Thyroid stimulating hormone (TSH) concentrations and menopausal status in women at the mid-life: SWAN
dc.contributor.author | Sowers, MaryFran R. | en_US |
dc.contributor.author | Luborsky, Judy | en_US |
dc.contributor.author | Perdue, Craig | en_US |
dc.contributor.author | Araujo, Katy L. B. | en_US |
dc.contributor.author | Goldman, Marlene B. | en_US |
dc.contributor.author | Harlow, Siobán D. | en_US |
dc.date.accessioned | 2010-06-01T20:49:06Z | |
dc.date.available | 2010-06-01T20:49:06Z | |
dc.date.issued | 2003-03 | en_US |
dc.identifier.citation | Sowers, MaryFran; Luborsky, Judy; Perdue, Craig; Araujo, Katy L. B.; Goldman, Marlene B.; Harlow, SiobÁn D. (2003). "Thyroid stimulating hormone (TSH) concentrations and menopausal status in women at the mid-life: SWAN." Clinical Endocrinology 58(3): 340-347. <http://hdl.handle.net/2027.42/73917> | en_US |
dc.identifier.issn | 0300-0664 | en_US |
dc.identifier.issn | 1365-2265 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/73917 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=12608940&dopt=citation | en_US |
dc.description.abstract | objective We evaluated menopausal symptoms, menstrual cycle bleeding characteristics and reproductive hormones for their associations with thyroid stimulating hormone (TSH) concentrations in women at the mid-life from five ethnic groups. methods This report is from the baseline evaluation of the Study of Women's Health Across the Nation (SWAN), a community-based multiethnic study of the natural history of the menopausal transition. Enrollees were 42–52 years old (pre- and early perimenopausal) African American, Caucasian, Chinese, Hispanic and Japanese women ( n = 3242). Enrollees were interviewed about self-reported diagnosed hypo- and hyperthyroidism or thyroid treatment, menopausal symptoms and menstrual cycle bleeding characteristics. Serum was assayed for TSH, oestradiol, testosterone, FSH and SHBG. results There were 6·2% of women with TSH > 5·0 mIU/ml and 3·2% with TSH < 0·5 IU/ml, cutpoints that have been used to encompass clinical and subclinical hypo- and hyperthyroidism, respectively. African American women had significantly lower mean TSH concentrations than Caucasian, Hispanic and Chinese women. Of the more than 15 menopause symptoms evaluated, only fearfulness was associated with having a TSH value > 5·0 mIU/ml ( P < 0·008) or < 0·5 mIU/ml ( P < 0·02). Women with TSH values outside the range of 0·5–5·0 mIU/ml were more likely to report shorter or longer menstrual periods ( P = 0·004 for both) than women within that range. FSH, SHBG, dehydroepiandrosterone sulphate (DHEA-S), testosterone, and oestradiol concentrations were not associated with TSH concentrations. conclusion In mid-aged women, there was a 9·6% prevalence of TSH values outside the euthyroid range of 0·5–5·0 mIU/ml. Although TSH was associated with bleeding length and self-reported fearfulness, it was not associated with indicators of the menopausal transition, including menopausal stage defined by bleeding regularity, menopausal symptoms or reproductive hormone concentrations. | en_US |
dc.format.extent | 146843 bytes | |
dc.format.extent | 3109 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Blackwell Science Ltd | en_US |
dc.rights | © 2003 Blackwell Publishing Ltd | en_US |
dc.title | Thyroid stimulating hormone (TSH) concentrations and menopausal status in women at the mid-life: SWAN | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | * University of Michigan, Ann Arbor, MI, | en_US |
dc.contributor.affiliationother | † Rush University, Rush-Presbyterian-St Luke's Medical Center, Chicago, IL and | en_US |
dc.contributor.affiliationother | † New England Research Institutes, Watertown, MA, USA | en_US |
dc.identifier.pmid | 12608940 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/73917/1/j.1365-2265.2003.01718.x.pdf | |
