Pavlovian fear conditioning as a behavioral assay for hippocampus and amygdala function: cautions and caveats
dc.contributor.author | Maren, Stephen | en_US |
dc.date.accessioned | 2010-06-01T21:24:21Z | |
dc.date.available | 2010-06-01T21:24:21Z | |
dc.date.issued | 2008-10 | en_US |
dc.identifier.citation | Maren, Stephen (2008). "Pavlovian fear conditioning as a behavioral assay for hippocampus and amygdala function: cautions and caveats." European Journal of Neuroscience 28(8): 1661-1666. <http://hdl.handle.net/2027.42/74466> | en_US |
dc.identifier.issn | 0953-816X | en_US |
dc.identifier.issn | 1460-9568 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/74466 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=18973583&dopt=citation | en_US |
dc.format.extent | 130087 bytes | |
dc.format.extent | 3109 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Blackwell Publishing Ltd | en_US |
dc.rights | Journal compilation © 2008 Federation of European Neuroscience Societies and Blackwell Publishing Ltd | en_US |
dc.subject.other | Behavioral Assay | en_US |
dc.subject.other | Context | en_US |
dc.subject.other | Cue | en_US |
dc.subject.other | Fear Responses | en_US |
dc.subject.other | Learning | en_US |
dc.title | Pavlovian fear conditioning as a behavioral assay for hippocampus and amygdala function: cautions and caveats | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.identifier.pmid | 18973583 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/74466/1/j.1460-9568.2008.06485.x.pdf | |
dc.identifier.doi | 10.1111/j.1460-9568.2008.06485.x | en_US |
dc.identifier.source | European Journal of Neuroscience | en_US |
dc.identifier.citedreference | Abel, T., Nguyen, P.V., Barad, M., Deuel, T.A., Kandel, E.R. & Bourtchouladze, R. ( 1997 ) Genetic demonstration of a role for PKA in the late phase of LTP and in hippocampus-based long-term memory. Cell, 88, 615 – 626. | en_US |
dc.identifier.citedreference | Anagnostaras, S.G., Maren, S., Sage, J.R., Goodrich, S. & Fanselow, M.S. ( 1999 ) Scopolamine and Pavlovian fear conditioning in rats: dose-effect analysis. Neuropsychopharmacol., 21, 731 – 744. | en_US |
dc.identifier.citedreference | Anagnostaras, S.G., Josselyn, S.A., Frankland, P.W. & Silva, A.J. ( 2000 ) Computer-assisted behavioral assessment of pavlovian fear conditioning in mice. Learn. Mem., 7, 58 – 72. | en_US |
dc.identifier.citedreference | Anagnostaras, S.G., Murphy, G.G., Hamilton, S.E., Mitchell, S.L., Rahnama, N.P., Nathanson, N.M. & Silva, A.J. ( 2003 ) Selective cognitive dysfunction in acetylcholine M1 muscarinic receptor mutant mice. Nat. Neurosci., 6, 51 – 58. | en_US |
dc.identifier.citedreference | Anglada-Figueroa, D. & Quirk, G.J. ( 2005 ) Lesions of the basal amygdala block expression of conditioned fear but not extinction. J. Neurosci., 25, 9680 – 9685. | en_US |
dc.identifier.citedreference | Antoniadis, E.A. & McDonald, R.J. ( 2000 ) Amygdala, hippocampus and discriminative fear conditioning to context. Behav. Brain Res., 108, 1 – 19. | en_US |
dc.identifier.citedreference | Blair, H.T., Schafe, G.E., Bauer, E.P., Rodrigues, S.M. & LeDoux, J.E. ( 2001 ) Synaptic plasticity in the lateral amygdala: A cellular hypothesis of fear conditioning. Learn. Mem., 8, 229 – 242. | en_US |
dc.identifier.citedreference | Blanchard, D.C. & Blanchard, R.J. ( 1972 ) Innate and conditioned reactions to threat in rats with amygdaloid lesions. J. Comp. Physiol. Psychol., 81, 281 – 290. | en_US |
dc.identifier.citedreference | Blanchard, R.J., Fukunaga, K.K. & Blanchard, D.C. ( 1976a ) Environmental-control of defensive reactions to a cat. Bull. Psychon. Soc., 8, 179 – 181. | en_US |
