen, U. and Weiler, R. ( 1991 ) PKC-mediated in vitro phosphorylation in isolated carp horizontal cells. Invest. Ophthalmol. Vis. Sci., 32 ( Suppl. ), 991.en_US
dc.identifier.citedreferenceKaczmarek, L. K. ( 1986 ) Phorbol esters, protein phosphorylation and the regulation of neuronal ion channels. J. Exp. Biol., 124, 375 – 392.en_US
dc.identifier.citedreferenceKaneko, A. ( 1971 ) Electrical connexions between horizontal cells in the dogfish retina. J. Physiol. (Lond.), 213, 95 – 105.en_US
dc.identifier.citedreferenceKato, S., Ishita, S., Mawatari, K., Matsukawa, T. and Negishi, K. ( 1990 ) Dopamine release via protein kinase C activation in the fish retina. J. Neurochem., 54, 2082 – 2090.en_US
dc.identifier.citedreferenceKnapp, A. G. and Dowling, J. E. ( 1987 ) Dopamine enhances excitatory amino acid-gated conductances in cultured retinal horizontal cells. Nature, 325, 437 – 439.en_US
dc.identifier.citedreferenceKohler, K. and Weiler, R. ( 1990 ) Dopaminergic modulation of transient neurite outgrowth from horizontal cells of the fish retina is not mediated by cAMP. Eur. J. Neurosci., 2, 788 – 794.en_US
dc.identifier.citedreferenceKolb, H., Cline, C., Wang, H. H. and Brecha, N. ( 1987 ) Distribution and morphology of dopaminergic amacrine cells in the retina of the turtle (Pseudemys scripta elegans). J. Neurocytol., 16, 577 – 588.en_US
dc.identifier.citedreferenceLasater, E. M. ( 1987 ) Retinal horizontal cell gap junction conductance is modulated by dopamine through a cyclic AMP-dependent protein kinase. Proc. Natl. Acad. Sci. USA, 84, 7319 – 7323.en_US
dc.identifier.citedreferenceLasater, E. M. and Dowling, J. E. ( 1985 ) Dopamine decreases conductance of the electrical junctions between cultured retinal horizontal cells. Proc. Natl. Acad. Sci. USA, 82, 3025 – 3029.en_US
dc.identifier.citedreferenceMalinow, R., Schulman, H. and Tsien, R. W. ( 1989 ) Inhibition of post synaptic PKC or CaMKII blocks induction but not expression of LTP. Science, 245, 862 – 866.en_US
dc.identifier.citedreferenceMangel, S. C. and Dowling, J. E. ( 1985 ) Responsiveness and receptive field size of carp horizontal cells are reduced by prolonged darkness and dopamine. Science, 229, 1107 – 1109.en_US
dc.identifier.citedreferenceNegishi, K., Kato, S. and Teranishi, T. ( 1988 ) Dopamine cells and rod-bipolar cells contain protein kinase C-like immunoreactivity in some vertebrate retinas. Neurosci. Lett., 94, 247 – 252.en_US
dc.identifier.citedreferenceNishizuka, Y. ( 1984 ) The role of protein kinase C in cell surface signal transduction and tumour promotion. Nature, 308, 693 – 698.en_US
dc.identifier.citedreferenceNishizuka, Y. ( 1986 ) Studies and perspectives of protein kinase C. Science, 233, 305 – 312.en_US
dc.identifier.citedreferencePiccolino, M., Neyton, J. and Gerschenfeld, H. M. ( 1984 ) Decrease of gap junction permeability induced by dopamine and cyclic adeonsine 3′:5′-monophosphate in horizontal cells of turtle retina. J. Neurosci., 4, 2477 – 2488.en_US
dc.identifier.citedreferenceRodrigues, P. dos S. and Dowling, J. E. ( 1990 ) Dopamine induces neurite retraction in retinal horizontal cells via diacylglycerol and protein kinase C. Proc. Natl. Acad. Sci. USA, 87, 9693 – 9697.en_US
dc.identifier.citedreferenceSpray, D. C and Burt, J. M. ( 1990 ) Structure–activity relations of the cardiac gap junction channel. Am. J. Physiol., 258, C195 – C205.en_US
dc.identifier.citedreferenceTamaoki, T., Nomoto, H., Takahashi, I., Kat, Y., Morimoto, M. and Tomita, F. ( 1986 ) Staurosporine, a potent inhibitor of phospholipid/Ca- dependent protein kinase. Biochem. Biophys. Res. Commun., 135, 397 – 402.en_US
dc.identifier.citedreferenceVaney, D. I. ( 1991 ) Many diverse types of retinal neurons show tracer coupling when injected with biocytin or neurobiotin. Neurosci. Lett., 125, 187 – 190.en_US
dc.identifier.citedreferenceWagner, H.-J. ( 1980 ) Light dependent plasticity of the morphology of horizontal cell terminals in cone pedicles of fish retinas. J. Neurocytol., 9, 573 – 590.en_US
dc.identifier.citedreferenceWeiler, R. and Wagner, H.-J. ( 1984 ) Light-dependent change of cone–horizontal cell interactions in carp retina. Brain Res., 298, 1 – 9.en_US
dc.identifier.citedreferenceWeiler, R., Kohler, K. and Janssen, U. ( 1991 ) Protein kinase C mediates transient spinule-type neurite outgrowth in the retina during light adaptation. Proc. Natl. Acad. Sci. USA, 88, 3603 – 3607.en_US
dc.identifier.citedreferenceWitkovsky, P., Eldred, W. and Karten, H. J. ( 1984 ) Catecholamine- and indoleamine-containing neurons in the turtle retina. J. Comp. Neurol., 228, 217 – 225.en_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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