Concentrations of fibronectin in the sera and crevicular fluid in various stages of periodontal disease *
dc.contributor.author | Lopatin, Dennis E. | en_US |
dc.contributor.author | Caffesse, Elena R. | en_US |
dc.contributor.author | Bye, Fred. L. | en_US |
dc.contributor.author | Caffesse, Raul G. | en_US |
dc.date.accessioned | 2010-06-01T21:00:41Z | |
dc.date.available | 2010-06-01T21:00:41Z | |
dc.date.issued | 1989-07 | en_US |
dc.identifier.citation | Lopatin, Dennis E.; Caffesse, Elena R.; Bye, Fred. L.; Caffesse, Raul G. (1989). "Concentrations of fibronectin in the sera and crevicular fluid in various stages of periodontal disease * ." Journal of Clinical Periodontology 16(6): 359-364. <http://hdl.handle.net/2027.42/74103> | en_US |
dc.identifier.issn | 0303-6979 | en_US |
dc.identifier.issn | 1600-051X | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/74103 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2668348&dopt=citation | en_US |
dc.description.abstract | . While fibronectin (FN) has previously been demonstrated to be present in gingival crevicular fluid (GCF), its quality and quantity has not been reported. Since this information is relevant for ongoing studies on the use of FN for gingival reattachment, we performed these measurements and compared plasma levels in healthy subjects, patients with gingivitis and periodontitis, and in patients undergoing maintenance therapy. Plasma and GCF samples were obtained from 4 sites in each subject using a Periotron to permit quantification of samples. FN concentrations were determined in a microELISA using hyperimmune anti-FN antibody. Purified FN served as a reference for quantification. The functional activity of each sample was assessed by examining the natural affinity of FN for gelatin. Subjects with gingivitis and those in maintenance had significantly depressed levels of plasma fibronectin. While little fibronectin could be detected in the GCF of healthy sites regardless of patient category, examination of the most diseased sites in each group revealed that the concentration of FN in the GCF was highest in health and reduced when there was gingival inflammation. In no case was GCF FN found to be biologically active. | en_US |
dc.format.extent | 1599630 bytes | |
dc.format.extent | 3109 bytes | |
dc.format.mimetype | application/octet-stream | |
dc.format.mimetype | text/plain | |
dc.publisher | Blackwell Publishing Ltd | en_US |
dc.rights | Munksgaard 1989 | en_US |
dc.subject.other | Fibronectin | en_US |
dc.subject.other | Gingival Crevicular Fluid | en_US |
dc.subject.other | Plasma | en_US |
dc.subject.other | EIISA | en_US |
dc.title | Concentrations of fibronectin in the sera and crevicular fluid in various stages of periodontal disease * | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Dentistry | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Oral Biology, School of Dentistry, The University of Michigan, Ann Arbor, Michigan 48109-0402, USA | en_US |
dc.contributor.affiliationum | Department of Periodontics, School of Dentistry, The University of Michigan, Ann Arbor, Michigan 48109-0402, USA | en_US |
dc.contributor.affiliationum | The Dental Research Institute, School of Dentistry, The University of Michigan, Ann Arbor, Michigan 48109-0402, USA | en_US |
dc.identifier.pmid | 2668348 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/74103/1/j.1600-051X.1989.tb00005.x.pdf | |
dc.identifier.doi | 10.1111/j.1600-051X.1989.tb00005.x | en_US |
dc.identifier.source | Journal of Clinical Periodontology | en_US |
dc.identifier.citedreference | Babu, J. P. Simpson, W. A., Courtney, H. S. & Beachey, E.H. ( 1983 ) Interaction of human plasma fibronectin with cariogenic and non-cariogenic oral streptococci, Infect. Immunity 162 – 168. | en_US |