dc.identifier.citedreference | Blanchard, R.J., Fukunaga, K.K. & Blanchard, D.C. ( 1976b ) Environmental-control of defensive reactions to footshock. Bull. Psychon. Soc., 8, 129 – 130. | en_US |
dc.identifier.citedreference | Blanchard, D.C., Blanchard, R.J., Lee, E.M.C. & Fukunaga, K.K. ( 1977 ) Movement arrest and the hippocampus. Physiol. Psychol., 5, 331 – 335. | en_US |
dc.identifier.citedreference | Bolles, R.C. ( 1970 ) Species-specific defense reactions and avoidance learning. Psychol. Rev., 77, 32 – 48. | en_US |
dc.identifier.citedreference | Bolles, R.C. & Collier, A.C. ( 1976 ) Effect of predictive cues on freezing in rats. Anim. Learn. Behav., 4, 6 – 8. | en_US |
dc.identifier.citedreference | Bouton, M.E., Mineka, S. & Barlow, D.H. ( 2001 ) A modern learning theory perspective on the etiology of panic disorder. Psychol. Rev., 108, 4 – 32. | en_US |
dc.identifier.citedreference | Burman, M.A., Starr, M.J. & Gewirtz, J.C. ( 2006 ) Dissociable effects of hippocampus lesions on expression of fear and trace fear conditioning memories in rats. Hippocampus, 16, 103 – 113. | en_US |
dc.identifier.citedreference | Cho, Y.H., Friedman, E. & Silva, A.J. ( 1999 ) Ibotenate lesions of the hippocampus impair spatial learning but not contextual fear conditioning in mice. Behav. Brain Res., 98, 77 – 87. | en_US |
dc.identifier.citedreference | Choi, J.S. & Brown, T.H. ( 2003 ) Central amygdala lesions block ultrasonic vocalization and freezing as conditional but not unconditional responses. J. Neurosci., 23, 8713 – 8721. | en_US |
dc.identifier.citedreference | Corcoran, K.A., Lu, Y., Turner, R.S. & Maren, S. ( 2002 ) Overexpression of hAPPswe impairs rewarded alternation and contextual fear conditioning in a transgenic mouse model of Alzheimer’s disease. Learn. Mem., 9, 243 – 252. | en_US |
dc.identifier.citedreference | Davis, M. ( 1992 ) The role of the amygdala in fear and anxiety. Annu. Rev. Neurosci., 15, 353 – 375. | en_US |
dc.identifier.citedreference | Estes, W.K. & Skinner, B.F. ( 1941 ) Some quantitative properties of anxiety. J. Exp. Psychol., 29, 390. | en_US |
dc.identifier.citedreference | Fanselow, M.S. ( 1984 ) Shock-induced analgesia on the formalin test: effects of shock severity, naloxone, hypophysectomy, and associative variables. Behav. Neurosci., 98, 79 – 95. | en_US |
dc.identifier.citedreference | Fanselow, M.S. ( 1986 ) Associative vs topographical accounts of the immediate shock-freezing deficit in rats: Implications for the response selection rules governing species-specific defensive reactions. Learn. Motiv., 17, 16 – 39. | en_US |
dc.identifier.citedreference | Fanselow, M.S. & Lester, L.S. ( 1988 ) A functional behavioristic approach to aversively motivated behavior: Predatory imminence as a determinant of the topography of defensive behavior. In Bolles, R.C. & Beecher, M.D. ( eds ), Evolution and Learning. Erlbaum, Hillsdale, NJ, pp. 185 – 211. | en_US |
dc.identifier.citedreference | Fanselow, M.S. & Poulos, A.M. ( 2005 ) The neuroscience of mammalian associative learning. Annu. Rev. Psychol., 56, 207 – 234. | en_US |
dc.identifier.citedreference | Frankland, P.W., Cestari, V., Filipkowski, R.K., McDonald, R.J. & Silva, A.J. ( 1998 ) The dorsal hippocampus is essential for context discrimination but not for contextual conditioning. Behav. Neurosci., 112, 863 – 874. | en_US |
dc.identifier.citedreference | Fu, Y. & Shinnick-Gallagher, P. ( 2005 ) Two intra-amygdaloid pathways to the central amygdala exhibit different mechanisms of long-term potentiation. J. Neurophysiol., 93, 3012 – 3015. | en_US |
dc.identifier.citedreference | Gerlai, R. ( 2001 ) Behavioral tests of hippocampal function: simple paradigms complex problems. Behav. Brain Res., 125, 269 – 277. | en_US |
