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A Clinical Trial of Gene Therapy for Chronic Pain
dc.contributor.authorWolfe, Darrenen_US
dc.contributor.authorWechuck, Jamesen_US
dc.contributor.authorKrisky, Daviden_US
dc.contributor.authorMata, Marinaen_US
dc.contributor.authorFink, David J.en_US
dc.date.accessioned2010-06-01T21:17:56Z
dc.date.available2010-06-01T21:17:56Z
dc.date.issued2009-10en_US
dc.identifier.citationWolfe, Darren; Wechuck, James; Krisky, David; Mata, Marina; Fink, David J. (2009). "A Clinical Trial of Gene Therapy for Chronic Pain." Pain Medicine 10(7): 1325-1330. <http://hdl.handle.net/2027.42/74369>en_US
dc.identifier.issn1526-2375en_US
dc.identifier.issn1526-4637en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/74369
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=19818042&dopt=citationen_US
dc.description.abstractThe first human trial of gene therapy for chronic pain, a phase 1 study of a nonreplicating herpes simplex virus (HSV)-based vector engineered to express preproenkephalin in patients with intractable pain from cancer, began enrolling subjects in December 2008. In this article, we describe the rationale underlying this potential approach to treatment of pain, the preclinical animal data in support of this approach, the design of the study, and studies with additional HSV-based vectors that may be used to develop treatment for other types of pain.en_US
dc.format.extent122356 bytes
dc.format.extent3109 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherBlackwell Publishing Incen_US
dc.rights© 2009 American Academy of Pain Medicineen_US
dc.subject.otherPain Managementen_US
dc.subject.otherPersistent Painen_US
dc.subject.otherNeurologyen_US
dc.subject.otherTherapyen_US
dc.titleA Clinical Trial of Gene Therapy for Chronic Painen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelMedicine (General)en_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumUniversity of Michigan and Ann Arbor VA Healthcare System, Ann Arbor, Michigan, USAen_US
dc.contributor.affiliationother* Diamyd Inc., Pittsburgh, Pennsylvania;en_US
dc.identifier.pmid19818042en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/74369/1/j.1526-4637.2009.00720.x.pdf
dc.identifier.doi10.1111/j.1526-4637.2009.00720.xen_US
dc.identifier.sourcePain Medicineen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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