The Endocrinology of the Reproductive Years
dc.contributor.author | Randolph Jr, John F. | en_US |
dc.date.accessioned | 2010-06-01T21:10:00Z | |
dc.date.available | 2010-06-01T21:10:00Z | |
dc.date.issued | 2008-10 | en_US |
dc.identifier.citation | Randolph Jr, John F. (2008). "The Endocrinology of the Reproductive Years." Journal of Sexual Medicine 5(10): 2274-2281. <http://hdl.handle.net/2027.42/74248> | en_US |
dc.identifier.issn | 1743-6095 | en_US |
dc.identifier.issn | 1743-6109 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/74248 | |
dc.description.abstract | Introduction. The relationship between reproductive physiology and reproductive behavior, a central theme in Professor Lorraine Dennerstein's career, is complex but presumably serves to optimize human reproduction. Aim. To review the endocrinology of the reproductive years and significant work by Professor Dennerstein relating that endocrinology with reproductive behavior. Methods/Main Outcome Measures. Published works of reproductive endocrinology by Professor Dennerstein. Results. An exquisitely controlled signaling loop between the ovaries and the hypothalamus and pituitary in the brain represents the overlay of a dynamic neuroendocrine system on a responsive but ultimately decaying gonadal system. The most visible hallmark of this elegant interplay is the menstrual cycle, with coordinated hormone patterns directing the maturation and release of oocytes, and either supporting an early pregnancy or resetting the system for the next cycle. The recognition that these hormone patterns, or their perturbation, are related to psychosocial behaviors is reflected in Professor Dennerstein's earliest writings relating sex steroids to sexual behavior and menstrual cycles to affect, leading to studies describing psychological symptoms in the premenstrual syndrome (PMS). These were followed by clinical trials of progestins for PMS with conflicting results, and an emerging interest in measuring endogenous hormones in that disorder. Her study of reproductive hormones across the menstrual cycle in women with PMS definitively refuted the theory that deficient progesterone secretion was the etiology of cyclic symptoms. Extension of that work demonstrated the cyclic pattern of sexual behavior, but the absence of a defined relationship with measured sex steroid patterns. Her interest in the effect of age on menstrual cyclicity evolved into her landmark work on the menopausal transition, the ultimate result of ovarian gamete depletion and absolute loss of spontaneous reproductive capacity. Conclusion. Professor Dennerstein clearly demonstrated that reproductive behavior is related to reproductive physiology, and can be measured and quantified. Randolph JF Jr. The endocrinology of the reproductive years. J Sex Med 2008;5:2274–2281. | en_US |
dc.format.extent | 144581 bytes | |
dc.format.extent | 3109 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Blackwell Publishing Inc | en_US |
dc.rights | © 2008 International Society for Sexual Medicine | en_US |
dc.subject.other | Menstrual Cycle | en_US |
dc.subject.other | Premenstrual Syndrome | en_US |
dc.subject.other | Reproductive Hormones | en_US |
dc.title | The Endocrinology of the Reproductive Years | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Medicine (General) | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/74248/1/j.1743-6109.2008.00919.x.pdf | |
dc.identifier.doi | 10.1111/j.1743-6109.2008.00919.x | en_US |
dc.identifier.source | Journal of Sexual Medicine | en_US |
dc.identifier.citedreference | Messinis IE. Ovarian feedback, mechanism of action and possible clinical implications. Hum Reprod Update 2006; 12: 557 – 71. | en_US |
dc.identifier.citedreference | Dennerstein L, Burrows G. Oral contraception and sexuality. Med J Aust 1976; 1: 796 – 8. | en_US |
dc.identifier.citedreference | Dennerstein L, Burrows GD. Affect and the menstrual cycle. J Affect Disord 1979; 1: 77 – 92. | en_US |
dc.identifier.citedreference | Dennerstein L, Judd F, Davies B. Psychosis and the menstrual cycle. Med J Aust 1983; 1: 524 – 6. | en_US |
dc.identifier.citedreference | Dennerstein L, Spencer-Gardner C, Gotts G, Brown JB, Smith MA, Burrows GD. Progesterone and the premenstrual syndrome: A double blind crossover trial. Br Med J (Clin Res Ed) 1985; 290: 1617 – 21. | en_US |
dc.identifier.citedreference | Dennerstein L, Morse C, Gotts G, Brown J, Smith M, Oats J, Burrows G. Treatment of premenstrual syndrome. A double-blind trial of dydrogesterone. J Affect Disord 1986; 11: 199 – 205. | en_US |
dc.identifier.citedreference | Dennerstein L, Morse C, Burrows G, Oats J, Brown J, Smith M. Menstrual migraine: A double-blind trial of percutaneous estradiol. Gynecol Endocrinol 1988; 2: 113 – 20. | en_US |
dc.identifier.citedreference | Dennerstein L, Burrows GD, Wood C, Poynton C. The development of a scale for the assessment of sexual behaviour in Australian women. Aust N Z J Psychiatry 1977; 11: 233 – 40. | en_US |
dc.identifier.citedreference | Watts S, Dennerstein L, Horne DJ. The premenstrual syndrome. A psychological evaluation. J Affect Disord 1980; 2: 257 – 66. | en_US |
dc.identifier.citedreference | Morse CA, Dennerstein L, Varnavides K, Burrows GD. Menstrual cycle symptoms: Comparison of a non-clinical sample with a patient group. J Affect Disord 1988; 14: 41 – 50. | en_US |
dc.identifier.citedreference | Dennerstein L, Brown JB, Gotts G, Morse CA, Farley TM, Pinol A. Menstrual cycle hormonal profiles of women with and without premenstrual syndrome. J Psychosom Obstet Gynecol 1993; 14: 259 – 68. | en_US |
dc.identifier.citedreference | Dennerstein L, Gotts G, Brown JB, Morse CA, Farley TM, Pinol A. The relationship between the menstrual cycle and female sexual interest in women with PMS complaints and volunteers. Psychoneuroendocrinology 1994; 19: 293 – 304. | en_US |
dc.identifier.citedreference | Dennerstein L, Gotts G, Brown JB. Effects of age and non-hormonal contraception on menstrual cycle characteristics. Gynecol Endocrinol 1997; 11: 127 – 33. | en_US |
dc.identifier.citedreference | Morse CA, Dudley E, Guthrie J, Dennerstein L. Relationships between premenstrual complaints and perimenopausal experiences. J Psychosom Obstet Gynecol 1998; 19: 182 – 91. | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.