dc.identifier.citedreference | Goosens, K.A. & Maren, S. ( 2001 ) Contextual and auditory fear conditioning are mediated by the lateral, basal, and central amygdaloid nuclei in rats. Learn. Mem., 8, 148 – 155. | en_US |
dc.identifier.citedreference | Goosens, K.A. & Maren, S. ( 2002 ) Long-term potentiation as a substrate for memory: evidence from studies of amygdaloid plasticity and Pavlovian fear conditioning. Hippocampus, 12, 592 – 599. | en_US |
dc.identifier.citedreference | Goosens, K.A. & Maren, S. ( 2003 ) Pretraining NMDA receptor blockade in the basolateral complex, but not the central nucleus, of the amygdala prevents savings of conditional fear. Behav. Neurosci., 117, 738 – 750. | en_US |
dc.identifier.citedreference | Hirsh, R. ( 1974 ) The hippocampus and contextual retrieval of information from memory: a theory. Behav. Biol., 12, 421 – 444. | en_US |
dc.identifier.citedreference | Hitchcock, J. & Davis, M. ( 1986 ) Lesions of the amygdala, but not of the cerebellum or red nucleus, block conditioned fear as measured with the potentiated startle paradigm. Behav. Neurosci., 100, 11 – 22. | en_US |
dc.identifier.citedreference | Holt, W. & Maren, S. ( 1999 ) Muscimol inactivation of the dorsal hippocampus impairs contextual retrieval of fear memory. J. Neurosci., 19, 9054 – 9062. | en_US |
dc.identifier.citedreference | Kamprath, K. & Wotjak, C.T. ( 2004 ) Nonassociative learning processes determine expression and extinction of conditioned fear in mice. Learn. Mem., 11, 770 – 786. | en_US |
dc.identifier.citedreference | Kapp, B.S., Frysinger, R.C., Gallagher, M. & Haselton, J.R. ( 1979 ) Amygdala central nucleus lesions: effect on heart rate conditioning in the rabbit. Physiol. Behav., 23, 1109 – 1117. | en_US |
dc.identifier.citedreference | Kellicutt, M.H. & Schwartzbaum, J.S. ( 1963 ) Formation of a conditioned emotional response (CER) following lesions of the amygdaloid complex in rats. Psychol. Rep., 12, 351 – 358. | en_US |
dc.identifier.citedreference | Kim, J.J. & Fanselow, M.S. ( 1992 ) Modality-specific retrograde amnesia of fear. Science, 256, 675 – 677. | en_US |
dc.identifier.citedreference | Kim, J.J., Rison, R.A. & Fanselow, M.S. ( 1993 ) Effects of amygdala, hippocampus, and periaqueductal gray lesions on short- and long-term contextual fear. Behav. Neurosci., 107, 1093 – 1098. | en_US |
dc.identifier.citedreference | Kim, J.J., Clark, R.E. & Thompson, R.F. ( 1995 ) Hippocampectomy impairs the memory of recently, but not remotely, acquired trace eyeblink conditioned-responses. Behav. Neurosci., 109, 195 – 203. | en_US |
dc.identifier.citedreference | Leaton, R.N. & Borszcz, G.S. ( 1985 ) Potentiated startle – its relation to freezing and shock-intensity in rats. J. Exp. Psychol. Anim. B, 11, 421 – 428. | en_US |
dc.identifier.citedreference | LeDoux, J.E. ( 2000 ) Emotion circuits in the brain. Annu. Rev. Neurosci., 23, 155 – 184. | en_US |
dc.identifier.citedreference | LeDoux, J.E., Sakaguchi, A. & Reis, D.J. ( 1984 ) Subcortical efferent projections of the medial geniculate nucleus mediate emotional responses conditioned to acoustic stimuli. J. Neurosci., 4, 683 – 698. | en_US |
dc.identifier.citedreference | Lee, T. & Kim, J.J. ( 2004 ) Differential effects of cerebellar, amygdalar, and hippocampal lesions on classical eyeblink conditioning in rats. J. Neurosci., 24, 3242 – 3250. | en_US |
dc.identifier.citedreference | Lee, H.J., Choi, J.S., Brown, T.H. & Kim, J.J. ( 2001 ) Amygdalar NMDA receptors are critical for the expression of multiple conditioned fear responses. J. Neurosci., 21, 4116 – 4124. | en_US |
dc.identifier.citedreference | Maren, S. ( 1998 ) Overtraining does not mitigate contextual fear conditioning deficits produced by neurotoxic lesions of the basolateral amygdala. J. Neurosci., 18, 3088 – 3097. | en_US |
