Inverse expression of P k and Luke blood group antigens on human RBCs
dc.contributor.author | Cooling, Laura L. | en_US |
dc.contributor.author | Kelly, Kathleen | en_US |
dc.date.accessioned | 2010-06-01T20:48:59Z | |
dc.date.available | 2010-06-01T20:48:59Z | |
dc.date.issued | 2001-07 | en_US |
dc.identifier.citation | Cooling, Laura L . ; Kelly, Kathleen (2001). "Inverse expression of P k and Luke blood group antigens on human RBCs." Transfusion 41(7): 898-907. <http://hdl.handle.net/2027.42/73915> | en_US |
dc.identifier.issn | 0041-1132 | en_US |
dc.identifier.issn | 1537-2995 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/73915 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=11452158&dopt=citation | en_US |
dc.description.abstract | Luke (LKE) is a high-frequency RBC antigen, related to the P blood group system. A LKE-negative phenotype is found in 1 to 2 percent of donors and may be associated with increased P k . Because P k and similar glycolipids are receptors for shiga toxin on cell membranes, a LKE-negative phenotype could have implications for infections by Shigella dysenteriae and enterohemorrhagic Escherichia coli . STUDY DESIGN AND METHODS: Volunteer donors (n = 257) were serologically typed for LKE with a LKE MoAb, MC813-70. LKE-strong-positive, LKE-weak-positive and LKE-negative RBCs were analyzed for P k , P, LKE, and shiga toxin binding by immunofluorescence flow cytometry, high-performance thin-layer chromatography, scanning densitometry, and high-performance thin-layer chromatography immunostaining. RESULTS: Among Iowa donors, 78.6 percent were LKE-strong-positive, 20.2 percent were LKE-weak-positive, and 1.2 percent were LKE-negative. There was an inverse expression of P k and LKE on RBCs. P k expression was increased on LKE-negative RBCs and was associated with increased shiga toxin binding. A LKE-active glycolipid was identified in the ganglioside fraction of LKE-strong-positive RBCs. CONCLUSION: A LKE-negative phenotype is associated with increased expression of P k on RBCs. Differences in P k and LKE expression may play a role in host susceptibility to infection with S. dysenteriae and E. coli . | en_US |
dc.format.extent | 260037 bytes | |
dc.format.extent | 3109 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Blackwell Science Inc | en_US |
dc.rights | 2001 American Association of Blood Banks | en_US |
dc.subject.other | C-M = Chloroform-methanol | en_US |
dc.subject.other | C-M-W = C-M-Water | en_US |
dc.subject.other | DPA = Diphenylamine | en_US |
dc.subject.other | GSL(S) = Glycosphingolipid(S) | en_US |
dc.subject.other | HPTLC = High-performance Thin-layer Chromatography | en_US |
dc.subject.other | HUS = Hemolytic Uremic Syndrome | en_US |
dc.subject.other | LKE-neg = Luke-negative | en_US |
dc.subject.other | LKE-str+ = Luke-strong-Positive | en_US |
dc.subject.other | LKE-wk+ = Luke-weak-Positive | en_US |
dc.subject.other | MCFI = MCF Intensity | en_US |
dc.subject.other | MSGG = Monosialo-galactosyl-Globoside | en_US |
dc.subject.other | SSEA = Stage-specific Embryonic Antigen | en_US |
dc.subject.other | ST = Shiga Toxin | en_US |
dc.subject.other | STEC = ST-producing E. Coli | en_US |
dc.title | Inverse expression of P k and Luke blood group antigens on human RBCs | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Oncology and Hematology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | From the Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan; and the Department of Pathology, The University of Iowa College of Medicine, Iowa City, Iowa. | en_US |
dc.identifier.pmid | 11452158 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/73915/1/j.1537-2995.2001.41070898.x.pdf | |
dc.identifier.doi | 10.1046/j.1537-2995.2001.41070898.x | en_US |
dc.identifier.source | Transfusion | en_US |
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dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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