Mitogen-induced stimulation and suppression of erythroid burst promoting activity production by human mononuclear cells
dc.contributor.author | Zuckerman, Kenneth S. | en_US |
dc.contributor.author | Haak, Mary | en_US |
dc.date.accessioned | 2010-06-01T20:42:16Z | |
dc.date.available | 2010-06-01T20:42:16Z | |
dc.date.issued | 1983-09 | en_US |
dc.identifier.citation | Zuckerman, Kenneth S.; Haak, Mary (1983). "Mitogen-induced stimulation and suppression of erythroid burst promoting activity production by human mononuclear cells." British Journal of Haematology 55(1): 145-153. <http://hdl.handle.net/2027.42/73808> | en_US |
dc.identifier.issn | 0007-1048 | en_US |
dc.identifier.issn | 1365-2141 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/73808 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6603863&dopt=citation | en_US |
dc.description.abstract | Exposure of human peripheral blood mononuclear cells or highly enriched monocytes to various plant lectins substantially alters their production of erythroid burst promoting activity (BPA). Neither unstimulated, nor mitogen stimulated, enriched T lymphocytes produced demonstrable BPA. Each of the lectins tested resulted in a different pattern of alteration of BPA production by mononuclear cells. Increasing concentrations of phytohaemagglutinin (PHA) caused a progressive increase in BPA production up to a plateau level at concentrations above 0·25–0·5 Μ1/ml. Concanavalin A (Con A) at concentrations of 0·05–0·1 Μg/ml stimulated BPA production, but Con A concentrations > 1 Μg/ml never augmented BPA production by mononuclear cells. Pokeweed mitogen inhibited BPA production by mononuclear cells in a concentration-dependent manner. Since PHA and Con A can bind to and stimulate both monocytes/macrophages and T lymphocytes, some production of BPA by stimulated T cells in the presence of monocytes cannot be ruled out. Earlier studies demonstrated that T cells augment monocyte production of BPA. Thus, monocyte–T cell interactions, as well as activation of monocytes and perhaps lymphocytes, play an important role in regulation of BPA production in vitro . | en_US |
dc.format.extent | 576095 bytes | |
dc.format.extent | 3109 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Blackwell Publishing Ltd | en_US |
dc.rights | 1983 Blackwell Publishing Ltd | en_US |
dc.title | Mitogen-induced stimulation and suppression of erythroid burst promoting activity production by human mononuclear cells | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Oncology and Hematology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Division of Hematology and Oncology, Department of Internal Medicine, Simpson Memorial Research Institute, University of Michigan, Ann Arbor, Michigan, U.S.A. | en_US |
dc.identifier.pmid | 6603863 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/73808/1/j.1365-2141.1983.tb01232.x.pdf | |
dc.identifier.doi | 10.1111/j.1365-2141.1983.tb01232.x | en_US |
dc.identifier.source | British Journal of Haematology | en_US |
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dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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