dc.identifier.doi | 10.1046/j.1365-2265.2003.01718.x | en_US |
dc.identifier.source | Clinical Endocrinology | en_US |
dc.identifier.citedreference | American Psychiatric Association ( 1987 ) Diagnostic and Statistical Manual of Mental Disorders, 3rd edn (revised). American Psychiatric Association, Washington, DC. | en_US |
dc.identifier.citedreference | Bagchi, N., Brown, T. & Parish, R. ( 1990 ) Thyroid dysfunction in adults over age 55 years: a study in an urban US community. Archives of Internal Medicine, 150, 785 – 787 | en_US |
dc.identifier.citedreference | Danese, M.D., Powe, N.R., Sawin, C.T. & Ladenson, P.W. ( 1996 ) Screening for mild thyroid failure at the periodic health examination: a decision and cost-effectiveness analysis. Journal of the American Medical Association, 276, 285 – 292. | en_US |
dc.identifier.citedreference | de Aloysio, D., Altieri, P., Penacchinioni, P., Mauloni, M. & Bottiglioni, F. ( 1996 ) Premenopause-dependent changes. Gynecologic and Obstetric Investigation, 42, 120 – 127. | en_US |
dc.identifier.citedreference | Avis, N.E., Kaufert, P.A., Lock, M., McKinlay, S.M. & Vass, K. ( 1993 ) The evolution of menopausal symptoms. Bailliere's Clinical Endocrinology and Metabolism, 7, 17 – 32. | en_US |
dc.identifier.citedreference | Ballinger, C.B., Browning, M.C.K. & Smith, A.H.W. ( 1987 ) Hormone profiles and psychological symptoms in peri-menopausal women. Maturitas, 9, 235 – 251. | en_US |
dc.identifier.citedreference | Bowry, T.R., Muturi, I.L., Radia, R. & Gitau, W. ( 1984 ) Autoantibody profile in thyroid diseases in black Kenyans. Journal of Clinical and Laboratory Immunology, 15, 133 – 136. | en_US |
dc.identifier.citedreference | Brenta, G., Schnitman, M., Gurfinkiel, M., Damilano, S., Pierini, A., Sinay, I. & Pisarev, M.A. ( 1999 ) Variations of sex hormone-binding globulin in thyroid dysfunction. Thyroid, 9, 273 – 277. | en_US |
dc.identifier.citedreference | Canaris, G., Manowitz, N., Mayor, G. & Ridgeway, E. ( 2000 ) The Colorado Thyroid Disease Prevalence Study. Archives of Internal Medicine, 160, 526 – 534. | en_US |
dc.identifier.citedreference | Doufas, A.G. & Mastorakos, G. ( 2000 ) The hypothalamic–pituitary axis and female reproductive system. Annals of the New York Academy of Sciences, 900, 65 – 76. | en_US |
dc.identifier.citedreference | Falkenberg, M., Bertil, K. & Noor, A. ( 1983 ) Screening of an elderly female population for hypo- and hyperthyroidism by use of a thyroid hormone panel. Acta Medica Scandinavica, 214, 361 – 365. | en_US |
dc.identifier.citedreference | Faughnan, M., Lepage, R., Fugere, P., Bissonnette, F., Brossard, J.H. & D’Amour, P. ( 1995 ) Screening for thyroid disease at the menopausal clinic. Clinical and Investigative Medicine, 18, 11 – 18. | en_US |
dc.identifier.citedreference | Fechner-Bates, S., Coyne, J.C. & Schwenk, T.L. ( 1994 ) The relationship of self-reported distress to depressive disorders and other psychopathology. Journal of Consulting and Clinical Psychology, 62, 550 – 559. | en_US |
dc.identifier.citedreference | Ford, M.C., Cooke, R.R., Keightley, E.A. & Feek, C.M. ( 1992 ) Serum levels of free and bound testosterone in hyperthyroidism. Clinical Endocrinology, 36, 187 – 192. | en_US |
dc.identifier.citedreference | Harsch, I., Paschke, R. & Usadel, K.H. ( 1992 ) The possible etiological role of psychological disturbances in Graves’ disease. Acta Medica Austriaca, 19 ( Suppl. 1 ), 62 – 65. | en_US |
dc.identifier.citedreference | Higham, J.M. & Shaw, R.W. ( 1992 ) The effect of thyroxine replacement on menstrual blood loss in a hypothyroid patient. British Journal of Obstetrics and Gynaecology, 99, 695 – 696. | en_US |
dc.identifier.citedreference | Joshi, J.V., Bhandarkar, S.D., Chadha, M., Balaiah, D. & Shah, R. ( 1993 ) Menstrual irregularities and lactation failure may precede thyroid dysfunction or goiter. Journal of Postgraduate Medicine, 39, 137 – 141. | en_US |
