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Molecular Mechanisms of Photoaging in Human Skin In Vivo and Their Prevention by All-Trans Retinoic Acid
dc.contributor.authorFisher, Gary J.en_US
dc.contributor.authorTalwar, Harvinder S.en_US
dc.contributor.authorLin, Jiayuhen_US
dc.contributor.authorVoorhees, John J.en_US
dc.date.accessioned2010-06-01T20:52:50Z
dc.date.available2010-06-01T20:52:50Z
dc.date.issued1999-02en_US
dc.identifier.citationFisher, Gary J.; Talwar, Harvinder S.; Lin, Jiayuh; Voorhees, John J. (1999). "Molecular Mechanisms of Photoaging in Human Skin In Vivo and Their Prevention by All-Trans Retinoic Acid." Photochemistry and Photobiology 69(2): 154-157. <http://hdl.handle.net/2027.42/73977>en_US
dc.identifier.issn0031-8655en_US
dc.identifier.issn1751-1097en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/73977
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=10048311&dopt=citationen_US
dc.description.abstractSolar UV radiation damages human skin, affecting skin tone and resiliency and leading to premature aging (photoaging), the symptoms of which include leathery texture, wrinkles, mottled pigmentation, laxity and sallowness. We propose that photoaging results largely from UV induction of matrix metalloproteinases (MMP) that degrade skin collagen. We find that pretreatment of human skin with all- trans retinoic acid (tRA) inhibits UV induction of MMP, suggesting that tRA can protect against UV-induced collagen destruction and may therefore be able to lessen the effects of photoaging. The tRA prevents UV-induced accumulation of c-Jun protein, which is required for MMP gene expression. Activation of c-Jun transcriptional activity requires N-terminal phosphorylation. The majority of c-Jun in human skin in vivo is Nterminal phosphorylated. Topically applied t RA does not inhibit N-terminal phosphorylation by UV-induced c-Jun kinase activity in human skin. The tRA likely acts to reduce UV induction of c-Jun protein by stimulating its breakdown through the ubiquitin-proteasome pathway.en_US
dc.format.extent490849 bytes
dc.format.extent3109 bytes
dc.format.mimetypeapplication/pdf
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dc.publisherBlackwell Publishing Ltden_US
dc.rights1999 American Society for Photobiologyen_US
dc.titleMolecular Mechanisms of Photoaging in Human Skin In Vivo and Their Prevention by All-Trans Retinoic Aciden_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelChemistryen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Dermatology, University of Michigan, Ann Arbor, Ml, USAen_US
dc.identifier.pmid10048311en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/73977/1/j.1751-1097.1999.tb03268.x.pdf
dc.identifier.doi10.1111/j.1751-1097.1999.tb03268.xen_US
dc.identifier.sourcePhotochemistry and Photobiologyen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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