dc.identifier.citedreference | Maren, S. ( 1999a ) Long-term potentiation in the amygdala: a mechanism for emotional learning and memory. Trends Neurosci., 22, 561 – 567. | en_US |
dc.identifier.citedreference | Maren, S. ( 1999b ) Neurotoxic basolateral amygdala lesions impair learning and memory but not the performance of conditional fear in rats. J. Neurosci., 19, 8696 – 8703. | en_US |
dc.identifier.citedreference | Maren, S. ( 2001a ) Is there savings for Pavlovian fear conditioning after neurotoxic basolateral amygdala lesions in rats? Neurobiol. Learn. Mem., 76, 268 – 283. | en_US |
dc.identifier.citedreference | Maren, S. ( 2001b ) Neurobiology of Pavlovian fear conditioning. Annu. Rev. Neurosci., 24, 897 – 931. | en_US |
dc.identifier.citedreference | Maren, S. & Fanselow, M.S. ( 1997 ) Electrolytic lesions of the fimbria/fornix, dorsal hippocampus, or entorhinal cortex produce anterograde deficits in contextual fear conditioning in rats. Neurobiol. Learn. Mem., 67, 142 – 149. | en_US |
dc.identifier.citedreference | Maren, S. & Holt, W.G. ( 2004 ) Hippocampus and Pavlovian fear conditioning in rats: muscimol infusions into the ventral, but not dorsal, hippocampus impair the acquisition of conditional freezing to an auditory conditional stimulus. Behav. Neurosci., 118, 97 – 110. | en_US |
dc.identifier.citedreference | Maren, S. & Quirk, G.J. ( 2004 ) Neuronal signalling of fear memory. Nat. Rev. Neurosci., 5, 844 – 852. | en_US |
dc.identifier.citedreference | Maren, S., Aharonov, G. & Fanselow, M.S. ( 1997 ) Neurotoxic lesions of the dorsal hippocampus and Pavlovian fear conditioning in rats. Behav. Brain Res., 88, 261 – 274. | en_US |
dc.identifier.citedreference | Maren, S., Anagnostaras, S.G. & Fanselow, M.S. ( 1998 ) The startled seahorse: Is the hippocampus necessary for contextual fear conditioning? Trends Cogn. Sci., 2, 39 – 42. | en_US |
dc.identifier.citedreference | Matus-Amat, P., Higgins, E.A., Barrientos, R.M. & Rudy, J.W. ( 2004 ) The role of the dorsal hippocampus in the acquisition and retrieval of context memory representations. J. Neurosci., 24, 2431 – 2439. | en_US |
dc.identifier.citedreference | McNish, K.A., Gewirtz, J.C. & Davis, M. ( 1997 ) Evidence of contextual fear after lesions of the hippocampus: a disruption of freezing but not fear-potentiated startle. J. Neurosci., 17, 9353 – 9360. | en_US |
dc.identifier.citedreference | Moyer, J.R. Jr, Deyo, R.A. & Disterhoft, J.F. ( 1990 ) Hippocampectomy disrupts trace eye-blink conditioning in rabbits. Behav. Neurosci., 104, 243 – 252. | en_US |
dc.identifier.citedreference | Murchison, C.F., Zhang, X.Y., Zhang, W.P., Ming, O.Y., Lee, A. & Thomas, S.A. ( 2004 ) A distinct role for norepinephrine in memory retrieval. Cell, 117, 131 – 143. | en_US |
dc.identifier.citedreference | Nader, K., Majidishad, P., Amorapanth, P. & LeDoux, J.E. ( 2001 ) Damage to the lateral and central, but not other, amygdaloid nuclei prevents the acquisition of auditory fear conditioning. Learn. Mem., 8, 156 – 163. | en_US |
dc.identifier.citedreference | O’Keefe, J. & Nadel, L. ( 1978 ) The hippocampus as a cognitive map. Oxford University Press, Clarendon Press, Oxford. | en_US |
dc.identifier.citedreference | ParÉ, D., Quirk, G.J. & Ledoux, J.E. ( 2004 ) New vistas on amygdala networks in conditioned fear. J. Neurophysiol., 92, 1 – 9. | en_US |
dc.identifier.citedreference | Penick, S. & Solomon, P.R. ( 1991 ) Hippocampus, context, and conditioning. Behav. Neurosci., 105, 611 – 617. | en_US |
dc.identifier.citedreference | Phillips, R.G. & LeDoux, J.E. ( 1992 ) Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning. Behav. Neurosci., 106, 274 – 285. | en_US |