dc.identifier.citedreference | Kasim, S. & Bessman, A. ( 1984 ) Thyroid autoimmunity in type 2 (non-insulin-dependent) diabetic patients of Caucasoid, Black and Mexican origin. Diabetologia, 27, 59 – 61. | en_US |
dc.identifier.citedreference | Kathol, R.G. & Delahunt, J.W. ( 1986 ) The relationship of anxiety and depression to symptoms of hyperthyroidism using operational criteria. General Hospital Psychiatry, 8, 23 – 28. | en_US |
dc.identifier.citedreference | Konno, N., Yuri, K., Taguchi, H., Miura, K., Taguchi, S., Hagiwara, K. & Murakami, S. ( 1993 ) Screening for thyroid disease in an iodine sufficient area with sensitive thyrotropin assays and serum thyroid autoantibody and urinary iodide determinations. Clinical Endocrinology, 38, 273 – 281. | en_US |
dc.identifier.citedreference | Koutras, D.A. ( 1995 ) Disturbances of menstruation in thyroid disease. Annals of the New York Academy of Sciences, 816, 280 – 284. | en_US |
dc.identifier.citedreference | Krassas, G.E., Pontikides, N., Kaltsas, T., Papadopoulou, P., Paunkovic, J., Paunkovic, N. & Duntas, L.H. ( 1999 ) Disturbances of menstruation in hypothyroidism. Clinical Endocrinology, 50, 655 – 659. | en_US |
dc.identifier.citedreference | Longcope, C., Abend, S., Braverman, L.E. & Emerson, C.H. ( 1990 ) Androstenedione and estrone dynamics in hypothyroid women. Journal of Clinical Endocrinology and Metabolism, 70, 903 – 907. | en_US |
dc.identifier.citedreference | Massoudi, M.S., Meilahn, E.N., Orchard, T.J., Foley, T.P. Jr, Kuller, L.H., Costantino, J.P. & Buhari, A.M. ( 1995 ) Prevalence of thyroid antibodies among healthy middle-aged women. Findings from the Thyroid Study in Healthy Women. Annals of Epidemiology, 5, 229 – 233. | en_US |
dc.identifier.citedreference | Massoudi, M.S., Meilahn, E.N., Orchard, T.J., Foley, T.P. Jr, Kuller, L.H., Costantino, J.P. & Buhari, A.M. ( 1997 ) Thyroid function and perimenopausal lipid and weight changes: the Thyroid Study in Healthy Women (TSH-W). Journal of Women's Health, 6, 553 – 558. | en_US |
dc.identifier.citedreference | Matsubayashi, S., Tamai, H., Matsumoto, Y., Tamagawa, K., Mukuta, T., Morita, T. & Kubo, C. ( 1996 ) Graves’ disease after the onset of panic disorder. Psychotherapy and Psychosomatics, 65, 277 – 280. | en_US |
dc.identifier.citedreference | Matthews, K.A., Kuller, L.H., Wing, R.R. & Meilahn, E.N. ( 1993 ) Biobehavioral aspects of menopause: lessons from the Healthy Women Study. Experimental Gerontology, 29, 337 – 342. | en_US |
dc.identifier.citedreference | Neugarten, B.L. & Kraines, R.J. ( 1965 ) ‘Menopausal symptoms’ in women of various ages. Psychosomatic Medicine, 27, 266 – 273. | en_US |
dc.identifier.citedreference | Nolan, J.P., Tarsa, N.J. & DiBenedetto, G. ( 1985 ) Case finding for unsuspected thyroid disease: cost and health benefits. American Journal of Clinical Pathology, 83, 346 – 355. | en_US |
dc.identifier.citedreference | Overlie, I., Moen, M.H., Skjaeraasen, J.S. & Holte, A. ( 1999 ) The endocrine transition around menopause – a five years prospective study with profiles of gonadotropins, estrogens, androgens and SHBG. Acta Obstetrica et Gynecologica Scandinavica, 78, 642 – 647. | en_US |
dc.identifier.citedreference | Paschke, R., Harsch, I., Schlote, B., Vardarli, I., Schaaf, L., Kaumeier, S., Teuber, J. & Usadel, K.H. ( 1990 ) Sequential psychological testing during the course of autoimmune hyperthyroidism. Klinische Wochenschrift, 68, 942 – 950. | en_US |
dc.identifier.citedreference | Petersen, K., Lendstedt, G., Lundberg, P., Bengtsson, C., Lapidus, L. & Hystrom, E. ( 1991 ) Thyroid disease in middle-aged and elderly Swedish women: thyroid-related hormones, thyroid dysfunctions and goitre in relation to age and smoking. Journal of Internal Medicine, 22, 407 – 414. | en_US |