dc.identifier.citedreference | Blumenstock, F., Saba, T., Weber, P., Laffin, R. ( 1978 ) Biochemical and immunological characterization of human opsonic alpha 2 SB glycoprotein: its identity with cold-insoluble globulin. J. Biol. Chem. 253, 4287 – 4291. | en_US |
dc.identifier.citedreference | Brodin, B. von Schenck, H., Schildt, B. & Liljedahl, S. ( 1984 ) Low plasma fibronectin indicates septicaemia in major burns. Acta. Chir. Scantl 150, 5 – 11. | en_US |
dc.identifier.citedreference | Caffesse, R. G., Holden, M. J-, Kon, S. & Nasjleti, C. E. ( 1985 ) The effect of citric acid and fibronectin application on healing following surgical treatment of naturally occurring periodontal disease in Beagle dogs. J. Clin. Perio. 12, 578 – 590. | en_US |
dc.identifier.citedreference | Dejgaard, A., Andersen, T. Christoffersen, R. Clemmensen, I. & Gluud, C. ( 1984 ) Plasma fibronectin concentrations in morbidly obese patients. Scand, J. Clin, Lab, Invent. 44, 207 – 210. | en_US |
dc.identifier.citedreference | Gerdes, J., Yoder, M., Douglas, S. & Poulin, R. ( 1983 ) Decreased plasma fibronectin in neonatal sepsis. Pediatrics 72, 877 – 881. | en_US |
dc.identifier.citedreference | Grossman, J., Pohlman, T. Koerner, F. & Mosher, D. ( 1983 ) Plasma fibronectin concentration in animal models of sepsis and endotoxemia. J. Surg. Res. 34, 145 – 150. | en_US |
dc.identifier.citedreference | Imai, S., Okahashi, N., Koga, T., Nisizawa, T. & Hamada, S. ( 1984 ) Ability of various oral bacteria to bind human plasma fibronectin. Microbiol. Immunol. 28, 863 – 871. | en_US |
dc.identifier.citedreference | Loesche, W. J., Syed, S. A., Schmidt, E. & Morrison, E. C. ( 1985 ) Bacterial profiles of subgingival plaques in periodontitis. J. Periodontol. 56, 447 – 456. | en_US |
dc.identifier.citedreference | Marchase, R., Vosbeck, K. & Roth, S. ( 1976 ) Intercellular adhesive specificity. Biochem. Biophys. ACTA 457, 385 – 415. | en_US |
dc.identifier.citedreference | McDonald, J. A. & Kelley, D. G. ( 1980 ) Degradation of fibronectin by human leukocyte elastase. J. Biot. Chem. 225, 8848 – 8858. | en_US |
dc.identifier.citedreference | Morrison, P. R., Edsall, J- T. & Miller, S. G. ( 1948 ) Preparation and properties of serum and plasma proteins XIIX. The separation of purified fibrinogen from fraction I of human plasma. J. Amer. Chem. Soc. 70, 3103 – 3108. | en_US |
dc.identifier.citedreference | Mosesson, M. W. & Atnrani, D. L. ( 1980 ) The structure and biological activities of plasma fibronectin. Blood 56, 145 – 158. | en_US |
dc.identifier.citedreference | Mosher, D. & Williams, E. ( 1978 ) Fibronectin concentration is decreased in plasma of severely ill patients with disseminated intravascular coagulation. J. Lab. dm. Med. 91, 792 – 735. | en_US |
dc.identifier.citedreference | Mosher, D. ( 1984 ) Physiology of fibronectin- Am. Rev. Med. 35 561 – 575. | en_US |
dc.identifier.citedreference | Nasjleti, C. E., Caffesse, R. G., Castelli, W. A., Lopatin, D. E. & Kowalski, C. J. ( 1986 ) Effect of lyophilized autologous plasma on periodontal healing of replanted teeth. J. Periodontol. 57, 568 – 78. | en_US |
dc.identifier.citedreference | Nasjleli, C. E., Caffessc, R. G., Castelli, W. A., Lopatin, D. E. & Kowalski, C. J. ( 1987 ) Effect of fibronectin on healing of replanted teeth in monkeys: A histologic and autoradiographic study. Oral Surg. 63, 291 – 299. | en_US |
dc.identifier.citedreference | Porvaznik, M., Cohen, M. E., Bockowski, S. W., Mueller, E. J. & Wirthlin, M. R. ( 1982 ) Enhancement of cell attachment to a stubstrate coated with oral bacterial endotoxin by plasma fibronectin. J. Perio. Res. 17, 154 – 168. | en_US |
dc.identifier.citedreference | Ramfjord, S. P. ( 1967 ) The periodontal disease index (PDI). J. Periodontol. 38, 602 – 610. | en_US |