dc.identifier.citedreference | Quinn, J.J., Oommen, S.S., Morrison, G.E. & Fanselow, M.S. ( 2002 ) Post-training excitotoxic lesions of the dorsal hippocampus attenuate forward trace, backward trace, and delay fear conditioning in a temporally specific manner. Hippocampus, 12, 495 – 504. | en_US |
dc.identifier.citedreference | Quinn, J.J., Wied, H.M., Ma, Q.D., Tinsley, M.R. & Fanselow, M.S. ( 2008 ) Dorsal hippocampus involvement in delay fear conditioning depends upon the strength of the tone-footshock association. Hippocampus, 18, 640 – 654. | en_US |
dc.identifier.citedreference | Rabenstein, R.L., Addy, N.A., Caldarone, B.J., Asaka, Y., Gruenbaum, L.M., Peters, L.L., Gilligan, D.M., Fitzsimonds, R.M. & Picciotto, M.R. ( 2005 ) Impaired synaptic plasticity and learning in mice lacking beta-adducin, an actin-regulating protein. J. Neurosci., 25, 2138 – 2145. | en_US |
dc.identifier.citedreference | Rabinak, C.A. & Maren, S. ( in press ) Associative structure of fear memory after basolateral amygdala lesions in rats. Behav. Neurosci.. | en_US |
dc.identifier.citedreference | Richmond, M.A., Yee, B.K., Pouzet, B., Veenman, L., Rawlins, J.N., Feldon, J. & Bannerman, D.M. ( 1999 ) Dissociating context and space within the hippocampus: effects of complete, dorsal, and ventral excitotoxic hippocampal lesions on conditioned freezing and spatial learning. Behav. Neurosci., 113, 1189 – 1203. | en_US |
dc.identifier.citedreference | Rudy, J.W., Huff, N.C. & Matus-Amat, P. ( 2004 ) Understanding contextual fear conditioning: insights from a two-process model. Neurosci. Biobehav. Rev., 28, 675 – 685. | en_US |
dc.identifier.citedreference | Samson, R.D. & ParÉ, D. ( 2005 ) Activity-dependent synaptic plasticity in the central nucleus of the amygdala. J. Neurosci., 25, 1847 – 1855. | en_US |
dc.identifier.citedreference | Schafe, G.E., Nader, K., Blair, H.T. & LeDoux, J.E. ( 2001 ) Memory consolidation of Pavlovian fear conditioning: a cellular and molecular perspective. Trends Neurosci., 24, 540 – 546. | en_US |
dc.identifier.citedreference | Schmajuk, N.A. ( 1984 ) Psychological theories of hippocampal function. Physiol. Psychol., 12, 166 – 183. | en_US |
dc.identifier.citedreference | Selden, N.R., Everitt, B.J., Jarrard, L.E. & Robbins, T.W. ( 1991 ) Complementary roles for the amygdala and hippocampus in aversive conditioning to explicit and contextual cues. Neuroscience, 42, 335 – 350. | en_US |
dc.identifier.citedreference | Solomon, P.R., Vander Schaaf, E.R., Thompson, R.F. & Weisz, D.J. ( 1986 ) Hippocampus and trace conditioning of the rabbit’s classically conditioned nictitating membrane response. Behav. Neurosci., 100, 729 – 744. | en_US |
dc.identifier.citedreference | Sutherland, R.J. & Rudy, J.W. ( 1989 ) Configural association theory: The role of the hippocampal formation in learning, memory, and amnesia. Psychobiol., 17, 129 – 144. | en_US |
dc.identifier.citedreference | Wilensky, A.E., Schafe, G.E., Kristensen, M.P. & LeDoux, J.E. ( 2006 ) Rethinking the fear circuit: the central nucleus of the amygdala is required for the acquisition, consolidation, and expression of Pavlovian fear conditioning. J. Neurosci., 26, 12387 – 12396. | en_US |
dc.identifier.citedreference | Wiltgen, B.J., Sanders, M.J., Anagnostaras, S.G., Sage, J.R. & Fanselow, M.S. ( 2006 ) Context fear learning in the absence of the hippocampus. J. Neurosci., 26, 5484 – 5491. | en_US |
dc.identifier.citedreference | Winocur, G., Rawlins, J.N. & Gray, J.A. ( 1987 ) The hippocampus and conditioning to contextual cues. Behav. Neurosci., 101, 617 – 625. | en_US |
dc.identifier.citedreference | Zimmerman, J.M., Rabinak, C.A., McLachlan, I.G. & Maren, S. ( 2007 ) The central nucleus of the amygdala is essential for acquiring and expressing conditional fear after overtraining. Learn. Mem., 14, 634 – 644. | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.