dc.identifier.citedreference | Prentice, A. ( 1999 ) Medical management of menorraghia. British Medical Journal, 319, 1343 – 1345. | en_US |
dc.identifier.citedreference | Radloff, L.S. ( 1977 ) The CES-D Scale: a self-report depression scale for research in the general population. Applied Psychological Measurement, 1, 385 – 401. | en_US |
dc.identifier.citedreference | Samuels, M.H., Veldhuis, J.D., Henry, P. & Ridgway, E.C. ( 1990 ) Pathophysiology of pulsatile and copulsatile release of thyroid-stimulating hormone, luteinizing hormone, follicle-stimulating hormone, and Α-subunit. Journal of Clinical Endocrinology and Metabolism, 71, 425 – 432. | en_US |
dc.identifier.citedreference | Sawin, C.T., Hershman, J.M., Boyd, A.E., Longcope, C. & Bacharach, P. ( 1978 ) The relationship of changes in serum estradiol and progeserone during the menstrual cycle to the thyrotropin and prolactin responses to thyrotropin-releasing hormone. Journal of Clinical Endocrinology and Metabology, 47, 1296 – 1302. | en_US |
dc.identifier.citedreference | Schectman, J.M., Kallenberg, G.A., Hirsch, R.P. & Shumacher, R.J. ( 1991 ) Report of an association between race and thyroid stimulating hormone level. American Journal of Public Health, 81, 505 – 506. | en_US |
dc.identifier.citedreference | Sowers, M.F., Crawford, S., Sternfeld, B., Morgenstein, D., Gold, E., Greendale, G., Evans, D., Neer, R., Matthews, K., Sherman, S., Lo, A., Weiss, G. & Kelsey, J. ( 2000 ) Design, survey sampling and recruitment methods of SWAN: a multi-center, multi-ethnic, community-based cohort study of women and the menopausal transition. In Menopause: Biology and Pathobiology (eds J. Wren, R. A. Lobo, J. Kelsey & R. Marcus ), pp. 175 – 188. Academic Press, San Diego, CA. | en_US |
dc.identifier.citedreference | Stern, R.A., Robinson, B., Thorner, A.R., Arruda, J.E., Prohaska, M.L. & Prange, A.J. Jr ( 1996 ) A survey study of neuropsychiatric complaints in patients with Graves’ disease. The Journal of Neuropsychiatry and Clinical Neurosciences, 8, 181 – 185. | en_US |
dc.identifier.citedreference | Stoffer, S.S. ( 1982 ) Menstrual disorders and mild thyroid insufficiency: intriguing cases suggesting an association. Journal of Postgraduate Medicine, 72 ( 75–7 ), 80 – 82. | en_US |
dc.identifier.citedreference | Tunbridge, W.M.G., Evered, D.C., Hall, R., Appleton, D., Brewis, M., Clark, F., Evans, J.G., Young, E., Bird, T. & Smith, P.A. ( 1977 ) The spectrum of thyroid disease in a community. The Whickham Survey. Clinical Endocrinology, 7, 481 – 493. | en_US |
dc.identifier.citedreference | Van den Beld, A., de Jong, F.H., Grobbee, D.E., Pols, H.A.P. & Lamberts, S.W.J. ( 2000 ) Measures of bioavailable serum testosterone and estradiol and their relationships with muscle strength, bone density and body composition in elderly men. Journal of Clinical Endocrinology and Metabolism, 85, 3276 – 3282. | en_US |
dc.identifier.citedreference | Vanderpump, M., Tunbridge, W., French, J., Appleton, D., Bates, D., Clark, F., Evans, J., Hasan, D., Rodgers, H., Tunbridge, F. & Young, E. ( 1995 ) The incidence of thyroid disorders in the community: a twenty-year follow-up of the Whickham Survey. Clinical Endocrinology, 43, 55 – 68. | en_US |
dc.identifier.citedreference | Wilansky, D.L. & Greisman, B. ( 1989 ) Early hypothyroidism in patients with menorraghia. American Journal of Obstetrics and Gynecology, 160, 673 – 677. | en_US |
dc.identifier.citedreference | Wilson, J.D. & Foster, D.E. ( 1985 ) Williams Textbook of Endocrinology, 7th edn. W. B. Saunders Co., Philadelphia. | en_US |
dc.identifier.citedreference | Yarwood, N.J., Gurr, J.A., Sheppard, M.C. & Franklyn, J.A. ( 1993 ) Estradiol modulation thyroid hormone regulation of the human glycoprotein hormone Α subunit gene. Journal of Biological Chemistry, 268, 21894 – 21899. | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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