dc.identifier.citedreference | Ruoslahti, E., Engvall, E. & Hayman, E. ( 1981 ) Fibronectin: Current concepts of its structure and functions. Coll. Res. 1, 95 – 128. | en_US |
dc.identifier.citedreference | Ryan, P. C., Waring, C. & Seymour, G. J. ( 1987 ) Periodontal healing with citric acid and fibronectin treatment in cats. Aust. Dental Journ. 32, 99 – 103. | en_US |
dc.identifier.citedreference | Schroeder, H. E. ( 1977 ) Histopathology of the gingival sulcus. In: ( ed.) Lehner, T.: The borderland between caries and periodontal disease, pp. 43 – 78, London: Academic Press, pp. 3 – 78. | en_US |
dc.identifier.citedreference | Scott, D. L., Farr, M., Crockson, A. P. & Walton, K. W. ( 1981a ) Synovial fluid and plasma fibronectin levels in rheumatoid arthritis. Clin. Sci. 62, 71 – 76. | en_US |
dc.identifier.citedreference | Scott, D. L., Wainwright, A. C., Walton, K. W. & Williamson, N. ( 1981b ) Significance of fibronectin in rheumatoid arthritis and osteoarthritis. Ann. Rheum. Dis. 40, 142 – 153. | en_US |
dc.identifier.citedreference | Selmer, J., Eriksen, H. & Gemmensen, I. ( 1984 ) Native and degraded fibronectin: new immunological methods for distinction. Scan, J. Clin. Lab. Invest. 44, 57 – 63. | en_US |
dc.identifier.citedreference | Silness, J. and Loe, H- ( 1964 ) Periodontal disease in pregnancy. II. Correlation between oral hygiene and periodontal condition. Acta Odontol Scand, 121 – 135. | en_US |
dc.identifier.citedreference | Slots, J. ( 1979 ) Subgingival microflora and periodontal disease. J. Clin. Periodontol. 6, 51 – 382. | en_US |
dc.identifier.citedreference | Smith, B. A., Smith, J. S., Caffesse, R. G., Nasjleti, C. E., Lopatin, D. E. & Kowalski, C. J. ( 1987 ) Effect of citric acid and various concentrations of fibronectin on healing after periodontal flap surgery. J. Periodontol. 58, 667 – 673. | en_US |
dc.identifier.citedreference | Stanislawski, L., Simpson, A., Hasty, D., Sharon, N., Beachy, E. & Ofek, I. ( 1985 ) Role of fibronectin in attachment of streptococcus pyogenes and Escherichia coli to human cell lines and isolated oral epithelial cells. Infect. Immun 48, 257 – 259. | en_US |
dc.identifier.citedreference | Stathakis, N. E., Founias, A. & Tsianos, E. ( 1981 ) Plasma fibronectin in normal subjects and in various disease states. J. Clin. Pathol. 34, 504 – 508. | en_US |
dc.identifier.citedreference | Terranova, V. & Martin, S. ( 1982 ) Molecular factors determining gingival tissue interactions with tooth structure. J. Periodont. Res. 17, 530 – 533. | en_US |
dc.identifier.citedreference | Tynelius-Bratthall, G., Ericson, D. & Araujo, H. ( 1986 ) Fibronectin in saliva and gingival crevices. J. Periodont. Res. 21, 563 – 568. | en_US |
dc.identifier.citedreference | Vuento, M. & Vaheri, A. ( 1979 ) Purification of fibronectin from human plasma by affinity chromatography under non-denaturing conditions. Biochem, J. 183, 331 – 337. | en_US |
dc.identifier.citedreference | Wikstrom, M. & Linde, A. ( 1986 ) Ability of oral bacteria to degrade fibronectin. Infect. Immun. 51, 707 – 711. | en_US |
dc.identifier.citedreference | Yamada, K. U., Hasegawa, T., Hasegawa, E., Kennedy, D. W., Hirano, H., Hayashi, M., Akiyama, S. K. & Olden, K. ( 1984 ) Fibronectin and interactions at the cell surface. Prog. Clin. Biol. Res. 151, 1 – 15. | en_US |
dc.identifier.citedreference | Yamada, K., Yamada, S. & Pastan, I. ( 1976 ) Cell surface protein partially restored morphology, adhesiveness and contact inhibition of movement Lo transformed fibroblasts. Proc. Natl. Acad. Sci. USA 73, 1217 – 1221. | en_US |
dc.identifier.citedreference | Yamada, M., Akiyama, S. K., Hasegawa, T., Hasegawa, E., Humphries, M., Kennedy, D. Nagata, K., Urushihara, H., Olden, K. & Chen, W. ( 1985 ) Recent advances in research on fibronectin and other cell attachment proteins. J. Cell. Biochem. 28, 79 – 97. | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.